gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 6

Interleukin-6, IL-6
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: IL-10, CAN, HAD, IL-8, V1a
Papers using Interleukin-6 antibodies
Enzymatic-nonenzymatic cellular antioxidant defence systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity
Supplier
Fineschi Vittorio et al., In Diagnostic Pathology, 2009
... IL-6 (Santa Cruz, CA, USA)5 min Proteolytic Enzyme (Dako, Copenhagen, Denmark), 20°C.
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease
Supplier
Longo Vincenzo et al., In The Indian Journal of Medical Research, 2008
... Medium concentrations of ET-1 and interleukin-6 (IL-6) were evaluated by two different kit of ELISA technique employing a solid-phase sandwich, enzyme-linked immuno-sorbent assay (Cayman, Ann Arbor MI, USA; ...
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Supplier
Mossman Karen L., In PLoS ONE, 2008
... Murine IL-27, IL-6, TGFβ were purchased from R&D Systems (Minneapolis, MN); Murine IFNα and IFNβ proteins were from PBL Biomedical Laboratories (Piscataway, NJ); Anti-CD3, ...
Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking.
Supplier
Zaytseva Nadezhda V. et al., In Croatian Medical Journal, 2008
... We measured the serum concentration of adiponectin, VEGF, and IL-6 using the BioVendor (Modrice, Czech Republic), Invitrogen ...
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene
Supplier
Lin Yu-Chin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... , IL-6, and TNF-α enzyme-link immunosorbent assay (ELISA) Development Kit was purchased from BioLegend, Inc (California, USA) ...
more suppliers
Papers on Interleukin-6
Chronic Normobaric Hypoxia Induces Pulmonary Hypertension in Rats: Role of NF-κB.
New
Gong et al., Wenzhou, China. In High Alt Med Biol, Feb 2016
Lung tissue levels of NF-κB activity, and interleukin (IL)-1β, IL-6, and cyclooxygenase-2 mRNAs, were determined, and mean pulmonary arterial pressure, right ventricular hypertrophy, and right heart function were evaluated.
miRNA-Regulated Key Components of Cytokine Signaling Pathways and Inflammation in Rheumatoid Arthritis.
Review
New
Chakraborty et al., Ch'unch'ŏn, South Korea. In Med Res Rev, Feb 2016
Moreover, we have tried to portray the role of various miRNAs in different cytokines such as TNF-α, IL-1, IL-6, IL-10, IL-17, IL-18, IL-21, and granulocyte macrophage colony-stimulating factor (GMCSF).
Changes of synapses in experimental autoimmune encephalomyelitis by using Fasudil.
New
Xiao et al., Datong, China. In Wound Repair Regen, Feb 2016
Neurotrophic factor BDNF and GDNF as well as immunomodulatory cytokine IL-10 in spinal cord were elevated in Fasudil-treated mice, while inflammatory cytokine IL-17, IL-1β, IL-6 and TNF-⟨ were obviously inhibited, accompanied by the decrease of inflammatory M1 iNOS and the increase of anti-inflammatory M2 Arg-1, providing a microenvironment that contributes to synaptic protection.
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model.
New
Artico et al., Padova, Italy. In Autoimmunity, Feb 2016
In particular, selective HDAC3, HDAC6, and HDAC8 inhibitors have been described to downregulate the expression of pro-inflammatory cytokines (TNF-α, TGF-β, IL-1β, and IL-6).
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
New
Watanabe et al., In Digestion, Feb 2016
Pro-tumorigenic cytokines such as interleukin (IL)-1β, IL-6 and macrophage inflammatory protein-2 at the lamina propria were increased in the setting of colitis and further increased in tumor tissues with upregulated epithelial TNFR2 and MLCK expressions in an animal model of CAC.
Strategy for treatment of fibrosis in systemic sclerosis: Present and future.
Review
New
Yanaba, Tokyo, Japan. In J Dermatol, Jan 2016
immunoglobulins, B-cell depletion, anti-interleukin-6 receptor antibody, autologous hematopoietic stem cell transplantation, rapamycin, pirfenidone and imatinib mesylate are potential candidates for the treatment of SSc, although their efficacy has not been validated.
Biomarkers in systemic sclerosis: Their potential to predict clinical courses.
Review
New
Hasegawa, Fukui, Japan. In J Dermatol, Jan 2016
Other potential serum/plasma biomarkers for fibrosis and vascular involvement of SSc are connective tissue growth factor, interleukin-6, CCL2, CXCL4, intercellular adhesion molecule (ICAM)-1, P-selectin, vascular endothelial growth factor, von Willebrand factor, endostatin, endoglin and endothelin-1.
Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications.
Review
New
Fernandes et al., Divinópolis, Brazil. In J Diabetes Complications, Jan 2016
Moreover, it has been observed that several endothelial, inflammatory and pro-coagulant biomarkers, such as VWF, IL-6, TNF-α, D-dimer and PAI-1, are increased in diabetic patients who have microvascular and macrovascular complications, including nephropathy or cardiovascular disease.
Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
New
Kim et al., Ch'ŏnan, South Korea. In Plos One, Dec 2015
Tβ4 activation with a Tβ4 peptide attenuated the H2O2-induced production of NO and PGE2 and up-regulated iNOS, COX-2, and osteoclastogenic cytokines (TNF-α, IL-1β, IL-6, IL-8, and IL-17) as well as reversed the effect on RANKL and OPG in PDLCs.
T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.
New
Impact
Su et al., Chapel Hill, United States. In Immunity, Nov 2015
UTX-deficient T cells showed decreased expression of interleukin-6 receptor-α and other Tfh cell-related genes that were associated with increased H3K27 methylation.
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.
New
Impact
Cao et al., Beijing, China. In Nature, Oct 2015
Here we show that Tet2 selectively mediates active repression of interleukin-6 (IL-6) transcription during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.
New
Impact
Gaffen et al., Pittsburgh, United States. In Immunity, Oct 2015
MCPIP1 degraded Il6 mRNA directly but only modestly downregulated the IL-6 promoter.
dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.
New
Impact
Garza et al., Baltimore, United States. In Cell Stem Cell, Sep 2015
Here, we show that dsRNA, which is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors IL-6 and STAT3 to promote hair follicle regeneration.
NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.
New
Impact
June et al., Baltimore, United States. In Nat Med, Aug 2015
Infusions were well tolerated without clinically apparent cytokine-release syndrome, despite high IL-6 levels.
Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis.
Review
MSSRF Canadian B cells in MS Team et al., Montréal, Canada. In Front Immunol, 2014
These have included regulatory (Breg) B cells (secreting interleukin (IL)-10 or IL-35) and pro-inflammatory B cells (secreting tumor necrosis factor α, LTα, IL-6, and granulocyte macrophage colony-stimulating factor).
IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses.
GeneRIF
Murakami et al., Ōsaka, Japan. In J Immunol, 2012
These results show that IL-6 amplifier activation in grafts plays a critical role for graft rejection responses after allogeneic transplantation, including chronic rejection.
Context-specific roles for paracrine IL-6 in lymphomagenesis.
GeneRIF
Hemann et al., Cambridge, United States. In Genes Dev, 2012
It was shown that paracrine IL-6 signaling promoted the survival of transplanted hematopoietic stem cells, while also initiating a secretory program in the bone marrow that inhibits the development of B-cell malignancies.
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
GeneRIF
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
Alterations in the masseter muscle and plasma IL-6 level following experimentally induced occlusal interference and chronic stress--a study in rats.
GeneRIF
Braut et al., Rijeka, Croatia. In Coll Antropol, 2012
High concentrations of muscle interleukin-6 and its correlation with pain point to inflammatory background of masticatory muscle pain.
Impact of the -174G/C interleukin-6 (IL-6) gene polymorphism on the risk of paediatric ischemic stroke, its symptoms and outcome.
GeneRIF
Zak et al., Poland. In Folia Neuropathol, 2011
Our study did not show any associations between the IL-6 -174 G>C polymorphism and the occurrence of stroke
More papers using Interleukin-6 antibodies
The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.
Supplier
Bobé Pierre, In PLoS ONE, 2007
... Recombinant mouse IL-6, anti-alfa tubulin antibody, fluorescein isothiocyanate (FITC) conjugate anti goat antibody, and propidium iodide were purchased from Sigma Aldrich (St ...
Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
Supplier
Hung Chien-Hui et al., In Carcinogenesis, 2007
... IL-6 enzyme immunoassay kit was purchased from Cayman Chemical (Ann Arbor, MI) ...
Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test?
Supplier
Creatsas G. et al., In Mediators of Inflammation, 2007
... Enzyme-linked immunosorbent assay was used for quantitative detection of soluble human IL-6, Bender Medsystems GmbH (BMS213HS), Austria ...
Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities
Supplier
Sohn Uy Dong et al., In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2006
... Korea); absolute ethanol and DMSO were from Thermo Fisher Scientific (Waltham, MA, USA); actin and IL-6 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Supplier
Ramqvist Torbjorn, In PLoS ONE, 2006
... Human recombinant IL-6 and CK2 kinase were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
Supplier
Yamaoka Yoshio, In PLoS ONE, 2006
... Interleukin-6 (IL-6) was purchased from BD Biosciences (San Diego, CA) ...
Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice
Supplier
King Lui Edmund Man et al., In Chinese Medicine, 2006
... BD OptEIA ELISA kits tumour necrosis factor-α and interleukin-6 (BD Biosciences, USA) ...
Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
Supplier
Yang Ping-Chang et al., In North American Journal of Medical Sciences, 2006
... SCF, NGF and IL-6 (Leinco Technologies.
The impact of cigarette smoking on periodontal disease and treatment.
Supplier
II Roy Martin Roop, In PLoS ONE, 2006
... TNF-α and IL-6 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
Supplier
Combs Colin, In PLoS ONE, 2004
... Mouse IL-6 ELISA kit was obtained from eBioscience (San Diego, CA) ...
