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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inversin

Inv, NPHP2, INVS
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, NPHP1, V1a
Papers on Inv
Role of β1 integrins and bacterial adhesins for Yop injection into leukocytes in Yersinia enterocolitica systemic mouse infection.
New
Schütz et al., Tübingen, Germany. In Int J Med Microbiol, Jan 2016
In this process Ye invasin (Inv) binds directly while Yersinia adhesin A (YadA) binds indirectly via extracellular matrix (ECM) proteins to β1 integrins on host cells.
Distinction of Invasive Carcinoma Derived From Intraductal Papillary Mucinous Neoplasms From Concomitant Ductal Adenocarcinoma of the Pancreas Using Molecular Biomarkers.
New
Tanaka et al., Fukuoka, Japan. In Pancreas, Jan 2016
RESULTS: KRAS/GNAS mutation status of invasive and noninvasive components in Inv-IPMN was consistent in 18 (86%) of 21 patients.
Structural basis of the Inv compartment and ciliary abnormalities in inv/nphp2 mutant mice.
New
Yokoyama et al., Kyoto, Japan. In Cytoskeleton (hoboken), Dec 2015
Inv gene is a responsible gene for human nephronophthisis type2 (NPHP2).
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation.
New
Impact
Kuo et al., Duarte, United States. In Cell Stem Cell, Dec 2015
Here, we show that p53 activity is inhibited in inv(16)(+) AML LSCs via interactions with the CBFβ-SMMHC (CM) fusion protein and histone deacetylase 8 (HDAC8).
Down-regulation of a wheat alkaline/neutral invertase correlates with reduced host susceptibility to wheat stripe rust caused by Puccinia striiformis.
New
Kang et al., Taiwan. In J Exp Bot, Oct 2015
The majority of Suc metabolism-associated reports refer to acid invertases (Ac-Invs).
Transcriptome Profiling of Pediatric Core Binding Factor AML.
Meshinchi et al., Huntsville, United States. In Plos One, 2014
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CBFA) and beta (CBFB), respectively.
Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder.
Review
Day et al., Indianapolis, United States. In Postgrad Med, 2014
RESULTS: ATX demonstrated significantly greater improvement than placebo (PBO) on the Conners Adult ADHD Rating Scale-Investigator rated:Screening Version (CAARS-Inv:SV) in all trials (N = 6; total score difference ranged from -3.5 to -5.5).
Cell-wall invertases, key enzymes in the modulation of plant metabolism during defence responses.
Review
Hückelhoven et al., Freising, Germany. In Mol Plant Pathol, 2014
This enhanced metabolic activity is accompanied by the reduced export of sucrose or enhanced import of hexoses at the site of infection, which is mediated by an induced activity of cell-wall invertase (Cw-Inv).
Early presentation of cystic kidneys in a family with a homozygous INVS mutation.
Review
Arts et al., Nijmegen, Netherlands. In Am J Med Genet A, 2014
INVS encodes the ciliary protein inversin, and mutations induce dysfunction of the primary cilia.
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.
Impact
Lienkamp et al., Freiburg, Germany. In Nat Genet, 2013
Here we identify ANKS6 as a new NPHP family member that connects NEK8 (NPHP9) to INVS (NPHP2) and NPHP3.
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Impact
Downing et al., Memphis, United States. In Cancer Cell, 2012
Our analysis identified a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric cases, which encodes a CBFA2T3-GLIS2 fusion protein.
The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish.
GeneRIF
Yokoyama et al., Kyoto, Japan. In Febs Lett, 2012
Nek8 acts downstream of Inv function
Bacterial cell surface structures in Yersinia enterocolitica.
Review
Skurnik et al., Katowice, Poland. In Arch Immunol Ther Exp (warsz), 2012
These include outer membrane (OM) glycolipids such as lipopolysaccharide (LPS) and enterobacterial common antigen (ECA) and several cell surface adhesion proteins present only in virulent Y. enterocolitica, i.e., Inv, YadA and Ail.
The ciliary transitional zone and nephrocystins.
Review
Yokoyama et al., Kyoto, Japan. In Differentiation, 2012
Group I nephrocystins are localized in the transitional zone, whereas group II nephrocystins are localized in the Inv compartment.
A homozygous mutation in INVS causing juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathway.
GeneRIF
Pirson et al., Brussels, Belgium. In Nephrol Dial Transplant, 2010
INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathway.
Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia.
GeneRIF
Yokoyama et al., Kyoto, Japan. In Cytoskeleton (hoboken), 2010
Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia.
Mutations of NPHP2 and NPHP3 in infantile nephronophthisis.
GeneRIF
Salomon et al., Paris, France. In Kidney Int, 2009
screened 43 families with infantile nephronophthisis (ESRD less than 5 years of age) for NPHP2 and NPHP3 mutations and determined genotype-phenotype correlations
Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region.
GeneRIF
Yokoyama et al., Kyoto, Japan. In J Cell Sci, 2009
Results show that the Inv protein (also known as inversin) is localized at a distinctive proximal segment of the primary cilium.
Short hairpin RNA-expressing bacteria elicit RNA interference in mammals.
Impact
Li et al., Boston, United States. In Nat Biotechnol, 2006
Nonpathogenic Escherichia coli were engineered to transcribe shRNAs from a plasmid containing the invasin gene Inv and the listeriolysin O gene HlyA, which encode two bacterial factors needed for successful transfer of the shRNAs into mammalian cells.
Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
Impact
Hildebrandt et al., Ann Arbor, United States. In Nat Genet, 2003
Here, we identify inversin (INVS) as the gene mutated in NPHP2 with and without situs inversus.
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