GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 6
Interleukin-6, IL-6
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] (from
NCBI)
Papers using
Interleukin-6
antibodies
Enzymatic-nonenzymatic cellular antioxidant defence systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity
Supplier
In Diagnostic Pathology, 2009
... IL-6 (Santa Cruz, CA, USA)5 min Proteolytic Enzyme (Dako, Copenhagen, Denmark), 20°C.
Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking.
Supplier
In Croatian Medical Journal, 2008
... We measured the serum concentration of adiponectin, VEGF, and IL-6 using the BioVendor (Modrice, Czech Republic), Invitrogen ...
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease
Supplier
In The Indian Journal of Medical Research, 2008
... Medium concentrations of ET-1 and interleukin-6 (IL-6) were evaluated by two different kit of ELISA technique employing a solid-phase sandwich, enzyme-linked immuno-sorbent assay (Cayman, Ann Arbor MI, USA; ...
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Supplier
In PLoS ONE, 2008
... Murine IL-27, IL-6, TGFβ were purchased from R&D Systems (Minneapolis, MN); Murine IFNα and IFNβ proteins were from PBL Biomedical Laboratories (Piscataway, NJ); Anti-CD3, ...
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene
more suppliersSupplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... , IL-6, and TNF-α enzyme-link immunosorbent assay (ELISA) Development Kit was purchased from BioLegend, Inc (California, USA) ...
Papers on
Interleukin-6
Does non-transferrin bound iron contribute to transfusion related immune-modulation in preterms?
New
Adelaide, Australia. In Arch Dis Child Fetal Neonatal Ed, 09 Apr 2013
Post-transfusion NTBI level correlated with the age of transfused blood (p<0.001) and was positively correlated with plasma MDA (p=0.01) but not IL-1β, IL-6, IL8 or TNFα.
Dietary phytophenols reduce infection-induced inflammatory pathways in human gestational tissues.
New
Melbourne, Australia. In Mol Hum Reprod, 07 Apr 2013
In placenta and fetal membranes, all treatments significantly reduced LPS-stimulated release and gene expression of pro-inflammatory cytokines IL-6 and IL-8; placenta decreased cyclooxygenase (COX-2) mRNA expression, subsequent release of prostaglandins PGE2 and PGF2α; and expression and activity of matrix degrading enzyme matrix metalloproteinase (MMP)-9.
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
New
Impact
Cleveland, United States. In Nat Immunol, 28 Feb 2013
The absence of signaling via C3aR and C5aR resulted in lower expression of costimulatory molecules and interleukin 6 (IL-6) and more production of IL-10.
Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer.
New
Impact
Glasgow, United Kingdom. In Cancer Cell, 14 Feb 2013
In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-κB/IL-6/STAT3 pathway.
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
New
Impact
Richmond, United States. In Cancer Cell, 14 Feb 2013
S1P is essential for production of the multifunctional NF-κB-regulated cytokine IL-6, persistent activation of the transcription factor STAT3, and consequent upregulation of the S1P receptor, S1PR1.
Inflammation in complex regional pain syndrome: a systematic review and meta-analysis.
Review
New
Sydney, Australia. In Neurology, Feb 2013
In chronic CRPS, significant increases were found in 1) TNFα, bradykinin, sIL-1RI, IL-1Ra, IL-2, sIL-2Ra, IL-4, IL-7, interferon-γ, monocyte chemoattractant protein-1 (MCP-1), and sRAGE (soluble receptor for advanced glycation end products) in blood; 2) IL-1Ra, MCP-1, MIP-1β, and IL-6 in blister fluid; and 3) IL-1β and IL-6 in CSF.
Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis.
New
Impact
Roma, Italy. In N Engl J Med, Jan 2013
Interleukin-6 plays a pathogenic role in systemic JIA.
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria.
New
Impact
Birmingham, United States. In Immunity, Jan 2013
Whereas IL-22 production by ILCs was strictly IL-23 dependent, development of IL-22-producing CD4(+) T cells occurred via an IL-6-dependent mechanism that was augmented by, but not dependent on, IL-23 and was dependent on both transcription factors T-bet and AhR.
Inflammation in atrial fibrillation.
Review
New
Birmingham, United Kingdom. In J Am Coll Cardiol, Jan 2013
Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-8) have been associated with AF.
The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis: a narrative review and proposed model.
New
Gold Coast, Australia. In Evid Based Complement Alternat Med, Dec 2012
Other reported anti-inflammatory effects of acupuncture include an antihistamine action and downregulation of proinflammatory cytokines (such as TNF- , IL-1 , IL-6, and IL-10), proinflammatory neuropeptides (such as SP, CGRP, and VIP), and neurotrophins (such as NGF and BDNF) which can enhance and prolong inflammatory response.
