gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 May 2015.

Interleukin 6

Interleukin-6, IL-6
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: IL-10, CAN, IL-8, HAD, V1a
Papers using Interleukin-6 antibodies
Enzymatic-nonenzymatic cellular antioxidant defence systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity
Supplier
Fineschi Vittorio et al., In Diagnostic Pathology, 2009
... IL-6 (Santa Cruz, CA, USA)5 min Proteolytic Enzyme (Dako, Copenhagen, Denmark), 20°C.
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 correlates with oxidative stress markers in stable coronary artery disease
Supplier
Longo Vincenzo et al., In The Indian Journal of Medical Research, 2008
... Medium concentrations of ET-1 and interleukin-6 (IL-6) were evaluated by two different kit of ELISA technique employing a solid-phase sandwich, enzyme-linked immuno-sorbent assay (Cayman, Ann Arbor MI, USA; ...
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Supplier
Mossman Karen L., In PLoS ONE, 2008
... Murine IL-27, IL-6, TGFβ were purchased from R&D Systems (Minneapolis, MN); Murine IFNα and IFNβ proteins were from PBL Biomedical Laboratories (Piscataway, NJ); Anti-CD3, ...
Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking.
Supplier
Zaytseva Nadezhda V. et al., In Croatian Medical Journal, 2008
... We measured the serum concentration of adiponectin, VEGF, and IL-6 using the BioVendor (Modrice, Czech Republic), Invitrogen ...
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene
Supplier
Lin Yu-Chin et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2008
... , IL-6, and TNF-α enzyme-link immunosorbent assay (ELISA) Development Kit was purchased from BioLegend, Inc (California, USA) ...
more suppliers
Papers on Interleukin-6
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
New
Impact
Xiao et al., Shanghai, China. In Nat Immunol, 30 Jun 2015
We found that DC-derived SHP-2 was crucial for the induction of interleukin 1β (IL-1β), IL-6 and IL-23 and anti-fungal responses of the TH17 subset of helper T cells in controlling infection with Candida albicans.
Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population.
New
Ahmad et al., Lucknow, India. In Meta Gene, 30 Jun 2015
PURPOSE: Interleukin-6 (IL-6) encodes a cytokine protein, which causes inflammation, maintains immune homeostasis and plays an essential role in oral pathogenesis.
Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.
Review
New
Lyerly et al., Durham, United States. In Carcinogenesis, 22 Jun 2015
Our overarching objective was to review related signaling pathways influencing immune surveillance such as the pathways involving PI3K/Akt, chemokines, TGF-β, FAK, IGF-1, HIF-1α, IL-6, IL-1α, CTLA-4 and PD-1/PDL-1 could individually or collectively impact immunosurveillance.
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
New
Impact
O'Shea et al., Bethesda, United States. In Immunity, 19 Jun 2015
Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique and overlapping functions.
Fever and the thermal regulation of immunity: the immune system feels the heat.
New
Impact
Fisher et al., Buffalo, United States. In Nat Rev Immunol, 15 Jun 2015
We further highlight the unexpected multiplicity of roles of the pyrogenic cytokine interleukin-6 (IL-6), both during fever induction and during the mobilization of lymphocytes to the lymphoid organs that are the staging ground for immune defence.
Gene-gene, gene-environment, gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines.
Review
New
Ahmad et al., Islamabad, Pakistan. In World J Diabetes, 15 Jun 2015
This review highlights the impact of these interactions on determining the role of single nucleotide polymorphism of IL-6, TNF-α, resistin and adiponectin in pathogenesis of T2DM.
Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells.
New
Impact
Tenen et al., Boston, United States. In Cancer Cell, 11 Jun 2015
Indeed, IL-6 was responsible for most of these changes.
Convert and conquer: the strategy of chronic myelogenous leukemic cells.
New
Impact
de Castillejo et al., Madrid, Spain. In Cancer Cell, 11 Jun 2015
In this issue of Cancer Cell, Welner and colleagues show that, during the development of chronic myeloid leukemia, mutated cells transform normal hematopoietic progenitors into "leukemic like" cells through IL-6 secretion, proposing a new cellular target.
