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Interleukin 2

Interleukin-2, IL-2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, Interleukin-6, CAN, IL-4, CD4
Papers using Interleukin-2 antibodies
Protein-protein interaction inhibitors get into the groove
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Kanellopoulos Jean, In PLoS ONE, 2011
... Anti IL-2: MQ1-17H2 (capture reagent, Biolegend), poly5111 (probe reagent, Biolegend); ...
The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system
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Kloetzel Peter-Michael et al., In Cellular and Molecular Life Sciences, 2010
... Unless specified, all recombinant cytokines used in this study (IL-2, TNF-α, IFN-γ) were purchased from Miltenyi Biotec.
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
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Takeuchi Tsutomu et al., In Journal of Biomedicine and Biotechnology, 2009
... Antibodies against CD3 (HIT3a), IL-2 (MQ1-17H12 and B33-2), and IFN-γ (B27 and 4S.B3) were purchased from BD Biosciences Pharmingen (San Diego, USA.) ...
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Hill Adrian VS et al., In Molecular Therapy, 2008
(BD), anti-IFN-γ APC (clone XMG1.2), anti-IL-2 PE-Cy7 (clone JES6-5H4), anti-TNF-α FITC (Clone MP6-XT22), all from eBioscience).
Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma
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Fatehi F et al., In Iranian Journal of Public Health, 2007
... ).IL-2 and TNF-α ELISA kits were obtained from Bender Medsystems GmbH (Vienna, Austria) ...
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Papers on Interleukin-2
Signaling pathway involved in the immunomodulatory effect of Ganoderma atrum polysaccharide in spleen lymphocytes.
New
Xie et al., In J Agric Food Chem, 25 Mar 2015
PKC was involved in induction of NFAT activity by PSG-1, as evidenced by abrogation of NFAT activity by PKC inhibitor Calphostin C, which significantly decreased PSG-1-induced IL-2 production.
Evaluation of Immune Restoration Potential of PD-1 Blockers.
New
Tong et al., Wuhan, China. In J Immunoassay Immunochem, 25 Mar 2015
We found anti-human PD-1 antibody could reverse PD-L1 induced suppression of human CD3+ cells proliferation and IL-2 production.
Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse.
New
Ito et al., Kawasaki, Japan. In J Immunol, 23 Mar 2015
UNASSIGNED: We generated a severe immunodeficient NOD/Shi-scid-IL-2Rγ(null) (NOG) mouse substrain expressing the transgenic human IL-2 gene (NOG-IL-2 Tg).
Relationship between serum cytokines and growth factors level and coronary artery disease.
New
Ghayour-Mobarhan et al., Mashhad, Iran. In Clin Biochem, 21 Mar 2015
Twelve cytokines (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, MCP-1, IFN-γ, EGF, and VEGF) were measured using a sandwich chemi-luminescence assays, on the Evidence Investigator® system.
P-glycoprotein in autoimmune rheumatic diseases.
Review
New
Ruiz-Arguelles et al., Mexico. In Autoimmun Rev, 21 Mar 2015
Many cytokines like interleukin 2 and tumor necrosis factor alpha increase Pgp expression and activity.
Translational research and biomarkers in neonatal sepsis.
Review
New
Speeckaert et al., Gent, Belgium. In Clin Chim Acta, 04 Mar 2015
Soluble interleukin-2 receptor has been used to identify bacteremia, whereas low plasma RANTES concentrations are characteristic for septicemia.
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.
New
Impact
Turka et al., Boston, United States. In Nat Immunol, 28 Feb 2015
Diminished control of PI(3)K activity in Treg cells led to reduced expression of the interleukin-2 (IL-2) receptor α subunit CD25, accumulation of Foxp3(+)CD25(-) cells and, ultimately, loss of expression of the transcription factor Foxp3 in these cells.
Endophilin marks and controls a clathrin-independent endocytic pathway.