The Role of IL-6, 8, and 10, sTNFr, CRP, and Pancreatic Elastase in the Prediction of Systemic Complications in Patients with Acute Pancreatitis.
New
Rijeka, Croatia. In Gastroenterol Res Pract, Dec 2012
Elevation of IL-6 showed the highest significance as a predictor ( = 0.001).
Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance.
New
Chongqing, China. In Mediators Inflamm, Dec 2012
Plasma progranulin concentrations correlated positively with weight, waist circumferences, BMI, HbA1c, TG, IL-6, FINS and HOMA-IR ( < 0.05), while correlated negatively with HOMA- ( < 0.05).
The periprosthetic capsule and connective tissue diseases: a piece in the puzzle of autoimmune/autoinflammatory syndrome induced by adjuvants.
Review
New
Padova, Italy. In Exp Biol Med (maywood), Nov 2012
We focused on the relationship between tissue growth factor-β, interleukin (IL)-1, IL-6 and T helper 17 or T regulatory cells, as well as on their effects on the different steps of capsular tissue formation.
Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells.
GeneRIF
New Haven, United States. In J Immunol, 2012
IL-6 released from injured allograft vessels enhances allogeneic T cell infiltration and intimal expansion in a model of human allograft rejection by inhibiting an increase in CD161-positive regulatory T cells.
A novel pathway responsible for lipopolysaccharide-induced translational regulation of TNF-α and IL-6 expression involves protein kinase C and fascin.
GeneRIF
Taegu, South Korea. In J Immunol, 2012
Suppression of fascin expression results in substantial reduction in lipopolysaccharide-induced expression of tumor necrosis factor (TNF)-alpha and IL-6.
[Molecular basis of Waldenström macroglobulinemia].
Review
Brno, Czech Republic. In Klin Onkol, 2011
Molecular basis of this disease remains unclear even though deletion of 6q, trisomy of chromosomes 4 and 8, deletion of 13q and increased expression of IL-6 seem to be typical for this disease.
IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development.
Impact
GeneRIF
San Francisco, United States. In Cancer Cell, 2011
Chronic myelogenous leukemia multipotent progenitors (MPPs) exhibit an aberrant B-lymphoid potential but are redirected toward the myeloid lineage by the action of the proinflammatory cytokine IL-6.
[Changes of alveolar macrophage phagocytosis and TNF-alpha, IL-6 of rats with Pneumocystis pneumonia].
GeneRIF
Zhangjiakou, China. In Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2011
TNF-alpha and IL-6 level in bronchoalveolar lavage fluid of Pneumocystis pneumonia rat were significantly higher than the control.
Genetic susceptibility of intervertebral disc degeneration among young Finnish adults.
GeneRIF
Oulu, Finland. In Bmc Med Genet, 2010
IL-6 is involved in the etiology of intervertebral disc degeneration among young adults.
[Biochemical markers in assessment of severity and prognosis of acute pancreatitis].
More papers using
Interleukin-6
antibodies
Review
Zagreb, Croatia. In Lijec Vjesn, 2008
These parameters include trypsinogen activation peptide (TAP), C-reactive protein (CRP, tripsinogen-2, procalcitonin, phospholipase-A2 (PLA2), carboxypeptidase activation peptide (CAPAP) and interleukin-6 and 8 (IL-6, IL-8).
The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.
Supplier
In PLoS ONE, 2007
... Recombinant mouse IL-6, anti-alfa tubulin antibody, fluorescein isothiocyanate (FITC) conjugate anti goat antibody, and propidium iodide were purchased from Sigma Aldrich (St ...
Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test?
Supplier
In Mediators of Inflammation, 2007
... Enzyme-linked immunosorbent assay was used for quantitative detection of soluble human IL-6, Bender Medsystems GmbH (BMS213HS), Austria ...
Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
Supplier
In Carcinogenesis, 2007
... IL-6 enzyme immunoassay kit was purchased from Cayman Chemical (Ann Arbor, MI) ...
The impact of cigarette smoking on periodontal disease and treatment.
Supplier
In PLoS ONE, 2006
... TNF-α and IL-6 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities
Supplier
In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2006
... Korea); absolute ethanol and DMSO were from Thermo Fisher Scientific (Waltham, MA, USA); actin and IL-6 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Supplier
In PLoS ONE, 2006
... Human recombinant IL-6 and CK2 kinase were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
Supplier
In North American Journal of Medical Sciences, 2006
... SCF, NGF and IL-6 (Leinco Technologies.
Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice
Supplier
In Chinese Medicine, 2006
... BD OptEIA ELISA kits tumour necrosis factor-α and interleukin-6 (BD Biosciences, USA) ...
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
Supplier
In PLoS ONE, 2006
... Interleukin-6 (IL-6) was purchased from BD Biosciences (San Diego, CA) ...
