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Interaction protein for cytohesin exchange factors 1

IPCEF1, interaction protein for cytohesin exchange factors 1
binds guanine nucleotide exchange factor cytohesin 2 and increases cytohesin 2 mediated formation of ADP-ribosylation factor GTP-ase [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: CAN, SET, BRAF, Actin, ARF6
Papers on IPCEF1
Somatic amplifications and deletions in genome of papillary thyroid carcinomas.
New
Damante et al., Udine, Italy. In Endocrine, Nov 2015
Most frequent deletions occurred at regions 6q25.2, containing OPMR1 and IPCEF1 genes and 7q14.2, containing AOAH and ELMO1 genes.
Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).
New
Family Investigation of Nephropathy and Diabetes (FIND) et al., Phoenix, United States. In Plos Genet, Aug 2015
SNPs are located between the SCAF8 and CNKSR3 genes, a region with DKD relevant changes in gene expression and an eQTL with IPCEF1, a gene co-translated with CNKSR3.
Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid.
Al-Maghrabi et al., In Bmc Genomics, 2014
The most significantly downregulated genes in FVPTCs included interaction protein for cytohesin exchange factors 1 (IPCEF1), G protein-coupled receptor 155 (GPR155), Purkinje cell protein 4 (PCP4), chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1), and glutamate receptor interacting protein 1 (GRIP1).
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
Impact
Houlston et al., United Kingdom. In Nat Genet, 2014
A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)).
CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.
GeneRIF
Santy et al., United States. In Exp Cell Res, 2012
CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration.
GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.
GeneRIF
Santy et al., United States. In Mol Biol Cell, 2010
protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF
Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion.
GeneRIF
Tao et al., Baltimore, United States. In Naunyn Schmiedebergs Arch Pharmacol, 2009
correlation of IPCEF1 mRNA expression with nerve injury input in injured dorsal root ganglion suggests that IPCEF1 might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking
[Expression of tumor suppressor gene PTEN, PIP3 and cyclin D1 in oral squamous cell carcinoma and their correlations].
GeneRIF
Yao et al., Guangzhou, China. In Zhonghua Kou Qiang Yi Xue Za Zhi, 2006
PTEN may down-regulate the expression of PIP3, and then down-regulate the expression of cyclin D1, which leads to the suppression of cell growth.
Analysis of the interaction between cytohesin 2 and IPCEF1.
Venkateswarlu, Bristol, United Kingdom. In Methods Enzymol, 2004
IPCEF1 has been reported to interact with ADP-ribosylation factor GTP exchange factors of the cytohesin family and function by modulating the cytohesin 2 activity.
Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.
GeneRIF
Venkateswarlu, Bristol, United Kingdom. In J Biol Chem, 2003
IPCEF1 increases the in vitro and in vivo stimulation of ARFGTP formation by cytohesin 2
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