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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Nov 2015.

Interferon regulatory factor 7

IRF-7, Interferon Regulatory Factor-7
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, Interferon Regulatory Factor-3, CAN, V1a, MyD88
Papers using IRF-7 antibodies
Development of reverse genetics systems for bluetongue virus: recovery of infectious virus from synthetic RNA transcripts
Roy Polly et al., In Virology Journal, 2007
... Anti-IRF-3 (FL-425, sc9082) and anti-IRF-7 (H-246, sc9083) polyclonal antibodies were purchased from Santa Cruz.Alkaline phophatase conjugated secondary antibodies were purchased from Millipore (mouse) and Sigma Aldrich (guinea pig and rabbit) ...
Papers on IRF-7
Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering anti-viral responses.
Carr et al., Adelaide, Australia. In J Gen Virol, 05 Dec 2015
Additionally, higher basal levels of anti-viral factors (IRF7, CXCL10 and OAS1) were observed in uninfected SK1-/- iMEF but not 1oMEF.
Fish IRF3 up-regulates the transcriptional level of IRF1, IRF2, IRF3 and IRF7 in CIK cells.
Hu et al., Nanchang, China. In Fish Shellfish Immunol, 03 Dec 2015
UNASSIGNED: Interferon Regulatory Factors (IRFs) belong to a family of transcription factor involved in transcriptional regulation of type I IFN and IFN-stimulated genes (ISG) in cells.
Induction of Interferon-λ Contributes to TLR3 and RIG-I Activation-Mediated Inhibition of Herpes Simplex Virus Type 2 Replication in Human Cervical Epithelial Cells.
Ho et al., Wuhan, China. In Mol Hum Reprod, 26 Nov 2015
Expression of interferon regulatory factor 3 (IRF3), IRF7, IFN-stimulated gene 56 (ISG56), 2'-5'-oligoadenylate synthetase I (OAS-1) and myxovirus resistance A (MxA) were determined by the real-time PCR and Western-blot.
Age-related changes in murine myometrial transcript profile are mediated by exposure to the female sex hormones.
Charnock-Jones et al., Cambridge, United Kingdom. In Aging Cell, 21 Nov 2015
Interferon regulatory factor 7 (Irf7) mRNA was regulated by age and hormonal exposure, and was identified as a predicted regulator of the other differentially expressed transcripts by both promoter sequence and canonical pathway activation analysis (P = 8.47 × 10(-5) and P < 10(-10) , respectively).
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.
Sadelain et al., New York City, United States. In Cancer Cell, 12 Nov 2015
Remarkably, induction of the IRF7/IFNβ pathway was required for optimal anti-tumor activity.
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
De Carvalho et al., Toronto, Canada. In Cell, Sep 2015
This is associated with induction of dsRNAs derived at least in part from endogenous retroviral elements, activation of the MDA5/MAVS RNA recognition pathway, and downstream activation of IRF7.
Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6/IL-6Rα axis.
Bianchi et al., Milano, Italy. In Genom Data, Jun 2015
By using a 'pathway-oriented' analysis strategy we were able to identify a network of 105 genes modulated by L1 through the predicted activation of five transcription factors: STAT1, STAT2, STAT3, IRF7, and ATF4.
Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.
Casanova et al., New York City, United States. In Science, May 2015
We report compound heterozygous null mutations in IRF7, which encodes the transcription factor interferon regulatory factor 7, in an otherwise healthy child who suffered life-threatening influenza during primary infection.
Immune evasion in ebolavirus infections.
Kobinger et al., Winnipeg, Canada. In Viral Immunol, Feb 2015
The viral protein 35 (VP35) is capable of capping dsRNA and interacts with IRF7 to prevent detection of the virus by immune cells.
The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
Toyama-Sorimachi et al., Tokyo, Japan. In Immunity, Oct 2014
SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit.
[Current research on picornavirus 3C protease].
Duan et al., Beijing, China. In Bing Du Xue Bao, Sep 2014
Innate immune adaptors such as TRIF, MAVS, IRF3, IRF7 and NEMO have various potential cleavage sites in picornavirus 3Cpro (TRIF and NEMO show considerable diversity in their cleavage sites).
IRF5-mediated signaling and implications for SLE.
Jefferies et al., Dublin, Ireland. In Clin Immunol, Aug 2014
In addition to IRF3 and IRF7, the transcription factor IRF5 has been shown to be involved in type I IFN production and interestingly, polymorphisms of the IRF5 gene in humans can result in risk or protective haplotypes with regard to SLE susceptibility.
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
Hacohen et al., Cambridge, United States. In Science, Apr 2014
We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection.
[Multilevel maturation of Toll-like receptor 9].
Siednienko et al., Panama. In Postepy Hig Med Dosw (online), 2012
Ligand binding to TLR9 causes conformational changes in the structure of this receptor which facilitates recruitment of MyD88 adaptor protein and activation of two distinct cytokine-inducing pathways: IRF-7- and NF-κB-dependent.
The role of type 1 interferon in systemic sclerosis.
Assassi et al., Houston, United States. In Front Immunol, 2012
Polymorphisms in the Interferon regulatory factor (IRF)-5, IRF7, and IRF8 are associated with SSc, Similarly, polymorphism of Signal Transducer and Activator of Transcription (STAT)-4, has been established as a genetic risk factor of SSc.
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery.
Thomsen et al., Copenhagen, Denmark. In J Virol, 2012
Collectively, these data demonstrate that the early type I IFN response to lymphocytic choriomeningitis virus infection in the central nervous system is controlled by a concerted action of IRF3 and -7.
IRF7, a functional factor associates with systemic lupus erythematosus.
Ye et al., Hefei, China. In Cytokine, 2012
discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in
Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection.
Albert et al., Paris, France. In J Immunol, 2012
IRF-3 & IRF-7 are functionally redundant in an age-dependent manner. Lack of both results in lethal Chikungunya infection in adult mice.
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