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Interleukin 2

Interleukin-2, IL-2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, Interleukin-6, IL-4, CAN, HAD
Papers using Interleukin-2 antibodies
Protein-protein interaction inhibitors get into the groove
Kanellopoulos Jean, In PLoS ONE, 2011
... Anti IL-2: MQ1-17H2 (capture reagent, Biolegend), poly5111 (probe reagent, Biolegend); ...
The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system
Kloetzel Peter-Michael et al., In Cellular and Molecular Life Sciences, 2010
... Unless specified, all recombinant cytokines used in this study (IL-2, TNF-α, IFN-γ) were purchased from Miltenyi Biotec.
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
Takeuchi Tsutomu et al., In Journal of Biomedicine and Biotechnology, 2009
... Antibodies against CD3 (HIT3a), IL-2 (MQ1-17H12 and B33-2), and IFN-γ (B27 and 4S.B3) were purchased from BD Biosciences Pharmingen (San Diego, USA.) ...
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Hill Adrian VS et al., In Molecular Therapy, 2008
(BD), anti-IFN-γ APC (clone XMG1.2), anti-IL-2 PE-Cy7 (clone JES6-5H4), anti-TNF-α FITC (Clone MP6-XT22), all from eBioscience).
Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma
Fatehi F et al., In Iranian Journal of Public Health, 2007
... ).IL-2 and TNF-α ELISA kits were obtained from Bender Medsystems GmbH (Vienna, Austria) ...
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Papers on Interleukin-2
Reduction of Foxp3+ T cell subsets involved in incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Huang et al., Hangzhou, China. In Hematol Oncol, 06 Nov 2015
Serum cytokine levels of IL-2, tumour necrosis factor-α, interferon-γ and transforming growth factor-β1 (TGF-β1) were evaluated by ELISA.
Exploratory study for identifying systemic biomarkers that correlate with pain response in patients with intervertebral disc disorders.
Chahine et al., United States. In Immunol Res, 06 Nov 2015
Our results indicate that a single ESI significantly decreased systemic levels of SCGF-β and IL-2.
In vitro evaluation of γδ T cells regulatory function in Behçet's disease patients and healthy controls.
Benique et al., Palma, Spain. In Hum Immunol, 03 Nov 2015
We tested their suppressive activity on CD4(+)CD25(-) T effector cells (Teff) proliferation by a CFSE dilution protocol, after suboptimal activation with anti-CD3, in the absence or presence of IL-2.
Dynamics of immune parameters during the treatment of active tuberculosis showing negative interferon-gamma response at the time of diagnosis.
Keicho et al., Tokyo, Japan. In Int J Infect Dis, 03 Nov 2015
Plasma concentrations of interleukin-1 receptor antagonist, interleukin-2, and interferon-gamma-induced protein 10 remained low after MTB-specific antigen stimulation at months 2 and 7 in the continuously QFT-IT-negative group, whereas the parameters were elevated only in the transiently QFT-IT-negative group.
Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.
Staal et al., Leiden, Netherlands. In J Allergy Clin Immunol, 02 Nov 2015
RESULTS: Arrests in T-cell development caused by mutations in IL-7 receptor α (IL7RA) and IL-2 receptor γ (IL2RG) were observed at the most immature thymocytes much earlier than expected based on gene expression profiling of human thymocyte subsets and studies with corresponding mouse mutants.
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
Matarese et al., Napoli, Italy. In Nat Immunol, 28 Oct 2015
The Foxp3-E2-related suppressive activity of iTreg cells was altered in human autoimmune diseases, including multiple sclerosis and type 1 diabetes, and was associated with impaired glycolysis and signaling via interleukin 2. This link between glycolysis and Foxp3-E2 variants via enolase-1 shows a previously unknown mechanism for controlling the induction and function of Treg cells in health and in autoimmunity.
Renal-Cell Cancer - Targeting an Immune Checkpoint or Multiple Kinases.
Lara et al., Sacramento, United States. In N Engl J Med, 25 Oct 2015
Before 2005, the widely used systemic agents were cytokines - interferon alfa and interleukin-2, which yielded modest efficacy and substantial toxicity.
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Craft et al., New Haven, United States. In Immunity, 21 Oct 2015
These data identify the interleukin-2 (IL-2)-mTORc1 axis as a critical orchestrator of the reciprocal balance between Tfh and Th1 cell fates and their respective metabolic activities after acute viral infection.
Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis.
Shi et al., Beijing, China. In Immunity, 18 Sep 2015
Transforming growth factor-β (TGF-β)-activated Smad3 and interleukin-2 (IL-2)-activated Stat5 facilitated Tet1 and Tet2 binding to Foxp3.
TETs Link Hydrogen Sulfide to Immune Tolerance.
Li et al., New York City, United States. In Immunity, 18 Sep 2015
(2015) show that the gasotransmitter hydrogen sulfide co-operates with growth factor TGF-β and interleukin-2 to activate Tet-mediated DNA demethylation of Foxp3 to promote immune tolerance.
Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2.
Joh et al., Nagoya, Japan. In World J Gastroenterol, 07 Sep 2015
Proposed mediators of inflammation in UC include pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-2, and the cell-surface adhesive molecule integrin α4β7.