New
Impact
McMahon et al., Cambridge, United Kingdom. In Nature, 22 Feb 2015
This pathway mediates the ligand-triggered uptake of several G-protein-coupled receptors such as α2a- and β1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, the receptor tyrosine kinases EGFR, HGFR, VEGFR, PDGFR, NGFR and IGF1R, as well as interleukin-2 receptor.
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
New
Impact
Brenner et al., Boston, United States. In Nat Immunol, Jan 2015
Here we found that iNKT cells in adipose tissue had a unique transcriptional program and produced interleukin 2 (IL-2) and IL-10.
Insights Into Cytokine-Receptor Interactions from Cytokine Engineering.
New
Impact
Garcia et al., Stanford, United States. In Annu Rev Immunol, Jan 2015
Here we review the theory and practice of cytokine engineering and rationalize the mechanisms of several engineered cytokines in the context of structure.Wediscuss specific examples of how structure-based cytokine engineering has opened new opportunities for cytokines as drugs, with a focus on the immunotherapeutic cytokines interferon, interleukin-2, and interleukin-4.
Tailored therapy for severe asthma.
Review
New
Zucchi et al., Reggio nell'Emilia, Italy. In Multidiscip Respir Med, Dec 2014
The most promising agents are targeted against cytokines of Th2 pattern and related receptors, such as IL-2 (daclizumab) and IL-13 (lebrikizumab) or IL-5 in patients with hypereosinophilia (mepolizumab, reslizumab and benralizumab).
A central role for Notch in effector CD8(+) T cell differentiation.
New
Impact
Amsen et al., Amsterdam, Netherlands. In Nat Immunol, Dec 2014
Expression of Notch was induced on naive CD8(+) T cells by inflammatory mediators and interleukin 2 (IL-2) via pathways dependent on the metabolic checkpoint kinase mTOR and the transcription factor T-bet.
Immunomodulatory effects of triphala and its individual constituents: a review.
Review
New
Tiwari-Barua et al., Indore, India. In Indian J Pharm Sci, Nov 2014
Under stress condition such as noise, Triphala significantly prevents elevation of IL-4 levels as well as corrects decreased IL-2 and IFN-γ levels.
The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
Review
New
Atanasiu et al., Bucureşti, Romania. In J Med Life, Oct 2014
Abbreviations: RCAN1 = regulator of calcineurin, LDL = low density lipoproteins, HMG-CoA - 3 = hydroxy-3-methylglutaryl coenzyme A, VSMCs = vascular smooth muscle cells, PDGF = platelet-derived growth factor, FGF = fibroblast growth factor, EGF = epidermal growth factor, IGF = insulin-like growth factor, VEGF = vascular endothelial growth factor, NFAT = nuclear factor of activated T cells, IL-2, IL-6, IL-10, IL-12 = interleukin type 2, 6, 10, 12, AP-1 = activator protein 1, Mef-2 = myocyte enhancer factor-2, GATA-4 = transcription factor, CK1 = casein kinase 1, GSK3 = glycogen synthase kinase 3, DYRK = dual specificity tyrosine phosphorylation regulated kinase, DSCR1 = Down Syndrome Critical Region 1, MCIP1 = myocyte-enriched calcineurin-interacting protein, MLP = muscle lim protein, cAMP = cyclic adenosine monophosphate, PC12 = pheochromocytoma, NMR = nuclear magnetic resonance, SOD = superoxide dismutase, APP = amyloid precursor protein, eNOS = nitric oxide endothelial synthase, Cygb = cytoglobin, HUVEC = human umbilical vein endothelial cells, VDR = vitamin D receptor.
Serum cytokine levels in patients with colorectal cancers according to tumor stages and VEGF gene polymorphism.
New
Cekmen et al., In Hepatogastroenterology, Oct 2014
METHODS: In this study, we measured serum IL-18, IL-2, VEGF, endothelin (ET), and nitric oxide (NO) levels in 44 patients with colorectal cancer and 44 healthy controls.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
GeneRIF
Silva-Santos et al., Lisbon, Portugal. In J Immunol, 2012
Freshly isolated lymphoid gammadelta T cells synergize with the T cell receptor to induce autocrine IL-2 production that promotes gammadelta cell survival and proliferation following Plasmodium infection.
