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Interleukin 11

Interleukin-11, IL-11
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, HAD, NMDA receptor, LIF
Papers using Interleukin-11 antibodies
Gradient-tailored water suppression for H-1-N-15 Hsqc experiments optimized to retain full sensitivity.
Supplier
Antopolsky Maxim, In PLoS ONE, 1992
... The following antibodies were obtained commercially: monoclonal anti-IL-11 (R&D Systems, Minneapolis, MN), polyclonal anti-IL-11Rα (Santa Cruz Biotechnology, Santa Cruz, CA), anti-glutathione ...
Papers on Interleukin-11
Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.
New
Zhou et al., Wuhan, China. In J Natl Cancer Inst, Apr 2016
TJ-M2010-5 treatment also inhibited production of inflammatory cytokines and chemokines (TNF-α, IL-6,G-CSF, MIP-1β, TGF-β1, IL-11, IL-17A, IL-22 and IL-23) and infiltration of immune cells (macrophages, dendritic cells, neutropihls and CD(+)4 T cells) in colon tissues of mice.
Collagen Membranes Adsorb the Transforming Growth Factor-β Receptor I Kinase-dependent Activity of Enamel Matrix Derivative.
New
Gruber et al., Bern, Switzerland. In J Periodontol, Feb 2016
The expression of the TGF-β target genes interleukin 11 and proteoglycan 4 was evaluated by real time PCR.
Interleukin-11 binds specific EF-hand proteins via their conserved structural motifs.
New
Permyakov et al., Moscow, Russia. In J Biomol Struct Dyn, Feb 2016
UNASSIGNED: Interleukin-11 (IL-11) is a hematopoietic cytokine engaged in numerous biological processes and validated as a target for treatment of various cancers.
Cytokines and Blastocyst Hatching.
Review
New
Madhulika et al., Bengaluru, India. In Am J Reprod Immunol, Jan 2016
Pro-inflammatory (IL-6, LIF, GM-CSF) and anti-inflammatory (IL-11, CSF-1) cytokines improve hatching rates; they modulate proteases (MMPs, tPAs, cathepsins and ISP1).
Autologous bone marrow stromal cell transplantation as a treatment for acute radiation enteritis induced by a moderate dose of radiation in dogs.
New
Guo et al., Zhangjiakou, China. In Transl Res, Jan 2016
Furthermore, ABMSC transplantation resulted in elevated serum levels of the anti-inflammatory cytokine interleukin-11 (IL10) and intestinal radioprotective factors, such as keratinocyte growth factor, basic fibroblast growth factor-2, and platelet-derived growth factor-B while reducing the serum level of the inflammatory cytokine IL17.
Protective immunity in gibel carp, Carassius gibelio of the truncated proteins of cyprinid herpesvirus 2 expressed in Pichia pastoris.
New
Zeng et al., Wuhan, China. In Fish Shellfish Immunol, Dec 2015
Interleukin 11 (IL-11) expression in the spleens of the immunized fish peaked at day 4 and the complement component C3 (C3) genes were significantly up-regulated at day 7 post-immunization.
Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases.
Review
New
Athanasou et al., Oxford, United Kingdom. In Clin Rev Allergy Immunol, Dec 2015
These humoral factors can generally be divided into those which, like RANKL, are tumour necrosis family (TNF) superfamily members and those which are not; the former include TNFα lymphotoxin exhibiting inducible expression and competing with herpes simplex virus glycoprotein D for herpesvirus entry mediator, a receptor expressed by T lymphocytes (LIGHT), a proliferation inducing ligand (APRIL) and B cell activating factor (BAFF); the latter include transforming growth factor beta (TGF-β), interleukin-6 (IL-6), IL-8, IL-11, nerve growth factor (NGF), insulin-like growth factor-I (IGF-I) and IGF-II.
Constitutive activation of STAT3 in breast cancer cells: A review.
Review
New
Resat et al., Pullman, United States. In Int J Cancer, Dec 2015
Signaling through the IL6/JAK/STAT3 pathway initiated by the binding of IL6 family of cytokines (i.e., IL-6, IL-11) to their receptors have been implicated in breast cancer development.
Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer.
Review
New
Ernst et al., Australia. In Cytokine Growth Factor Rev, Oct 2015
In addition of its long recognized activities as a hemopoietic growth factor, IL-11 has an emerging role in epithelial cancer biology.
A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.
Impact
Kang et al., Princeton, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.
A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma.
Impact
Sun et al., Shanghai, China. In Cancer Cell, 2014
In addition, lncRNA-ATB promoted organ colonization of disseminated tumor cells by binding IL-11 mRNA, autocrine induction of IL-11, and triggering STAT3 signaling.
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.
Impact
Ernst et al., Melbourne, Australia. In Cancer Cell, 2013
However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal cancers.
IL-11: a prominent pro-tumorigenic member of the IL-6 family.
Impact
Grivennikov, Philadelphia, United States. In Cancer Cell, 2013
In this issue of Cancer Cell, Putoczki and colleagues report the importance of interleukin 11 in a variety of gastrointestinal malignances and lay down a framework for its potential inhibition in a variety of human cancers.
The Roles of Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Epithelial Transition (MET) in Breast Cancer Bone Metastasis: Potential Targets for Prevention and Treatment.
Review
Demirkan, İzmir, Turkey. In J Clin Med, 2012
Transforming growth factor β (TGFβ), insulin-like growth factor I & II (IGF I & II), platelet-derived growth factor (PDGF), parathyroid hormone-related protein (PTH(rP)), vascular endothelial growth factor (VEGF), epithelial growth factors II/I (ErbB/EGF), interleukin 6 (IL-6), IL-8, IL-11, IL-1, integrin αvβ3, matrix metalloproteinases (MMPs), catepsin K, hypoxia, notch, Wnt, bone morphogenetic proteins (BMP), and hedgehog signaling pathways are important EMT and MET effectors identified in the bone microenviroment facilitating bone metastasis formation.
Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart.
GeneRIF
Fujio et al., Ōsaka, Japan. In Am J Physiol Heart Circ Physiol, 2012
IL-11 administration exhibits postconditioning effects through cardiac STAT3 activation, preventing myocardial ischemia-reperfusion injury.
IL10, IL11, IL18 are differently expressed in CD14+ TAMs and play different role in regulating the invasion of gastric cancer cells under hypoxia.
GeneRIF
Puolakkainen et al., Beijing, China. In Cytokine, 2012
The up-regulation of IL10, IL11 and IL18 expression in tumor-associated macrophage by hypoxia differed in gastric cancer cell lines.
Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3.
GeneRIF
Dimitriadis et al., Australia. In Int J Oncol, 2012
IL11 may be involved in endometrial cancer development
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
GeneRIF
Scheller et al., Düsseldorf, Germany. In J Biol Chem, 2012
the mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling
[Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells].
GeneRIF
Haruta, Tokyo, Japan. In Kokubyo Gakkai Zasshi, 2012
IL-11 production was suppressed by capsazepine
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Impact
Tuckermann et al., Jena, Germany. In Cell Metab, 2010
The inhibitory GC effects on osteoblasts can be explained by a mechanism involving suppression of cytokines, such as interleukin 11, via interaction of the monomeric GR with AP-1, but not NF-kappaB.
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