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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Jul 2015.

Interleukin 3

Interleukin-3, IL-3
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, CAN, GM-CSF, Interleukin-6, IL-4
Papers using Interleukin-3 antibodies
Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance
Supplier
Nakamura T et al., In Cell Death & Disease, 2009
... IL-3 signaling inhibitor, PD98059 (Cell Signaling Technologies, Beverly, MA, USA) ...
Interferometry in flow to sort unstained X- and Y-chromosome-bearing bull spermatozoa.
Supplier
Cimini Daniela, In PLoS ONE, 2001
... 100× penicillin-streptomycin solution (Gemini), 0.5 mg/ml Geneticin[TM] (Invitrogen), 55 mM 2-Mercaptoethanol and 3 ng/ml mouse recombinant Interleukin-3 (BD Biosciences, # 354058) ...
Crystal structure of a γ-herpesvirus cyclin-cdk complex.
Supplier
Covas Dimas Tadeu, In PLoS ONE, 1999
... 16% fetal bovine serum, 4% WEHI-3B conditioned media, 20 ng/mL SCF, 2 ng/mL IL-6, 0.2 ng/mL IL-3; all cytokines from Fitzgerald Laboratories) ...
Papers on Interleukin-3
The βc receptor family - Structural insights and their functional implications.
Review
New
Parker et al., Australia. In Cytokine, 31 Aug 2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 are members of a small family of cytokines that share a beta receptor subunit (βc).
EGFR exon 18 mutations in lung cancer: molecular predictors of augmented sensitivity to afatinib and neratinib as compared with first or third generation TKIs.
New
Mitsudomi et al., Nagoya, Japan. In Clin Cancer Res, 23 Aug 2015
Transfected Ba/F3 cells grew in the absence of interleukin-3, and NIH/3T3 cells formed foci with marked pile-up, indicating their oncogenic abilities.
The novel structure make LDM effectively remove CD123+ AML stem cells in combination with interleukin 3.
New
Wang et al., Tianjin, China. In Cancer Biol Ther, 17 Aug 2015
UNASSIGNED: CD123 bacame a therapeutic target for acute myelocytic leukemia(AML) because of its overexpression only on AML stem cells.It is αsubunit of interleukin-3 (multi-CSF, IL3) receptor.
Increased IL-3 serum levels in chronic patients with schizophrenia: Associated with psychopathology.
New
Zhang et al., Beijing, China. In Psychiatry Res, 16 Aug 2015
In this study, we examined the association of serum IL-3 levels with psychopahological symtoms in chronic schizophrenia.
Heterogeneity of in vitro-cultured CD34+ cells isolated from peripheral blood.
New
Néron et al., Québec, Canada. In Cytotherapy, 08 Aug 2015
METHODS: CD34+ cells were purified from leuko-reduction system chambers and cultured with a defined custom medium without animal protein and supplemented with interleukin-3, interleukin-6, Fms-like tyrosine kinase 3, stem cell factor and thrombopoietin.
IL-3 contributes to development of lupus nephritis in MRL/lpr mice.
New
Mack et al., Regensburg, Germany. In Kidney Int, 01 Aug 2015
Little is known about the role of IL-3 in SLE.
Innate Response Activator B cells: origins and functions.
Review
New
Swirski et al., Boston, United States. In Int Immunol, 08 Jun 2015
UNASSIGNED: Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors GM-CSF and IL-3.
Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time.
Review
New
McKenzie et al., Cambridge, United Kingdom. In Genes Immun, Apr 2015
Notch, GATA-3 (GATA-binding protein 3), Nfil3 (nuclear factor interleukin-3) and Id2 (inhibitor of DNA-binding 2) are identified as early factors that suppress B- and T-cell potentials and are turned on in favour of ILC commitment.
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.
New
Impact
Swirski et al., Boston, United States. In Science, Apr 2015
Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis.
CD123 and its potential clinical application in leukemias.
Review
New
Xiao et al., Changchun, China. In Life Sci, Mar 2015
The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function.
Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.
Review
Kankaanranta et al., Tampere, Finland. In J Cell Death, 2013
Eosinophils are inflammatory cells that require an external survival-prolonging stimulus such as granulocyte macrophage-colony-stimulating factor (GM-CSF), interleukin (IL)-5, or IL-3 for survival.
Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis.
Impact
Campbell et al., Indianapolis, United States. In Nat Med, 2012
DPP4 cleaved within the N-termini of the CSFs granulocyte-macrophage (GM)-CSF, G-CSF, interleukin-3 (IL-3) and erythropoietin and decreased their activity.
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophils.
GeneRIF
Jarjour et al., Madison, United States. In Cytokine, 2012
data indicate that within microenvironments rich in betac-family cytokines and TNF, eosinophils are a source of proMMP-9 and highlight a previously unrecognized role for synergistic interaction between TNF and betac-family cytokinea, for proMMP-9 synthesis
Up-regulation of IL-33 expression in various types of murine cells by IL-3 and IL-4.
GeneRIF
Hu et al., Tokyo, Japan. In Cytokine, 2012
confirm for the first time that IL-3 and IL-4 are critical for IL-33 intracrine in murine cells of various types, indicating that IL-3 and IL-4 may play an important role in the constitutive expression of IL-33 in vivo
Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.
GeneRIF
Aouizerat et al., San Francisco, United States. In J Pain, 2012
This study demonistrated that Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P = .019).
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation.
GeneRIF
O'Neill et al., Dublin, Ireland. In Inflamm Res, 2012
Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation
p53-Dependent transcriptional responses to interleukin-3 signaling.
GeneRIF
Ekert et al., Australia. In Plos One, 2011
p53(-/-) cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Impact
Artis et al., Philadelphia, United States. In Nature, 2011
Critically, TSLP could elicit basophil responses in both IL-3-IL-3R-sufficient and -deficient environments, and genome-wide transcriptional profiling and functional analyses identified heterogeneity between TSLP-elicited versus IL-3-elicited basophils.
Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition.
Impact
Corey et al., Seattle, United States. In Nat Med, 2009
The CD4(+) T cells that persisted reacted to HSV-2 antigen, were enriched for expression of the chemokine receptor CCR5, and were contiguous to DCs expressing the interleukin-3 receptor CD123 or DC-SIGN.
Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells.
Impact
Lock et al., Toronto, Canada. In Cell Stem Cell, 2009
We report that an anti-interleukin-3 (IL-3) receptor alpha chain (CD123)-neutralizing antibody (7G3) targeted AML-LSCs, impairing homing to bone marrow (BM) and activating innate immunity of nonobese diabetic/severe-combined immunodeficient (NOD/SCID) mice.
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