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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Mar 2014.

Interferon regulatory factor 7

IRF-7, Interferon Regulatory Factor-7
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, Interferon Regulatory Factor-3, CAN, Interferon-beta, V1a
Papers using IRF-7 antibodies
Development of reverse genetics systems for bluetongue virus: recovery of infectious virus from synthetic RNA transcripts
Supplier
Roy Polly et al., In Virology Journal, 2007
... Anti-IRF-3 (FL-425, sc9082) and anti-IRF-7 (H-246, sc9083) polyclonal antibodies were purchased from Santa Cruz.Alkaline phophatase conjugated secondary antibodies were purchased from Millipore (mouse) and Sigma Aldrich (guinea pig and rabbit) ...
Papers on IRF-7
Borrelia burgdorferi RNA induces type I and type III interferons via TLR7 and contributes to the production of NF-κB-dependent cytokines.
New
Petzke et al., Valhalla, United States. In Infect Immun, 24 Apr 2014
IFN-α protein and transcripts for IRF7, MX1, and OAS1 were induced by endosomal delivery of B. burgdorferi DNA, RNA or whole-cell lysate, but not by lysate that had been treated with DNase and RNase.
Identification, characterization and immunological response analysis of stimulator of interferon gene (STING) from grass carp Ctenopharyngodon idella.
New
Su et al., China. In Dev Comp Immunol, 11 Apr 2014
Taken together, these results demonstrated that CiSTING may be involved in board innate immune responses via the TBK1-IRF3/IRF7 cascade, responding to not only dsRNA analogue in an IFN-dependent pathway, but also virus and bacterial PAMPs in an IFN-independent pathway.
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
New
Impact
Hacohen et al., Cambridge, United States. In Science, 07 Apr 2014
We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection.
Cloning and expression analyses of interferon regulatory factor (IRF) 3 and 7 genes in European eel, Anguilla anguilla with the identification of genes involved in IFN production.
New
Nie et al., Xiamen, China. In Fish Shellfish Immunol, 21 Mar 2014
UNLABELLED: Interferon regulatory factor (IRF) 3 and IRF7 have been identified as regulators of type I interferon (IFN) gene expression in mammals.
Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response.
New
Li et al., In Cell Mol Immunol, 17 Mar 2014
Here, we identified death-associated protein kinase 1 (DAPK1) as an IRF7-interacting protein by tandem affinity purification (TAP).
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
New
Impact
Mota et al., Lisbon, Portugal. In Nat Med, Jan 2014
This response, initiated by liver-resident cells through the adaptor molecule for cytosolic RNA sensors, Mavs, and the transcription factors Irf3 and Irf7, is propagated by hepatocytes in an interferon-α/β receptor-dependent manner.
Late multiple organ surge in interferon-regulated target genes characterizes staphylococcal enterotoxin B lethality.
New
Danner et al., Bethesda, United States. In Plos One, Dec 2013
Furthermore, IFN regulatory factors including Irf1, Irf7 and Irf8, and Zbp1, a DNA sensor/transcription factor that can directly elicit an IFN innate immune response, participated in this host-wide SEB signature.
ELF4 is critical for induction of type I interferon and the host antiviral response.
New
Impact
Fikrig et al., New Haven, United States. In Nat Immunol, Dec 2013
Cooperative binding with ELF4 increases the binding affinity of interferon regulatory factors IRF3 and IRF7, which is mediated by EICE elements.
Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.
New
Impact
Ardavín et al., Madrid, Spain. In Immunity, Jul 2013
Type I IFN (IFN-α and IFN-β) is produced after virus or bacteria recognition by cytosolic receptors or membrane-bound TLR receptors following the activation of the transcription factors IRF3 or IRF7.
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells.
New
Impact
Regev et al., Cambridge, United States. In Nature, Jul 2013
Using cells from knockout mice, we show that variability in this module may be propagated through an interferon feedback circuit, involving the transcriptional regulators Stat2 and Irf7.
NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Review
Gewurz et al., Boston, United States. In Viruses, 2012
LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation.
Requirements for innate immune pathways in environmentally induced autoimmunity.
Review
Kono et al., Los Angeles, United States. In Bmc Med, 2012
Some of these differences may be related to the bifurcation of toll-like receptor signaling that distinguishes interferon regulatory factor 7-mediated type I interferon production from nuclear factor-κB-driven proinflammatory cytokine expression.
The Role of Type 1 Interferon in Systemic Sclerosis.
Review
Assassi et al., Houston, United States. In Front Immunol, 2012
Polymorphisms in the Interferon regulatory factor (IRF)-5, IRF7, and IRF8 are associated with SSc, Similarly, polymorphism of Signal Transducer and Activator of Transcription (STAT)-4, has been established as a genetic risk factor of SSc.
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
GeneRIF
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
GeneRIF
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery.
GeneRIF
Thomsen et al., Copenhagen, Denmark. In J Virol, 2012
Collectively, these data demonstrate that the early type I IFN response to lymphocytic choriomeningitis virus infection in the central nervous system is controlled by a concerted action of IRF3 and -7.
IRF7, a functional factor associates with systemic lupus erythematosus.
Review
GeneRIF
Ye et al., Hefei, China. In Cytokine, 2012
discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in
[Analysis of the application of host innate immune response to control and prevent infection].
Review
Abe, Suita, Japan. In Uirusu, 2012
The cytoplasmic helicase proteins RIG-I (retinoic-acid-inducible protein I) and MDA5 (melanoma-differentiation-associated gene 5) have been identified as viral dsRNA detectors and the adaptor IPS-1 (IFN-beta promoter stimulator-1) interacts with RIG-I and MDA5 to facilitate type-I IFN production mediated interferon regulatory factor 3 (IRF3) and 7 (IRF7).
[Nucleic acids recognition by innate immunity].
Review
Kawai et al., Ōsaka, Japan. In Uirusu, 2012
Viperin interacted with the signal mediators IRAK1 and TRAF6 to recruit them to the lipid bodies and facilitated K63-linked ubiquitination of IRAK1 to induce the nuclear translocation of transcription factor IRF7. Thus, besides direct inhibition of viral replication, this finding reveals that Viperin mediates its antiviral function via the regulation of the TLR7 and TLR9-IRAK1 signaling axis in pDCs.
Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection.
GeneRIF
Albert et al., Paris, France. In J Immunol, 2012
IRF-3 & IRF-7 are functionally redundant in an age-dependent manner. Lack of both results in lethal Chikungunya infection in adult mice.
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