Anticancer Cytokines: Biology and Clinical Effects of Interferon-α2, Interleukin (IL)-2, IL-15, IL-21, and IL-12.
Tarhini et al., Pittsburgh, United States. In Semin Oncol, Aug 2015
Significant advances were achieved with interleukin-2 (IL-2) and interferon-α (IFN-α), primarily in the treatment of patients with melanoma and renal cell carcinoma.
Thyroid dysfunction: an autoimmune aspect.
Tabassum et al., Riyadh, Saudi Arabia. In Int J Clin Exp Med, Dec 2014
Various cytokines IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, TNF-α and IFN-γ are found in thyroid follicular cells which enhance inflammatory response with nitric oxide (NO) and prostaglandins.
Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications.
Childs et al., Bethesda, United States. In Front Immunol, Dec 2014
Improving NK cell persistence in vivo via autocrine IL-2 and IL-15 stimulation, enhancing tumor targeting by silencing inhibitory NK cell receptors such as NKG2A, and redirecting tumor killing via chimeric antigen receptors, all represent approaches that hold promise in preclinical studies.
Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily.
Fremont et al., Saint Louis, United States. In Viruses, Dec 2014
Reported ligands include chemokines, GM-CSF, IL-2, MHC class I, and glycosaminoglycans.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
Silva-Santos et al., Lisbon, Portugal. In J Immunol, 2012
Freshly isolated lymphoid gammadelta T cells synergize with the T cell receptor to induce autocrine IL-2 production that promotes gammadelta cell survival and proliferation following Plasmodium infection.
In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: potential mediating mechanisms and sex differences.
Ben-Eliyahu et al., Tel Aviv-Yafo, Israel. In Brain Behav Immun, 2012
our findings indicate a generic and robust stress-induced reduction in plasma IL-12
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Kuchroo et al., Boston, United States. In Nat Immunol, 2012
study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo
Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.
Kambayashi et al., Philadelphia, United States. In J Immunol, 2012
Regulatory T (Treg) cell division does not absolutely require cell-autonomous transgenic T cell receptor signaling in vivo, depending on the degree of IL-2-mediated stimulation provided.
IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling.
Fest et al., Rennes, France. In J Immunol, 2012
IL-2 drives activated B cell differentiation toward plasma cells independently of its proliferation and survival functions.
More papers using Interleukin-2 antibodies
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
Teague Ryan M., In PLoS ONE, 2004
... /ml in AIM-V medium (Invitrogen, Carlsbad, CA) supplemented with 300 IU/ml IL-2 (Chiron, Emmerville, CA) and 5% heat-inactivated human AB serum (Valley Biomedical, Winchester, VA) ...
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells
Rothenberg Ellen V. et al., In Nucleic Acids Research, 2003
... expression as a monitoring tool for IL-2 expression in primary T-cells of transgenic mice ...
Cytokines in cancer pathogenesis and cancer therapy
Alitheen Noorjahan Banu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Recombinant murine interleukin 2 (rmIL-2; Dako, USA) was used as ...
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Unutmaz Derya, In PLoS ONE, 2002
... For antibody blocking in culture assays, non-specific isotype matched control, IL-2, IFNγ, IL-12p70 and CD40L specific mAbs without preservatives were obtained from BD Biosciences and IL-18 specific mAb ...
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
Sommer Peter, In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...
A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition
Söderström Kalle et al., In The Journal of Experimental Medicine, 1998
... serum, 200 U IL-2/ml (PeproTech), 2 mM l-glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin (Life Technologies).
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
Strober Warren et al., In The Journal of Experimental Medicine, 1997
... with 10% FCS, 100 μg/ml streptomycin, 100 U/ml penicillin, 50 μM 2-ME, 10 U/ml human IL-2 (Life Technologies), and 6% rat Con ...
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
Allison James P. et al., In The Journal of Experimental Medicine, 1996
... IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice ...
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
Galy Anne et al., In Molecular Therapy, 1996
... plate (Millipore, Bedford, MA) were coated overnight with 5 µg/ml anti-mouse IFN-γ mAb or 3 µg/ml anti-mouse IL-2 mAb (BD Biosciences) at 4 °C, washed, and ...
A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
Ricciardi-Castagnoli Paola et al., In The Journal of Experimental Medicine, 1995
... ), from ascite-purified anti–IL-2 (S4B6, rat IgG2a) or from total rat IgG (Bethyl).
The interleukin-2 receptor
Royuela Mar et al., In Breast Cancer Research, 1988
... The primary antibodies used were goat anti-human IL-2, rabbit anti-human IL-2Rα, rabbit anti-human IL-2Rβ and rabbit anti-human IL-2Rγ (Santa Cruz Biotechnology, California, CA, USA).
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
Schreiber Gideon, In PLoS ONE, 1986
... 15 medium (Cambrex); fetal calf serum (FCS; HyClone, Belgium); L-glutamine (Flow Laboratories, UK); recombinant interleukin-2 (IL-2; Biotech, Russia); phosphate buffered saline (PBS; PanEco, Russia); goat serum (DakoCytomation); phycoerythrin-conjugated goat anti-rabbit IgG (GAR-PE) (Santa Cruz Biotechnology); RNA molecular weight standard ...
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