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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Interleukin 6

Interleukin-6, IL-6
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: IL-10, CAN, HAD, IL-8, V1a
Papers using Interleukin-6 antibodies
Enzymatic-nonenzymatic cellular antioxidant defence systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity
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Fineschi Vittorio et al., In Diagnostic Pathology, 2009
... IL-6 (Santa Cruz, CA, USA)5 min Proteolytic Enzyme (Dako, Copenhagen, Denmark), 20°C.
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease
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Longo Vincenzo et al., In The Indian Journal of Medical Research, 2008
... Medium concentrations of ET-1 and interleukin-6 (IL-6) were evaluated by two different kit of ELISA technique employing a solid-phase sandwich, enzyme-linked immuno-sorbent assay (Cayman, Ann Arbor MI, USA; ...
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
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Mossman Karen L., In PLoS ONE, 2008
... Murine IL-27, IL-6, TGFβ were purchased from R&D Systems (Minneapolis, MN); Murine IFNα and IFNβ proteins were from PBL Biomedical Laboratories (Piscataway, NJ); Anti-CD3, ...
Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking.
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Zaytseva Nadezhda V. et al., In Croatian Medical Journal, 2008
... We measured the serum concentration of adiponectin, VEGF, and IL-6 using the BioVendor (Modrice, Czech Republic), Invitrogen ...
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene
Supplier
Lin Yu-Chin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... , IL-6, and TNF-α enzyme-link immunosorbent assay (ELISA) Development Kit was purchased from BioLegend, Inc (California, USA) ...
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Papers on Interleukin-6
Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis.
New
Impact
Choi et al., Kwangju, South Korea. In Nat Med, 23 Apr 2014
Hepatic ERRγ expression was induced by S. typhimurium-stimulated interleukin-6 signaling, resulting in an induction of hepcidin and eventual hypoferremia in mice.
Adult-onset Still's disease.
Review
New
Sève et al., Lyon, France. In Autoimmun Rev, 18 Apr 2014
IL-18 and IL-1β, two proinflammatory cytokines processed through the inflammasome machinery, are key factors in the pathogenesis of AOSD; they cause IL-6 and Th1 cytokine secretion as well as NK cell dysregulation leading to macrophage activation.
The IL-6 feed-forward loop: A driver of tumorigenesis.
Review
New
Bromberg et al., New York City, United States. In Semin Immunol, 06 Apr 2014
UNLABELLED: IL-6 signaling plays a prominent role in tumorigenesis and metastasis.
A56: macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis treated with tocilizumab.
New
De Benedetti et al., Genova, Italy. In Arthritis Rheumatol, 31 Mar 2014
Interleukin-6 (IL-6) plays a major pathogenic role in sJIA; data in animals suggest that high IL-6 levels contribute to the triggering of MAS.
A54: Insulin Sensitivity Is Improved in sJIA Children With Insulin Resistance After Tocilizumab Treatment: Results From the TENDER Study.
New
De Benedetti et al., Welwyn Garden City, United Kingdom. In Arthritis Rheumatol, 31 Mar 2014
Interleukin-6 (IL-6) is postulated to play a mechanistic role in IR.
A66: Assessment of Radiographic Progression in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Tocilizumab: 2-Year Results From the TENDER Trial.
New
Ravelli et al., Genova, Italy. In Arthritis Rheumatol, 31 Mar 2014
BACKGROUND/PURPOSE: A phase 3 trial (TENDER) demonstrated the efficacy of the interleukin-6 receptor inhibitor tocilizumab (TCZ) in patients with systemic juvenile idiopathic arthritis (sJIA) ().
Circadian Clock Proteins and Immunity.
Review
New
Impact
O'Neill et al., Dublin, Ireland. In Immunity, 20 Mar 2014
Examples include the BMAL1:CLOCK heterodimer regulating toll-like receptor 9 (TLR9) expression and repressing expression of the inflammatory monocyte chemokine ligand (CCL2) as well as REV-ERBα suppressing the induction of interleukin-6.
Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis.
New
Impact
Baltimore et al., Pasadena, United States. In Cell Stem Cell, 19 Mar 2014
Among cytokines produced by HSPCs, IL-6 is a particularly important regulator of myeloid differentiation and HSPC proliferation in a paracrine manner and in mediating rapid myeloid cell recovery during neutropenia.
Insights into the Role of Follicular Helper T Cells in Autoimmunity.
Review
New
Choi et al., Seoul, South Korea. In Immune Netw, 28 Feb 2014
IL-6 and IL-21 cytokine-mediated STAT signaling pathways, including STAT1 and STAT3, are crucial for inducing Bcl-6 expression and TFH cell differentiation.
Yoga's Impact on Inflammation, Mood, and Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial.
