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Interleukin-1 receptor-associated kinase 2

IRAK2, interleukin-1 receptor-associated kinase 2
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRAK, IL-1beta, MyD88, TRAF6, IRAK-4
Papers on IRAK2
Lipoteichoic acid modulates inflammatory response in macrophages after phagocytosis of titanium particles through Toll-like receptor 2 cascade and inflammasomes.
Takagi et al., Yamagata, Japan. In J Biomed Mater Res A, Feb 2016
Finally, the same cells with silenced Irak2, an adaptor protein in the TLR2 cascade, suppressed this NLRP3 upregulation.
Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
Fraser et al., Bethesda, United States. In Sci Signal, Dec 2015
Whereas TLR signaling in mouse macrophages depended primarily on IRAK4 and IRAK2, with little or no role for IRAK1, TLR signaling and proinflammatory cytokine production in human macrophages depended on IRAK1, with knockdown of IRAK4 or IRAK2 having less of an effect.
A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.
East-German and Swiss Hepatitis C Virus Study Groups et al., Heidelberg, Germany. In Hepatology, Nov 2015
We discovered a comparatively frequent coding variant of the enigmatic human IRAK2, L392V (rs3844283), which is found homozygously in ∼15% of Caucasians, to be associated with a reduced ability to induce interferon-alpha in primary human plasmacytoid dendritic cells in response to hepatitis C virus (HCV).
Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Molnár et al., Budapest, Hungary. In Plos One, 2014
MYD88, IRAK2, NFκB, IL8, IL-1β), STING pathway (ADAR, IRF7, CXCL10, CASP1) and the FGF2 gene.
Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans.
Condino-Neto et al., São Paulo, Brazil. In Arch Immunol Ther Exp (warsz), 2013
The classical pathway results in the activation of both nuclear factor κB and MAPKs via the IRAK complex, with two active kinases (IRAK-1 and IRAK-4) and two non-catalytic subunits (IRAK-2 and IRAK-3/M).
IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance.
Davila et al., Albany, United States. In Front Immunol, 2013
The IRAK family is comprised of four family members, IRAK-1, IRAK-2, IRAK-3 (also known as IRAK-M), and IRAK-4, which play important roles in both positively and negatively regulating the expression of inflammatory molecules.
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Hu et al., New York City, United States. In Nat Immunol, 2012
RBP-J promoted the synthesis of IRF8 protein by selectively augmenting kinase IRAK2-dependent signaling via TLR4 to the kinase MNK1 and downstream translation-initiation control through eIF4E.
Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts--from the point of view of mouse genomics.
Gu et al., Harbin, China. In Int Immunopharmacol, 2012
The 13 partner genes include IL-1r1, IL-1β, IL-1α, Myd88, Irak1, Irak2, Irak4, Traf6, Tlr4, IL-1rap, Ikbkap, Nfkb1, and Nfkb2.
Helical assembly in the death domain (DD) superfamily.
Wu et al., New York City, United States. In Curr Opin Struct Biol, 2012
Recently structural information on a ternary complex containing the DDs of MyD88, IRAK4, and IRAK2 and a binary complex containing Fas and FADD DDs has become available.
IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection.
Stadecker et al., Boston, United States. In Plos Pathog, 2011
IRAK-2 mediates pathology in a CD4 T cell specific manner by promoting Th17 cell development through enhancement of IL-1beta-induced activation of transcription factors RORgammat and BATF.
MicroRNA in TLR signaling and endotoxin tolerance.
Chan et al., Gainesville, United States. In Cell Mol Immunol, 2011
Tolerance is established and sustained by the activity of the microRNA miR-146a, which is known to target key elements of the myeloid differentiation factor 88 (MyD88) signaling pathway, including IL-1 receptor-associated kinase (IRAK1), IRAK2 and tumor-necrosis factor (TNF) receptor-associated factor 6 (TRAF6).
Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.
Bowie et al., Dublin, Ireland. In J Biol Chem, 2011
Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.
The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation.
Li et al., Hengyang, China. In J Interferon Cytokine Res, 2011
the kinase activity of IRAK2 is required for the optimal activation of mitogen-activated protein kinase signaling, which regulates cytokine and chemokine production at posttranscriptional levels.
The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production.
Li et al., Cleveland, United States. In J Immunol, 2011
IRAK2 is a negative regulator of Toll-like receptor (TLR)9-induced interferon production in plasmacytoid dendritic cells.
Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease.
Lukiw et al., New Orleans, United States. In J Biol Chem, 2011
analysis of differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
Wu et al., New York City, United States. In Nature, 2010
the crystal structure of the MyD88-IRAK4-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Akira et al., Suita, Japan. In Nat Immunol, 2008
Here we show that IRAK2 was essential for sustaining TLR-induced expression of genes encoding cytokines and activation of the transcription factor NF-kappaB, despite the fact that IRAK2 was dispensable for activation of the initial signaling cascades.
IRAK-M is a negative regulator of Toll-like receptor signaling.
Flavell et al., New Haven, United States. In Cell, 2002
The IRAK family consists of two active kinases, IRAK and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M.
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Yeh et al., Toronto, Canada. In Nature, 2002
Signal transduction between MyD88 and TRAF6 is known to involve the serine-threonine kinase IL-1 receptor-associated kinase 1 (IRAK-1) and two homologous proteins, IRAK-2 (ref.
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