Regulatory T cell proliferative potential is impaired in human autoimmune disease.
Napoli, Italy. In Nat Med, 31 Jan 2014
Here we report that proliferation of Treg cells after TCR stimulation is impaired in subjects with relapsing-remitting multiple sclerosis (RRMS) because of altered interleukin-2 (IL-2) secretion and IL-2 receptor (IL-2R)-signal transducer and activator of transcription 5 (STAT5) signaling.
Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.
New York City, United States. In Front Immunol, Dec 2013
In addition, studies of TCR complex signaling of immature thymocytes compared with mature T cells were consistent with the interpretation that negative selection occurs as a consequence of the incapacity of immature cells to produce IL-2, resulting in cytokine deprivation apoptosis.
A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.
Stanford, United States. In Immunity, Dec 2013
We found that naive T cells, T cell blasts, and memory T cells could all be triggered by a single pMHC to secrete tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) cytokines with a rate of ∼1,000, ∼10,000, and ∼10,000 molecules/min, respectively, and that additional pMHCs did not augment secretion, indicating a digital response pattern.
Regulation of Mouse NK Cell Development and Function by Cytokines.
More papers using
Lyon, France. In Front Immunol, 2012
Moreover, numerous other activating or inhibitory cytokines such as IL-2, IL-4, IL-7, IL-10, IL-12, IL-18, IL-21, Transforming growth factor-β (TGFβ) and type I interferons regulate their activation and their effector functions at different stages of the immune response.
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...