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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Feb 2015.

Interleukin 3

Interleukin-3, IL-3
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, GM-CSF, Interleukin-6, IL-4
Papers using Interleukin-3 antibodies
Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
Supplier
Nakamura T et al., In Cell Death & Disease, 2009
... IL-3 signaling inhibitor, PD98059 (Cell Signaling Technologies, Beverly, MA, USA) ...
Interferometry in flow to sort unstained X- and Y-chromosome-bearing bull spermatozoa.
Supplier
Cimini Daniela, In PLoS ONE, 2001
... 100× penicillin-streptomycin solution (Gemini), 0.5 mg/ml Geneticin[TM] (Invitrogen), 55 mM 2-Mercaptoethanol and 3 ng/ml mouse recombinant Interleukin-3 (BD Biosciences, # 354058) ...
Crystal structure of a γ-herpesvirus cyclin-cdk complex.
Supplier
Covas Dimas Tadeu, In PLoS ONE, 1999
... 16% fetal bovine serum, 4% WEHI-3B conditioned media, 20 ng/mL SCF, 2 ng/mL IL-6, 0.2 ng/mL IL-3; all cytokines from Fitzgerald Laboratories) ...
Papers on Interleukin-3
Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.
New
Moritz et al., Hannover, Germany. In Stem Cell Reports, 10 Mar 2015
Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in myeloid differentiation.
Developing a co-culture system for effective megakaryo/thrombopoiesis from umbilical cord blood hematopoietic stem/progenitor cells.
New
da Silva et al., Lisbon, Portugal. In Cytotherapy, 10 Mar 2015
The megakaryocytic commitment and platelet generation were studied, considering the impact of exogenous addition of thrombopoietin (TPO) in the expansion stage and a cytokine cocktail (Cyt) including TPO and interleukin-3 in the differentiation stage, with the use of different culture medium formulations, and in the presence/absence of BM-MSCs (direct versus non-direct cell-cell contact).
Phenotypic and functional comparison of two distinct subsets of programmable cell of monocytic origin (PCMOs)-derived dendritic cells with conventional monocyte-derived dendritic cells.
New
Delirezh et al., Sārī, Iran. In Cell Mol Immunol, 09 Mar 2015
Here we report the generation of two functionally distinct subsets of DCs derived from programmable cells of monocytic origin (PCMOs) in the presence of IL-3 or tumor necrosis factor alpha (TNF-α).
Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time.
Review
New
McKenzie et al., Cambridge, United Kingdom. In Genes Immun, 22 Feb 2015
Notch, GATA-3 (GATA-binding protein 3), Nfil3 (nuclear factor interleukin-3) and Id2 (inhibitor of DNA-binding 2) are identified as early factors that suppress B- and T-cell potentials and are turned on in favour of ILC commitment.
Dendrobium chrysotoxum Lindl. Alleviates Diabetic Retinopathy by Preventing Retinal Inflammation and Tight Junction Protein Decrease.
New
Wang et al., Shanghai, China. In J Diabetes Res, Dec 2014
DC also reduced the increased serum levels of TNFα, interferon-γ (IFN-γ), IL-6, IL-1β, IL-8, IL-12, IL-2, IL-3, and IL-10 in diabetic rats.
CD123 and its potential clinical application in leukemias.
Review
New
Xiao et al., Changchun, China. In Life Sci, Dec 2014
The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function.
[Impairments of rats' behavioral reactions, concentration of corticosterone and expression of cytokine's gene under experimental postviral fatigue].
New
In Ross Fiziol Zh Im I M Sechenova, May 2014
The aim of the main research was investigated of interaction of neural, endocrine and immune systems under experimental postviral fatigue, behavioral reactions, level of corticosterone, changes of IL-3 and IL-10 gene expression in rats' hypothalamus and INF-α in hypothalamus and spleen were analyzed.
Adaptive response in mammalian cells exposed to non-ionizing radiofrequency fields: A review and gaps in knowledge.
Review
New
Scarfi et al., In Mutat Res Rev Mutat Res, Mar 2014
In in vivo studies, exposure of rodents to radiofrequency fields and then to lethal/sub-lethal doses of γ-radiation showed survival advantage, significantly decreased damage in hematopoietic tissues, decreased genetic damage in blood leukocytes and bone marrow cells, increased numbers of colony forming units in bone marrow, increased levels of colony stimulating factor and interleukin-3 in the serum and increased expression of genes related to cell cycle.
Eosinophil apoptosis as a therapeutic target in allergic asthma.
Review
Kankaanranta et al., Tampere, Finland. In Basic Clin Pharmacol Toxicol, 2014
In the absence of any inflammatory survival-prolonging factors, eosinophils die by apoptosis in few days but in inflamed airways, eosinophil survival is thought to be prolonged due to the surrounding pro-inflammatory factors such as IL-5, IL-3 and GM-CSF.
Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.
Review
Kankaanranta et al., Tampere, Finland. In J Cell Death, 2013
Eosinophils are inflammatory cells that require an external survival-prolonging stimulus such as granulocyte macrophage-colony-stimulating factor (GM-CSF), interleukin (IL)-5, or IL-3 for survival.
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
Impact
Campbell et al., Indianapolis, United States. In Nat Med, 2012
DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G-CSF, interleukin-3 (IL-3) and erythropoietin and decreased their activity.
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils.
GeneRIF
Jarjour et al., Madison, United States. In Cytokine, 2012
data indicate that within microenvironments rich in betac-family cytokines and TNF, eosinophils are a source of proMMP-9 and highlight a previously unrecognized role for synergistic interaction between TNF and betac-family cytokinea, for proMMP-9 synthesis
Up-regulation of IL-33 expression in various types of murine cells by IL-3 and IL-4.
GeneRIF
Hu et al., Tokyo, Japan. In Cytokine, 2012
confirm for the first time that IL-3 and IL-4 are critical for IL-33 intracrine in murine cells of various types, indicating that IL-3 and IL-4 may play an important role in the constitutive expression of IL-33 in vivo
Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.
GeneRIF
Aouizerat et al., San Francisco, United States. In J Pain, 2012
This study demonistrated that Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P = .019).
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation.
GeneRIF
O'Neill et al., Dublin, Ireland. In Inflamm Res, 2012
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation
p53-Dependent transcriptional responses to interleukin-3 signaling.
GeneRIF
Ekert et al., Australia. In Plos One, 2011
p53(-/-) cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Impact
Artis et al., Philadelphia, United States. In Nature, 2011
Critically, TSLP could elicit basophil responses in both IL-3-IL-3R-sufficient and -deficient environments, and genome-wide transcriptional profiling and functional analyses identified heterogeneity between TSLP-elicited versus IL-3-elicited basophils.
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.
Impact
Corey et al., Seattle, United States. In Nat Med, 2009
The CD4(+) T cells that persisted reacted to HSV-2 antigen, were enriched for expression of the chemokine receptor CCR5, and were contiguous to DCs expressing the interleukin-3 receptor CD123 or DC-SIGN.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Impact
Lock et al., Toronto, Canada. In Cell Stem Cell, 2009
We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of nonobese diabetic/severe-combined immunodeficient (NOD/SCID) mice.
Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.
Impact
Nakanishi et al., Nishinomiya, Japan. In Nat Immunol, 2009
Here we show that when incubated with IL-3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized, processed and presented antigen as complexes of peptide and major histocompatibility complex class II and produced IL-4.
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