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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NLR family, CARD domain containing 4

Ipaf, Clan, NLRC4, CARD12
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: PrP, NOD, IL-18, ASC, AIM2
Papers on Ipaf
Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.
New
Yang et al., Taiwan. In Dna Cell Biol, Feb 2016
We evaluated NLRP3, NLRC4, AIM2, and ASC inflammasome complex gene expression on real-time polymerase chain reaction (PCR).
NLRC4 inflammasomes: "their appearance and their work was a wheel in the middle of a wheel".
New
Brownstein, Bethlehem, United States. In Oral Dis, Jan 2016
UNASSIGNED: Cells of the immune system protect us from pathogens, environmental toxins, and even cancer.
The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages.
New
Amer et al., Columbus, United States. In Plos One, Dec 2015
The restriction of L. pneumophila replication has been shown to require bacterial flagellin, a component of the type IV secretion system as well as the cytosolic NOD-like receptor (NLR) Nlrc4/ Ipaf.
Inflammasomes in non-alcoholic fatty liver disease.
New
Tipoe et al., In Front Biosci, Dec 2015
Currently, there are several identified inflammasomes, including nod-like receptor protein (NLRP)-1, 2, 3, 6, 10, 12, NLRC4 and absent in melanoma 2 (AIM2) inflammasomes.
Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
New
Impact
Miao et al., Chapel Hill, United States. In Immunity, Dec 2015
Here, we identified one such ubiquitous environmental bacterium, Chromobacterium violaceum, whose extreme virulence was fully counteracted by the NLRC4 inflammasome.
Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.
New
Impact
Ayres et al., Los Angeles, United States. In Science, Nov 2015
This effect was dependent on engagement of the NLRC4 inflammasome.
Structural and biochemical basis for induced self-propagation of NLRC4.
New
Impact
Chai et al., Beijing, China. In Science, Nov 2015
Recognition of bacterial pathogens by NLR apoptosis inhibitory proteins (NAIPs) induces NLR family CARD domain-containing protein 4 (NLRC4) activation and formation of NAIP-NLRC4 inflammasomes.
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
New
Impact
Wu et al., Boston, United States. In Science, Nov 2015
The NLR family apoptosis inhibitory proteins (NAIPs) bind conserved bacterial ligands, such as the bacterial rod protein PrgJ, and recruit NLR family CARD-containing protein 4 (NLRC4) as the inflammasome adapter to activate innate immunity.
Regulation and Function of the NLRP3 Inflammasome in Lung Disease.
Review
New
Choi et al., New York City, United States. In Am J Respir Cell Mol Biol, Oct 2015
Several NOD-like receptor (NLR) family members (i.e., NLRP1, NLRP3, and NLRC4) as well as the PYHIN family member AIM2 can form inflammasome complexes in human cells.
Newly recognized Mendelian disorders with rheumatic manifestations.
Review
New
Goldbach-Mansky et al., Bethesda, United States. In Curr Opin Rheumatol, Sep 2015
Gain-of-function mutations in NLRC4 add a novel inflammasome disorder associated with predisposition to macrophage-activation syndrome and highly elevated IL-18 levels.
Inflammasomes of the intestinal epithelium.
Review
New
Hardt et al., Zürich, Switzerland. In Trends Immunol, Aug 2015
Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis.
The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.
Review
New
Wu et al., Boston, United States. In Curr Opin Struct Biol, Apr 2015
In particular, these include a crystal structure of the CARD-containing NOD-like receptor NLRC4, the crystallographic and electron microscopy (EM) studies of the dsDNA sensors AIM2 and IFI16, and of the regulatory protein p202, and the cryo-EM filament structure of the PYD domain of the inflammasome adapter ASC.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
New
Impact
Dixit et al., New Haven, United States. In Nat Med, Mar 2015
BHB did not inhibit caspase-1 activation in response to pathogens that activate the NLR family, CARD domain containing 4 (NLRC4) or absent in melanoma 2 (AIM2) inflammasome and did not affect non-canonical caspase-11, inflammasome activation.
Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.
Yang et al., Changchun, China. In Sci Rep, 2014
In the current study, we demonstrated that genipin inhibits the induction of IL-1β production and caspase-1 activation by NLRP3 and NLRC4 inflammasomes.
Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity.
Review
Kretsinger et al., Sapporo, Japan. In Biomolecules, 2014
The structures of the LRR domains of NLRC4, NLRP1, and NLRX1 in NLRs and of TLR1-5, TLR6, TLR8, TLR9 in TLRs have been determined.
NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection.
GeneRIF
Jeyaseelan et al., Baton Rouge, United States. In J Immunol, 2012
NLRC4 is important for host survival and bacterial clearance, as well as neutrophil-mediated inflammation in the lungs following Klebsiella pneumoniae infection.
Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges.
GeneRIF
Gewirtz et al., Atlanta, United States. In Mucosal Immunol, 2012
protects mice against mucosal and systemic challenges
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.
Impact
GeneRIF
Núñez et al., Ann Arbor, United States. In Nat Immunol, 2012
NLRC4-dependent production of IL-1beta by intestinal phagocytes represents a specific response that discriminates pathogenic bacteria from commensal bacteria and contributes to host defense in the intestine.
Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.
GeneRIF
Duarte et al., São Paulo, Brazil. In J Acquir Immune Defic Syndr, 2012
Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects.
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells.
Impact
GeneRIF
Bedoui et al., Melbourne, Australia. In Nat Immunol, 2012
It was shown that CD8alpha+ dendritic cells were particularly efficient at sensing bacterial flagellin through NLRC4 inflammasomes.
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