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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Endoplasmic reticulum to nucleus signaling 1

IRE1, IRE1alpha, Ire1p
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using IRE1 antibodies
Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the β-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
Liu Li-Bin et al., In International Journal of Endocrinology, 2008
... Primary antibodies, including rabbit polyclonal antibodies to sheep P-IRE1α and IRE-1α, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
Hofmann Thomas G., In PLoS ONE, 2008
... Antibodies against GRP78, GADD153, GRP94, PERK, eIF2α, phospho-eIF2α, PARP, HSP70, caspase-3, IRE1 were purchased from Cell Signaling Technology (Beverly, MA); Anti-β-actin ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... (1:200, sc-101670, Santa Cruz Biotechnology), anti-ATF4 (1:200, sc-200, Santa Cruz Biotechnology), anti-IRE1α (1:500, #3294, Cell Signaling Technology), anti-p-IRE1 ...
Papers on IRE1
SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.
Puglielli et al., Madison, United States. In J Biol Chem, 2012
IRE1/XBP1 controls the induction of autophagy/ERAD(II) during the unfolded protein response by activating the ER membrane transporter SLC33A1/AT-1
Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice.
Hussain et al., United States. In Circ Res, 2012
Ire1beta regulates intestinal lipid absorption and that increased intestinal lipoprotein production contributes to atherosclerosis.
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
Hetz et al., Santiago, Chile. In Embo J, 2012
The authors identified the BCL-2 family member PUMA as a novel IRE1alpha interactor. Immun oprecipitation experiments confirmed this interaction and further detected the association of IRE1alpha with BIM, another BH3-only protein.
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
Harding et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
Inhibition of IRE1 endonuclease activity does not sensitize cells to the consequences of acute endoplasmic reticulum stress, but rather interferes with the expansion of secretory capacity.
Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP.
Polizzi et al., London, United Kingdom. In Biochem Biophys Res Commun, 2012
BiP binds to IRE1 and PERK in a different manner.
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