Low-grade inflammatory polarization of monocytes impairs wound healing.
Denver, United States. In J Pathol, Jan 2016
Mechanistically, super-low dose endotoxin caused cellular stress, altered lysosome function and increased the transcription factor IRF5. TUDCA, a potent inhibitor of cellular stress, effectively blocked the monocyte polarization, and improved wound healing in mice injected with super-low dose endotoxin.
Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
Oklahoma City, United States. In Arthritis Rheumatol, Jan 2016
We replicated ten previously established SLE risk loci: STAT1-STAT4, TNFSF4, TNFAIP3, IKZF1, HIP1, IRF5, BLK, WDFY4, ETS1 and IRAK1-MECP2.
Activation and function of interferon regulatory factor 5.
Oxford, United Kingdom. In J Interferon Cytokine Res, Feb 2015
Interferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity.
Different pathways of macrophage activation and polarization.
Gdańsk, Poland. In Postepy Hig Med Dosw (online), 2014
Mediators of M1 macrophage TLR-dependent polarization include transcription factors such as NF-κB, AP-1, PU.1, CCAAT/enhancer-binding protein α (C/EBP-α), STAT1 as well as interferon regulatory factor 5 (IRF5), while the transcription factors which promote M2 activation include IRF4, C/EBP-β, Krüppel-like factor 4 (KLF4), STAT6 and PPARγ receptor.