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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tripartite motif containing 63

IRF, TFIIIB, eRF1, MuRF1
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: Interferon Regulatory Factor-3, CAN, V1a, Interferon Regulatory Factor-1, ACID
Papers using IRF antibodies
Optimal computer folding of large RNA sequences using thermodynamic and auxiliary information
Supplier
Long Manyuan et al., In Molecular Biology and Evolution, 1980
... The IRF program assesses IDs using a scoring function in ...
Papers on IRF
Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau.
New
Zhao et al., Xining, China. In Fish Shellfish Immunol, Feb 2016
In this study, we first identified 10 interferon regulatory factor (IRF) genes from Tibetan naked carp Gymnocypris przewalskii.
Rules of UGA-N decoding by near-cognate tRNAs and analysis of readthrough on short uORFs in yeast.
New
Valášek et al., Praha, Czech Republic. In Rna, Feb 2016
UNASSIGNED: The molecular mechanism of stop codon recognition by the release factor eRF1 in complex with eRF3 has been described in great detail; however, our understanding of what determines the difference in termination efficiencies among various stop codon tetranucleotides and how near-cognate (nc) tRNAs recode stop codons during programmed readthrough in Saccharomyces cerevisiae is still poor.
Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression.
New
Xiang et al., Hefei, China. In Plos Genet, Jan 2016
Here we report that the ethylene-responsive AP2 transcription factor, ETHYLENE RESPONSE FACTOR1 (ERF1), plays an important role in primary root elongation of Arabidopsis.
Ethylene response factors in Arabidopsis immunity.
Review
New
Zimmerli et al., In J Exp Bot, Jan 2016
Notably, ethylene response factor (ERF) TFs are integrators of hormonal pathways and are directly responsible for the transcriptional regulation of several jasmonate (JA)/ethylene (ET)-responsive defence genes.
Sequence and Expression Analysis of Interferon Regulatory Factor 10 (IRF10) in Three Diverse Teleost Fish Reveals Its Role in Antiviral Defense.
New
Wang et al., Jingzhou, China. In Plos One, Dec 2015
BACKGROUND: Interferon regulatory factor (IRF) 10 was first found in birds and is present in the genome of other tetrapods (but not humans and mice), as well as in teleost fish.
The catcher in the RIG-I.
Review
New
Weber, Gießen, Germany. In Cytokine, Nov 2015
Activated RIG-I switches into a conformation that locks the ligand RNA and signals via the MAVS-IRF-3 axis, resulting in the upregulation of antiviral interferons.
Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.
New
Willis et al., Chapel Hill, United States. In Cardiovasc Pathol, Nov 2015
UNASSIGNED: The muscle-specific ubiquitin ligase muscle ring finger-1 (MuRF1) is critical in regulating both pathological and physiological cardiac hypertrophy in vivo.
Structural basis for stop codon recognition in eukaryotes.
New
Impact
Ramakrishnan et al., Cambridge, United Kingdom. In Nature, Sep 2015
By contrast, eukaryotes rely on an evolutionarily unrelated omnipotent release factor (eRF1) to recognize all three stop codons.
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
New
Impact
Murphy et al., Saint Louis, United States. In Nat Immunol, Jul 2015
However, after specification of pre-CD8 DCs, autoactivation of Irf8 became Batf3 dependent at a CD8α(+) cDC-specific enhancer with multiple transcription factor AP1-IRF composite elements (AICEs) within the Irf8 superenhancer.
NMD: At the crossroads between translation termination and ribosome recycling.
Review
New
Jacobson et al., Worcester, United States. In Biochimie, Jul 2015
This surveillance pathway requires detection of the nonsense codon by the eukaryotic release factors (eRF1 and eRF3) and the activities of the Upf proteins, but the exact mechanism by which a nonsense codon is recognized as premature, and the individual roles of the Upf proteins, are poorly understood.
A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.
New
Impact
Bishai et al., Baltimore, United States. In Nat Med, Apr 2015
We found that a di-adenylate cyclase (disA or dacA)-overexpressing M. tuberculosis strain that secretes excess c-di-AMP activates the interferon regulatory factor (IRF) pathway with enhanced levels of IFN-β, elicits increased macrophage autophagy, and exhibits substantial virulence attenuation in mice.
[Ubiquitin as a regulator of IFN production in the antiviral response].
Review
Matuszyk et al., Panama. In Postepy Hig Med Dosw (online), 2014
Such mechanisms engage signaling cascades which, in the initial phase of infection, lead to the activation of the NF-κB pathway and IFN regulatory factors (IRF-3, IRF-7) which directly control the production of IFNs.
Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors.
Review
Backert et al., Erlangen, Germany. In Biomed Res Int, 2014
Activation of TLRs and resulting signal transduction events lead to the production of pro- and anti-inflammatory mediators through activation of NF-κB, MAP kinases, and IRF signaling pathways.
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
Impact
Hacohen et al., Cambridge, United States. In Science, 2014
We localized and validated causal variants to binding sites of pathogen-activated STAT (signal transducer and activator of transcription) and IRF (IFN-regulatory factor) transcription factors.
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Impact
Li et al., College Station, United States. In Immunity, 2014
It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2',5' cGAMP, that binds to STING and mediates the activation of TBK1 and IRF-3.
The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development.
GeneRIF
Schorle et al., Bonn, Germany. In Reprod Biomed Online, 2012
results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells[review]
Identification of eRF1 residues that play critical and complementary roles in stop codon recognition.
GeneRIF
Bedwell et al., Birmingham, United States. In Rna, 2012
The results indicated that changes near cavities two and three frequently mediated significant effects on stop codon selectivity by eRF1 (SUP45). Changes in the YCF motif correlated most consistently with variant code stop codon selectivity.
Binding of transcription factor activating protein 2 γ on the 5'-proximal promoter region of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B.
GeneRIF
Miyazawa et al., Kyoto, Japan. In Xenotransplantation, 2012
We demonstrated that TFAP-2gamma is one of the transcription factors involved in the HuPAR-2 expression in human villous trophoblast cells.
[The influence of UPF genes on the severity of SUP45 mutations].
GeneRIF
Gryzina et al., In Mol Biol (mosk), 2012
Deletion of each UPF gene leads to allosuppresson of ade1-14 mutation without changing eRF1 amount
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.
GeneRIF
Chang et al., Taipei, Taiwan. In Int J Biol Sci, 2011
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR) of MAPK phosphatase-1 (MKP-1) mRNA and downregulated Mkp-1 3'UTR-mediated luciferase activity.
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