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Interferon regulatory factor 7

IRF-7, Interferon Regulatory Factor-7
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, Interferon Regulatory Factor-3, CAN, V1a, Interferon-beta
Papers using IRF-7 antibodies
Development of reverse genetics systems for bluetongue virus: recovery of infectious virus from synthetic RNA transcripts
Supplier
Roy Polly et al., In Virology Journal, 2007
... Anti-IRF-3 (FL-425, sc9082) and anti-IRF-7 (H-246, sc9083) polyclonal antibodies were purchased from Santa Cruz.Alkaline phophatase conjugated secondary antibodies were purchased from Millipore (mouse) and Sigma Aldrich (guinea pig and rabbit) ...
Papers on IRF-7
MAP kinase p38α regulates type III interferon (IFN-λ1) gene expression in human monocyte-derived dendritic cells in response to RNA stimulation.
New
Julkunen et al., Helsinki, Finland. In J Leukoc Biol, 03 Jan 2015
Moreover, the RIG-I/MDA5-MAVS-IRF3 pathway was required for p38α MAPK to up-regulate IFN-λ1 promoter activation, whereas the MyD88-IRF7 pathway was not needed, and the regulation was not involved directly in IRF7-dependent IFN-α1 gene expression.
Enhanced immune response of BMDCs pulsed with H9N2 AIV and CpG.
New
Yang et al., Nanjing, China. In Vaccine, 28 Dec 2014
Further analysis proved that co-stimulatory molecules (CD40, CD80, CD86 and MHC-II), regulatory protein (IRF-7 and TRAF-6) and pro-inflammatory cytokines (IL-1, IL-6 and IL-12) were all changed and involved in DCs maturation.
Hantaan virus can infect human keratinocytes and activate an interferon response through the nuclear translocation of IRF-3.
New
Zhang et al., Xi'an, China. In Infect Genet Evol, 20 Dec 2014
Furthermore, we suggest that interferon regulatory factor (IRF)-3, as opposed to NF-κB/p65 or IRF-7, is translocated to the nucleus to induce IFN-β.
Toll-like receptor 3 signaling inhibits simian immunodeficiency virus replication in macrophages from rhesus macaques.
New
Ho et al., Wuhan, China. In Antiviral Res, 23 Nov 2014
TLR3 activation-mediated anti-SIV effect could be compromised by the knockdown of IRF3 and IRF7.
The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
New
Impact
Toyama-Sorimachi et al., Tokyo, Japan. In Immunity, Oct 2014
SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit.
IRF5-mediated signaling and implications for SLE.
Review
New
Jefferies et al., Dublin, Ireland. In Clin Immunol, Aug 2014
In addition to IRF3 and IRF7, the transcription factor IRF5 has been shown to be involved in type I IFN production and interestingly, polymorphisms of the IRF5 gene in humans can result in risk or protective haplotypes with regard to SLE susceptibility.
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
New
Impact
Hacohen et al., Cambridge, United States. In Science, Apr 2014
We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection.
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
New
Impact
Mota et al., Lisbon, Portugal. In Nat Med, Jan 2014
This response, initiated by liver-resident cells through the adaptor molecule for cytosolic RNA sensors, Mavs, and the transcription factors Irf3 and Irf7, is propagated by hepatocytes in an interferon-α/β receptor-dependent manner.
Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway.
New
Kloog et al., Tel Aviv-Yafo, Israel. In Cell Death Dis, Dec 2013
This yielded a substantial number of commonly altered genes, many of which we identified as downstream targets of the interferon (IFN) regulatory factor 7 (IRF7) transcription factor, a central activator of the IFN type 1 immune response.
ELF4 is critical for induction of type I interferon and the host antiviral response.
New
Impact
Fikrig et al., New Haven, United States. In Nat Immunol, Dec 2013
Cooperative binding with ELF4 increases the binding affinity of interferon regulatory factors IRF3 and IRF7, which is mediated by EICE elements.
Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.
New
Impact
Ardavín et al., Madrid, Spain. In Immunity, Jul 2013
Type I IFN (IFN-α and IFN-β) is produced after virus or bacteria recognition by cytosolic receptors or membrane-bound TLR receptors following the activation of the transcription factors IRF3 or IRF7.
NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Review
New
Gewurz et al., Boston, United States. In Viruses, Jun 2013
LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation.
[Multilevel maturation of Toll-like receptor 9].
Review
Siednienko et al., Panama. In Postepy Hig Med Dosw (online), 2012
Ligand binding to TLR9 causes conformational changes in the structure of this receptor which facilitates recruitment of MyD88 adaptor protein and activation of two distinct cytokine-inducing pathways: IRF-7- and NF-κB-dependent.
The role of type 1 interferon in systemic sclerosis.
Review
Assassi et al., Houston, United States. In Front Immunol, 2012
Polymorphisms in the Interferon regulatory factor (IRF)-5, IRF7, and IRF8 are associated with SSc, Similarly, polymorphism of Signal Transducer and Activator of Transcription (STAT)-4, has been established as a genetic risk factor of SSc.
Requirements for innate immune pathways in environmentally induced autoimmunity.
Review
Kono et al., Los Angeles, United States. In Bmc Med, 2012
Some of these differences may be related to the bifurcation of toll-like receptor signaling that distinguishes interferon regulatory factor 7-mediated type I interferon production from nuclear factor-κB-driven proinflammatory cytokine expression.
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
GeneRIF
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
GeneRIF
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery.
GeneRIF
Thomsen et al., Copenhagen, Denmark. In J Virol, 2012
Collectively, these data demonstrate that the early type I IFN response to lymphocytic choriomeningitis virus infection in the central nervous system is controlled by a concerted action of IRF3 and -7.
IRF7, a functional factor associates with systemic lupus erythematosus.
Review
GeneRIF
Ye et al., Hefei, China. In Cytokine, 2012
discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in
Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection.
GeneRIF
Albert et al., Paris, France. In J Immunol, 2012
IRF-3 & IRF-7 are functionally redundant in an age-dependent manner. Lack of both results in lethal Chikungunya infection in adult mice.
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