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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Aug 2015.

Interleukin 3

Interleukin-3, IL-3
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, GM-CSF, Interleukin-6, IL-4
Papers using Interleukin-3 antibodies
Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
Supplier
Nakamura T et al., In Cell Death & Disease, 2009
... IL-3 signaling inhibitor, PD98059 (Cell Signaling Technologies, Beverly, MA, USA) ...
Interferometry in flow to sort unstained X- and Y-chromosome-bearing bull spermatozoa.
Supplier
Cimini Daniela, In PLoS ONE, 2001
... 100× penicillin-streptomycin solution (Gemini), 0.5 mg/ml Geneticin[TM] (Invitrogen), 55 mM 2-Mercaptoethanol and 3 ng/ml mouse recombinant Interleukin-3 (BD Biosciences, # 354058) ...
Crystal structure of a γ-herpesvirus cyclin-cdk complex.
Supplier
Covas Dimas Tadeu, In PLoS ONE, 1999
... 16% fetal bovine serum, 4% WEHI-3B conditioned media, 20 ng/mL SCF, 2 ng/mL IL-6, 0.2 ng/mL IL-3; all cytokines from Fitzgerald Laboratories) ...
Papers on Interleukin-3
Molecular control of capillary morphogenesis and maturation by recognition and remodeling of the extracellular matrix: functional roles of endothelial cells and pericytes in health and disease.
New
Bowers et al., Columbia, United States. In Connect Tissue Res, 25 Sep 2015
These processes occur under serum-free conditions in 3D collagen or fibrin matrices and in response to five key growth factors which are stem cell factor, interleukin-3, stromal-derived factor-1α, fibroblast growth factor-2 and insulin.
Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing.
New
Bueno et al., Santiago, Chile. In Cytokine, 20 Sep 2015
We observed elevated levels of Th2 cytokines (IL-3, IL-4, IL-10 and IL-13), pro-inflammatory cytokines and chemokines (IL-1β, IL-6, TNF-β, MCP-1/CCL2, MIP-1α/CCL3 and IL-8/CXCL8) in BALF from infants with RSV bronchiolitis, as compared to controls.
IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils.
New
Jarjour et al., Madison, United States. In J Immunol, 14 Sep 2015
However, all of the eosinophil-activating cytokines, such as IL-5, IL-3, and GM-CSF, are typically present in atopic diseases, including allergic asthma.
Association of interleukin 3 (IL-3) polymorphisms with schizophrenia in Han Chinese population.
New
Wu et al., Kunming, China. In Neurosci Lett, 13 Sep 2015
Recent genetic analyses showed that the interleukin 3 (IL-3) gene and its receptors are significantly associated with schizophrenia, especially in Irish populations.
The βc receptor family - Structural insights and their functional implications.
Review
New
Parker et al., Australia. In Cytokine, 31 Aug 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc).
Innate Response Activator B cells: origins and functions.
Review
New
Swirski et al., Boston, United States. In Int Immunol, Jun 2015
UNASSIGNED: Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors GM-CSF and IL-3.
Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time.
Review
New
McKenzie et al., Cambridge, United Kingdom. In Genes Immun, Apr 2015
Notch, GATA-3 (GATA-binding protein 3), Nfil3 (nuclear factor interleukin-3) and Id2 (inhibitor of DNA-binding 2) are identified as early factors that suppress B- and T-cell potentials and are turned on in favour of ILC commitment.
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.
New
Impact
Swirski et al., Boston, United States. In Science, Apr 2015
Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis.
CD123 and its potential clinical application in leukemias.
Review
New
Xiao et al., Changchun, China. In Life Sci, Mar 2015
The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function.
Allium cepa L. and Quercetin Inhibit RANKL/Porphyromonas gingivalis LPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway.
New
Prakki et al., Salvador, Brazil. In Evid Based Complement Alternat Med, Dec 2014
We observed lower production of IL-6 and IL-1α and an increased production of IL-3 and IL-4.
Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.
Review
Kankaanranta et al., Tampere, Finland. In J Cell Death, 2013
Eosinophils are inflammatory cells that require an external survival-prolonging stimulus such as granulocyte macrophage-colony-stimulating factor (GM-CSF), interleukin (IL)-5, or IL-3 for survival.
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
Impact
Campbell et al., Indianapolis, United States. In Nat Med, 2012
DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G-CSF, interleukin-3 (IL-3) and erythropoietin and decreased their activity.
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils.
GeneRIF
Jarjour et al., Madison, United States. In Cytokine, 2012
data indicate that within microenvironments rich in betac-family cytokines and TNF, eosinophils are a source of proMMP-9 and highlight a previously unrecognized role for synergistic interaction between TNF and betac-family cytokinea, for proMMP-9 synthesis
Up-regulation of IL-33 expression in various types of murine cells by IL-3 and IL-4.
GeneRIF
Hu et al., Tokyo, Japan. In Cytokine, 2012
confirm for the first time that IL-3 and IL-4 are critical for IL-33 intracrine in murine cells of various types, indicating that IL-3 and IL-4 may play an important role in the constitutive expression of IL-33 in vivo
Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.
GeneRIF
Aouizerat et al., San Francisco, United States. In J Pain, 2012
This study demonistrated that Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P = .019).
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation.
GeneRIF
O'Neill et al., Dublin, Ireland. In Inflamm Res, 2012
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation
p53-Dependent transcriptional responses to interleukin-3 signaling.
GeneRIF
Ekert et al., Australia. In Plos One, 2011
p53(-/-) cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Impact
Artis et al., Philadelphia, United States. In Nature, 2011
Critically, TSLP could elicit basophil responses in both IL-3-IL-3R-sufficient and -deficient environments, and genome-wide transcriptional profiling and functional analyses identified heterogeneity between TSLP-elicited versus IL-3-elicited basophils.
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.
Impact
Corey et al., Seattle, United States. In Nat Med, 2009
The CD4(+) T cells that persisted reacted to HSV-2 antigen, were enriched for expression of the chemokine receptor CCR5, and were contiguous to DCs expressing the interleukin-3 receptor CD123 or DC-SIGN.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Impact
Lock et al., Toronto, Canada. In Cell Stem Cell, 2009
We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of nonobese diabetic/severe-combined immunodeficient (NOD/SCID) mice.
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