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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Nov 2015.

Interleukin 3

Interleukin-3, IL-3
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, GM-CSF, Interleukin-6, IL-4
Papers using Interleukin-3 antibodies
Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
Nakamura T et al., In Cell Death & Disease, 2009
... IL-3 signaling inhibitor, PD98059 (Cell Signaling Technologies, Beverly, MA, USA) ...
Interferometry in flow to sort unstained X- and Y-chromosome-bearing bull spermatozoa.
Cimini Daniela, In PLoS ONE, 2001
... 100× penicillin-streptomycin solution (Gemini), 0.5 mg/ml Geneticin[TM] (Invitrogen), 55 mM 2-Mercaptoethanol and 3 ng/ml mouse recombinant Interleukin-3 (BD Biosciences, # 354058) ...
Crystal structure of a γ-herpesvirus cyclin-cdk complex.
Covas Dimas Tadeu, In PLoS ONE, 1999
... 16% fetal bovine serum, 4% WEHI-3B conditioned media, 20 ng/mL SCF, 2 ng/mL IL-6, 0.2 ng/mL IL-3; all cytokines from Fitzgerald Laboratories) ...
Papers on Interleukin-3
Basophil Markers for Identification and Activation in the Indirect Basophil Activation Test by Flow Cytometry for Diagnosis of Autoimmune Urticaria.
Won et al., Taegu, South Korea. In Ann Lab Med, 31 Jan 2016
We aimed to identify better donor basophils (from atopic vs. non-atopic donors and interleukin-3 primed vs. unprimed basophils) and improve basophil identification and activation markers (eotaxin CC chemokine receptor-3 [CCR3] vs. CD123 and CD63 vs. CD203c).
ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9.
Emi et al., Japan. In Genes Chromosomes Cancer, 06 Dec 2015
ETV6-LPXN, an in-frame fusion between exon 4 of ETV6 and exon 2 of LPXN, did not transform the interleukin-3-dependent 32D myeloid cell line to cytokine independence; however, an enhanced proliferative response was observed when these cells were treated with G-CSF without inhibition of granulocytic differentiation.
Serum interferon-inducible protein 10 levels predict hepatitis B s antigen seroclearance in patients with chronic hepatitis B.
Wong et al., Hong Kong, Hong Kong. In Aliment Pharmacol Ther, 03 Dec 2015
Relevant serum cytokines [interleukin (IL)-2, IL-3, IL-4, IL-7, IL-9, IL-10, IL-12, IL-15, IL-21 interferon-γ, tumour necrosis factor-α (TNF-α), granulocyte macrophage colony-stimulating factor (GM-CSF) and interferon-inducible protein 10 (IP-10)] were assayed at the time (Year 0) and 3 years before (Year -3) HBsAg seroclearance.
Innate response activator B cells: origins and functions.
Swirski et al., Boston, United States. In Int Immunol, 30 Nov 2015
Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors granulocyte macrophage colony stimulating factor and IL-3.
ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro.
Suo et al., Zhengzhou, China. In Oncotarget, 21 Nov 2015
In this study, the cell stemness influence of a group of interleukins including IL-3, 6, 10, 11 and 24 on human prostate cancer cell lines LNCaP and PC-3 was explored in vitro.
The βc receptor family - Structural insights and their functional implications.
Parker et al., Australia. In Cytokine, Aug 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc).
Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time.
McKenzie et al., Cambridge, United Kingdom. In Genes Immun, Apr 2015
Notch, GATA-3 (GATA-binding protein 3), Nfil3 (nuclear factor interleukin-3) and Id2 (inhibitor of DNA-binding 2) are identified as early factors that suppress B- and T-cell potentials and are turned on in favour of ILC commitment.
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.
Swirski et al., Boston, United States. In Science, Apr 2015
Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis.
CD123 and its potential clinical application in leukemias.
Xiao et al., Changchun, China. In Life Sci, Mar 2015
The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function.
Determinants of eosinophil survival and apoptotic cell death.
Malter et al., Dallas, United States. In Apoptosis, Feb 2015
During both transit to and residence in the lung, Eos contact prosurvival cytokines, particularly IL-3, IL-5 and GM-CSF, that attenuate cell death.
Characterizing Phenotypes and Signaling Networks of Single Human Cells by Mass Cytometry.
Irish et al., Nashville, United States. In Methods Mol Biol, Dec 2014
In the second protocol, a mass cytometry signaling network profile measures 25 node states comprised of five key signaling effectors (AKT, ERK1/2, STAT1, STAT5, and p38) quantified under five conditions (Basal, FLT3L, SCF, IL-3, and IFNγ).
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
Campbell et al., Indianapolis, United States. In Nat Med, 2012
DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G-CSF, interleukin-3 (IL-3) and erythropoietin and decreased their activity.
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils.
Jarjour et al., Madison, United States. In Cytokine, 2012
data indicate that within microenvironments rich in betac-family cytokines and TNF, eosinophils are a source of proMMP-9 and highlight a previously unrecognized role for synergistic interaction between TNF and betac-family cytokinea, for proMMP-9 synthesis
Up-regulation of IL-33 expression in various types of murine cells by IL-3 and IL-4.
Hu et al., Tokyo, Japan. In Cytokine, 2012
confirm for the first time that IL-3 and IL-4 are critical for IL-33 intracrine in murine cells of various types, indicating that IL-3 and IL-4 may play an important role in the constitutive expression of IL-33 in vivo
Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.
Aouizerat et al., San Francisco, United States. In J Pain, 2012
This study demonistrated that Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P = .019).
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation.
O'Neill et al., Dublin, Ireland. In Inflamm Res, 2012
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation
p53-Dependent transcriptional responses to interleukin-3 signaling.
Ekert et al., Australia. In Plos One, 2011
p53(-/-) cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Artis et al., Philadelphia, United States. In Nature, 2011
Critically, TSLP could elicit basophil responses in both IL-3-IL-3R-sufficient and -deficient environments, and genome-wide transcriptional profiling and functional analyses identified heterogeneity between TSLP-elicited versus IL-3-elicited basophils.
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.
Corey et al., Seattle, United States. In Nat Med, 2009
The CD4(+) T cells that persisted reacted to HSV-2 antigen, were enriched for expression of the chemokine receptor CCR5, and were contiguous to DCs expressing the interleukin-3 receptor CD123 or DC-SIGN.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Lock et al., Toronto, Canada. In Cell Stem Cell, 2009
We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of nonobese diabetic/severe-combined immunodeficient (NOD/SCID) mice.
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