Antiviral gene expression in psoriasis.
San Francisco, United States. In J Eur Acad Dermatol Venereol, 23 Apr 2015
RESULTS: We observed significant overexpression of 16 antiviral genes in lesional psoriatic skin, with a greater than two-fold increase in ISG15, RSAD2, IRF7, MX2 and TRIM22 (P < 1E-07).
[Current research on picornavirus 3C protease].
Beijing, China. In Bing Du Xue Bao, Sep 2014
Innate immune adaptors such as TRIF, MAVS, IRF3, IRF7 and NEMO have various potential cleavage sites in picornavirus 3Cpro (TRIF and NEMO show considerable diversity in their cleavage sites).
IRF5-mediated signaling and implications for SLE.
Dublin, Ireland. In Clin Immunol, Aug 2014
In addition to IRF3 and IRF7, the transcription factor IRF5 has been shown to be involved in type I IFN production and interestingly, polymorphisms of the IRF5 gene in humans can result in risk or protective haplotypes with regard to SLE susceptibility.
[Multilevel maturation of Toll-like receptor 9].
Panama. In Postepy Hig Med Dosw (online), 2012
Ligand binding to TLR9 causes conformational changes in the structure of this receptor which facilitates recruitment of MyD88 adaptor protein and activation of two distinct cytokine-inducing pathways: IRF-7- and NF-κB-dependent.
The role of type 1 interferon in systemic sclerosis.
Houston, United States. In Front Immunol, 2012
Polymorphisms in the Interferon regulatory factor (IRF)-5, IRF7, and IRF8 are associated with SSc, Similarly, polymorphism of Signal Transducer and Activator of Transcription (STAT)-4, has been established as a genetic risk factor of SSc.