Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity.
Inch'ŏn, South Korea. In Channels (austin), Jan 2016
The main goal of the present study was to investigate potential regulators, such as spinophilin (SPL), inositol-1,4,5-trisphosphate [IP3] receptors binding protein released with IP3 (IRBIT), STE20/S;PS1-related proline/a;lanine-rich kinase (SPAK) kinase, and carbonic anhydrase XII (CA XII).
Role of IP3 receptor signaling in cell functions and diseases.
Wako, Japan. In Adv Biol Regul, 2015
Moreover, IP3 was found not only to release Ca(2+), but also to release IRBIT (IP3receptor binding protein released with inositol trisphosphate) essential for the regulation of acid-base balance, RNA synthesis and ribonucleotide reductase.
IRBIT: a regulator of ion channels and ion transporters.
Wako, Japan. In Biochim Biophys Acta, 2014
IRBIT (also called AHCYL1) was originally identified as a binding protein of the intracellular Ca(2+) channel inositol 1,4,5-trisphosphate (IP3) receptor and functions as an inhibitory regulator of this receptor.
Mechanism and synergism in epithelial fluid and electrolyte secretion.
Bethesda, United States. In Pflugers Arch, 2014
The function of the transporters is regulated by multiple inputs, which in the duct include major regulation by the WNK/SPAK pathway that inhibit secretion and the IRBIT/PP1 pathway that antagonize the effects of the WNK/SPAK pathway to both stimulate and coordinate the secretion.