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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Oct 2014.

Interleukin 2

Interleukin-2, IL-2
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, Interleukin-6, CAN, IL-4, CD4
Papers using Interleukin-2 antibodies
Protein-protein interaction inhibitors get into the groove
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Kanellopoulos Jean, In PLoS ONE, 2011
... Anti IL-2: MQ1-17H2 (capture reagent, Biolegend), poly5111 (probe reagent, Biolegend); ...
The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system
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Kloetzel Peter-Michael et al., In Cellular and Molecular Life Sciences, 2010
... Unless specified, all recombinant cytokines used in this study (IL-2, TNF-α, IFN-γ) were purchased from Miltenyi Biotec.
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
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Takeuchi Tsutomu et al., In Journal of Biomedicine and Biotechnology, 2009
... Antibodies against CD3 (HIT3a), IL-2 (MQ1-17H12 and B33-2), and IFN-γ (B27 and 4S.B3) were purchased from BD Biosciences Pharmingen (San Diego, USA.) ...
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Hill Adrian VS et al., In Molecular Therapy, 2008
(BD), anti-IFN-γ APC (clone XMG1.2), anti-IL-2 PE-Cy7 (clone JES6-5H4), anti-TNF-α FITC (Clone MP6-XT22), all from eBioscience).
Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1beta-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma
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Fatehi F et al., In Iranian Journal of Public Health, 2007
... ).IL-2 and TNF-α ELISA kits were obtained from Bender Medsystems GmbH (Vienna, Austria) ...
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Papers on Interleukin-2
Continuous requirement for the TCR in regulatory T cell function.
New
Impact
Rudensky et al., New York City, United States. In Nat Immunol, 30 Nov 2014
Here we demonstrated that inducible ablation of the TCR resulted in Treg cell dysfunction that could not be attributed to impaired expression of the transcription factor Foxp3, decreased expression of Treg cell signature genes or altered ability to sense and consume interleukin 2 (IL-2).
Effects of Dendritic Cells from Hepatitis B Virus Transgenic Mice-Stimulated Autologous Lymphocytes on Hepatitis B Virus Replication: A Study on the Impact of Specific Sensitized Effector Cells on In Vitro Virus Replication.
New
Song et al., Tianjin, China. In Viral Immunol, 24 Nov 2014
Secretion of inflammatory cytokines in the supernatant showed that when HBV DNA was highly expressed, the concentration of IFN-γ and IL-2 decreased, while IL-10 increased.
Murine Granulocyte-Macrophage Colony-Stimulating Factor Expressed from a Bicistronic Simian Immunodeficiency Virus-Based Integrase-Defective Lentiviral Vector Does Not Enhance T-Cell Responses in Mice.
New
Cara et al., Roma, Italy. In Viral Immunol, 24 Nov 2014
Results indicated that the mGM-CSF was unable to improve the magnitude and quality of the immune response against the eGFP transgene in the context of the SIV-based IDLV, as evaluated by enzyme-linked immunosorbent spot (ELISPOT) assays for interferon-γ (IFN-γ) and by intracellular cytokine staining for IFN-γ, interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-α).
T-bet:Eomes Balance, Effector Function, and Proliferation of Cytomegalovirus-Specific CD8+ T Cells during Primary Infection Differentiates the Capacity for Durable Immune Control.
New
McDyer et al., Pittsburgh, United States. In J Immunol, 22 Nov 2014
LTR relapsers demonstrated reduced CD8(+)Ki67(+) cells ex vivo and substantially impaired CD8(+)pp65-specific in vitro proliferative responses at 6 d, with concomitantly lower pp65-specific CD4(+)IL-2(+) frequencies, as compared with LTR controllers.
Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion.
New
Mackay et al., Freiburg, Germany. In J Immunol, 22 Nov 2014
Both these conditions contribute to autoimmune pathogenesis and were accompanied by decreases in the availability of IL-2 and increases in levels of IL-21.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
New
Impact
Thrasher et al., London, United Kingdom. In N Engl J Med, 09 Nov 2014
BACKGROUND: In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients.
Bcl-6 directly represses the gene program of the glycolysis pathway.
