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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

S-antigen; retina and pineal gland

IRBP, Ku70, S-antigen, SAG, Arrestin
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, beta-arrestin
Papers using IRBP antibodies
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
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Callaerts Patrick, In PLoS ONE, 2008
... Primary antibodies used were; mouse anti-polyglutamine (1∶2000, 1C2, Milipore), mouse anti-Ku70 (1∶500, N3H10, Kamiya Biomedical, Seattle) and mouse anti-actin ...
Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes
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Mungenast Alison E., In Neural Plasticity, 2007
... Other experimental reagents included 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG, 60 mM stock in DMSO, Biomol), Suramin (stock fresh in ...
Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation
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Suh Eok Soo et al., In Korean Journal of Ophthalmology : KJO, 2005
... Rabbit polyclonal IRBP and secondary goat anti-mouse or rabbit IgG-HRP antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits
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Weaver Alissa M. et al., In Oncogene, 2004
... Commercial antibodies: anti-β-actin (Sigma (AC-74)), Ku70 (Abcam), and pan-Cytokeratin (Dako Cytomation) ...
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response
Supplier
Legerski Randy J. et al., In Oncogene, 2003
... Ku80 siRNA (NM-021141) and Ku70 siRNA (SC-29383) were purchased from Dharmacon and Santa Cruz Biotechnology, Inc., respectively ...
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Papers on IRBP
Genomic landscapes of endogenous retroviruses unveil intricate genetics of conventional and genetically-engineered laboratory mouse strains.
New
Cho et al., Sacramento, United States. In Exp Mol Pathol, Feb 2016
Second, an examination of superantigen (SAg, a "TREome gene") coding sequences of mouse mammary tumor virus-type ERVs in the genomes of the 46 conventional strains revealed a high diversity, suggesting a potential role of SAgs in strain-specific immune phenotypes.
Feedback Regulation of G Protein-Coupled Receptor Signaling by GRKs and Arrestins.
Review
New
Daaka et al., Durham, United States. In Semin Cell Dev Biol, Feb 2016
Mechanistically, GPCR signaling was identified to occur vectorially through heterotrimeric G proteins that are negatively regulated by GRK and arrestin effectors.
Sonic Hedgehog Improves Ischemia-Induced Neovascularization by Enhancing Endothelial Progenitor Cell Function in Type 1 Diabetes.
New
Luo et al., Guangzhou, China. In Mol Cell Endocrinol, Feb 2016
vs control), and all were improved by in vivo administration of the Shh pathway receptor agonist SAG (p<0.05 vs diabetes).
Signalling beyond photon absorption: Extracellular retinoids and growth factors modulate rod photoreceptor sensitivity.
New
Kraft et al., Birmingham, United States. In J Physiol, Jan 2016
Interphotoreceptor retinoid-binding protein (IRBP) is the most abundant protein in the IPM, and it promotes removal of bleached chromophore and recycling in the nearby retinal pigment epithelium.
Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction.
New
Prossnitz et al., Albuquerque, United States. In Plos One, Dec 2015
To better understand the role of Src kinase in this process, in the current study we employed a previously described arrestin-2 (arr2) mutant deficient in Src kinase binding (arr2-P91G/P121E).
Emerging Functional Divergence of β-Arrestin Isoforms in GPCR Function.
Review
New
Shukla et al., Kānpur, India. In Trends Endocrinol Metab, Nov 2015
Two isoforms of β-arrestin sharing more than 70% sequence identity and overall very similar 3D structures, β-arrestins 1 and 2, were originally expected to be functionally redundant.
[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats].
New
Li et al., Hefei, China. In Zhonghua Yan Ke Za Zhi, Oct 2015
Lewis rats were immunized with interphotoreceptor retinoid-binding peptide (IRBP) in order to build the model of EAU.
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
New
Impact
Xu et al., Grand Rapids, United States. In Nature, Aug 2015
Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent pathways.
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
New
Impact
Kühn et al., Berlin, Germany. In Nat Biotechnol, May 2015
To enhance HDR, enabling the insertion of precise genetic modifications, we suppressed the NHEJ key molecules KU70, KU80 or DNA ligase IV by gene silencing, the ligase IV inhibitor SCR7 or the coexpression of adenovirus 4 E1B55K and E4orf6 proteins in a 'traffic light' and other reporter systems.
Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis.
Review
Caspi et al., Guangzhou, China. In Curr Mol Med, 2014
The "classical" EAU model is induced by active immunization of mice with the retinal protein IRBP in adjuvant, and has proved to be a useful tool to study basic mechanisms and novel therapy in human uveitis.
Staphylococcal superantigens interact with multiple host receptors to cause serious diseases.
Review
Schlievert et al., Iowa City, United States. In Immunol Res, 2014
This review discusses the association of SAgs with human diseases and particularly the "outside-in" signaling mechanism that leads to SAg-associated diseases.
Soluble T cell receptor Vβ domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens.
Review
Kranz et al., Urbana, United States. In Toxins (basel), 2014
The molecular basis of action involves the binding of the SAg to both a T cell receptor (TCR) on a T cell and a class II product of the major histocompatibility complex (MHC) on an antigen presenting cell.
DMBT1 homozygous deletion in diffuse astrocytomas is associated with unfavorable clinical outcome.
GeneRIF
Ohgaki et al., Lyon, France. In J Neuropathol Exp Neurol, 2012
a DMBT1 homozygous deletion is present in a fraction of diffuse astrocytomas and that it is associated with an unfavorable clinical outcome
Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors.
GeneRIF
Liu et al., Cambridge, United Kingdom. In J Neurosci, 2012
Rapid calcium/calmodulin-dependent release of arrestin (Arr)2 from NINAC upon Ca2+ influx accounts for the acceleration of translocation by phototransduction.
The effect of DN (dominant-negative) Ku70 and reoxygenation on hypoxia cell-kill: evidence of hypoxia-induced potentially lethal damage.
GeneRIF
Ling et al., United States. In Int J Radiat Biol, 2012
Hypoxia-induced cell lethality was facilitated by DNKu70, but substantially repaired upon reoxygenation.
Association between the Ku70-1310C/G promoter polymorphism and cancer risk: a meta-analysis.
GeneRIF
You et al., Nanjing, China. In Asian Pac J Cancer Prev, 2011
Ku70-1310C/G promoter polymorphism is associated with cancer
Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
GeneRIF
Freson et al., Leuven, Belgium. In Plos One, 2011
H19 and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients.
Meningococcus Hijacks a β2-adrenoceptor/β-Arrestin pathway to cross brain microvasculature endothelium.
Impact
Marullo et al., Paris, France. In Cell, 2011
We report that N. meningitidis specifically stimulates a biased β2-adrenoceptor/β-arrestin signaling pathway in endothelial cells, which ultimately traps β-arrestin-interacting partners, such as the Src tyrosine kinase and junctional proteins, under bacterial colonies.
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.
Impact
Emr et al., San Diego, United States. In Cell, 2008
Here, we describe a family of proteins in yeast (ARTs, for arrestin-related trafficking adaptors) that function by targeting specific PM proteins to the endocytic system.
Beta-arrestin-mediated localization of smoothened to the primary cilium.
Impact
Lefkowitz et al., Durham, United States. In Science, 2008
beta-Arrestin 1 or beta-arrestin 2 depletion prevented the localization of Smo to primary cilia and the Smo-dependent activation of Gli.
More papers using IRBP antibodies
SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IκB-α/NF-κB
Supplier
Sun Yi et al., In The Journal of Cell Biology, 2001
... Generation of SAG transgenic mice and epidermal primary ...
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