The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation.
Novara, Italy. In J Interferon Cytokine Res, 25 Mar 2015
rIFI16 caused dose/time-dependent upregulation of IL-6, IL-8, CCL2, CCL5, CCL20, ICAM1, VCAM1, and TLR4, while secretion of IL-6 and IL-8 was amplified with lipopolysaccharide synergy.
IL-17 cuts to the chase in colon cancer.
Australia. In Immunity, Jan 2015
In this issue of Immunity, Wang et al. (2014) now demonstrate that IL-17A receptors on the intestinal epithelium promote progression of APC mutant adenomas associated with IL-6 expression and that IL-17A confers chemotherapy resistance.
Platelet transfusion - the new immunology of an old therapy.
Rochester, United States. In Front Immunol, Dec 2014
With the recognition that platelets are immune cells came the discoveries that supernatant IL-6, IL-27 sCD40L, and OX40L are closely linked to febrile reactions and sCD40L with acute lung injury.
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Bucureşti, Romania. In J Med Life, Oct 2014
Abbreviations: RCAN1 = regulator of calcineurin, LDL = low density lipoproteins, HMG-CoA - 3 = hydroxy-3-methylglutaryl coenzyme A, VSMCs = vascular smooth muscle cells, PDGF = platelet-derived growth factor, FGF = fibroblast growth factor, EGF = epidermal growth factor, IGF = insulin-like growth factor, VEGF = vascular endothelial growth factor, NFAT = nuclear factor of activated T cells, IL-2, IL-6, IL-10, IL-12 = interleukin type 2, 6, 10, 12, AP-1 = activator protein 1, Mef-2 = myocyte enhancer factor-2, GATA-4 = transcription factor, CK1 = casein kinase 1, GSK3 = glycogen synthase kinase 3, DYRK = dual specificity tyrosine phosphorylation regulated kinase, DSCR1 = Down Syndrome Critical Region 1, MCIP1 = myocyte-enriched calcineurin-interacting protein, MLP = muscle lim protein, cAMP = cyclic adenosine monophosphate, PC12 = pheochromocytoma, NMR = nuclear magnetic resonance, SOD = superoxide dismutase, APP = amyloid precursor protein, eNOS = nitric oxide endothelial synthase, Cygb = cytoglobin, HUVEC = human umbilical vein endothelial cells, VDR = vitamin D receptor.
Context-specific roles for paracrine IL-6 in lymphomagenesis.
More papers using
Cambridge, United States. In Genes Dev, 2012
It was shown that paracrine IL-6 signaling promoted the survival of transplanted hematopoietic stem cells, while also initiating a secretory program in the bone marrow that inhibits the development of B-cell malignancies.
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
In Journal of Neuroinflammation, 2003
... Systems, Abingdon, UK), IL-6 and non-target (NT) siRNA (Invitrogen, Paisley, UK), recombinant IL-6 (R&D Systems), anti-IL-6 receptor and isotype (IgG2b) control antibodies (Biolegend, San Diego, CA, USA), ... Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002
... of growth factors: 10pg/ml GM-CSF, 10pg/ml G-CSF, 10ng/ml SCF, 10ng/ml LIF, 10ng/ml MIP-1α, 0.2 ng/ml IL-6 (PeproTech Inc., Rocky Hill, NJ, USA, and StemCell Technologies).