New
Impact
Weinmann et al., Seattle, United States. In Nat Immunol, 31 Oct 2014
Here we found that the transcription factor Bcl-6 directly repressed genes encoding molecules involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm and Hk2, in type 1 helper T cells (TH1 cells) exposed to low concentrations of interleukin 2 (IL-2).
Use of enhanced interleukin-2 formulations for improved immunotherapy against cancer.
Review
New
Boyman et al., Zürich, Switzerland. In Curr Opin Chem Biol, 27 Oct 2014
UNLABELLED: The use of interleukin-2 (IL-2) for the stimulation of an effector immune response against metastatic cancer dates back to the early 1980s.
CD8αα(+) Innate-Type Lymphocytes in the Intestinal Epithelium Mediate Mucosal Immunity.
New
Impact
Olivares-Villagómez et al., Nashville, United States. In Immunity, 18 Oct 2014
Development of iCD8α cells depends on expression of interleukin-2 receptor γ chain (IL-2Rγc), IL-15, and the major histocompatibility complex (MHC) class Ib protein H2-T3, also known as the thymus leukemia antigen or TL.
Salivary markers of inflammation in response to acute stress.
Review
New
Engeland et al., Penn Hills, United States. In Brain Behav Immun, 06 Oct 2014
Results from each study are reviewed by analyte (IL-1β, TNF-α, IL-6, IL-2, IL-4, IL-10, IL-12, CRP) and stress type (social-cognitive and exercise-physical), after which methodological issues and limitations are addressed.
Anti-cytokine biologic treatment beyond anti-TNF in Behçet's disease.
Review
New
Sfikakis et al., Athens, Greece. In Clin Exp Rheumatol, 30 Sep 2014
The anti-IL-17 antibody secukinumab and the anti-IL-2 receptor antibody daclizumab were not superior to placebo for ocular Behçet's in randomised controlled trials, comprising 118 and 17 patients, respectively.
Paradoxical signaling by a secreted molecule leads to homeostasis of cell levels.
New
Impact
Friedman et al., Israel. In Cell, 28 Sep 2014
For example, the cytokine IL-2 can promote proliferation and death of T cells.
CELLULAR RESPONSES TO EGG-OIL (CHARISMON©).
Review
New
Zöller et al., Frankfurt am Main, Germany. In Acta Medica (hradec Kralove), Dec 2013
IL-8 production by HaCaT cells is stimulated by egg-oil whilst in phythemagglutinin-activated PBMLs production of the interleukins IL-2, IL-6, IL-10 and IFN-γ and TFN-α is reduced.
Low-Dose Interleukin-2 Therapy: A Driver of an Imbalance between Immune Tolerance and Autoimmunity.
Review
New
Kosmaczewska, Wrocław, Poland. In Int J Mol Sci, Dec 2013
UNLABELLED: For many years, the role of interleukin-2 (IL-2) in autoimmune responses was established as a cytokine possessing strong pro-inflammatory activity.
LPS Nephropathy in Mice Is Ameliorated by IL-2 Independently of Regulatory T Cells Activity.
New
Ghiggeri et al., Genova, Italy. In Plos One, Dec 2013
In this study, we thought to define whether Tregs can modify the outcome of LPS nephropathy utilizing IL-2 as inducer of tissue and circulating Tregs.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
GeneRIF
Silva-Santos et al., Lisbon, Portugal. In J Immunol, 2012
Freshly isolated lymphoid gammadelta T cells synergize with the T cell receptor to induce autocrine IL-2 production that promotes gammadelta cell survival and proliferation following Plasmodium infection.
In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: potential mediating mechanisms and sex differences.
GeneRIF
Ben-Eliyahu et al., Tel Aviv-Yafo, Israel. In Brain Behav Immun, 2012
our findings indicate a generic and robust stress-induced reduction in plasma IL-12
Aiolos promotes TH17 differentiation by directly silencing Il2 expression.
Impact
GeneRIF
Kuchroo et al., Boston, United States. In Nat Immunol, 2012
study demonstrated that Aiolos silenced the Il2 locus, promoting TH17 differentiation in vitro and in vivo
Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.
