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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Interferon regulatory factor 7

IRF-7, Interferon Regulatory Factor-7
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, Interferon Regulatory Factor-3, CAN, V1a, Interferon-beta
Papers using IRF-7 antibodies
Development of reverse genetics systems for bluetongue virus: recovery of infectious virus from synthetic RNA transcripts
Supplier
Roy Polly et al., In Virology Journal, 2007
... Anti-IRF-3 (FL-425, sc9082) and anti-IRF-7 (H-246, sc9083) polyclonal antibodies were purchased from Santa Cruz.Alkaline phophatase conjugated secondary antibodies were purchased from Millipore (mouse) and Sigma Aldrich (guinea pig and rabbit) ...
Papers on IRF-7
Spatio-temporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection.
New
Haque et al., Brisbane, Australia. In Eur J Immunol, 16 Nov 2014
Interferon regulatory factor 7 (IRF7) is considered to be a master regulator of type I IFN responses.
Differentiation of Neurons Restricts Arbovirus Replication and Increases Expression of the Alpha Isoform of IRF-7.
New
Griffin et al., Baltimore, United States. In J Virol, 15 Nov 2014
Expression of key transcription factors was increased, including interferon regulatory factor-3 and -7 (IRF-3 and IRF-7) and STAT-1, suggesting that neuronal maturation may enhance the capacity for antiviral signaling upon infection.
The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production.
New
Impact
Toyama-Sorimachi et al., Tokyo, Japan. In Immunity, 18 Oct 2014
SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit.
IRF5-mediated signaling and implications for SLE.
Review
New
Jefferies et al., Dublin, Ireland. In Clin Immunol, Aug 2014
In addition to IRF3 and IRF7, the transcription factor IRF5 has been shown to be involved in type I IFN production and interestingly, polymorphisms of the IRF5 gene in humans can result in risk or protective haplotypes with regard to SLE susceptibility.
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
New
Impact
Hacohen et al., Cambridge, United States. In Science, Apr 2014
We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection.
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
New
Impact
Mota et al., Lisbon, Portugal. In Nat Med, Jan 2014
This response, initiated by liver-resident cells through the adaptor molecule for cytosolic RNA sensors, Mavs, and the transcription factors Irf3 and Irf7, is propagated by hepatocytes in an interferon-α/β receptor-dependent manner.
High Basal Expression of Interferon-Stimulated Genes in Human Bronchial Epithelial (BEAS-2B) Cells Contributes to Influenza A Virus Resistance.
New
Kuchipudi et al., Nottingham, United Kingdom. In Plos One, Dec 2013
IAV resistance in BEAS-2B cells was accompanied by an activated antiviral state with high basal expression of interferon (IFN) regulatory factor-7 (IRF-7), stimulator of IFN genes (STING) and IFN stimulated genes (ISGs).
Interferon regulatory factor 7 protects against vascular smooth muscle cell proliferation and neointima formation.
New
Li et al., Wuhan, China. In J Am Heart Assoc, Dec 2013
BACKGROUND: Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factor family, plays important roles in innate immunity and immune cell differentiation.
Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate.
New
Choi et al., Seoul, South Korea. In Plos One, Dec 2013
Nine proteins, including immunoglobulin and its variants and interferon regulatory factor 7, were found only in the inner ear fluid of patients with Meniere's disease.
ELF4 is critical for induction of type I interferon and the host antiviral response.
New
Impact
Fikrig et al., New Haven, United States. In Nat Immunol, Dec 2013
Cooperative binding with ELF4 increases the binding affinity of interferon regulatory factors IRF3 and IRF7, which is mediated by EICE elements.
Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.
New
Impact
Ardavín et al., Madrid, Spain. In Immunity, Jul 2013
Type I IFN (IFN-α and IFN-β) is produced after virus or bacteria recognition by cytosolic receptors or membrane-bound TLR receptors following the activation of the transcription factors IRF3 or IRF7.
NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Review
New
Gewurz et al., Boston, United States. In Viruses, Jun 2013
LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation.
[Multilevel maturation of Toll-like receptor 9].
Review
Siednienko et al., Panama. In Postepy Hig Med Dosw (online), 2012
Ligand binding to TLR9 causes conformational changes in the structure of this receptor which facilitates recruitment of MyD88 adaptor protein and activation of two distinct cytokine-inducing pathways: IRF-7- and NF-κB-dependent.
The role of type 1 interferon in systemic sclerosis.
Review
Assassi et al., Houston, United States. In Front Immunol, 2012
Polymorphisms in the Interferon regulatory factor (IRF)-5, IRF7, and IRF8 are associated with SSc, Similarly, polymorphism of Signal Transducer and Activator of Transcription (STAT)-4, has been established as a genetic risk factor of SSc.
Requirements for innate immune pathways in environmentally induced autoimmunity.
Review
Kono et al., Los Angeles, United States. In Bmc Med, 2012
Some of these differences may be related to the bifurcation of toll-like receptor signaling that distinguishes interferon regulatory factor 7-mediated type I interferon production from nuclear factor-κB-driven proinflammatory cytokine expression.
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
GeneRIF
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
GeneRIF
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery.
GeneRIF
Thomsen et al., Copenhagen, Denmark. In J Virol, 2012
Collectively, these data demonstrate that the early type I IFN response to lymphocytic choriomeningitis virus infection in the central nervous system is controlled by a concerted action of IRF3 and -7.
IRF7, a functional factor associates with systemic lupus erythematosus.
Review
GeneRIF
Ye et al., Hefei, China. In Cytokine, 2012
discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in
Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection.
GeneRIF
Albert et al., Paris, France. In J Immunol, 2012
IRF-3 & IRF-7 are functionally redundant in an age-dependent manner. Lack of both results in lethal Chikungunya infection in adult mice.
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