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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Interleukin 6

Interleukin-6, IL-6
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: IL-10, HAD, CAN, IL-8, V1a
Papers using Interleukin-6 antibodies
Enzymatic-nonenzymatic cellular antioxidant defence systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity
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Fineschi Vittorio et al., In Diagnostic Pathology, 2009
... IL-6 (Santa Cruz, CA, USA)5 min Proteolytic Enzyme (Dako, Copenhagen, Denmark), 20°C.
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease
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Longo Vincenzo et al., In The Indian Journal of Medical Research, 2008
... Medium concentrations of ET-1 and interleukin-6 (IL-6) were evaluated by two different kit of ELISA technique employing a solid-phase sandwich, enzyme-linked immuno-sorbent assay (Cayman, Ann Arbor MI, USA; ...
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
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Mossman Karen L., In PLoS ONE, 2008
... Murine IL-27, IL-6, TGFβ were purchased from R&D Systems (Minneapolis, MN); Murine IFNα and IFNβ proteins were from PBL Biomedical Laboratories (Piscataway, NJ); Anti-CD3, ...
Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking.
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Zaytseva Nadezhda V. et al., In Croatian Medical Journal, 2008
... We measured the serum concentration of adiponectin, VEGF, and IL-6 using the BioVendor (Modrice, Czech Republic), Invitrogen ...
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene
Supplier
Lin Yu-Chin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... , IL-6, and TNF-α enzyme-link immunosorbent assay (ELISA) Development Kit was purchased from BioLegend, Inc (California, USA) ...
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Papers on Interleukin-6
Oral Infections, Metabolic Inflammation, Genetics, and Cardiometabolic Diseases.
Review
New
Meurman et al., Boston, United States. In J Dent Res, 03 May 2015
Consequently, adipose tissue is now considered a dynamic endocrine organ that expresses many proinflammatory cytokines such as TNF-α, IL-6, plasminogen activator inhibitor 1, and IL-1β.
CD5 Instructs Extrathymic Regulatory T Cell Development in Response to Self and Tolerizing Antigens.
New
Impact
Hawiger et al., Saint Louis, United States. In Immunity, 17 Apr 2015
Treg cell conversion of Cd5(-/-) and CD5(lo) T cells was inhibited by even small amounts of interleukin-4 (IL-4), IL-6, and interferon-γ (IFN-γ) produced by bystander lymphocytes, while CD5(hi) T cells resisted this inhibition of Treg cell induction.
Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization.
New
Impact
Artyomov et al., Cambridge, United States. In Immunity, 17 Apr 2015
Consistently, inhibition of aspartate-aminotransferase, a key enzyme of the shunt, inhibited nitric oxide and interleukin-6 production in M1 macrophages, while promoting mitochondrial respiration.
A gp130-Src-YAP module links inflammation to epithelial regeneration.
New
Impact
Karin et al., San Diego, United States. In Nature, 05 Apr 2015
Here we show in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control tissue growth and regeneration, independently of the gp130 effector STAT3.
Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance.
New
Impact
Febbraio et al., Melbourne, Australia. In Cell Metab, 03 Apr 2015
Interleukin-6 (IL-6) plays a paradoxical role in inflammation and metabolism.
Gambogic Acid Disrupts Toll-like Receptor4 Activation by Blocking Lipopolysaccharides Binding to Myeloid Differentiation Factor 2.
New
Lee et al., Puch'ŏn, South Korea. In Toxicol Res, 31 Mar 2015
Our results demonstrated that gambogic acid decreased the expression of pro-inflammatory cytokines (TNF-α, IL-6, IL-12, and IL-1β) in both mRNA and protein levels in bone marrow-derived primary macrophages after stimulation with LPS.
Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.
New
Impact
Kaplan et al., Minneapolis, United States. In Immunity, 17 Mar 2015
We found that only yeast induced Th17 cell responses through a mechanism that required Dectin-1-mediated expression of interleukin-6 (IL-6) by Langerhans cells.
The role of interleukin-6 in malignant mesothelioma.
Review
New
Coward et al., Brisbane, Australia. In Transl Lung Cancer Res, Feb 2015
In recent years, the pleiotropic proinflammatory cytokine, interleukin-6 (IL-6) has emerged as a mediator of pivotal processes such as cell proliferation and chemoresistance within the mesothelioma tumour microenvironment in addition to clinical symptoms commonly witnessed in this disease.
Hydrogen-Rich Saline Protects against Ischemia/Reperfusion Injury in Grafts after Pancreas Transplantations by Reducing Oxidative Stress in Rats.
New
Tian et al., Chengdu, China. In Mediators Inflamm, Dec 2014
In addition, TNF-α, IL-1β, and IL-6 were reduced markedly in the HPT + HS group.
Copy Number Variants and Genetic Polymorphisms in TBX21, GATA3, Rorc, Foxp3 and Susceptibility to Behcet's Disease and Vogt-Koyanagi-Harada Syndrome.
New
Yang et al., Chongqing, China. In Sci Rep, Dec 2014
Increased production of IL-1β and IL-6 was found in individuals carrying a high CNV of Rorc.