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
Supplier
In PLoS ONE, 2004
... Mouse IL-6 ELISA kit was obtained from eBioscience (San Diego, CA) ...
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
Supplier
In PLoS ONE, 2004
... IL-6 and cAMP EIA kits were from Cayman Chemical, All reagents for ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
Supplier
In Journal of Neuroinflammation, 2003
... Systems, Abingdon, UK), IL-6 and non-target (NT) siRNA (Invitrogen, Paisley, UK), recombinant IL-6 (R&D Systems), anti-IL-6 receptor and isotype (IgG2b) control antibodies (Biolegend, San Diego, CA, USA), ...
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
Supplier
In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002
... of growth factors: 10pg/ml GM-CSF, 10pg/ml G-CSF, 10ng/ml SCF, 10ng/ml LIF, 10ng/ml MIP-1α, 0.2 ng/ml IL-6 (PeproTech Inc., Rocky Hill, NJ, USA, and StemCell Technologies).
Intracellular phospho-protein staining techniques for flow
cytometry: monitoring single cell signaling events.
Supplier
In PLoS ONE, 2002
... Anti-mouse IL-6 mAbs (MP5-20F3 and MP5-32C11, biotin-conjugated) used for ELISA were also obtained from eBioscience.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
In Cell Death & Disease, 2001
... and IL-6 assays (Becton Dickinson Co., Franklin Lakes, NJ, ...
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
Supplier
In Critical Care, 2001
... We used ELISA kits to determine serum concentrations of Il-6 (R&D Systems, Minneapolis, MN, USA), sVCAM-1 (Bender MedSystems, Vienna, Austria), and sICAM-1 ...
Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil–endothelial cell adhesion
Supplier
In Basic Research in Cardiology, 2000
... human (rh) Flt-3 ligand (100 ng/ml), rh stem cell factor (100 ng/ml), rh IL-3 (20 ng/ml) and rh IL-6 (20 ng/ml), all purchased from StemCell Technologies.
The microinflammatory state in uremia: causes and potential consequences
Supplier
In Journal of Biomedicine and Biotechnology, 2000
... Serum ferritin was measured by routine laboratory methods, IL-6 by enzyme-linked immunoadsorbent assay (by Human IL-6 ELISA BMS213/2CE Bender MedSystems GmbH, Vienna, Austria), and ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Supplier
In PLoS ONE, 2000
... Recombinant mouse IL-6 (RMIL6I) was obtained from Thermo Scientific (Rockford, IL) while a mouse ...
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite.
Supplier
In PLoS ONE, 1999
... Goat antibody to mouse IgG (horseradish peroxidase) (0.8 mg/mL), TNF-α, IL-1β and IL-6 mouse ELISA kits were purchased from Abcam (Cambridge, United Kingdom) ...
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW 264.7 macrophages
Supplier
In BMC Complementary and Alternative Medicine, 1998
... (Santa Cruz, CA, USA) and TNF-α, IL-6 antibody, biotinylated TNF-α and IL-6 antibodies were purchased from BD Biosciences (San Jose, CA, USA) ...
Interleukin-6-blocking agents
Supplier
In The Journal of Experimental Medicine, 1996
... TNF, IL-6 mice were obtained by intercrossing TNF-α transgenic mice ( ...
Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats.
Supplier
In PLoS Biology, 1996
... anti-phospho-PERK (rabbit polyclonal, SC-32577), anti-CHOP (GADD 153) (rabbit polyclonal, SC-575), anti-IL-10 (goat polyclonal, SC-1783), and anti-IL-6 (rabbit polyclonal, SC-7920) antibodies were from Santa Cruz Biotechnology, Inc ...
MIF Signal Transduction Initiated by Binding to CD74
Supplier
In The Journal of Experimental Medicine, 1995
... Recombinant human IL-6 and IFN-γ were obtained from R&D Systems.Human anti–human CD74 mAbs (clones LN2 and M-B741) were obtained from BD Biosciences, and dialyzed free of ...
flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
Supplier
In The Journal of Experimental Medicine, 1994
... The generation of human sIL-6R and human IL-6 transgenic mice has been described ...
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
Supplier
In The Journal of Experimental Medicine, 1991
... Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
Supplier
In European Journal of Immunology, 1991
... Siamon Gordon, Sir William Dunn School of Pathology, Oxford, UK), and IL-6 knockout mice were obtained from and housed in the Biomedical Services Unit, John Radcliffe ...
Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen
Supplier
In Arthritis Research & Therapy, 1990
... Exudate IL-6, PGE2 and PGD2 levels were determined by commercially available immunoassays (eBioscience, San Diego, CA, USA ...
Glutathione S transferases. The first enzymatic step in mercapturic acid formation
Supplier
In Oxidative Medicine and Cellular Longevity, 1973
... and IL-6 antibody procured from Anaspec Inc ...