In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: potential mediating mechanisms and sex differences.
GeneRIF
Ben-Eliyahu et al., Tel Aviv-Yafo, Israel. In Brain Behav Immun, 2012
our findings indicate a generic and robust stress-induced reduction in plasma IL-12
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Impact
GeneRIF
Kuchroo et al., Boston, United States. In Nat Immunol, 2012
study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo
Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.
GeneRIF
Kambayashi et al., Philadelphia, United States. In J Immunol, 2012
Regulatory T (Treg) cell division does not absolutely require cell-autonomous transgenic T cell receptor signaling in vivo, depending on the degree of IL-2-mediated stimulation provided.
IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling.
GeneRIF
Fest et al., Rennes, France. In J Immunol, 2012
IL-2 drives activated B cell differentiation toward plasma cells independently of its proliferation and survival functions.
More papers using Interleukin-2 antibodies
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
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Teague Ryan M., In PLoS ONE, 2004
... /ml in AIM-V medium (Invitrogen, Carlsbad, CA) supplemented with 300 IU/ml IL-2 (Chiron, Emmerville, CA) and 5% heat-inactivated human AB serum (Valley Biomedical, Winchester, VA) ...
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells
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Rothenberg Ellen V. et al., In Nucleic Acids Research, 2003
... expression as a monitoring tool for IL-2 expression in primary T-cells of transgenic mice ...
Cytokines in cancer pathogenesis and cancer therapy
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Alitheen Noorjahan Banu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Recombinant murine interleukin 2 (rmIL-2; Dako, USA) was used as ...
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
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Unutmaz Derya, In PLoS ONE, 2002
... For antibody blocking in culture assays, non-specific isotype matched control, IL-2, IFNγ, IL-12p70 and CD40L specific mAbs without preservatives were obtained from BD Biosciences and IL-18 specific mAb ...
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
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Sommer Peter, In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...
A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition
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Söderström Kalle et al., In The Journal of Experimental Medicine, 1998
... serum, 200 U IL-2/ml (PeproTech), 2 mM l-glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin (Life Technologies).
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
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Strober Warren et al., In The Journal of Experimental Medicine, 1997
... with 10% FCS, 100 μg/ml streptomycin, 100 U/ml penicillin, 50 μM 2-ME, 10 U/ml human IL-2 (Life Technologies), and 6% rat Con ...
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
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Allison James P. et al., In The Journal of Experimental Medicine, 1996
... IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice ...
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
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Galy Anne et al., In Molecular Therapy, 1996
... plate (Millipore, Bedford, MA) were coated overnight with 5 µg/ml anti-mouse IFN-γ mAb or 3 µg/ml anti-mouse IL-2 mAb (BD Biosciences) at 4 °C, washed, and ...
A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
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Ricciardi-Castagnoli Paola et al., In The Journal of Experimental Medicine, 1995
... ), from ascite-purified anti–IL-2 (S4B6, rat IgG2a) or from total rat IgG (Bethyl).
The interleukin-2 receptor
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Royuela Mar et al., In Breast Cancer Research, 1988
... The primary antibodies used were goat anti-human IL-2, rabbit anti-human IL-2Rα, rabbit anti-human IL-2Rβ and rabbit anti-human IL-2Rγ (Santa Cruz Biotechnology, California, CA, USA).
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
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Schreiber Gideon, In PLoS ONE, 1986
... 15 medium (Cambrex); fetal calf serum (FCS; HyClone, Belgium); L-glutamine (Flow Laboratories, UK); recombinant interleukin-2 (IL-2; Biotech, Russia); phosphate buffered saline (PBS; PanEco, Russia); goat serum (DakoCytomation); phycoerythrin-conjugated goat anti-rabbit IgG (GAR-PE) (Santa Cruz Biotechnology); RNA molecular weight standard ...
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