New
Impact
Glaser et al., Columbus, United States. In J Clin Oncol, 27 Feb 2014
The main outcome measures were lipopolysaccharide-stimulated production of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β), and scores on the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), the vitality scale from the Medical Outcomes Study 36-item Short Form (SF-36), and the Center for Epidemiological Studies-Depression (CES-D) scale.
Interleukin-6 signaling drives fibrosis in unresolved inflammation.
New
Impact
Jones et al., Cardiff, United Kingdom. In Immunity, 16 Feb 2014
In this context, fibrosis was strictly dependent on interleukin-6 (IL-6).
The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders.
Review
New
Núñez et al., Santiago, Chile. In Front Pharmacol, Dec 2013
In addition, a connection between the loss of iron homeostasis and inflammation is starting to emerge; thus, inflammatory cytokines like TNF-alpha and IL-6 induce the synthesis of the divalent metal transporter 1 and promote iron accumulation in neurons and microglia.
Obesity Associated Hypertension: New Insights into Mechanism.
Review
New
Kang, Ansan, South Korea. In Electrolyte Blood Press, Dec 2013
Adipose tissue produce and secretes several molecules such as leptin, resistin, adiponectin, and visfatin, as well as cytokines such as TNF-α, IL-6, MCP-1, and IL-1.
Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial.
New
Ghayour-Mobarhan et al., Mashhad, Iran. In Scientificworldjournal, Dec 2013
Serum levels of IL-1 α , IL-1 β , IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN γ , EGF, MCP-1, and TNF α were measured using a multiplex Biochip Array Technology based method.
Modulation of keratin 1, 10 and involucrin expression as part of the complex response of the human keratinocyte cell line HaCaT to ultraviolet radiation.
New
Kubala et al., Czech Republic. In Interdiscip Toxicol, Dec 2013
This was accompanied by increased expression of c-Jun and MMP-1 and IL-6 and IL-8 production.
IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses.
GeneRIF
Murakami et al., Ōsaka, Japan. In J Immunol, 2012
These results show that IL-6 amplifier activation in grafts plays a critical role for graft rejection responses after allogeneic transplantation, including chronic rejection.
Context-specific roles for paracrine IL-6 in lymphomagenesis.
GeneRIF
Hemann et al., Cambridge, United States. In Genes Dev, 2012
It was shown that paracrine IL-6 signaling promoted the survival of transplanted hematopoietic stem cells, while also initiating a secretory program in the bone marrow that inhibits the development of B-cell malignancies.
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
GeneRIF
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
Alterations in the masseter muscle and plasma IL-6 level following experimentally induced occlusal interference and chronic stress--a study in rats.
GeneRIF
Braut et al., Rijeka, Croatia. In Coll Antropol, 2012
High concentrations of muscle interleukin-6 and its correlation with pain point to inflammatory background of masticatory muscle pain.
Impact of the -174G/C interleukin-6 (IL-6) gene polymorphism on the risk of paediatric ischemic stroke, its symptoms and outcome.
GeneRIF
Zak et al., Poland. In Folia Neuropathol, 2011
Our study did not show any associations between the IL-6 -174 G>C polymorphism and the occurrence of stroke
More papers using Interleukin-6 antibodies
The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.
Supplier
Bobé Pierre, In PLoS ONE, 2007
... Recombinant mouse IL-6, anti-alfa tubulin antibody, fluorescein isothiocyanate (FITC) conjugate anti goat antibody, and propidium iodide were purchased from Sigma Aldrich (St ...
Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
Supplier
Hung Chien-Hui et al., In Carcinogenesis, 2007
... IL-6 enzyme immunoassay kit was purchased from Cayman Chemical (Ann Arbor, MI) ...
Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test?
Supplier
Creatsas G. et al., In Mediators of Inflammation, 2007
... Enzyme-linked immunosorbent assay was used for quantitative detection of soluble human IL-6, Bender Medsystems GmbH (BMS213HS), Austria ...
Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities
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Sohn Uy Dong et al., In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2006
... Korea); absolute ethanol and DMSO were from Thermo Fisher Scientific (Waltham, MA, USA); actin and IL-6 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
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Ramqvist Torbjorn, In PLoS ONE, 2006
... Human recombinant IL-6 and CK2 kinase were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
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Yamaoka Yoshio, In PLoS ONE, 2006
... Interleukin-6 (IL-6) was purchased from BD Biosciences (San Diego, CA) ...
Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice
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King Lui Edmund Man et al., In Chinese Medicine, 2006
... BD OptEIA ELISA kits tumour necrosis factor-α and interleukin-6 (BD Biosciences, USA) ...
Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
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Yang Ping-Chang et al., In North American Journal of Medical Sciences, 2006
... SCF, NGF and IL-6 (Leinco Technologies.
The impact of cigarette smoking on periodontal disease and treatment.
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II Roy Martin Roop, In PLoS ONE, 2006
... TNF-α and IL-6 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
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Combs Colin, In PLoS ONE, 2004
... Mouse IL-6 ELISA kit was obtained from eBioscience (San Diego, CA) ...
