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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 16

Interleukin-16, IL-16, LCF
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: CD4, CAN, Interleukin-6, HAD, IL-8
Papers on Interleukin-16
Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
New
Takeuchi et al., Tokyo, Japan. In Cytokine, Feb 2016
RESULTS: Proteomics showed that serum IL-16 levels were most positively correlated with those of MMP-3 (ρ=0.51,
Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.
New
Houghton et al., Canada. In Cytokine, Feb 2016
To our knowledge, we are the first to test for levels of IL-16 in ME/CFS patients.
Chemokine and cytokine levels in inflammatory bowel disease patients.
New
Nagarkatti et al., Columbia, United States. In Cytokine, Jan 2016
Further, we also report increases in the inflammatory cytokines IL-16, IFN-γ, IL-1β and TNF-α in IBD patients when compared to healthy donors (P<0.05).
Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes.
New
Roep et al., Leiden, Netherlands. In Plos One, Dec 2015
Patterns of cytokines could distinguish good graft function from insufficient function including IFN-α, LIF, SCF and IL-1RII before and after transplantation, by IL-16, CCL3, BDNF and M-CSF only before and by IL-22, IL-33, KIM-1, S100A12 and sCD14 after transplantation.
Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves' Disease.
New
Chow et al., Tainan City, Taiwan. In World J Surg, Dec 2015
The average reductions were blood flow: 60 % (0.294 vs. 0.117 L/min), serum VEGF: 55 % (169.8 vs. 76.7 pg/mL), and serum IL-16: 50 % (427.2 vs. 214.2;
[The discriminant analysis of the silicosis's induction on cytokines in phlegm and combined multi-markers].
New
Zhang et al., Jinan, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, May 2015
Compared with the control group, silica dust exposed group, the observation group of objects, the pneumosilicosis patients of IL-16 in induced sputum IL-16 (21.40 ± 9.24) decreased, the content of PDGF [(5.96 ± 0.51) ng/L], MMP-2 [(447.86 ± 27.10) ng/L], MMP-9 [(223.91 ± 12.28) ng/L], MCP-1 [(122.87 ± 6.08) ng/L] increased, the differences are statistically significant (P < 0.05).
Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands.
Tran et al., Montréal, Canada. In Sci Rep, 2014
Protein arrays detected several angiogenesis-related factors (CD26, FGF, HGF, MMP-8, MMP-9, OPN, PF4, SDF-1) and cytokines (IL-1ra, IL-16) in BM Soup.
The correlation between pretreatment cytokine expression patterns in peripheral blood mononuclear cells with chronic hepatitis c outcome.
Radkowski et al., Warsaw, Poland. In Bmc Infect Dis, 2014
The differentially expressed factors included IL-8, IL-16, TNF-α, GM-CSF, MCP-2, TGF-β, and IP-10.
p21WAF1 Is Required for Interleukin-16-Induced Migration and Invasion of Vascular Smooth Muscle Cells via the p38MAPK/Sp-1/MMP-9 Pathway.
Moon et al., South Korea. In Plos One, 2014
Interleukin-16 (IL-16) is a lymphocyte chemoattractant factor well known for its role in immune responses, but its role in vascular disease is unknown.
Regulation of cellular processes by interleukin-16 in homeostasis and cancer.
Review
Center et al., Boston, United States. In J Cell Physiol, 2014
Interleukin-16 (IL-16) is generated as a precursor molecule that is cleaved by caspase-3 to produce a pro-IL-16 molecule that functions as a regulator of T cell growth, and a secreted peptide that functions as a CD4 and/or CD9 ligand for induction of cell motility and activation.
Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions.
Review
Zhang et al., Oklahoma City, United States. In Cytokine Growth Factor Rev, 2013
Extracellular PBEF has been shown to increase inflammatory cytokines, such as TNF-α, IL-1β, IL-16, and TGF-β1, and the chemokine receptor CCR3.
Whipple's disease.
Review
Puéchal, Paris, France. In Ann Rheum Dis, 2013
T whipplei replication in vitro is dependent on interleukin 16 and is accompanied by the apoptosis of host cells, facilitating dissemination of the bacterium.
Atopic dermatitis and cytokines: recent patents in immunoregulatory and therapeutic implications of cytokines in atopic dermatitis--part I: cytokines in atopic dermatitis.
Review
Rhim et al., Taejŏn, South Korea. In Recent Pat Inflamm Allergy Drug Discov, 2012
Recently, the roles of new cytokines including IL-16, IL-17, IL-21, IL-22, IL-23, IL-27, IL-31, IL-33, IL-35 and thymus stromal lymphopoietin (TSLP), and Th2 polarization in the immunopathogenesis of skin inflammation and physically injured skin have been described, in addition to roles for IL-4, IL- 5, IL-9, IL-13, IFN-γ and TGF-β.
Role of interleukin 16 in multiple myeloma.
GeneRIF
Kröger et al., Hamburg, Germany. In J Natl Cancer Inst, 2012
IL-16 was strongly overexpressed in the bone marrow of myeloma patients compared with healthy donors. IL-16 is an important growth-promoting factor in multiple myeloma.
Genetic polymorphism of interleukin-16 influences susceptibility to HBV-related hepatocellular carcinoma in a Chinese population.
GeneRIF
Zhao et al., Nanning, China. In Infect Genet Evol, 2011
Data show that IL16 single nucleotide polymorphisms are associated with chronic hepatitis B virus infection and hepatocellular carcinoma.
Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma.
GeneRIF
Cruikshank et al., Boston, United States. In J Clin Invest, 2011
Mutations in the 5' end of the PDZ1 region of pro-IL-16 cause loss of its nuclear localization & facilitate CTCL cell proliferation by decreasing p27Kip1 expression thru increasing Skp2.
[Genetics of contact allergy].
Review
Schnuch, Göttingen, Germany. In Hautarzt, 2011
The following polymorphisms and mutations were studied: (1) filaggrin, (2) N-acetyltransferase (NAT1 and 2), (3) glutathione-S-transferase (GST M and T), (4) manganese superoxide dismutase, (5) angiotensin-converting enzyme (ACE), (6) tumor necrosis factor (TNF), and (7) interleukin-16 (IL16).
IL-16 rs11556218 gene polymorphism is associated with coronary artery disease in the Chinese Han population.
GeneRIF
Zeng et al., Chengdu, China. In Clin Biochem, 2011
IL-16 rs11556218 G/T polymorphism is significantly associated with the risk of coronary artery disease in the Chinese Han population.
Association between serum IL-16 levels and the degree of sensitization in patients with atopic dermatitis.
GeneRIF
Szegedi et al., Debrecen, Hungary. In Int Arch Allergy Immunol, 2010
Serum IL-16 levels of atopic dermatitis patients correlate to some extent with sensitization.
Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression.
Impact
Notkins et al., Bethesda, United States. In Nat Med, 1997
Interleukin-16 (IL-16) is secreted by activated CD8+ T lymphocytes and acts on CD4+ T lymphocytes, monocytes and eosinophils.
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