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... IL-6 and cAMP EIA kits were from Cayman Chemical, All reagents for ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
Supplier
Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... Systems, Abingdon, UK), IL-6 and non-target (NT) siRNA (Invitrogen, Paisley, UK), recombinant IL-6 (R&D Systems), anti-IL-6 receptor and isotype (IgG2b) control antibodies (Biolegend, San Diego, CA, USA), ...
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
Supplier
Skorski Tomasz et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002
... of growth factors: 10pg/ml GM-CSF, 10pg/ml G-CSF, 10ng/ml SCF, 10ng/ml LIF, 10ng/ml MIP-1α, 0.2 ng/ml IL-6 (PeproTech Inc., Rocky Hill, NJ, USA, and StemCell Technologies).
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
Supplier
Lichterfeld Mathias, In PLoS ONE, 2002
... Anti-mouse IL-6 mAbs (MP5-20F3 and MP5-32C11, biotin-conjugated) used for ELISA were also obtained from eBioscience.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
Potempa J S et al., In Cell Death & Disease, 2001
... and IL-6 assays (Becton Dickinson Co., Franklin Lakes, NJ, ...
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
Supplier
Weigand Markus A et al., In Critical Care, 2001
... We used ELISA kits to determine serum concentrations of Il-6 (R&D Systems, Minneapolis, MN, USA), sVCAM-1 (Bender MedSystems, Vienna, Austria), and sICAM-1 ...
Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil–endothelial cell adhesion
Supplier
Peter K. et al., In Basic Research in Cardiology, 2000
... human (rh) Flt-3 ligand (100 ng/ml), rh stem cell factor (100 ng/ml), rh IL-3 (20 ng/ml) and rh IL-6 (20 ng/ml), all purchased from StemCell Technologies.
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Supplier
Aguila Marcia B., In PLoS ONE, 2000
... Recombinant mouse IL-6 (RMIL6I) was obtained from Thermo Scientific (Rockford, IL) while a mouse ...
The microinflammatory state in uremia: causes and potential consequences
Supplier
Girelli Domenico et al., In Journal of Biomedicine and Biotechnology, 2000
... Serum ferritin was measured by routine laboratory methods, IL-6 by enzyme-linked immunoadsorbent assay (by Human IL-6 ELISA BMS213/2CE Bender MedSystems GmbH, Vienna, Austria), and ...
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite.
Supplier
Sambhara Suryaprakash, In PLoS ONE, 1999
... Goat antibody to mouse IgG (horseradish peroxidase) (0.8 mg/mL), TNF-α, IL-1β and IL-6 mouse ELISA kits were purchased from Abcam (Cambridge, United Kingdom) ...
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW 264.7 macrophages
Supplier
Ma Jin Yeul et al., In BMC Complementary and Alternative Medicine, 1998
... (Santa Cruz, CA, USA) and TNF-α, IL-6 antibody, biotinylated TNF-α and IL-6 antibodies were purchased from BD Biosciences (San Jose, CA, USA) ...
Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats.
Supplier
Vidal-Puig Antonio J., In PLoS Biology, 1996
... anti-phospho-PERK (rabbit polyclonal, SC-32577), anti-CHOP (GADD 153) (rabbit polyclonal, SC-575), anti-IL-10 (goat polyclonal, SC-1783), and anti-IL-6 (rabbit polyclonal, SC-7920) antibodies were from Santa Cruz Biotechnology, Inc ...
Interleukin-6-blocking agents
Supplier
Ciliberto Gennaro et al., In The Journal of Experimental Medicine, 1996
... TNF, IL-6 mice were obtained by intercrossing TNF-α transgenic mice ( ...
MIF Signal Transduction Initiated by Binding to CD74
Supplier
Bucala Richard et al., In The Journal of Experimental Medicine, 1995
... Recombinant human IL-6 and IFN-γ were obtained from R&D Systems.Human anti–human CD74 mAbs (clones LN2 and M-B741) were obtained from BD Biosciences, and dialyzed free of ...
flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
Supplier
Rose-John Stefan et al., In The Journal of Experimental Medicine, 1994
... The generation of human sIL-6R and human IL-6 transgenic mice has been described ...
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
Supplier
Potter Michael et al., In The Journal of Experimental Medicine, 1991
... Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
Supplier
Bushell Andrew et al., In European Journal of Immunology, 1991
... Siamon Gordon, Sir William Dunn School of Pathology, Oxford, UK), and IL-6 knockout mice were obtained from and housed in the Biomedical Services Unit, John Radcliffe ...
Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen
Supplier
Pessler Frank et al., In Arthritis Research & Therapy, 1990
... Exudate IL-6, PGE2 and PGD2 levels were determined by commercially available immunoassays (eBioscience, San Diego, CA, USA ...
Glutathione S transferases. The first enzymatic step in mercapturic acid formation
Supplier
Sarkar Biswajit et al., In Oxidative Medicine and Cellular Longevity, 1973
... and IL-6 antibody procured from Anaspec Inc ...
share on facebooktweetadd +1mail to friends