A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
In PLoS ONE, 2009
... (Tyr1146), insulin receptor β, Akt, phospho-Akt (Ser473), SAPK/JNK, phospho-SAPK/JNK (Thr183/Tyr185), phospho-GSK-3 (Ser21/9), and phosphor-serine636 of IRS-1 were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1.
Oullins, France. In Gen Comp Endocrinol, Feb 2016
Using a porcine model of spontaneous IUGR, we determined in utero (71, 112 days post-conception) and early-postnatal (2 days post-birth) IGF-1, insulin and leptin levels, and in parallel we investigated, in skeletal muscle, the developmental expression patterns of sirtuins and metabolic and signaling genes IRS1, GLUT4, HK2 and GAPDH.
Brain-derived neurotrophic factor and its clinical implications.
Vishākhapatnam, India. In Arch Med Sci, Jan 2016
BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival.
Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?
Roma, Italy. In Neurobiol Dis, Dec 2015
Indeed, postmortem AD brain shows all the signs of insulin resistance including: (i) reduced brain insulin receptor (IR) sensitivity, (ii) hypophosphorylation of the insulin receptor and downstream second messengers such as IRS-1, and (iii) attenuated insulin and insulin growth factor (IGF)-1 receptor expression.
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake.
Davis, United States. In Aging Cell, Aug 2015
IRS-1/s6K KO, mTOR inhibition) versus the important role of these signalling pathways in SkM growth and adaptation; (ii) the role of the sirtuins (SIRTs) in longevity versus their emerging role in SkM regeneration and survival under catabolic stress; (iii) the role of dietary restriction and its impact on longevity versus skeletal muscle mass regulation; (iv) the crosstalk between cellular energy metabolism (AMPK/TSC2/SIRT1) and survival (FOXO) versus growth and repair of SkM (e.g.
General aspects of muscle glucose uptake.
São Paulo, Brazil. In An Acad Bras Cienc, Mar 2015
The first, and widely investigated, is the insulin activated signaling pathway through insulin receptor substrate-1 and phosphatidylinositol 3-kinase.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Tehrān, Iran. In J Diabetes Res, 2014
We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications.
Connecting with an old partner in a new way.
Cambridge, United Kingdom. In Cancer Cell, 2013
In this issue of Cancer Cell, Hao and colleagues report a non-canonical interaction between the insulin receptor substrate 1 and certain oncogenic variants of the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K).