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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

IQ motif containing GTPase activating protein 3

Top mentioned proteins: Sar1, IQGAP2, ERK, Actin, HAD
Papers on IQGAP3
IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression.
Ridky et al., Philadelphia, United States. In J Invest Dermatol, Sep 2015
Using genetically engineered human skin tissue in vivo, we demonstrate that diminished, sub-physiologic expression of IQGAP1 or IQGAP3 is sufficient to maintain normal epidermal homeostasis, whereas significantly higher levels are required to support tumorigenesis.
IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development.
Thisse et al., Shanghai, China. In Cytoskeleton (hoboken), Aug 2015
Vertebrates express 3 family members: IQGAP1, IQGAP2, and IQGAP3.
The biology of IQGAP proteins: beyond the cytoskeleton.
Sacks et al., Bethesda, United States. In Embo Rep, Apr 2015
IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular system, pancreas, and lung.
IQGAPs choreograph cellular signaling from the membrane to the nucleus.
Sacks et al., Bethesda, United States. In Trends Cell Biol, Mar 2015
Investigation of the IQGAP2 and IQGAP3 homologs demonstrates unique functions, some of which differ from those of IQGAP1.
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
He et al., Shenzhen, China. In Nat Commun, 2014
Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis.
Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression.
Kumar et al., Riyadh, Saudi Arabia. In Int J Clin Exp Pathol, 2014
The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver cells of Balbc mice.
Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.
Tsukita et al., Kyoto, Japan. In Genes Cells, 2014
In this study, we showed that IQGAP3 specifically localized to the equatorial cortex at anaphase, whereas IQGAP1 localized to the cell cortex uniformly and IQGAP2 was unexpressed in HeLa cells.
Conserved sequence repeats of IQGAP1 mediate binding to Ezrin.
Worthylake et al., New Orleans, United States. In J Proteome Res, 2014
ITC also indicates that the ezrin FERM domain binds to the Repeats from IQGAP2 but not the Repeats from IQGAP3.
IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.
Zhang et al., Beijing, China. In Plos One, 2013
IQGAP3 is the latest addition to this family and its role in cancer development remains to be defined.
IQ-motif peptides as novel anti-microbial agents.
Timson et al., Belfast, United Kingdom. In Biochimie, 2013
Therefore, we tested eight peptides encoding the sequences of IQ-motifs derived from the human cytoskeletal scaffolding proteins IQGAP2 and IQGAP3.
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
Batty et al., Dundee, United Kingdom. In J Biol Chem, 2012
Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).
Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas.
Manne et al., Birmingham, United States. In Plos One, 2011
Of 49 down-regulated genes, LPAR6, PDLIM3, and PLAT, and, of 35 up-regulated genes, TRIM29, FUT3, IQGAP3, and SLC6A8 were confirmed by qNPA, qRT-PCR, and IHC platforms.
The interaction of IQGAPs with calmodulin-like proteins.
Timson et al., Belfast, United Kingdom. In Biochem Soc Trans, 2011
The three human IQGAP isoforms (IQGAP1, IQGAP2 and IQGAP3) all have four IQ motifs.
Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development.
Tsukita et al., Ōsaka, Japan. In J Cell Physiol, 2009
Report involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development.
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis.
Sacks et al., Boston, United States. In Febs Lett, 2009
IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined.
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.
Tsukita et al., Suita, Japan. In Nat Cell Biol, 2008
IQGAP3 is necessary and sufficient for driving cell proliferation and ERK acts downstream of IQGAP3
IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.
Kaibuchi et al., Nagoya, Japan. In J Cell Sci, 2007
Iqgap3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth.
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