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Interleukin 2

Interleukin-2, IL-2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, Interleukin-6, CAN, IL-4, CD4
Papers using Interleukin-2 antibodies
Protein-protein interaction inhibitors get into the groove
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Kanellopoulos Jean, In PLoS ONE, 2011
... Anti IL-2: MQ1-17H2 (capture reagent, Biolegend), poly5111 (probe reagent, Biolegend); ...
The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system
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Kloetzel Peter-Michael et al., In Cellular and Molecular Life Sciences, 2010
... Unless specified, all recombinant cytokines used in this study (IL-2, TNF-α, IFN-γ) were purchased from Miltenyi Biotec.
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
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Takeuchi Tsutomu et al., In Journal of Biomedicine and Biotechnology, 2009
... Antibodies against CD3 (HIT3a), IL-2 (MQ1-17H12 and B33-2), and IFN-γ (B27 and 4S.B3) were purchased from BD Biosciences Pharmingen (San Diego, USA.) ...
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Hill Adrian VS et al., In Molecular Therapy, 2008
(BD), anti-IFN-γ APC (clone XMG1.2), anti-IL-2 PE-Cy7 (clone JES6-5H4), anti-TNF-α FITC (Clone MP6-XT22), all from eBioscience).
Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma
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Fatehi F et al., In Iranian Journal of Public Health, 2007
... ).IL-2 and TNF-α ELISA kits were obtained from Bender Medsystems GmbH (Vienna, Austria) ...
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Papers on Interleukin-2
Fungal infections in renal transplant patients.
Review
New
El-Sayegh et al., United States. In J Clin Med Res, 30 Jun 2015
After transplant, the extent of the immune response is influenced by the amount of interleukin 2 (IL-2) being produced by the T-helper cells.
Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors.
New
Impact
Romagnoli et al., Toulouse, France. In Nat Immunol, 30 Jun 2015
In the thymus, the recirculating cells exerted their regulatory function by inhibiting interleukin 2 (IL-2)-dependent de novo differentiation of Treg cells.
Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.
New
Impact
Robey et al., Berkeley, United States. In Nat Immunol, 30 Jun 2015
The thymic production of regulatory T cells (Treg cells) requires interleukin 2 (IL-2) and agonist T cell antigen receptor (TCR) ligands and is controlled by competition for a limited developmental niche, but the thymic sources of IL-2 and the factors that limit access to the niche are poorly understood.
Oxidant and antioxidant status in neonatal proven and clinical sepsis in relation to selenium status.
New
Kocer-Gumusel et al., Ankara, Turkey. In Pediatr Int, 22 Jun 2015
Besides, plasma interleukin 2 and 6 levels were determined.
Obaculactone exerts a novel ameliorating effect on contact dermatitis through regulating T lymphocyte.
New
Xu et al., Nanjing, China. In Int Immunopharmacol, 20 Jun 2015
The mRNAs of IL-2, IL-17a, TNF-α and IFN-γ expressed in lymph nodes of mice with dermatitis were also decreased by obaculactone in a dose-dependent manner.
Prophylactic Interleukin-2 Treatment Prevents Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis.
New
Wolfs et al., Maastricht, Netherlands. In Inflamm Bowel Dis, 20 Jun 2015
We thus aimed to augment the Treg/Teff cell ratio in the fetal gut by prophylactic IL-2 treatment and evaluate whether it is sufficient to prevent chorioamnionitis-induced intestinal inflammation and mucosal injury.
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
New
Impact
Leonard et al., Bethesda, United States. In Immunity, 19 Jun 2015
Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits.
IL-2: Change Structure … Change Function.
New
Impact
Trotta et al., San Francisco, United States. In Immunity, 19 Jun 2015
demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.
Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
New
Impact
Garcia et al., Stanford, United States. In Immunity, 19 Jun 2015
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates immune cell homeostasis and has been used to treat a range of disorders including cancer and autoimmune disease.
IDO expressing dendritic cells suppress allograft rejection of small bowel transplantation in mice by expansion of Foxp3(+) regulatory T cells.
New
Dai et al., Tianjin, China. In Transpl Immunol, 19 Jun 2015
The expression of IL-2 was slightly lower with 3-HAA or IDO(+) DC treatment.
Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis.
New
Bielekova et al., Bethesda, United States. In Ann Clin Transl Neurol, 31 May 2015
In contrast, daclizumab, a humanized monoclonal antibody against the alpha chain of the IL-2 receptor, has a unique mechanism of action with multiple direct effects on innate immunity.
The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma.
Review
New
McDermott et al., Boston, United States. In Clin Ther, 27 Apr 2015
Toxicity with PD-1 blocking agents is less than the toxicity with previous immunotherapies (eg, interleukin 2, CTLA-4 blockade).
Molecular genetic analysis of orf virus: a poxvirus that has adapted to skin.
Review
New
Mercer et al., Dunedin, New Zealand. In Viruses, Mar 2015
Genes such as a chemokine binding protein and a protein that binds granulocyte-macrophage colony-stimulating factor and interleukin-2 appear to have evolved from a common poxvirus ancestral gene while three parapoxvirus nuclear factor (NF)-κB signalling pathway inhibitors have no homology to other known NF-κB inhibitors.
