Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
In PLoS ONE, 2008
... Antibodies against GRP78, GADD153, GRP94, PERK, eIF2α, phospho-eIF2α, PARP, HSP70, caspase-3, IRE1 were purchased from Cell Signaling Technology (Beverly, MA); Anti-β-actin ... Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
In Cell Death & Disease, 1994
... (1:200, sc-101670, Santa Cruz Biotechnology), anti-ATF4 (1:200, sc-200, Santa Cruz Biotechnology), anti-IRE1α (1:500, #3294, Cell Signaling Technology), anti-p-IRE1 ...
PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage.
Xi'an, China. In Clin Exp Pharmacol Physiol, Jan 2016
Furthermore, the expressions of ER stress-associated genes including PERK, ATF3, IRE1, phosphorylated eIF2α (p-eIF2α) and MMP13 were enhanced in OA cartilage explants, while they were decreased by AdPFKFB3 transfection.PFKFB3 also modulated the expressions of PERK, ATF3, IRE1, p-eIF2α and MMP13 in tunicamycin-exposed chondrocytes.
Cell death induced by endoplasmic reticulum stress.
l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well as other signaling nodes such as c-Jun N-terminal kinase 1 (JNK) and the downstream transcription factors XBP1, ATF4 and CHOP.
The unfolded protein response: the dawn of a new field.
Kyoto, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2014
Extremely competitive analyses using the budding yeast Saccharomyces cerevisiae revealed that although signaling from both the ER and cell surface is initiated by activation of a transmembrane protein kinase, the mechanism downstream of ER-resident Ire1p, a sensor molecule of the UPR, is unique.
Endoplasmic Reticulum Stress and Ethanol Neurotoxicity.
Lexington, United States. In Biomolecules, 2014
The accumulation of unfolded or misfolded proteins in the ER lumen triggers ER stress and induces unfolded protein response (UPR) which are mediated by three transmembrane ER signaling proteins: pancreatic endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6).
Endoplasmic reticulum stress responses in plants.
Ames, United States. In Annu Rev Plant Biol, 2012
Two arms of the UPR signaling pathway have been described in plants: one that involves two ER membrane-associated transcription factors (bZIP17 and bZIP28) and another that involves a dual protein kinase (RNA-splicing factor IRE1) and its target RNA (bZIP60).