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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adenosylhomocysteinase-like 1

IRBIT, S-adenosyl homocysteine hydrolase, DCAL
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, Cystic Fibrosis Transmembrane Conductance Regulator
Papers on IRBIT
Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.
Hong et al., Inch'ŏn, South Korea. In Channels (austin), Jan 2016
The main goal of the present study was to investigate potential regulators, such as spinophilin (SPL), inositol-1,4,5-trisphosphate [IP3] receptors binding protein released with IP3 (IRBIT), STE20/S;PS1-related proline/a;lanine-rich kinase (SPAK) kinase, and carbonic anhydrase XII (CA XII).
The IP3 R Binding Protein Released with Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.
Boekhoff et al., München, Germany. In J Cell Physiol, Nov 2015
UNASSIGNED: Besides its capacity to inhibit the 1,4,5-trisphosphate (IP3 ) receptor, the regulatory protein IRBIT (IP3 receptor-binding protein released with IP3 ) is also able to control the activity of numerous ion channels and electrolyte transporters and thereby creates an optimal electrolyte composition of various biological fluids.
Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss.
Yun et al., In J Clin Invest, Sep 2015
We found that the expression of Na+/H+ exchanger NHE3 and several scaffold proteins, including NHE3 regulatory factors (NHERFs), inositol trisphosphate (IP₃) receptor-binding protein released with IP₃ (IRBIT), and ezrin, was decreased in the intestinal brush border membrane (BBM) of mice with streptozotocin-induced diabetes.
IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation.
Mikoshiba et al., Wako, Japan. In Proc Natl Acad Sci U S A, May 2015
Inositol 1,4,5-trisphosphate receptor (IP3R) binding protein released with IP3 (IRBIT) contributes to various physiological events (electrolyte transport and fluid secretion, mRNA polyadenylation, and the maintenance of genomic integrity) through its interaction with multiple targets.
Intracellular Cl- as a signaling ion that potently regulates Na+/HCO3- transporters.
Muallem et al., Inch'ŏn, South Korea. In Proc Natl Acad Sci U S A, Feb 2015
IP3 receptor binding protein released with IP3 (IRBIT) activation of NBCe1-B unmasks a second high affinity Cl(-) in interacting GXXXP-dependent site.
Adenosine reagent-free detection by co-immobilization of adenosine deaminase and phenol red on an optical biostrip.
Clonis et al., Athens, Greece. In Biotechnol J, 2015
Adenosine can be determined enzymatically using either S-adenosyl-homocysteine hydrolase and (3) [H]-adenosine, or adenosine kinase combined with GTP and luciferase, or an amperometric biosensor carrying adenosine deaminase (ADA), purine nucleoside phosphorylase, and xanthine oxidase.
Role of IP3 receptor signaling in cell functions and diseases.
Mikoshiba, Wako, Japan. In Adv Biol Regul, 2015
Moreover, IP3 was found not only to release Ca(2+), but also to release IRBIT (IP3receptor binding protein released with inositol trisphosphate) essential for the regulation of acid-base balance, RNA synthesis and ribonucleotide reductase.
IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues.
Mikoshiba et al., Wako, Japan. In Plos One, 2014
IRBIT (IP3R-binding protein released with inositol 1,4,5-trisphosphate) is a multifunctional protein that regulates diverse target proteins.
IRBIT promotes allosteric inhibition of ribonucleotide reductase.
In Cancer Discov, 2014
IRBIT inhibits ribonucleotide reductase (RNR) by stabilizing dATP binding to the RNR activity site.
IRBIT: a regulator of ion channels and ion transporters.
Mikoshiba et al., Wako, Japan. In Biochim Biophys Acta, 2014
IRBIT (also called AHCYL1) was originally identified as a binding protein of the intracellular Ca(2+) channel inositol 1,4,5-trisphosphate (IP3) receptor and functions as an inhibitory regulator of this receptor.
Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes.
Dasso et al., Bethesda, United States. In Science, 2014
Here, we show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex with RNR, which stabilizes dATP in the activity site of RNR and thus inhibits the enzyme.
Epigenetic regulation of aortic remodeling in hyperhomocysteinemia.
Tyagi et al., Louisville, United States. In Faseb J, 2014
Aza treatment decreased the expression of DNMT1, MMP9, TIMP1, and S-adenosyl homocysteine hydrolase (SAHH) and upregulated methylene tetrahydrofolate reductase (MTHFR).
Mechanism and synergism in epithelial fluid and electrolyte secretion.
Muallem et al., Bethesda, United States. In Pflugers Arch, 2014
The function of the transporters is regulated by multiple inputs, which in the duct include major regulation by the WNK/SPAK pathway that inhibit secretion and the IRBIT/PP1 pathway that antagonize the effects of the WNK/SPAK pathway to both stimulate and coordinate the secretion.
cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism.
Muallem et al., Bethesda, United States. In Cell Calcium, 2014
In this review, we discuss crosstalk between the Ca(2+) and cAMP signaling and the function of IRBIT (IP3 receptors binding protein release with IP3) as a third messenger that mediates the synergistic action of the Ca(2+) and cAMP signaling.
The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport.
Muallem et al., Bethesda, United States. In Physiology (bethesda), 2012
A major regulatory pathway that immerged in the last several years is regulation of ion transporters by the WNK/SPAK kinases and IRBIT/PP1 pathways.
Paradoxical expression of AHCYL1 affecting ovarian carcinogenesis between chickens and women.
Song et al., Seoul, South Korea. In Exp Biol Med (maywood), 2012
conclude that AHCYL1 expression is associated with ovarian carcinogenesis as an oncogene in chickens, whereas it plays the role of tumor suppressor in human EOC, suggesting a paradoxical function of AHCYL1 in ovarian carcinogenesis
Relief of autoinhibition of the electrogenic Na-HCO(3) [corrected] cotransporter NBCe1-B: role of IRBIT vs.amino-terminal truncation.
Parker et al., Cleveland, United States. In Am J Physiol Cell Physiol, 2012
A NBCe1-B construct that lacks amino acid residues 2-16 of the amino-terminus is fully autoinhibited, but cannot be stimulated by IRBIT, indicating that autoinhibitory and IRBIT-binding determinants within the cytosolic amino-terminus are not identical.
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
Muallem et al., Bethesda, United States. In J Clin Invest, 2011
IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities
Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
Yun et al., Atlanta, United States. In J Biol Chem, 2010
IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway.
Primers on molecular pathways: bicarbonate transport by the pancreas.
Romero et al., Zagreb, Croatia. In Pancreatology, 2009
Both IRBIT (inositol 1,4,5-trisphosphate receptor-binding protein) and WNK [with no lysine (K)] kinase have been implicated as additional HCO(3)(-) secretory controllers.
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