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Interferon regulatory factor 7

IRF-7, Interferon Regulatory Factor-7
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, Interferon Regulatory Factor-3, CAN, V1a, Interferon-beta
Papers using IRF-7 antibodies
Development of reverse genetics systems for bluetongue virus: recovery of infectious virus from synthetic RNA transcripts
Roy Polly et al., In Virology Journal, 2007
... Anti-IRF-3 (FL-425, sc9082) and anti-IRF-7 (H-246, sc9083) polyclonal antibodies were purchased from Santa Cruz.Alkaline phophatase conjugated secondary antibodies were purchased from Millipore (mouse) and Sigma Aldrich (guinea pig and rabbit) ...
Papers on IRF-7
The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats.
Csont et al., Szeged, Hungary. In Cardiovasc Diabetol, 28 Jul 2015
complement factor B; complement component 4a; interferon regulatory factor 7; hepcidin).
Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics.
Suzuki et al., Yokohama, Japan. In Nucleic Acids Res, 27 Jul 2015
Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 and TBP that are commonly activated but have distinct activity dynamics in M1 and M2 activation.
Genetic characterization of bovine viral diarrhea virus strains in Beijing region of China and innate immune responses of PBMCs in persistently infected dairy cattle.
Wang et al., Beijing, China. In J Vet Sci, 26 Jul 2015
An immunoblotting analysis revealed that the expression of interferon regulatory factor 3 (IRF-3) and IRF-7 was lower in PI cattle than in healthy cattle.
Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.
Casanova et al., New York City, United States. In Science, May 2015
We report compound heterozygous null mutations in IRF7, which encodes the transcription factor interferon regulatory factor 7, in an otherwise healthy child who suffered life-threatening influenza during primary infection.
Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Molnár et al., Budapest, Hungary. In Plos One, Dec 2014
MYD88, IRAK2, NFκB, IL8, IL-1β), STING pathway (ADAR, IRF7, CXCL10, CASP1) and the FGF2 gene.
Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses and Decreasing Nuclear Factor Kappa B Expression Limit HIV-1 Replication in Cervical Tissues.
Asin et al., Norfolk, United States. In Plos One, Dec 2014
Reducing IRF7 expression up-regulated HIV-1 and NFκB transcription, providing proof of concept for the critical involvement of IRF7 in cervical tissues.
The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
Toyama-Sorimachi et al., Tokyo, Japan. In Immunity, Oct 2014
SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit.
[Current research on picornavirus 3C protease].
Duan et al., Beijing, China. In Bing Du Xue Bao, Sep 2014
Innate immune adaptors such as TRIF, MAVS, IRF3, IRF7 and NEMO have various potential cleavage sites in picornavirus 3Cpro (TRIF and NEMO show considerable diversity in their cleavage sites).
IRF5-mediated signaling and implications for SLE.
Jefferies et al., Dublin, Ireland. In Clin Immunol, Aug 2014
In addition to IRF3 and IRF7, the transcription factor IRF5 has been shown to be involved in type I IFN production and interestingly, polymorphisms of the IRF5 gene in humans can result in risk or protective haplotypes with regard to SLE susceptibility.
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.
Hacohen et al., Cambridge, United States. In Science, Apr 2014
We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection.
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Mota et al., Lisbon, Portugal. In Nat Med, 2014
This response, initiated by liver-resident cells through the adaptor molecule for cytosolic RNA sensors, Mavs, and the transcription factors Irf3 and Irf7, is propagated by hepatocytes in an interferon-α/β receptor-dependent manner.
ELF4 is critical for induction of type I interferon and the host antiviral response.
Fikrig et al., New Haven, United States. In Nat Immunol, 2013
Cooperative binding with ELF4 increases the binding affinity of interferon regulatory factors IRF3 and IRF7, which is mediated by EICE elements.
NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Gewurz et al., Boston, United States. In Viruses, 2013
LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation.
[Multilevel maturation of Toll-like receptor 9].
Siednienko et al., Panama. In Postepy Hig Med Dosw (online), 2012
Ligand binding to TLR9 causes conformational changes in the structure of this receptor which facilitates recruitment of MyD88 adaptor protein and activation of two distinct cytokine-inducing pathways: IRF-7- and NF-κB-dependent.
The role of type 1 interferon in systemic sclerosis.
Assassi et al., Houston, United States. In Front Immunol, 2012
Polymorphisms in the Interferon regulatory factor (IRF)-5, IRF7, and IRF8 are associated with SSc, Similarly, polymorphism of Signal Transducer and Activator of Transcription (STAT)-4, has been established as a genetic risk factor of SSc.
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery.
Thomsen et al., Copenhagen, Denmark. In J Virol, 2012
Collectively, these data demonstrate that the early type I IFN response to lymphocytic choriomeningitis virus infection in the central nervous system is controlled by a concerted action of IRF3 and -7.
IRF7, a functional factor associates with systemic lupus erythematosus.
Ye et al., Hefei, China. In Cytokine, 2012
discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in
Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection.
Albert et al., Paris, France. In J Immunol, 2012
IRF-3 & IRF-7 are functionally redundant in an age-dependent manner. Lack of both results in lethal Chikungunya infection in adult mice.
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