Continuous requirement for the TCR in regulatory T cell function.
New York City, United States. In Nat Immunol, 30 Nov 2014
Here we demonstrated that inducible ablation of the TCR resulted in Treg cell dysfunction that could not be attributed to impaired expression of the transcription factor Foxp3, decreased expression of Treg cell signature genes or altered ability to sense and consume interleukin 2 (IL-2).
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
London, United Kingdom. In N Engl J Med, 09 Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.
Bcl-6 directly represses the gene program of the glycolysis pathway.
Seattle, United States. In Nat Immunol, 31 Oct 2014
Here we found that the transcription factor Bcl-6 directly repressed genes encoding molecules involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm and Hk2, in type 1 helper T cells (TH1 cells) exposed to low concentrations of interleukin 2 (IL-2).
Salivary markers of inflammation in response to acute stress.
Penn Hills, United States. In Brain Behav Immun, 06 Oct 2014
Results from each study are reviewed by analyte (IL-1β, TNF-α, IL-6, IL-2, IL-4, IL-10, IL-12, CRP) and stress type (social-cognitive and exercise-physical), after which methodological issues and limitations are addressed.
CELLULAR RESPONSES TO EGG-OIL (CHARISMON©).
More papers using
Frankfurt am Main, Germany. In Acta Medica (hradec Kralove), Dec 2013
IL-8 production by HaCaT cells is stimulated by egg-oil whilst in phythemagglutinin-activated PBMLs production of the interleukins IL-2, IL-6, IL-10 and IFN-γ and TFN-α is reduced.
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...