GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Interleukin 3
Interleukin-3, IL-3
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
Interleukin-3
antibodies
Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
Supplier
In Cell Death & Disease, 2009
... IL-3 signaling inhibitor, PD98059 (Cell Signaling Technologies, Beverly, MA, USA) ...
Interferometry in flow to sort unstained X- and Y-chromosome-bearing bull spermatozoa.
Supplier
In PLoS ONE, 2001
... 100× penicillin-streptomycin solution (Gemini), 0.5 mg/ml Geneticin[TM] (Invitrogen), 55 mM 2-Mercaptoethanol and 3 ng/ml mouse recombinant Interleukin-3 (BD Biosciences, # 354058) ...
Crystal structure of a γ-herpesvirus cyclin-cdk complex.
Supplier
In PLoS ONE, 1999
... 16% fetal bovine serum, 4% WEHI-3B conditioned media, 20 ng/mL SCF, 2 ng/mL IL-6, 0.2 ng/mL IL-3; all cytokines from Fitzgerald Laboratories) ...
Papers on
Interleukin-3
Effect of shRNA targeting mouse CD99L2 gene in a murine B cell lymphoma in vitro and in vivo.
New
Guangzhou, China. In Oncol Rep, 30 Apr 2013
Several cytokines including CD30T, IL-12p40/p70, IL-3, IFN-γ, CXCL16, MIP-1α and CD40 were upregulated following mCD99L2 downregulation when detected using antibody arrays.
Induction of cytokines and growth factors by rapamycin in the microenvironment of brain metastases of lung cancer.
New
Seoul, South Korea. In Oncol Lett, 31 Mar 2013
We evaluated the expression of interleukin-1 (IL-1), interleukin-3 (IL-3), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1), platelet-derived growth factor (PDGF), chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in tumor cells in vivo.
The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR.
New
Wuhan, China. In Toxicol Lett, 26 Mar 2013
Serum levels of some hematopoietic growth factors significantly changed in 8μg/kg bw group, mainly including granulocyte-macrophage (GM-CSF), erythropoietin (EPO), interleukin-3 (IL-3) and TNF-α.
Effects of oral deoxynivalenol exposure on immune-related parameters in lymphoid organs and serum of mice vaccinated with porcine parvovirus vaccine.
New
Anyang, South Korea. In Mycotoxin Res, 24 Mar 2013
The concentrations of IL-2, IL-5, IL-6, IL-9, IL-12, IL-13 and Rantes in thymus, of IL-2 in spleen, and of IL-1α, IL-1β, IL-3, IL-5, IL-10, IL-17, G-CSF, GM-CSF and MCP-1 in mesenteric lymph nodes were significantly decreased in mice compared to those in the Vac group, while concentrations of IL-1α, IL-2, IL-9, IL-13,G-CSF, GM-CSF, IFN-γ, MCP-1, MIP-1α and TNF-α were significantly increased in serum compared to the Vac group.
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
New
Impact
Indianapolis, United States. In Nat Med, Dec 2012
DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G-CSF, interleukin-3 (IL-3) and erythropoietin and decreased their activity.
The Roles of Macrophages and Nitric Oxide in Interleukin-3-Enhanced HSV-Sr39tk-Mediated Prodrug Therapy.
New
Taiwan. In Plos One, Dec 2012
This study aimed to evaluate whether co-expression of interleukin-3 (IL-3) could enhance the anti-tumor activity of HSV-sr39tk/GCV prodrug gene therapy using a murine TRAMP-C1 prostate tumor model.
The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.
Review
New
Australia. In Immunol Rev, Nov 2012
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are members of a discrete family of cytokines that regulates the growth, differentiation, migration and effector function activities of many hematopoietic cells and immunocytes.
Basophil modulation by cytokine instruction.
Review
New
Erlangen, Germany. In Eur J Immunol, Oct 2012
IL-3, GM-CSF, and thymic stromal lymphopoietin activate the STAT5 pathway that promotes proliferation, activation, and cytokine secretion but also induces a negative feedback loop via Pim-1 and SOCS proteins.
Chapter 18: Allergic bronchopulmonary aspergillosis.
Review
New
Chicago, United States. In Allergy Asthma Proc, May 2012
There is an increased number of CD4(+) Th2 lymphocytes in bronchoalveolar lavage, and Aspergillus fumigatus can serve as a growth factor of eosinophils potentiating the effects of IL-3, IL-5, and granulocyte colony-stimulating factor.
The GM-CSF receptor family: mechanism of activation and implications for disease.
Review
New
Adelaide, Australia. In Growth Factors, Apr 2012
Understanding the molecular composition of these pathways, the interaction of the various components as well as the kinetics and dose-dependent mechanics of receptor activation provides valuable insights into the function of GM-CSF as well as the related cytokines, interleukin-3 and interleukin-5.
IL-3 is a novel target to interfere with tumor vasculature.
GeneRIF
Torino, Italy. In Oncogene, 2012
an IL-3 autocrine loop can drive a tumor endothelial switch and that targeting IL-3 might confer a significant therapeutic advantage to hamper tumor angiogenesis
Central role of paxillin phosphorylation in regulation of LFA-1 integrins activity and lymphocyte migration.
Review
Bethesda, United States. In Cell Adh Migr, 2011
In Baf3 murine pro-B lymphocytes, the former phenotype is induced by IL-3 that stimulates a FAK-mediated phosphorylation of paxillin at tyrosines (Y) 31 and 118 and a consequent Rac1 activation.
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Impact
Philadelphia, United States. In Nature, 2011
Critically, TSLP could elicit basophil responses in both IL-3-IL-3R-sufficient and -deficient environments, and genome-wide transcriptional profiling and functional analyses identified heterogeneity between TSLP-elicited versus IL-3-elicited basophils.
NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus.
GeneRIF
United States. In Mol Immunol, 2011
these findings suggest CNSa is a distal enhancer of the IL-3/GM-CSF gene cluster that binds BRG1 and NF-kappaB
Requirement for PLCγ2 in IL-3 and GM-CSF-stimulated MEK/ERK phosphorylation in murine and human hematopoietic stem/progenitor cells.
GeneRIF
São Paulo, Brazil. In J Cell Physiol, 2011
Data indicate a role for PLCgamma2 and Ca(2+) signaling through the modulation of MEK/ERK in IL3/GM-csf stimulated mouse hematopoietic stem/progenitor cells.
Complex interactions in EML cell stimulation by stem cell factor and IL-3.
GeneRIF
New Haven, United States. In Proc Natl Acad Sci U S A, 2011
Complex interactions in EML cell stimulation by stem cell factor and IL-3.
Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cells.
GeneRIF
Tokyo, Japan. In Cell Death Dis, 2010
Inhibition of IL-3 signaling and knockdown of Xbp1-induced apoptosis in hematopoietic cells.
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.
Impact
Seattle, United States. In Nat Med, 2009
The CD4(+) T cells that persisted reacted to HSV-2 antigen, were enriched for expression of the chemokine receptor CCR5, and were contiguous to DCs expressing the interleukin-3 receptor CD123 or DC-SIGN.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Impact
Toronto, Canada. In Cell Stem Cell, 2009
We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of nonobese diabetic/severe-combined immunodeficient (NOD/SCID) mice.
Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.
Impact
Nishinomiya, Japan. In Nat Immunol, 2009
Here we show that when incubated with IL-3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized, processed and presented antigen as complexes of peptide and major histocompatibility complex class II and produced IL-4.