GeneRIF
Kambayashi et al., Philadelphia, United States. In J Immunol, 2012
Regulatory T (Treg) cell division does not absolutely require cell-autonomous transgenic T cell receptor signaling in vivo, depending on the degree of IL-2-mediated stimulation provided.
IL-2 requirement for human plasma cell generation: coupling differentiation and proliferation by enhancing MAPK-ERK signaling.
GeneRIF
Fest et al., Rennes, France. In J Immunol, 2012
IL-2 drives activated B cell differentiation toward plasma cells independently of its proliferation and survival functions.
More papers using Interleukin-2 antibodies
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.
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Teague Ryan M., In PLoS ONE, 2004
... /ml in AIM-V medium (Invitrogen, Carlsbad, CA) supplemented with 300 IU/ml IL-2 (Chiron, Emmerville, CA) and 5% heat-inactivated human AB serum (Valley Biomedical, Winchester, VA) ...
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells
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Rothenberg Ellen V. et al., In Nucleic Acids Research, 2003
... expression as a monitoring tool for IL-2 expression in primary T-cells of transgenic mice ...
Cytokines in cancer pathogenesis and cancer therapy
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Alitheen Noorjahan Banu et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Recombinant murine interleukin 2 (rmIL-2; Dako, USA) was used as ...
Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
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Unutmaz Derya, In PLoS ONE, 2002
... For antibody blocking in culture assays, non-specific isotype matched control, IL-2, IFNγ, IL-12p70 and CD40L specific mAbs without preservatives were obtained from BD Biosciences and IL-18 specific mAb ...
Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses.
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Sommer Peter, In PLoS ONE, 1999
... (BioWhittaker, Verviers, Belgium) supplemented with 10% fetal calf serum (PAA Laboratories, Vienna, Austria), 10 U/ml IL-2 (National Institutes of Health, AIDS Repository), 2 mM L-glutamine (Invitrogen Life Technologies, Paisley, Scotland), and 1% ...
A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition
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Söderström Kalle et al., In The Journal of Experimental Medicine, 1998
... serum, 200 U IL-2/ml (PeproTech), 2 mM l-glutamine, 100 U/ml penicillin, and 100 μg/ml streptomycin (Life Technologies).
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
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Strober Warren et al., In The Journal of Experimental Medicine, 1997
... with 10% FCS, 100 μg/ml streptomycin, 100 U/ml penicillin, 50 μM 2-ME, 10 U/ml human IL-2 (Life Technologies), and 6% rat Con ...
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
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Allison James P. et al., In The Journal of Experimental Medicine, 1996
... IL-2 immunotoxin therapy modulates tumor-associated regulatory T cells and leads to lasting immune-mediated rejection of breast cancers in neu-transgenic mice ...
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
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Galy Anne et al., In Molecular Therapy, 1996
... plate (Millipore, Bedford, MA) were coated overnight with 5 µg/ml anti-mouse IFN-γ mAb or 3 µg/ml anti-mouse IL-2 mAb (BD Biosciences) at 4 °C, washed, and ...
A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
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Ricciardi-Castagnoli Paola et al., In The Journal of Experimental Medicine, 1995
... ), from ascite-purified anti–IL-2 (S4B6, rat IgG2a) or from total rat IgG (Bethyl).
The interleukin-2 receptor
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Royuela Mar et al., In Breast Cancer Research, 1988
... The primary antibodies used were goat anti-human IL-2, rabbit anti-human IL-2Rα, rabbit anti-human IL-2Rβ and rabbit anti-human IL-2Rγ (Santa Cruz Biotechnology, California, CA, USA).
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
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Schreiber Gideon, In PLoS ONE, 1986
... 15 medium (Cambrex); fetal calf serum (FCS; HyClone, Belgium); L-glutamine (Flow Laboratories, UK); recombinant interleukin-2 (IL-2; Biotech, Russia); phosphate buffered saline (PBS; PanEco, Russia); goat serum (DakoCytomation); phycoerythrin-conjugated goat anti-rabbit IgG (GAR-PE) (Santa Cruz Biotechnology); RNA molecular weight standard ...
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