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Isopentenyl-diphosphate delta isomerase 1

IPP isomerase, IDI1, isopentenyl-diphosphate delta isomerase, IDII
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, STEP, V1a, CAN, fibrillin-1
Papers on IPP isomerase
Spatial and temporal regulation of sterol biosynthesis in Nicotiana benthamiana.
New
Chappell et al., Ames, United States. In Physiol Plant, Jan 2016
showed the greatest modulation of levels, while the activity levels for IPP isomerase (EC 5.3.3.2) and prenyltransferases (EC 2.5.1.10
Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.
New
Wakabayashi et al., Sapporo, Japan. In Neuropathology, Oct 2015
IDI has two isoforms in humans: IDI1 and IDI2.
Regulation of gene expression in rats with spinal cord injury based on microarray data.
New
Yu et al., Beijing, China. In Mol Med Report, Aug 2015
HMGCS1, FDFT1 and IDI1) were negatively correlated with time, while injury genes (e.g.
Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo.
New
Patel et al., Richmond, United States. In Oncotarget, Jul 2015
More importantly, supplementation with dimethylallyl- and farnesyl-PP, MIB metabolites downstream of isopentenyl-diphosphate delta isomerase (IDI), but not mevalonate and isopentenyl-pp that are upstream of IDI, resulted in a near-complete reversal of the suppressive effect of the InAT axis inhibitors on CSCs growth.
STAT6 silencing up-regulates cholesterol synthesis via miR-197/FOXJ2 axis and induces ER stress-mediated apoptosis in lung cancer cells.
Saini et al., Delhi, India. In Biochim Biophys Acta, 2015
Previously, using genome-wide expression profiling studies, we have shown an inverse relationship of STAT6 and cholesterol biosynthesis and also identified FOXJ2 binding sites in the upstream region of 3 key genes (HMGCR, HMGCS1 and IDI1) of the cholesterol synthesis pathway.
Metabolic engineering for the high-yield production of isoprenoid-based C₅ alcohols in E. coli.
Lee et al., United States. In Sci Rep, 2014
Next, we expressed a fusion protein of IPP isomerase and the phosphatase (Idi1~NudB) along with a reductase (NemA) to diversify production to 3-methyl-2-buten-1-ol and 3-methyl-1-butanol.
IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum.
Wendisch et al., Bielefeld, Germany. In Febs J, 2014
Finally, application of prenyltransferase overexpression revealed that combined overexpression of idsA and the IPP isomerase gene idi in the absence of crtE led to the highest decaprenoxanthin titer reported to date.
Determination of kinetics and the crystal structure of a novel type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase from Streptococcus pneumoniae.
Poulter et al., Salt Lake City, United States. In Chembiochem, 2014
Type 1 IDI (IDI-1) is a metalloprotein that is found in eukaryotes, whereas the type 2 isoform (IDI-2) is a flavoenzyme found in bacteria that is completely absent from human.
Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae.
Zhou et al., Wuxi, China. In J Biotechnol, 2013
The results obtained revealed that the IDI1-encoded isopentenyl diphosphate isomerase is a rate-limiting enzyme in the biosynthesis of geraniol in S. cerevisiae, and overexpression of MAF1, a negative regulator in tRNA biosynthesis, is another effective method to increase geraniol production in S. cerevisiae.
[Regulation of isoprenoid pathway for enhanced production of linalool in Saccharomyces cerevisiae].
Chen et al., Wuxi, China. In Sheng Wu Gong Cheng Xue Bao, 2013
In order to increase the metabolic flux, we constructed the integrated expression plasmid pRS305-tHMG1 and free expression plasmid pYLIS-IDI1 to enhance the expression levels of isopentenyl diphosphate isomerase (IDI1) and a truncated 3-hydroxyl-3-methylglutaryl-CoA reductase gene (tHMG1).
Identification and characterization of genes that control fat deposition in chickens.
Zhang et al., Kigali, Rwanda. In J Anim Sci Biotechnol, 2012
Expression levels of genes for lipid metabolism (SULT1B1, ACSBG2, PNPLA3, LPL, AOAH) carbohydrate metabolism (MGAT4B, XYLB, GBE1, PGM1, HKDC1)cholesttrol biosynthesis (FDPS, LSS, HMGCR, NSDHL, DHCR24, IDI1, ME1) HSD17B7 and other reaction or processes (CYP1A4, CYP1A1, AKR1B1, CYP4V2, DDO) were higher in the fast-growing White Recessive Rock chickens than in the slow-growing Xinghua chickens.
Inhibition Studies on Enzymes Involved in Isoprenoid Biosynthesis: Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes.
Poulter et al., Salt Lake City, United States. In Curr Enzym Inhib, 2011
This review will discuss the enzymes in the mevalonate (MVA) and methylerythritol phosphate (MEP) biosynthetic pathways leading to IPP and DMAPP with a particular focus on MEP synthase (DXR) and IPP isomerase (IDI), which are potential targets for the development of antibiotic compounds.
Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis.
GeneRIF
Matsubara et al., Yamagata, Japan. In Biochem Biophys Res Commun, 2010
Within the 40-kb region on 10p15.3 subtelomere, which harbours two genes encoding isopentenyl diphosphate isomerase 1 (IDI1) and IDI2, there was found a segmental copy-number gain in a large proportion of sporadic amyotrophic lateral sclerosis patients.
Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes.
Review
Dairi, Kosugi, Japan. In J Antibiot (tokyo), 2005
All these clusters contained genes coding for mevalonate kinase, mevalonate diphosphate decarboxylase, phosphomevalonate kinase, type 2 IPP isomerase, HMG-CoA reductase, and HMG-CoA synthase.
Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate.
Review
Eisenreich et al., Garching bei München, Germany. In Bioorg Chem, 2004
IPP and DMAPP can be interconverted by IPP isomerase which is essential in microorganisms using the mevalonate pathway, whereas its presence is optional in microorganisms using the non-mevalonate pathway.
Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.
GeneRIF
Krisans et al., San Diego, United States. In J Mol Evol, 2003
only one of the two isoforms (IDI1) is highly conserved, ubiquitously expressed and most likely responsible for housekeeping isomerase activity
Diversity of the biosynthesis of the isoprene units.
Review
Seto et al., Tokyo, Japan. In Nat Prod Rep, 2003
This review covers the biosynthesis of the starter units of terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) via the nonmevalonate pathway together with a new enzyme involved in the conversion of IPP and DMAPP, i.e type 2 IPP isomerase.
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