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Interferon regulatory factor 3

Interferon Regulatory Factor-3, IRF-3
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: IRF, V1a, CAN, RIG-I, ACID
Papers using Interferon Regulatory Factor-3 antibodies
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
Meurs Eliane F., In PLoS ONE, 2010
... Recombinant GST-IRF3 was purchased from Abnova (Taiwan) ...
Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus.
Bozza Patricia T., In PLoS ONE, 2006
... protein (GFP) (sc-8334; Santa Cruz biotechnology, Santa Cruz, CA), pAb against human interferon regulatory factor 3 (IRF-3) (sc-9082; Santa Cruz biotechnology), mAb against double-stranded RNA ...
Papers on Interferon Regulatory Factor-3
Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau.
Zhao et al., Xining, China. In Fish Shellfish Immunol, Feb 2016
Within this gene family, IRF3, IRF5, IRF7 and IRF8 contained positive selection sites.
Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1.
Yoo et al., Urbana, United States. In Virology, Feb 2016
Of 16 PEDV nonstructural proteins (nsps), nsp1, nsp3, nsp7, nsp14, nsp15 and nsp16 were found to inhibit the IFN-β and IRF3 promoter activities.
Cloning and characterizing of the murine IRF-3 gene promoter region.
Zhou et al., Nanjing, China. In Immunol Res, Feb 2016
UNASSIGNED: The interferon regulatory factor 3 (IRF-3) plays essential roles in inflammation and immune response.
Membrane perturbation-associated Ca2+ signalling and incoming genome sensing are required for the host response to low-level enveloped virus particle entry.
Mossman et al., Seattle, United States. In J Virol, Jan 2016
UNASSIGNED: The type-I interferon (IFN) response is an important aspect of innate antiviral defense and the transcription factor IRF3 plays an important role in its induction.
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Guo et al., Wuhan, China. In Nat Immunol, Jan 2016
PTEN controlled the import of IRF3, a master transcription factor responsible for IFN-β production, into the nucleus.
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response.
Tan et al., Shanghai, China. In Sci Rep, Dec 2015
The cGAS-cGAMP-STING-IRF3 pathway of cytosolic DNA sensing plays a pivotal role in antiviral defense.
The catcher in the RIG-I.
Weber, Gießen, Germany. In Cytokine, Nov 2015
Activated RIG-I switches into a conformation that locks the ligand RNA and signals via the MAVS-IRF-3 axis, resulting in the upregulation of antiviral interferons.
Ligand-Independent EGFR Signaling.
Habib et al., Dallas, United States. In Cancer Res, Oct 2015
Recent studies have identified a noncanonical form of signaling triggered by EGFRwt exclusively in the absence of ligand that does not involve ERK or Akt activation but, instead, results in activation of the transcription factor IRF3.
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
Chanda et al., Sanford, United States. In Cell, Jul 2015
HIV-1 infection of DCs triggers an IRF3-dependent innate immune response, which requires the activity of cyclic GAMP synthase (cGAS).
Herpesviruses: interfering innate immunity by targeting viral sensing and interferon pathways.
Kumar et al., Bhopāl, India. In Rev Med Virol, May 2015
The pathways stimulated by different pattern-recognition receptors merge into common transcription factors IRF3 and IRF7, lead to the production of IFN-I.
Mitochondrial DNA stress primes the antiviral innate immune response.
Shadel et al., New Haven, United States. In Nature, May 2015
Mechanistically, we find that aberrant mtDNA packaging promotes escape of mtDNA into the cytosol, where it engages the DNA sensor cGAS (also known as MB21D1) and promotes STING (also known as TMEM173)-IRF3-dependent signalling to elevate interferon-stimulated gene expression, potentiate type I interferon responses and confer broad viral resistance.
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Chen et al., Dallas, United States. In Science, Apr 2015
Phosphorylated MAVS and STING then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recruit IRF3 for its phosphorylation and activation by TBK1.
[Ubiquitin as a regulator of IFN production in the antiviral response].
Matuszyk et al., Panama. In Postepy Hig Med Dosw (online), 2014
Such mechanisms engage signaling cascades which, in the initial phase of infection, lead to the activation of the NF-κB pathway and IFN regulatory factors (IRF-3, IRF-7) which directly control the production of IFNs.
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Gajewski et al., Chicago, United States. In Immunity, 2014
In vitro, IFN-? production and dendritic cell activation were triggered by tumor-cell-derived DNA, via cyclic-GMP-AMP synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3).
[Innate immune DNA sensing pathways].
Abe, New York City, United States. In Uirusu, 2013
After DNA or CDN stimulation, STING traffics with kinase TBK1 in an autophagic signaling complex, from ER to perinuclear endosomal compartments harboring IRF3 and NF-κB.
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter.
Wang et al., Wuhan, China. In J Immunol, 2012
Bocavirus nonstructural protein (NP)1 interacts with the DNA-binding domain of human IRF-3 and blocks its association with interferon (IFN)beta promoter.
Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism.
Gale et al., Seattle, United States. In J Virol, 2012
The authors define a molecular interaction between Vpu and IRF3 that redirects IRF3 to the endolysosome for proteolytic degradation, thus allowing HIV to avoid the innate antiviral immune response.
Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.
Vogel et al., Baltimore, United States. In J Immunol, 2012
Activated IRF-3 might bind directly to regulatory regions within the IL-33 gene to drive interleukin (IL)-33 transcription in macrophages stimulated by bacterial and viral agonists that engage distinct innate immune signaling pathways.
Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein.
Sakaguchi et al., Hiroshima, Japan. In J Virol, 2012
The authors showed that the V protein of Sendai virus appeared to inhibit translocation of IRF3 into the nucleus.
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