Biological actions of pentraxins.
Review
New
Badimon et al., Barcelona, Spain. In Vascul Pharmacol, 08 Jun 2015
Short constituents include C-reactive protein (CRP) and serum amyloid P-component which are synthesized in the liver mostly upon IL-6 stimulation.
Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy.
New
Angayarkanni et al., Chennai, India. In Metabolism, 01 Jun 2015
Serum IL-6 was significantly increased in the PDR group (p=0.04).
Honey bee is a potential antioxidant against cyclophosphamide-induced genotoxicity in albino male mice.
New
Ahmad et al., Cairo, Egypt. In Pak J Pharm Sci, 31 May 2015
This was achieved through study the effects of CPM and HB on oxidative status, chromosomal aberrations and gene expression of the tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), interleukin-1β (IL1β), interleukin 17A (IL-17A) and interferon-gamma (IFN-γ) in mice.
Aqueous Humor Levels of Different Interleukins 1-β, 2, 6 and 10, Tumor Necrosis Factor-α and Vascular Endothelial Growth Factor in Uveitis Treated with Adalimumab.
New
Cervera Taulet et al., Valencia, Spain. In J Ophthalmic Vis Res, Jan 2015
The levels of IL-1β, IL-2, IL-6, IL-10, TNF-α and VEGF were measured using a Luminex(®) 200™ flow cytometer (Merckmillipore, Merck KGaA, Darmstadt, Alemania) and a highly sensitive ELISA system.
Management of rheumatoid arthritis in People's Republic of China - focus on tocilizumab and patient considerations.
Review
New
Xu et al., Shanghai, China. In Int J Gen Med, Dec 2014
TCZ is the first biological agent approved for the treatment of RA inhibiting interlukin-6 (IL-6) by blocking both membrane-bound and soluble IL-6 receptors.
Current Trends and Recent Advances in Diagnosis, Therapy, and Prevention of Hepatocellular Carcinoma.
Review
New
Kuo et al., Tainan City, Taiwan. In Asian Pac J Cancer Prev, Dec 2014
Based on in-depth reviews of serological diagnosis of HCC, in addition to AFP, there are other biomarkers: Lens culinaris agglutinin-reactive AFP (AFP-L3), des- carboxyprothrombin (DCP), tyrosine kinase with Ig and eprdermal growth factor (EGF) homology domains 2 (TIE2)-espressing monocytes (TEMs), glypican-3 (GPC3), Golgi protein 73 (GP73), interleukin-6 (IL-6), and squamous cell carcinoma antigen (SCCA) have been proposed as biomarkers for the early detection of HCC.
Ferrous sulfate, but not iron polymaltose complex, aggravates local and systemic inflammation and oxidative stress in dextran sodium sulfate-induced colitis in rats.
New
Angerosa et al., Buenos Aires, Argentina. In Drug Des Devel Ther, Dec 2014
Gross colon anatomy, histology of colon and liver, stainings of L-ferritin, Prussian blue, hepcidin, tumor necrosis factor-α, and interleukin-6, as well serum levels of liver enzymes, inflammatory markers, and iron markers, were assessed.
IL-6 amplifier, NF-κB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses.
GeneRIF
Murakami et al., Ōsaka, Japan. In J Immunol, 2012
These results show that IL-6 amplifier activation in grafts plays a critical role for graft rejection responses after allogeneic transplantation, including chronic rejection.
Context-specific roles for paracrine IL-6 in lymphomagenesis.
GeneRIF
Hemann et al., Cambridge, United States. In Genes Dev, 2012
It was shown that paracrine IL-6 signaling promoted the survival of transplanted hematopoietic stem cells, while also initiating a secretory program in the bone marrow that inhibits the development of B-cell malignancies.
Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer.
