Toward an orofacial gene regulatory network.
East Lansing, United States. In Dev Dyn, Oct 2015
Among these, variants in interferon regulatory factor 6 (IRF6) cause syndromic orofacial clefting and contribute risk toward isolated cleft lip and palate (1/700 live births).
Genetic and environmental factors in human cleft lip and palate.
Pittsburgh, United States. In Front Oral Biol, 2011
The latest effort in gene identification and the associations between isolated cleft lip and palate and the loci harboring IRF6 (1q32) and 8q24.21 are highlighted, as well as the latest insight from more sophisticated phenotypical characterization and the inclusion of covariables related to the environment in the analysis of genetic variation.