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Interferon regulatory factor 3

Interferon Regulatory Factor-3, IRF-3
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Papers using Interferon Regulatory Factor-3 antibodies
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
Meurs Eliane F., In PLoS ONE, 2010
... Recombinant GST-IRF3 was purchased from Abnova (Taiwan) ...
Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus.
Bozza Patricia T., In PLoS ONE, 2006
... protein (GFP) (sc-8334; Santa Cruz biotechnology, Santa Cruz, CA), pAb against human interferon regulatory factor 3 (IRF-3) (sc-9082; Santa Cruz biotechnology), mAb against double-stranded RNA ...
Papers on Interferon Regulatory Factor-3
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
Wang et al., Wuhan, China. In J Immunol, 2012
Bocavirus nonstructural protein (NP)1 interacts with the DNA-binding domain of human IRF-3 and blocks its association with interferon (IFN)beta promoter.
Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism.
Gale et al., Seattle, United States. In J Virol, 2012
The authors define a molecular interaction between Vpu and IRF3 that redirects IRF3 to the endolysosome for proteolytic degradation, thus allowing HIV to avoid the innate antiviral immune response.
Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.
Vogel et al., Baltimore, United States. In J Immunol, 2012
Activated IRF-3 might bind directly to regulatory regions within the IL-33 gene to drive interleukin (IL)-33 transcription in macrophages stimulated by bacterial and viral agonists that engage distinct innate immune signaling pathways.
Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein.
Sakaguchi et al., Hiroshima, Japan. In J Virol, 2012
The authors showed that the V protein of Sendai virus appeared to inhibit translocation of IRF3 into the nucleus.
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