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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Iron-responsive element binding protein 2

IRP2, Iron Regulatory Protein 2
RNA-binding proteins that bind iron-responsive elements (IREs) [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Transferrin, CAN, ACID, HAD, transferrin receptor
Papers on IRP2
Characterization of avian pathogenic Escherichia coli isolated in eastern China.
Zou et al., Yangzhou, China. In Gene, Feb 2016
These isolates were characterized for serogroups (polymerase chain reaction and agglutination), the presence of virulence-associated genes (fimC, iss, ompA, fyuA, stx2f, iroC, iucD, hlyE, tsh, cvaC, irp2, and papC) and class I integrons (polymerase chain reaction), drug susceptibilities (disk diffusion method) and the biofilm-forming abilities (semi-quantitative method).
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Choi et al., New York City, United States. In Nat Med, Feb 2016
We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have shown that IRP2 protein is increased in the lungs of individuals with COPD.
Viability of Yersinia pestis subcultures in agar stabs.
Almeida et al., Recife, Brazil. In Lett Appl Microbiol, Jan 2016
Specifically, we found variation in the presence of plasmid and chromosomal virulence markers (genes pla, lcrV, caf1 and irp2) among multiple subcultures of Y. pestis strains in the 'Collection of Yersinia pestis' (Fiocruz-CYP) maintained by the SRP of FIOCRUZ-PE in Brazil.
Effects of ferrous carbamoyl glycine on iron state and absorption in an iron-deficient rat model.
Yin et al., Changsha, China. In Genes Nutr, Nov 2015
A comparison between Fe-CGly and FeSO4 group showed that iron regulatory protein 1 (IRP1) and iron regulatory protein (IRP2) expressions were reduced (P < 0.05) in rats administered FeSO4 than in rats administered with Fe-Cgly.
Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.
Rouault et al., Bethesda, United States. In Neurobiol Dis, Sep 2015
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that encode proteins involved in iron metabolism.
Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.
Iwai et al., Kyoto, Japan. In Immunol Rev, Jul 2015
Linear ubiquitinylation, a newly identified post-translational modification, is catalyzed by the linear ubiquitin assembly complex (LUBAC), which is composed of three different subunits, HOIL-1L (heme-oxidized IRP2 ligase 1L), HOIP (HOIL-1 interacting protein), and SHARPIN (SHANK-associated RH domain-interacting protein).
The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination.
Beyaert et al., Gent, Belgium. In Immunol Rev, Jul 2015
The E3 ubiquitin ligase HOIL-1 (heme-oxidized IRP2 ubiquitin ligase-1) is increasingly implicated in different signaling pathways and plays a vital role in immune regulation.
Iron regulatory proteins and their role in controlling iron metabolism.
Kühn, Lausanne, Switzerland. In Metallomics, Feb 2015
Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a central role in this regulation.
Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1.
Mochizuki et al., Suita, Japan. In Plos One, 2014
DMT1 and IRP2 were markedly upregulated in all examined brain regions of aged iPLA2β-KO mice compared to age-matched wild-type control mice.
The role of iron in pulmonary pathology.
Turner et al., Birmingham, United Kingdom. In Multidiscip Respir Med, 2014
IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which has a key role in iron homeostasis.
The IRP/IRE system in vivo: insights from mouse models.
Pantopoulos et al., Montréal, Canada. In Front Pharmacol, 2013
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism.
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Lill et al., Marburg an der Lahn, Germany. In Cell Metab, 2013
Surprisingly, a second layer of iron regulation involves the stabilization of IRP2 by CIA2A binding or upon depletion of CIA2B or MMS19, even though IRP2 lacks an Fe/S cluster.
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.
Eisenstein et al., Madison, United States. In Cell Metab, 2013
HIF-2α messenger RNA (mRNA) is derepressed in kidneys of Irp1(-/-) mice but not in kidneys of Irp2(-/-) mice, leading to increased renal erythropoietin (Epo) mRNA and inappropriately elevated serum Epo levels.
Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration.
Szaflik et al., Łódź, Poland. In Mol Biol Rep, 2012
Ggenetic polymorphisms of the iron regulatory protein 1 and 2 genes may be associated with development of age-related macular degeneration.
Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2.
Zhao et al., Harbin, China. In Nutrition, 2012
Vitamin A is involved in the regulation of IRP2, subsequently affecting iron metabolism gene expressions, such as Ferritin and transferrin receptor.
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency.
Demeo et al., Boston, United States. In Respir Res, 2011
The data showed that IREB2 and CHRNA3 are potential genetic modifiers of chronic obstructive pulmonary disease in individuals with severe alpha-1 antitrypsin deficiency and may be sex-specific in their impact.
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
Rouault et al., Bethesda, United States. In Cancer Cell, 2011
Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1α, but not HIF-2α.
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Nakayama et al., Fukuoka, Japan. In Cell Metab, 2011
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
[Regulating action of iron regulatory protein-2 in iron metabolism of lung cancer].
Chen et al., Zhengzhou, China. In Zhonghua Yi Xue Za Zhi, 2011
IRP2 may affect the expressions of transferrin receptor and ferritin in lung adenocarcinoma A549 cells by changing the amount of protein and regulating the iron metabolism.
Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.
Rouault et al., Bethesda, United States. In Plos One, 2010
misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy
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