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Interferon regulatory factor 3
Interferon Regulatory Factor-3, IRF-3
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (from
Vogel et al., Baltimore, United States. In J Immunol, 2012
Activated IRF-3 might bind directly to regulatory regions within the IL-33 gene to drive interleukin (IL)-33 transcription in macrophages stimulated by bacterial and viral agonists that engage distinct innate immune signaling pathways.