gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Interleukin 2

Interleukin-2, IL-2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, CAN, IL-4, CD4, Interleukin-6
Papers using Interleukin-2 antibodies
Protein-protein interaction inhibitors get into the groove
Supplier
Kanellopoulos Jean, In PLoS ONE, 2011
... Anti IL-2: MQ1-17H2 (capture reagent, Biolegend), poly5111 (probe reagent, Biolegend); ...
The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system
Supplier
Kloetzel Peter-Michael et al., In Cellular and Molecular Life Sciences, 2010
... Unless specified, all recombinant cytokines used in this study (IL-2, TNF-α, IFN-γ) were purchased from Miltenyi Biotec.
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
Supplier
Takeuchi Tsutomu et al., In Journal of Biomedicine and Biotechnology, 2009
... Antibodies against CD3 (HIT3a), IL-2 (MQ1-17H12 and B33-2), and IFN-γ (B27 and 4S.B3) were purchased from BD Biosciences Pharmingen (San Diego, USA.) ...
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Supplier
Hill Adrian VS et al., In Molecular Therapy, 2008
(BD), anti-IFN-γ APC (clone XMG1.2), anti-IL-2 PE-Cy7 (clone JES6-5H4), anti-TNF-α FITC (Clone MP6-XT22), all from eBioscience).
Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma
Supplier
Fatehi F et al., In Iranian Journal of Public Health, 2007
... ).IL-2 and TNF-α ELISA kits were obtained from Bender Medsystems GmbH (Vienna, Austria) ...
more suppliers
Papers on Interleukin-2
Combinations of Radiation Therapy and Immunotherapy for Melanoma: A Review of Clinical Outcomes.
Review
New
Postow et al., New York City, United States. In Int J Radiat Oncol Biol Phys, 01 May 2014
The cytokines interferon-α and interleukin-2 have been combined with radiation therapy in several small studies, with some evidence suggesting increased toxicity and/or efficacy.
Early specification of CD8(+) T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.
New
Impact
Chang et al., San Diego, United States. In Nat Immunol, 30 Apr 2014
Gene-expression signatures predictive of eventual fates could be discerned as early as the first T lymphocyte division and may have been influenced by asymmetric partitioning of the receptor for interleukin 2 (IL-2Rα) during mitosis.
B7-H4 as a potential target for immunotherapy for gynecologic cancers: A closer look.
Review
New
Powell et al., Philadelphia, United States. In Gynecol Oncol, 20 Apr 2014
UNLABELLED: B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production.
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
New
Impact
Farrar et al., Minneapolis, United States. In Nat Immunol, 16 Apr 2014
Conversely, TNFRSF agonists enhanced the differentiation of Treg cell progenitors by augmenting responsiveness of the interleukin 2 receptor (IL-2R) and transcription factor STAT5. Costimulation with the ligand of GITR elicited dose-dependent enrichment for cells of lower TCR affinity in the Treg cell repertoire.
Clinical utility of natural killer cells in cancer therapy and transplantation.
Review
New
Miller et al., Minneapolis, United States. In Semin Immunol, 04 Apr 2014
To enhance in vivo expansion, IL-2 has been used at low doses.
A161: Novel 3-Dimensional Explant Method Facilitates the Study of Lymphocyte Populations in the Synovium and Reveals a Large Population of Resident Memory T cells in Rheumatoid Arthritis.
New
Fuhlbrigge et al., Boston, United States. In Arthritis Rheumatol, 31 Mar 2014
Synovial tissue was cut into pieces with scissors, loaded on titanium matrices, and cultured in 24 well plates with T cell media enriched with IL-2, 15.
A113: TCR-independent Activation of T-cells Through CD31 Triggering as an Etiology of Cytokine Production in Juvenile Idiopathic Arthritis.
New
Vallejo et al., Pittsburgh, United States. In Arthritis Rheumatol, 31 Mar 2014
Results of CD31 cross-linking bioassays, using either specific antibody or its recombinant ligand CD38, showed high levels of induction of IL-2, IL-17 and IFNγ.
Intrinsic CD4(+) T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC.
New
Impact
Allen et al., Saint Louis, United States. In Nat Immunol, 31 Mar 2014
Specific and nonspecific stimulation of LLO56 and LLO118 T cells, which transgenically express a TCR specific for the same Listeria monocytogenes epitope, elicited distinct interleukin 2 (IL-2) and phosphorylated kinase Erk responses, the strength of which was set in the thymus and maintained in the periphery in proportion to the avidity of the binding of the TCR to the self peptide-MHC complex.
Immunologics and Chemotherapeutics for Renal Cell Carcinoma.
Review
New
Nanus et al., New York City, United States. In Semin Intervent Radiol, 31 Mar 2014
Traditional chemotherapy is ineffective and immunotherapy with interleukin-2 is only occasionally beneficial.
A15: predicting macrophage activation syndrome in pediatric systemic lupus erythematosus patients at diagnosis.
New
Hiraki et al., Toronto, Canada. In Arthritis Rheumatol, 31 Mar 2014
Data collection on: 1) Clinical features including fever, CNS dysfunction, splenomegaly, hepatomegaly and hemorrhage; 2) laboratory parameters; CBC, ESR, CRP, C3, C4, ferritin, AST, ALT, LDH, albumin, bilirubin, triglycerides, LDL, HDL, urea, creatinine, sodium, coagulation parameters including INR, PTT, fibrinogen and D-Dimer, and soluble IL-2 receptor (sIL-2R) and CD163.
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.
