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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Interleukin 3

Interleukin-3, IL-3
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, GM-CSF, Interleukin-6, IL-4
Papers using Interleukin-3 antibodies
Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
Supplier
Nakamura T et al., In Cell Death & Disease, 2009
... IL-3 signaling inhibitor, PD98059 (Cell Signaling Technologies, Beverly, MA, USA) ...
Interferometry in flow to sort unstained X- and Y-chromosome-bearing bull spermatozoa.
Supplier
Cimini Daniela, In PLoS ONE, 2001
... 100× penicillin-streptomycin solution (Gemini), 0.5 mg/ml Geneticin[TM] (Invitrogen), 55 mM 2-Mercaptoethanol and 3 ng/ml mouse recombinant Interleukin-3 (BD Biosciences, # 354058) ...
Crystal structure of a γ-herpesvirus cyclin-cdk complex.
Supplier
Covas Dimas Tadeu, In PLoS ONE, 1999
... 16% fetal bovine serum, 4% WEHI-3B conditioned media, 20 ng/mL SCF, 2 ng/mL IL-6, 0.2 ng/mL IL-3; all cytokines from Fitzgerald Laboratories) ...
Papers on Interleukin-3
Positive lymph-node breast cancer patients: Activation of NF-κB in tumor associated leukocytes stimulates cytokines secretion that promotes metastasis via CC-chemokine receptor CCR7.
New
Mohamed et al., Al Jīzah, Egypt. In Febs J, 18 Nov 2014
Furthermore, TALs of pLNs posses a significant increase by 5 fold in secretion of IL-1α, IFN-γ, IL-5, IL-3 and TNF-β, and are characterized by enhanced constitutive NF-κB/p65 signaling compared to TALs isolated from nLNs patients.
[Effect of endothelial cell-targeted soluble Notch ligand hD1R protein on expansion and engraftment of cord blood hematopoietic stem/progenitor cells].
New
Zhang et al., Beijing, China. In Zhonghua Xue Ye Xue Za Zhi, 14 Nov 2014
Human cord blood CD34⁺ cells were co-cultured on human umbilical vein endothelial cells (HUVECs) supplemented with a cocktail containing 5 types of human cytokines including TPO, SCF, FL, IL-6, IL-3 (5GF) and soluble hD1R.
Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.
New
Janne et al., Ad Dānā, Syria. In Clin Cancer Res, 07 Nov 2014
Expression of FGFR3-TACC3 led to IL-3 independent growth in Ba/F3 cells.
[Effects of three-dimensional culture on cell phenotype and hematopoietic cytokine expression of umbilical cord mesenchymal stem cells].
New
Xiao et al., Jinan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 30 Sep 2014
The expression of some cytokines associated with hematopoiesis, such as G-CSF, LIF, SCF, IL-1α, IL-1β, IL-3, IL-7 and IL-11, increased, especially for LIF, IL-3, IL-7.
Adaptive response in mammalian cells exposed to non-ionizing radiofrequency fields: A review and gaps in knowledge.
Review
New
Scarfi et al., San Antonio, United States. In Mutat Res, Mar 2014
In in vivo studies, exposure of rodents to radiofrequency fields and then to lethal/sub-lethal doses of γ-radiation showed survival advantage, significantly decreased damage in hematopoietic tissues, decreased genetic damage in blood leukocytes and bone marrow cells, increased numbers of colony forming units in bone marrow, increased levels of colony stimulating factor and interleukin-3 in the serum and increased expression of genes related to cell cycle.
Eosinophil apoptosis as a therapeutic target in allergic asthma.
Review
New
Kankaanranta et al., Tampere, Finland. In Basic Clin Pharmacol Toxicol, Jan 2014
In the absence of any inflammatory survival-prolonging factors, eosinophils die by apoptosis in few days but in inflamed airways, eosinophil survival is thought to be prolonged due to the surrounding pro-inflammatory factors such as IL-5, IL-3 and GM-CSF.
Clathrin Assembly Protein CALM Plays a Critical Role in KIT Signaling by Regulating Its Cellular Transport from Early to Late Endosomes in Hematopoietic Cells.
New
Matsumura et al., Ōsaka, Japan. In Plos One, Dec 2013
In addition, SCF, FLT3, and TPO-dependent growth was severely impaired in CALM-/- LSK cells, while they can normally proliferate in response to IL-3 and IL-6.
Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.
Review
New
Kankaanranta et al., Tampere, Finland. In J Cell Death, Dec 2013
Eosinophils are inflammatory cells that require an external survival-prolonging stimulus such as granulocyte macrophage-colony-stimulating factor (GM-CSF), interleukin (IL)-5, or IL-3 for survival.
Signalling by the βc family of cytokines.
Review
New
Lopez et al., Adelaide, Australia. In Cytokine Growth Factor Rev, Jun 2013
The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity.
[Modern condition and prospects of improvement of the specialized medical care for acute bone marrow syndrome of radiation etiology].
Review
Salukhov et al., In Voen Med Zh, 2013
It is shown, that the greatest prospects in perfection of the specialized medical aid at acute radiation syndrome are connected to complex application of interleukin-1beta, interleukin-3, granulocyte or granulocyte/macrophage colony stimulated factor, thrombopoietin and others cytokines.
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
Impact
Campbell et al., Indianapolis, United States. In Nat Med, 2012
DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G-CSF, interleukin-3 (IL-3) and erythropoietin and decreased their activity.
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils.
GeneRIF
Jarjour et al., Madison, United States. In Cytokine, 2012
data indicate that within microenvironments rich in betac-family cytokines and TNF, eosinophils are a source of proMMP-9 and highlight a previously unrecognized role for synergistic interaction between TNF and betac-family cytokinea, for proMMP-9 synthesis
Up-regulation of IL-33 expression in various types of murine cells by IL-3 and IL-4.
GeneRIF
Hu et al., Tokyo, Japan. In Cytokine, 2012
confirm for the first time that IL-3 and IL-4 are critical for IL-33 intracrine in murine cells of various types, indicating that IL-3 and IL-4 may play an important role in the constitutive expression of IL-33 in vivo
Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.
GeneRIF
Aouizerat et al., San Francisco, United States. In J Pain, 2012
This study demonistrated that Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P = .019).
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation.
GeneRIF
O'Neill et al., Dublin, Ireland. In Inflamm Res, 2012
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation
p53-Dependent transcriptional responses to interleukin-3 signaling.
GeneRIF
Ekert et al., Australia. In Plos One, 2011
p53(-/-) cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Impact
Artis et al., Philadelphia, United States. In Nature, 2011
Critically, TSLP could elicit basophil responses in both IL-3-IL-3R-sufficient and -deficient environments, and genome-wide transcriptional profiling and functional analyses identified heterogeneity between TSLP-elicited versus IL-3-elicited basophils.
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.
Impact
Corey et al., Seattle, United States. In Nat Med, 2009
The CD4(+) T cells that persisted reacted to HSV-2 antigen, were enriched for expression of the chemokine receptor CCR5, and were contiguous to DCs expressing the interleukin-3 receptor CD123 or DC-SIGN.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Impact
Lock et al., Toronto, Canada. In Cell Stem Cell, 2009
We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of nonobese diabetic/severe-combined immunodeficient (NOD/SCID) mice.
Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.
Impact
Nakanishi et al., Nishinomiya, Japan. In Nat Immunol, 2009
Here we show that when incubated with IL-3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized, processed and presented antigen as complexes of peptide and major histocompatibility complex class II and produced IL-4.
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