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Interleukin 1 receptor accessory protein

Interleukin-1 Receptor Accessory Protein, IL-1RAcP, IL-1 receptor accessory protein
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: IL-1beta, IL-1ra, IL-33, CAN, NF-kappaB
Papers on Interleukin-1 Receptor Accessory Protein
Elevated levels of Interleukin (IL)-33 induce bone pathology but absence of IL-33 does not negatively impact normal bone homeostasis.
Benschop et al., Indianapolis, United States. In Cytokine, Feb 2016
IL-33 effects are mediated through its receptor, ST2 and IL-1RAcP, and its signaling induces the production of a number of pro-inflammatory mediators, including TNFα, IL-1β, IL-6, and IFN-γ.
IL-33 promotes ICAM-1 expression via NF-kB in murine mast cells.
Tsuboi et al., Tokyo, Japan. In Allergol Int, Dec 2015
BACKGROUND: IL-33, a member of the IL-1 cytokine family, binds to heterodimeric receptors ST2 and IL-1 receptor accessory protein, and activates Th2-type immune responses.
[Cloning of VH and VL Gene of Human anti-IL1RAP McAb and Construction of Recombinant Chimeric Receptor].
Xu et al., Xuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Oct 2015
OBJECTIVE: To clone the variable region genes of human anti-IL1RAP (IL-1 receptor accessory protein) monoclonal antibodies (McAb) and to construct IL1RAP chimeric antigen receptors (CARs).
[Preparation and Assessment of IL1RAP Monoclonal Antibody].
Zhao et al., Xuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Aug 2015
OBJECTIVE: To prepare and identify human monoclonal antibody against IL-1 receptor accessory protein (IL1RAP), which is a new identified surface marker for leukemia stem cells (LSC).
The potential role of IL-33/ST2 signaling in fibrotic diseases.
Li et al., Ningbo, China. In J Leukoc Biol, Jul 2015
It has been identified as a functional ligand for the plasma membrane receptor complex that is a heterodimer consisting of membrane-bound ST2L, which is a member of the IL-1R family, and IL-1RAcP.
The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders.
Nawijn et al., Berlin, Germany. In Mol Immunol, 2015
IL-33 activates several immune cells, including Th2 cells, mast cells and basophils, following its interaction with a cell surface heterodimer consisting of an IL-1 receptor-related protein ST2 (IL-1RL1) and IL-1 receptor accessory protein (IL-1RAcP).
The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β.
Gram et al., Basel, Switzerland. In Mabs, 2014
As demonstrated by the X-ray structure of the complex with IL-1β, canakinumab binds IL-1β on the opposite side with respect to the IL-1RAcP binding site, and in an approximately orthogonal orientation with respect to IL-1RI.
Special aspects of interleukin-33 and the IL-33 receptor complex.
Martin, Gießen, Germany. In Semin Immunol, 2014
Free IL-33 acts as a classical cytokine by binding to target cells expressing receptors for IL-33 minimally consisting of ST2 and IL-1RAcP.
[Biological role of Interleukin 33 and its importance in pathophysiology of cardiovascular system].
Witkiewicz et al., In Postepy Hig Med Dosw (online), 2013
Its biological effect via interaction with membrane-bound ST2 receptor and IL-1 receptor accessory protein (IL-1RAcP) is associated with the induction of Th2-type immune response and IL-5 and IL-13 synthesis.
Role of interleukin-33 in innate-type immune cells in allergy.
Saito et al., Tokyo, Japan. In Allergol Int, 2013
IL-33 mainly activates Th2 cells and such innate-type immune cells as mast cells, basophils, eosinophils and natural helper cells that express IL-33R (a heterodimer of IL-1 receptor-like 1 [IL-1RL1; also called ST2, T1, Der4, fit-1] and IL-1 receptor accessory protein [IL-1RAcP]).
Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.
Steidl et al., United States. In Blood, 2012
Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells.
Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase.
Quan et al., Columbus, United States. In Proc Natl Acad Sci U S A, 2012
Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase.
Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.
Mishina et al., Tokyo, Japan. In J Neurosci, 2012
The results of this study suggested that IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain.
MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia.
Friedman et al., Philadelphia, United States. In J Pediatr Gastroenterol Nutr, 2012
In experimental biliary atresia, miR-29a/29b1 are upregulated, and reporter assays confirmed that Igf1 and Il1RAP are down-regulated by miR-29.
Interleukin-1ß and interleukin-1 receptor accessory protein gene polymorphisms are associated with persistent hepatitis B virus infection.
Cho et al., Suwŏn, South Korea. In Hepatogastroenterology, 2012
The genetic polymorphisms of IL-1ss-2023 C allele, IL- 1RAcP -8261 T allele and -8183 A allele are probable host factors for persistent HBV infection.
Structural insights into the assembly and activation of IL-1β with its receptors.
Wang et al., Beijing, China. In Nat Immunol, 2010
Interleukin 1β (IL-1β) is a key orchestrator of inflammation and host defense that exerts its effects through IL-1 receptor type I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
Disease-associated functions of IL-33: the new kid in the IL-1 family.
McInnes et al., Glasgow, United Kingdom. In Nat Rev Immunol, 2010
The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells.
A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1.
Sims et al., Seattle, United States. In Immunity, 2009
an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS.
The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.
Sims et al., Seattle, United States. In Immunity, 2003
soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Volpe et al., Biel, Switzerland. In Nat Cell Biol, 2000
Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip.
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