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
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Zheng Song Guo, In PLoS ONE, 2004
... IL-6 and cAMP EIA kits were from Cayman Chemical, All reagents for ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
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Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... Systems, Abingdon, UK), IL-6 and non-target (NT) siRNA (Invitrogen, Paisley, UK), recombinant IL-6 (R&D Systems), anti-IL-6 receptor and isotype (IgG2b) control antibodies (Biolegend, San Diego, CA, USA), ...
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
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Skorski Tomasz et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002
... of growth factors: 10pg/ml GM-CSF, 10pg/ml G-CSF, 10ng/ml SCF, 10ng/ml LIF, 10ng/ml MIP-1α, 0.2 ng/ml IL-6 (PeproTech Inc., Rocky Hill, NJ, USA, and StemCell Technologies).
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
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Lichterfeld Mathias, In PLoS ONE, 2002
... Anti-mouse IL-6 mAbs (MP5-20F3 and MP5-32C11, biotin-conjugated) used for ELISA were also obtained from eBioscience.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
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Potempa J S et al., In Cell Death & Disease, 2001
... and IL-6 assays (Becton Dickinson Co., Franklin Lakes, NJ, ...
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
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Weigand Markus A et al., In Critical Care, 2001
... We used ELISA kits to determine serum concentrations of Il-6 (R&D Systems, Minneapolis, MN, USA), sVCAM-1 (Bender MedSystems, Vienna, Austria), and sICAM-1 ...
Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil–endothelial cell adhesion
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Peter K. et al., In Basic Research in Cardiology, 2000
... human (rh) Flt-3 ligand (100 ng/ml), rh stem cell factor (100 ng/ml), rh IL-3 (20 ng/ml) and rh IL-6 (20 ng/ml), all purchased from StemCell Technologies.
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Aguila Marcia B., In PLoS ONE, 2000
... Recombinant mouse IL-6 (RMIL6I) was obtained from Thermo Scientific (Rockford, IL) while a mouse ...
The microinflammatory state in uremia: causes and potential consequences
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Girelli Domenico et al., In Journal of Biomedicine and Biotechnology, 2000
... Serum ferritin was measured by routine laboratory methods, IL-6 by enzyme-linked immunoadsorbent assay (by Human IL-6 ELISA BMS213/2CE Bender MedSystems GmbH, Vienna, Austria), and ...
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite.
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Sambhara Suryaprakash, In PLoS ONE, 1999
... Goat antibody to mouse IgG (horseradish peroxidase) (0.8 mg/mL), TNF-α, IL-1β and IL-6 mouse ELISA kits were purchased from Abcam (Cambridge, United Kingdom) ...
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW 264.7 macrophages
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Ma Jin Yeul et al., In BMC Complementary and Alternative Medicine, 1998
... (Santa Cruz, CA, USA) and TNF-α, IL-6 antibody, biotinylated TNF-α and IL-6 antibodies were purchased from BD Biosciences (San Jose, CA, USA) ...
Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats.
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Vidal-Puig Antonio J., In PLoS Biology, 1996
... anti-phospho-PERK (rabbit polyclonal, SC-32577), anti-CHOP (GADD 153) (rabbit polyclonal, SC-575), anti-IL-10 (goat polyclonal, SC-1783), and anti-IL-6 (rabbit polyclonal, SC-7920) antibodies were from Santa Cruz Biotechnology, Inc ...
Interleukin-6-blocking agents
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Ciliberto Gennaro et al., In The Journal of Experimental Medicine, 1996
... TNF, IL-6 mice were obtained by intercrossing TNF-α transgenic mice ( ...
MIF Signal Transduction Initiated by Binding to CD74
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Bucala Richard et al., In The Journal of Experimental Medicine, 1995
... Recombinant human IL-6 and IFN-γ were obtained from R&D Systems.Human anti–human CD74 mAbs (clones LN2 and M-B741) were obtained from BD Biosciences, and dialyzed free of ...
flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
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Rose-John Stefan et al., In The Journal of Experimental Medicine, 1994
... The generation of human sIL-6R and human IL-6 transgenic mice has been described ...
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
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Potter Michael et al., In The Journal of Experimental Medicine, 1991
... Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
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Bushell Andrew et al., In European Journal of Immunology, 1991
... Siamon Gordon, Sir William Dunn School of Pathology, Oxford, UK), and IL-6 knockout mice were obtained from and housed in the Biomedical Services Unit, John Radcliffe ...
Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen
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Pessler Frank et al., In Arthritis Research & Therapy, 1990
... Exudate IL-6, PGE2 and PGD2 levels were determined by commercially available immunoassays (eBioscience, San Diego, CA, USA ...
Glutathione S transferases. The first enzymatic step in mercapturic acid formation
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Sarkar Biswajit et al., In Oxidative Medicine and Cellular Longevity, 1973
... and IL-6 antibody procured from Anaspec Inc ...
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