GeneRIF
Tanzawa et al., Saitama, Japan. In Anticancer Res, 2012
levels of HGF and IL-6 in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy
Alterations in the masseter muscle and plasma IL-6 level following experimentally induced occlusal interference and chronic stress--a study in rats.
GeneRIF
Braut et al., Rijeka, Croatia. In Coll Antropol, 2012
High concentrations of muscle interleukin-6 and its correlation with pain point to inflammatory background of masticatory muscle pain.
Impact of the -174G/C interleukin-6 (IL-6) gene polymorphism on the risk of paediatric ischemic stroke, its symptoms and outcome.
GeneRIF
Zak et al., Poland. In Folia Neuropathol, 2011
Our study did not show any associations between the IL-6 -174 G>C polymorphism and the occurrence of stroke
More papers using Interleukin-6 antibodies
The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.
Supplier
Bobé Pierre, In PLoS ONE, 2007
... Recombinant mouse IL-6, anti-alfa tubulin antibody, fluorescein isothiocyanate (FITC) conjugate anti goat antibody, and propidium iodide were purchased from Sigma Aldrich (St ...
Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis
Supplier
Hung Chien-Hui et al., In Carcinogenesis, 2007
... IL-6 enzyme immunoassay kit was purchased from Cayman Chemical (Ann Arbor, MI) ...
Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test?
Supplier
Creatsas G. et al., In Mediators of Inflammation, 2007
... Enzyme-linked immunosorbent assay was used for quantitative detection of soluble human IL-6, Bender Medsystems GmbH (BMS213HS), Austria ...
Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities
Supplier
Sohn Uy Dong et al., In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2006
... Korea); absolute ethanol and DMSO were from Thermo Fisher Scientific (Waltham, MA, USA); actin and IL-6 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Supplier
Ramqvist Torbjorn, In PLoS ONE, 2006
... Human recombinant IL-6 and CK2 kinase were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
Supplier
Yamaoka Yoshio, In PLoS ONE, 2006
... Interleukin-6 (IL-6) was purchased from BD Biosciences (San Diego, CA) ...
Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice
Supplier
King Lui Edmund Man et al., In Chinese Medicine, 2006
... BD OptEIA ELISA kits tumour necrosis factor-α and interleukin-6 (BD Biosciences, USA) ...
Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats
Supplier
Yang Ping-Chang et al., In North American Journal of Medical Sciences, 2006
... SCF, NGF and IL-6 (Leinco Technologies.
The impact of cigarette smoking on periodontal disease and treatment.
Supplier
II Roy Martin Roop, In PLoS ONE, 2006
... TNF-α and IL-6 ELISA kits were purchased from eBioscience (San Diego, CA) ...
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.
Supplier
Combs Colin, In PLoS ONE, 2004
... Mouse IL-6 ELISA kit was obtained from eBioscience (San Diego, CA) ...
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... IL-6 and cAMP EIA kits were from Cayman Chemical, All reagents for ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
Supplier
Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... Systems, Abingdon, UK), IL-6 and non-target (NT) siRNA (Invitrogen, Paisley, UK), recombinant IL-6 (R&D Systems), anti-IL-6 receptor and isotype (IgG2b) control antibodies (Biolegend, San Diego, CA, USA), ...
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
Supplier
Skorski Tomasz et al., In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2002
... of growth factors: 10pg/ml GM-CSF, 10pg/ml G-CSF, 10ng/ml SCF, 10ng/ml LIF, 10ng/ml MIP-1α, 0.2 ng/ml IL-6 (PeproTech Inc., Rocky Hill, NJ, USA, and StemCell Technologies).
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events.
Supplier
Lichterfeld Mathias, In PLoS ONE, 2002
... Anti-mouse IL-6 mAbs (MP5-20F3 and MP5-32C11, biotin-conjugated) used for ELISA were also obtained from eBioscience.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
Potempa J S et al., In Cell Death & Disease, 2001
... and IL-6 assays (Becton Dickinson Co., Franklin Lakes, NJ, ...
Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study
Supplier
Weigand Markus A et al., In Critical Care, 2001
... We used ELISA kits to determine serum concentrations of Il-6 (R&D Systems, Minneapolis, MN, USA), sVCAM-1 (Bender MedSystems, Vienna, Austria), and sICAM-1 ...
Loss of pentameric symmetry of C-reactive protein is associated with promotion of neutrophil–endothelial cell adhesion
Supplier
Peter K. et al., In Basic Research in Cardiology, 2000
... human (rh) Flt-3 ligand (100 ng/ml), rh stem cell factor (100 ng/ml), rh IL-3 (20 ng/ml) and rh IL-6 (20 ng/ml), all purchased from StemCell Technologies.
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Supplier
Aguila Marcia B., In PLoS ONE, 2000
... Recombinant mouse IL-6 (RMIL6I) was obtained from Thermo Scientific (Rockford, IL) while a mouse ...
The microinflammatory state in uremia: causes and potential consequences
Supplier
Girelli Domenico et al., In Journal of Biomedicine and Biotechnology, 2000
... Serum ferritin was measured by routine laboratory methods, IL-6 by enzyme-linked immunoadsorbent assay (by Human IL-6 ELISA BMS213/2CE Bender MedSystems GmbH, Vienna, Austria), and ...
Dityrosine formation outcompetes tyrosine nitration at low steady-state concentrations of peroxynitrite.
Supplier
Sambhara Suryaprakash, In PLoS ONE, 1999
... Goat antibody to mouse IgG (horseradish peroxidase) (0.8 mg/mL), TNF-α, IL-1β and IL-6 mouse ELISA kits were purchased from Abcam (Cambridge, United Kingdom) ...
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW 264.7 macrophages
Supplier
Ma Jin Yeul et al., In BMC Complementary and Alternative Medicine, 1998
... (Santa Cruz, CA, USA) and TNF-α, IL-6 antibody, biotinylated TNF-α and IL-6 antibodies were purchased from BD Biosciences (San Jose, CA, USA) ...
Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats.
Supplier
Vidal-Puig Antonio J., In PLoS Biology, 1996
... anti-phospho-PERK (rabbit polyclonal, SC-32577), anti-CHOP (GADD 153) (rabbit polyclonal, SC-575), anti-IL-10 (goat polyclonal, SC-1783), and anti-IL-6 (rabbit polyclonal, SC-7920) antibodies were from Santa Cruz Biotechnology, Inc ...
Interleukin-6-blocking agents
Supplier
Ciliberto Gennaro et al., In The Journal of Experimental Medicine, 1996
... TNF, IL-6 mice were obtained by intercrossing TNF-α transgenic mice ( ...
MIF Signal Transduction Initiated by Binding to CD74
Supplier
Bucala Richard et al., In The Journal of Experimental Medicine, 1995
... Recombinant human IL-6 and IFN-γ were obtained from R&D Systems.Human anti–human CD74 mAbs (clones LN2 and M-B741) were obtained from BD Biosciences, and dialyzed free of ...
flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
Supplier
Rose-John Stefan et al., In The Journal of Experimental Medicine, 1994
... The generation of human sIL-6R and human IL-6 transgenic mice has been described ...
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
Supplier
Potter Michael et al., In The Journal of Experimental Medicine, 1991
... Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
Supplier
Bushell Andrew et al., In European Journal of Immunology, 1991
... Siamon Gordon, Sir William Dunn School of Pathology, Oxford, UK), and IL-6 knockout mice were obtained from and housed in the Biomedical Services Unit, John Radcliffe ...
Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen
Supplier
Pessler Frank et al., In Arthritis Research & Therapy, 1990
... Exudate IL-6, PGE2 and PGD2 levels were determined by commercially available immunoassays (eBioscience, San Diego, CA, USA ...
Glutathione S transferases. The first enzymatic step in mercapturic acid formation
Supplier
Sarkar Biswajit et al., In Oxidative Medicine and Cellular Longevity, 1973
... and IL-6 antibody procured from Anaspec Inc ...
share on facebooktweetadd +1mail to friends