Biomarkers for Evaluation of Prostate Cancer Prognosis.
Review
New
Panjehpour et al., Eşfahān, Iran. In Asian Pac J Cancer Prev, Dec 2014
We here selected a group of candidate biomarkers including PSA, PSA velocity, percentage free PSA, TGFβ1, AMACR, chromogranin A, IL-6, IGFBPs, PSCA, biomarkers related to cell cycle regulation, apoptosis, PTEN, androgen receptor, cellular adhesion and angiogenesis, and also prognostic biomarkers with Genomic tests for discussion.
EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression.
Review
New
Tseng-Rogenski et al., Ann Arbor, United States. In Genes (basel), Dec 2014
Specifically, EMAST is an acquired somatic defect observed in up to 60% of colorectal cancers and caused by unique dysfunction of the DNA MMR protein MSH3 (and its DNA MMR complex MutSβ, a heterodimer of MSH2-MSH3), and in particular a loss-of-function phenotype due to a reversible shift from its normal nuclear location into the cytosol in response to oxidative stress and the pro-inflammatory cytokine interleukin-6.
Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role.
Review
New
Ishida et al., Kasugai, Japan. In Int J Mol Sci, Dec 2014
On the other hand, direct UVA exposure of human fibroblasts significantly stimulates the secretion of IL-6 and also elicits a significant increase in the gene expression of matrix metallo-protease(MMP)-1 as well as neprilysin (to a lesser extent), which is followed by distinct increases in their protein and enzymatic activity levels.
Inflammatory and Antioxidant Pattern Unbalance in "Clopidogrel-Resistant" Patients during Acute Coronary Syndrome.
New
Parodi et al., Milano, Italy. In Mediators Inflamm, Dec 2014
In R patients the proinflammatory cytokine IL-6 decreased, while the anti-inflammatory cytokine IL-1Ra increased.
Toll-like receptor-4 mediated inflammation is involved in the cardiometabolic alterations induced by intermittent hypoxia.
New
Arnaud et al., Grenoble, France. In Mediators Inflamm, Dec 2014
IH induced insulin resistance, morphological and inflammatory changes of the epididymal fat (smaller pads and adipocytes, higher release of TNF-α and IL-6) and aorta (larger intima-media thickness and higher NFκB-p50 activity).
IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses.
GeneRIF
Murakami et al., Ōsaka, Japan. In J Immunol, 2012
These results show that IL-6 amplifier activation in grafts plays a critical role for graft rejection responses after allogeneic transplantation, including chronic rejection.
Context-specific roles for paracrine IL-6 in lymphomagenesis.
GeneRIF
Hemann et al., Cambridge, United States. In Genes Dev, 2012
It was shown that paracrine IL-6 signaling promoted the survival of transplanted hematopoietic stem cells, while also initiating a secretory program in the bone marrow that inhibits the development of B-cell malignancies.
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
GeneRIF
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
Alterations in the masseter muscle and plasma IL-6 level following experimentally induced occlusal interference and chronic stress--a study in rats.
GeneRIF
Braut et al., Rijeka, Croatia. In Coll Antropol, 2012
High concentrations of muscle interleukin-6 and its correlation with pain point to inflammatory background of masticatory muscle pain.
Impact of the -174G/C interleukin-6 (IL-6) gene polymorphism on the risk of paediatric ischemic stroke, its symptoms and outcome.
GeneRIF
Zak et al., Poland. In Folia Neuropathol, 2011
Our study did not show any associations between the IL-6 -174 G>C polymorphism and the occurrence of stroke
More papers using Interleukin-6 antibodies
The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.
Supplier
Bobé Pierre, In PLoS ONE, 2007
... Recombinant mouse IL-6, anti-alfa tubulin antibody, fluorescein isothiocyanate (FITC) conjugate anti goat antibody, and propidium iodide were purchased from Sigma Aldrich (St ...
Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
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Hung Chien-Hui et al., In Carcinogenesis, 2007
... IL-6 enzyme immunoassay kit was purchased from Cayman Chemical (Ann Arbor, MI) ...
Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test?
Supplier
Creatsas G. et al., In Mediators of Inflammation, 2007
... Enzyme-linked immunosorbent assay was used for quantitative detection of soluble human IL-6, Bender Medsystems GmbH (BMS213HS), Austria ...
Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities
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Sohn Uy Dong et al., In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2006
... Korea); absolute ethanol and DMSO were from Thermo Fisher Scientific (Waltham, MA, USA); actin and IL-6 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
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Ramqvist Torbjorn, In PLoS ONE, 2006
... Human recombinant IL-6 and CK2 kinase were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
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Yamaoka Yoshio, In PLoS ONE, 2006
... Interleukin-6 (IL-6) was purchased from BD Biosciences (San Diego, CA) ...
Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice
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King Lui Edmund Man et al., In Chinese Medicine, 2006
... BD OptEIA ELISA kits tumour necrosis factor-α and interleukin-6 (BD Biosciences, USA) ...
Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
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Yang Ping-Chang et al., In North American Journal of Medical Sciences, 2006
... SCF, NGF and IL-6 (Leinco Technologies.
The impact of cigarette smoking on periodontal disease and treatment.
