Host genetics of severe influenza: from mouse Mx1 to human IRF7.
New York City, United States. In Curr Opin Immunol, Feb 2016
Recently however, human IRF7 was shown to be essential for IFN-α/β- and IFN-λ-dependent protective immunity against primary influenza in vivo, as inferred from a patient with life-threatening influenza revealed to be IRF7-deficient by whole exome sequencing.
The Latent Membrane Protein 1 (LMP1).
München, Germany. In Curr Top Microbiol Immunol, 2014
LMP1 activates NF-κB, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3-K), IRF7, and STAT pathways.
[Current research on picornavirus 3C protease].
Beijing, China. In Bing Du Xue Bao, 2014
Innate immune adaptors such as TRIF, MAVS, IRF3, IRF7 and NEMO have various potential cleavage sites in picornavirus 3Cpro (TRIF and NEMO show considerable diversity in their cleavage sites).