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Pyrin and HIN domain family, member 1

interferon-inducible protein-10
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
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Top mentioned proteins: 18 U, IL-8, MIP, HAD, Interleukin-6
Papers on interferon-inducible protein-10
ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway.
New
Zhang et al., Chongqing, China. In Viral Immunol, Feb 2016
In this study, the ELISA assay was used to detect protein levels, and we found that HEV open reading frame 3 (ORF3) protein inhibited the expression of proinflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-1β, IL-6, IL-8, IL-12p40, and IL-18) and chemotactic factors (nitric oxide [NO], interferon-inducible protein-10 (IP-10), macrophage inflammatory protein (MIP)-1α, monocyte chemoattractant protein-1 (MCP-1), granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF)] in lipopolysaccharide (LPS)-stimulated human PMA-THP1 cells.
Serum interferon-inducible protein 10 levels predict hepatitis B s antigen seroclearance in patients with chronic hepatitis B.
New
Wong et al., Hong Kong, Hong Kong. In Aliment Pharmacol Ther, Jan 2016
Relevant serum cytokines [interleukin (IL)-2, IL-3, IL-4, IL-7, IL-9, IL-10, IL-12, IL-15, IL-21 interferon-γ, tumour necrosis factor-α (TNF-α), granulocyte macrophage colony-stimulating factor (GM-CSF) and interferon-inducible protein 10 (IP-10)] were assayed at the time (Year 0) and 3 years before (Year -3) HBsAg seroclearance.
Increased levels of interferon-inducible protein 10 (IP-10) in 22q11.2 Deletion Syndrome.
New
Abrahamsen et al., Oslo, Norway. In Scand J Immunol, Jan 2016
Interferon-inducible protein 10 (IP-10) was also measured by ELISA to confirm the multiplex results.
Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients.
New
Tayade et al., Kingston, Canada. In Fertil Steril, Jan 2016
In tissue, levels of GM-CSF and IL-15 were lower in eutopic tissue, while levels of basic fibroblast growth factor, interferon-inducible protein 10, IL-1 receptor antagonist, granulocyte colony-stimulating factor, macrophage inflammatory protein 1β, IL-7, and IL-5 were higher in eutopic than in ectopic tissue.
Interferon-γ, interleukin-10 and interferon-inducible protein 10 (CXCL10) as serum biomarkers for the early allograft dysfunction after liver transplantation.
New
Werner et al., Heidelberg, Germany. In Transpl Immunol, Jan 2016
UNASSIGNED: Orthotopic liver transplantation (LTP) is nowadays a standard procedure, and provides the chance of survival of patients with end-stage non-treatable chronic liver disease or acute liver failure.
Serum HBsAg kinetics and usefulness of interferon-inducible protein 10 serum in HBeAg-negative chronic hepatitis B patients treated with tenofovir disoproxil fumarate.
New
Manolakopoulos et al., Athens, Greece. In J Viral Hepat, Dec 2015
The kinetics of serum HBsAg and interferon-inducible protein 10 (IP10) levels in patients with chronic hepatitis B infection treated with tenofovir are unclear.
[Age-related macular degeneration: paradigm shift from recent findings].
Review
New
Yanagi, In Nihon Ganka Gakkai Zasshi, Mar 2015
The currently prevailing hypothesis is that premacular VEGF concentration is lower in eyes with posterior vitreous detachment (PVD) than in eyes without PVD, thus leading to good treatment outcomes; however, in the current study, we showed that not only VEGF but also anti-angiogenic factor, interferon-inducible protein 10 (IP-10), is affected according to PVD.
Hepatitis B virus infection and interferon-inducible protein-10.
Fabiani, Pisa, Italy. In Clin Ter, 2014
Interferon (IFN)-inducible protein-10 (IP-10) is a proinflammatory chemokine, binding the chemokine (C-X-C motif) receptor 3 (CXCR3), which is found mainly on activated T cells and natural killer (NK) cells, and plays an important role in T helper (Th) 1 type inflammatory disorders (autoimmune, neoplastic, and infectious diseases).
The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway.
Wang et al., Beijing, China. In Front Pharmacol, 2014
TGR5 overexpression with ligand treatment inhibited gene expression of interferon-inducible protein 10 (IP-10), TNF-α, and chemoattractant protein-1 (MCP-1) induced by LPS.
Statins and cancer.
Review
Kazazis et al., Athens, Greece. In Anticancer Agents Med Chem, 2014
Another mechanism involves the down-regulation of the nuclear factor-kappa-B, which is responsible for the transcription of many genes involved in immunologic mechanisms, such as interferon-inducible protein-10, monocyte chemo-attractant protein 1 and cyclooxygenase-2.
The multifaceted functions of CXCL10 in cardiovascular disease.
Review
Pasterkamp et al., Utrecht, Netherlands. In Biomed Res Int, 2013
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family.
Urinary-cell mRNA profile and acute cellular rejection in kidney allografts.
Impact
Clinical Trials in Organ Transplantation 04 (CTOT-04) Study Investigators et al., New York City, United States. In N Engl J Med, 2013
RESULTS: A three-gene signature of 18S ribosomal (rRNA)-normalized measures of CD3ε mRNA and interferon-inducible protein 10 (IP-10) mRNA, and 18S rRNA discriminated between biopsy specimens showing acute cellular rejection and those not showing rejection (area under the curve [AUC], 0.85; 95% confidence interval [CI], 0.78 to 0.91; P<0.001 by receiver-operating-characteristic curve analysis).
Biomarkers in immune reconstitution inflammatory syndrome: signals from pathogenesis.
Review
French et al., Bethesda, United States. In Curr Opin Hiv Aids, 2010
Markers of inflammation such as C-reactive protein, interferon-inducible protein 10 or interferon γ may be helpful as predictors of IRIS events.
Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity--a tale of conflict and conundrum.
Review
Campbell et al., Sydney, Australia. In Neuropathol Appl Neurobiol, 2010
The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum The chemokines CXCL9, CXCL10 and CXCL11 (also known as monokine induced by interferon-gamma, interferon-inducible protein-10 and interferon-inducible T cell alpha-chemoattractant, respectively) are structurally and functionally related molecules within the non-ELR CXC chemokine subgroup.
Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin.
GeneRIF
Hung et al., Houston, United States. In Mol Carcinog, 2008
IFIXalpha suppressed the invasion activity of MDA-MB-468 breast cancer cells, and its inhibitory effect was reversed by the knockdown of maspin
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.
Impact
Mandelboim et al., Jerusalem, Israel. In Nat Med, 2006
Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein-10 chemokines.
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GeneRIF
Yan et al., Houston, United States. In Mol Cell Biol, 2006
IFIX alpha1 isoform functions as a tumor suppressor by repressing HDM2 function
Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer.
GeneRIF
Yan et al., Houston, United States. In Oncogene, 2004
a new member of the hematopoietic interferon (IFN)-inducible nuclear protein. Six different alternatively spliced forms are transcribed from the IFIX gene
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