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II Roy Martin Roop, In PLoS ONE, 2006
... TNF-α and IL-6 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
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Combs Colin, In PLoS ONE, 2004
... Mouse IL-6 ELISA kit was obtained from eBioscience (San Diego, CA) ...
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
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Zheng Song Guo, In PLoS ONE, 2004
... IL-6 and cAMP EIA kits were from Cayman Chemical, All reagents for ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
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Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... Systems, Abingdon, UK), IL-6 and non-target (NT) siRNA (Invitrogen, Paisley, UK), recombinant IL-6 (R&D Systems), anti-IL-6 receptor and isotype (IgG2b) control antibodies (Biolegend, San Diego, CA, USA), ...
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
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Skorski Tomasz et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002
... of growth factors: 10pg/ml GM-CSF, 10pg/ml G-CSF, 10ng/ml SCF, 10ng/ml LIF, 10ng/ml MIP-1α, 0.2 ng/ml IL-6 (PeproTech Inc., Rocky Hill, NJ, USA, and StemCell Technologies).
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
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Lichterfeld Mathias, In PLoS ONE, 2002
... Anti-mouse IL-6 mAbs (MP5-20F3 and MP5-32C11, biotin-conjugated) used for ELISA were also obtained from eBioscience.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
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Potempa J S et al., In Cell Death & Disease, 2001
... and IL-6 assays (Becton Dickinson Co., Franklin Lakes, NJ, ...
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
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Weigand Markus A et al., In Critical Care, 2001
... We used ELISA kits to determine serum concentrations of Il-6 (R&D Systems, Minneapolis, MN, USA), sVCAM-1 (Bender MedSystems, Vienna, Austria), and sICAM-1 ...
Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil–endothelial cell adhesion
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Peter K. et al., In Basic Research in Cardiology, 2000
... human (rh) Flt-3 ligand (100 ng/ml), rh stem cell factor (100 ng/ml), rh IL-3 (20 ng/ml) and rh IL-6 (20 ng/ml), all purchased from StemCell Technologies.
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Aguila Marcia B., In PLoS ONE, 2000
... Recombinant mouse IL-6 (RMIL6I) was obtained from Thermo Scientific (Rockford, IL) while a mouse ...
The microinflammatory state in uremia: causes and potential consequences
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Girelli Domenico et al., In Journal of Biomedicine and Biotechnology, 2000
... Serum ferritin was measured by routine laboratory methods, IL-6 by enzyme-linked immunoadsorbent assay (by Human IL-6 ELISA BMS213/2CE Bender MedSystems GmbH, Vienna, Austria), and ...
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite.
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Sambhara Suryaprakash, In PLoS ONE, 1999
... Goat antibody to mouse IgG (horseradish peroxidase) (0.8 mg/mL), TNF-α, IL-1β and IL-6 mouse ELISA kits were purchased from Abcam (Cambridge, United Kingdom) ...
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW 264.7 macrophages
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Ma Jin Yeul et al., In BMC Complementary and Alternative Medicine, 1998
... (Santa Cruz, CA, USA) and TNF-α, IL-6 antibody, biotinylated TNF-α and IL-6 antibodies were purchased from BD Biosciences (San Jose, CA, USA) ...
Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats.
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Vidal-Puig Antonio J., In PLoS Biology, 1996
... anti-phospho-PERK (rabbit polyclonal, SC-32577), anti-CHOP (GADD 153) (rabbit polyclonal, SC-575), anti-IL-10 (goat polyclonal, SC-1783), and anti-IL-6 (rabbit polyclonal, SC-7920) antibodies were from Santa Cruz Biotechnology, Inc ...
Interleukin-6-blocking agents
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Ciliberto Gennaro et al., In The Journal of Experimental Medicine, 1996
... TNF, IL-6 mice were obtained by intercrossing TNF-α transgenic mice ( ...
MIF Signal Transduction Initiated by Binding to CD74
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Bucala Richard et al., In The Journal of Experimental Medicine, 1995
... Recombinant human IL-6 and IFN-γ were obtained from R&D Systems.Human anti–human CD74 mAbs (clones LN2 and M-B741) were obtained from BD Biosciences, and dialyzed free of ...
flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
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Rose-John Stefan et al., In The Journal of Experimental Medicine, 1994
... The generation of human sIL-6R and human IL-6 transgenic mice has been described ...
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
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Potter Michael et al., In The Journal of Experimental Medicine, 1991
... Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
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Bushell Andrew et al., In European Journal of Immunology, 1991
... Siamon Gordon, Sir William Dunn School of Pathology, Oxford, UK), and IL-6 knockout mice were obtained from and housed in the Biomedical Services Unit, John Radcliffe ...
Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen
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Pessler Frank et al., In Arthritis Research & Therapy, 1990
... Exudate IL-6, PGE2 and PGD2 levels were determined by commercially available immunoassays (eBioscience, San Diego, CA, USA ...
Glutathione S transferases. The first enzymatic step in mercapturic acid formation
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Sarkar Biswajit et al., In Oxidative Medicine and Cellular Longevity, 1973
... and IL-6 antibody procured from Anaspec Inc ...
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