New
Impact
Ebert et al., Boston, United States. In Science, 17 Feb 2014
Similarly, we found that lenalidomide-induced interleukin-2 production in T cells is due to depletion of IKZF1 and IKZF3.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
New
Impact
Matarese et al., Napoli, Italy. In Nat Med, Jan 2014
Here we report that proliferation of Treg cells after TCR stimulation is impaired in subjects with relapsing-remitting multiple sclerosis (RRMS) because of altered interleukin-2 (IL-2) secretion and IL-2 receptor (IL-2R)-signal transducer and activator of transcription 5 (STAT5) signaling.
Profile of pazopanib and its potential in the treatment of epithelial ovarian cancer.
Review
New
Secord et al., Durham, United States. In Int J Womens Health, Dec 2013
It also targets stem cell-factor receptor (c-kit), interleukin 2-inducible T-cell kinase, lymphocyte-specific protein tyrosine kinase, and colony-stimulating factor 1 receptor.
Tacrolimus associated posterior reversible encephalopathy syndrome - a case series and review.
New
Greene et al., Tampa, United States. In Mediterr J Hematol Infect Dis, Dec 2013
It is a macrolide which reduces peptidyl-propyl isomerase activity and inhibits calcineurin, thus inhibiting T-lymphocyte signal transduction and interleukin-2 (IL-2) transcription.
Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial.
New
Ghayour-Mobarhan et al., Mashhad, Iran. In Scientificworldjournal, Dec 2013
Serum levels of IL-1 α , IL-1 β , IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFN γ , EGF, MCP-1, and TNF α were measured using a multiplex Biochip Array Technology based method.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
GeneRIF
Silva-Santos et al., Lisbon, Portugal. In J Immunol, 2012
Freshly isolated lymphoid gammadelta T cells synergize with the T cell receptor to induce autocrine IL-2 production that promotes gammadelta cell survival and proliferation following Plasmodium infection.
In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: potential mediating mechanisms and sex differences.
GeneRIF
Ben-Eliyahu et al., Tel Aviv-Yafo, Israel. In Brain Behav Immun, 2012
our findings indicate a generic and robust stress-induced reduction in plasma IL-12
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Impact
GeneRIF
Kuchroo et al., Boston, United States. In Nat Immunol, 2012
study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo
Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.
GeneRIF
Kambayashi et al., Philadelphia, United States. In J Immunol, 2012
Regulatory T (Treg) cell division does not absolutely require cell-autonomous transgenic T cell receptor signaling in vivo, depending on the degree of IL-2-mediated stimulation provided.
IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling.
GeneRIF
Fest et al., Rennes, France. In J Immunol, 2012
IL-2 drives activated B cell differentiation toward plasma cells independently of its proliferation and survival functions.
More papers using Interleukin-2 antibodies
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
Supplier
Teague Ryan M., In PLoS ONE, 2004
... /ml in AIM-V medium (Invitrogen, Carlsbad, CA) supplemented with 300 IU/ml IL-2 (Chiron, Emmerville, CA) and 5% heat-inactivated human AB serum (Valley Biomedical, Winchester, VA) ...
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells
Supplier
Rothenberg Ellen V. et al., In Nucleic Acids Research, 2003
... expression as a monitoring tool for IL-2 expression in primary T-cells of transgenic mice ...
Cytokines in cancer pathogenesis and cancer therapy
Supplier
Alitheen Noorjahan Banu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Recombinant murine interleukin 2 (rmIL-2; Dako, USA) was used as ...
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Supplier
Unutmaz Derya, In PLoS ONE, 2002
... For antibody blocking in culture assays, non-specific isotype matched control, IL-2, IFNγ, IL-12p70 and CD40L specific mAbs without preservatives were obtained from BD Biosciences and IL-18 specific mAb ...
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
Supplier
Sommer Peter, In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...
A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition
Supplier
Söderström Kalle et al., In The Journal of Experimental Medicine, 1998
... serum, 200 U IL-2/ml (PeproTech), 2 mM l-glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin (Life Technologies).
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
Supplier
Strober Warren et al., In The Journal of Experimental Medicine, 1997
... with 10% FCS, 100 μg/ml streptomycin, 100 U/ml penicillin, 50 μM 2-ME, 10 U/ml human IL-2 (Life Technologies), and 6% rat Con ...
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
Supplier
Allison James P. et al., In The Journal of Experimental Medicine, 1996
... IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice ...
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
Supplier
Galy Anne et al., In Molecular Therapy, 1996
... plate (Millipore, Bedford, MA) were coated overnight with 5 µg/ml anti-mouse IFN-γ mAb or 3 µg/ml anti-mouse IL-2 mAb (BD Biosciences) at 4 °C, washed, and ...
A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
Supplier
Ricciardi-Castagnoli Paola et al., In The Journal of Experimental Medicine, 1995
... ), from ascite-purified anti–IL-2 (S4B6, rat IgG2a) or from total rat IgG (Bethyl).
The interleukin-2 receptor
Supplier
Royuela Mar et al., In Breast Cancer Research, 1988
... The primary antibodies used were goat anti-human IL-2, rabbit anti-human IL-2Rα, rabbit anti-human IL-2Rβ and rabbit anti-human IL-2Rγ (Santa Cruz Biotechnology, California, CA, USA).
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
Supplier
Schreiber Gideon, In PLoS ONE, 1986
... 15 medium (Cambrex); fetal calf serum (FCS; HyClone, Belgium); L-glutamine (Flow Laboratories, UK); recombinant interleukin-2 (IL-2; Biotech, Russia); phosphate buffered saline (PBS; PanEco, Russia); goat serum (DakoCytomation); phycoerythrin-conjugated goat anti-rabbit IgG (GAR-PE) (Santa Cruz Biotechnology); RNA molecular weight standard ...
share on facebooktweetadd +1mail to friends