PhiC31/PiggyBac modified stromal stem cells: effect of interferon gamma and/or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on murine melanoma.
In Mol Cancer, 26 Dec 2014
In contrast, results from in vivo studies showed that IFNgamma-expressing ADSCs, engrafted into tumor stroma, inhibited tumor growth and angiogenesis, prevented systemic increase of Tregs, increased PD-L1 expression and CD8+ infiltration (but not interleukin-2+ cells), and prolonged the survival of mice (68 days, 95% confidence interval [CI] =52 to 86 days compared to 36 days, 95% CI =29 to 39 days for control, P < .001).
Discrimination between active and latent tuberculosis based on the ratio of antigen-specific to mitogen-induced IP-10 production.
Seoul, South Korea. In J Clin Microbiol, 26 Dec 2014
Whole blood samples from 33 active TB patients and 20 individuals with LTBI, and 26 non-TB controls were applied to the commercial IFN-γ release assay QuantiFERON-TB Gold In Tube, and the plasma was analyzed for IL-2, IL-6, IL-8, IL-10, IL-13, TNF-α, IFN-γ, MIG, IP-10, I-TAG, and MCP-1 by using a commercial cytometric bead array.
Southwest Oncology Group S0008: A Phase III Trial of High-Dose Interferon Alfa-2b Versus Cisplatin, Vinblastine, and Dacarbazine, Plus Interleukin-2 and Interferon in Patients With High-Risk Melanoma-An Intergroup Study of Cancer and Leukemia Group B, Children's Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group.
Ann Arbor, United States. In J Clin Oncol, 20 Dec 2014
PATIENTS AND METHODS: S0008 (S0008: Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma) was an Intergroup phase III trial that enrolled high-risk patients (stage IIIA-N2a through IIIC-N3), randomly assigning them to receive either HDI or biochemotherapy consisting of dacarbazine, cisplatin, vinblastine, interleukin-2, IFN alfa-2b (IFN-α-2b) and granulocyte colony-stimulating factor given every 21 days for three cycles.
Continuous requirement for the TCR in regulatory T cell function.
New York City, United States. In Nat Immunol, 30 Nov 2014
Here we demonstrated that inducible ablation of the TCR resulted in Treg cell dysfunction that could not be attributed to impaired expression of the transcription factor Foxp3, decreased expression of Treg cell signature genes or altered ability to sense and consume interleukin 2 (IL-2).
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
London, United Kingdom. In N Engl J Med, 09 Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.
Salivary markers of inflammation in response to acute stress.
Penn Hills, United States. In Brain Behav Immun, 06 Oct 2014
Results from each study are reviewed by analyte (IL-1β, TNF-α, IL-6, IL-2, IL-4, IL-10, IL-12, CRP) and stress type (social-cognitive and exercise-physical), after which methodological issues and limitations are addressed.
Advances in the Systemic Treatment of Metastatic Melanoma.
More papers using
In Oncology (williston Park), Jun 2013
UNLABELLED: Prior to 2011, the only commercially available agents commonly used to treat metastatic melanoma-including dacarbazine, temozolomide (Temodar), fotemustine, carboplatin, paclitaxel, and interleukin-2-demonstrated limited efficacy, and no study involving these agents had shown an improvement in overall survival.
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...