Potential Predictors for Serofast State after Treatment among HIV-Negative Persons with Syphilis in China: A Systematic Review and Meta-Analysis.
Review
New
Liu et al., China. In Iran J Public Health, Feb 2015
Compared with healthy group and serological cure group, respectively, the levels of CD4 (+), IL-2, and IL-6 among serofast patients were decreased (standardized mean difference[SMD]<0, P<0.05), but the levels of CD8(+) and IL-10 were increased(SMD>0, P<0.05).
Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.
Review
New
Multhoff et al., München, Germany. In Front Immunol, Dec 2014
However, natural killer (NK), but not T cells were found to kill mHsp70-positive tumor cells after activation with a naturally occurring Hsp70 peptide (TKD) plus low dose IL-2 (TKD/IL-2).
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
GeneRIF
Silva-Santos et al., Lisbon, Portugal. In J Immunol, 2012
Freshly isolated lymphoid gammadelta T cells synergize with the T cell receptor to induce autocrine IL-2 production that promotes gammadelta cell survival and proliferation following Plasmodium infection.
In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: potential mediating mechanisms and sex differences.
GeneRIF
Ben-Eliyahu et al., Tel Aviv-Yafo, Israel. In Brain Behav Immun, 2012
our findings indicate a generic and robust stress-induced reduction in plasma IL-12
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Impact
GeneRIF
Kuchroo et al., Boston, United States. In Nat Immunol, 2012
study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo
Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.
GeneRIF
Kambayashi et al., Philadelphia, United States. In J Immunol, 2012
Regulatory T (Treg) cell division does not absolutely require cell-autonomous transgenic T cell receptor signaling in vivo, depending on the degree of IL-2-mediated stimulation provided.
IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling.
GeneRIF
Fest et al., Rennes, France. In J Immunol, 2012
IL-2 drives activated B cell differentiation toward plasma cells independently of its proliferation and survival functions.
More papers using Interleukin-2 antibodies
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
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Teague Ryan M., In PLoS ONE, 2004
... /ml in AIM-V medium (Invitrogen, Carlsbad, CA) supplemented with 300 IU/ml IL-2 (Chiron, Emmerville, CA) and 5% heat-inactivated human AB serum (Valley Biomedical, Winchester, VA) ...
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells
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Rothenberg Ellen V. et al., In Nucleic Acids Research, 2003
... expression as a monitoring tool for IL-2 expression in primary T-cells of transgenic mice ...
Cytokines in cancer pathogenesis and cancer therapy
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Alitheen Noorjahan Banu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Recombinant murine interleukin 2 (rmIL-2; Dako, USA) was used as ...
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
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Unutmaz Derya, In PLoS ONE, 2002
... For antibody blocking in culture assays, non-specific isotype matched control, IL-2, IFNγ, IL-12p70 and CD40L specific mAbs without preservatives were obtained from BD Biosciences and IL-18 specific mAb ...
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
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Sommer Peter, In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...
A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition
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Söderström Kalle et al., In The Journal of Experimental Medicine, 1998
... serum, 200 U IL-2/ml (PeproTech), 2 mM l-glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin (Life Technologies).
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
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Strober Warren et al., In The Journal of Experimental Medicine, 1997
... with 10% FCS, 100 μg/ml streptomycin, 100 U/ml penicillin, 50 μM 2-ME, 10 U/ml human IL-2 (Life Technologies), and 6% rat Con ...
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
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Allison James P. et al., In The Journal of Experimental Medicine, 1996
... IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice ...
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
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Galy Anne et al., In Molecular Therapy, 1996
... plate (Millipore, Bedford, MA) were coated overnight with 5 µg/ml anti-mouse IFN-γ mAb or 3 µg/ml anti-mouse IL-2 mAb (BD Biosciences) at 4 °C, washed, and ...
A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
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Ricciardi-Castagnoli Paola et al., In The Journal of Experimental Medicine, 1995
... ), from ascite-purified anti–IL-2 (S4B6, rat IgG2a) or from total rat IgG (Bethyl).
The interleukin-2 receptor
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Royuela Mar et al., In Breast Cancer Research, 1988
... The primary antibodies used were goat anti-human IL-2, rabbit anti-human IL-2Rα, rabbit anti-human IL-2Rβ and rabbit anti-human IL-2Rγ (Santa Cruz Biotechnology, California, CA, USA).
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
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Schreiber Gideon, In PLoS ONE, 1986
... 15 medium (Cambrex); fetal calf serum (FCS; HyClone, Belgium); L-glutamine (Flow Laboratories, UK); recombinant interleukin-2 (IL-2; Biotech, Russia); phosphate buffered saline (PBS; PanEco, Russia); goat serum (DakoCytomation); phycoerythrin-conjugated goat anti-rabbit IgG (GAR-PE) (Santa Cruz Biotechnology); RNA molecular weight standard ...
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