Rules of UGA-N decoding by near-cognate tRNAs and analysis of readthrough on short uORFs in yeast.
Praha, Czech Republic. In Rna, Feb 2016
UNASSIGNED: The molecular mechanism of stop codon recognition by the release factor eRF1 in complex with eRF3 has been described in great detail; however, our understanding of what determines the difference in termination efficiencies among various stop codon tetranucleotides and how near-cognate (nc) tRNAs recode stop codons during programmed readthrough in Saccharomyces cerevisiae is still poor.
Ethylene response factors in Arabidopsis immunity.
In J Exp Bot, Jan 2016
Notably, ethylene response factor (ERF) TFs are integrators of hormonal pathways and are directly responsible for the transcriptional regulation of several jasmonate (JA)/ethylene (ET)-responsive defence genes.
The catcher in the RIG-I.
Gießen, Germany. In Cytokine, Nov 2015
Activated RIG-I switches into a conformation that locks the ligand RNA and signals via the MAVS-IRF-3 axis, resulting in the upregulation of antiviral interferons.
NMD: At the crossroads between translation termination and ribosome recycling.
Worcester, United States. In Biochimie, Jul 2015
This surveillance pathway requires detection of the nonsense codon by the eukaryotic release factors (eRF1 and eRF3) and the activities of the Upf proteins, but the exact mechanism by which a nonsense codon is recognized as premature, and the individual roles of the Upf proteins, are poorly understood.