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Interferon regulatory factor 2

Interferon Regulatory Factor-2, IRF-2
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, Interferon Regulatory Factor-1, IFN-gamma, CAN, Interferon-beta
Papers on Interferon Regulatory Factor-2
The Expression of BAFF Is Controlled by IRF Transcription Factors.
Espinosa et al., Stockholm, Sweden. In J Immunol, Feb 2016
We identify IRF1 and IRF2 as positive regulators of BAFF transcription and IRF4 and IRF8 as potent repressors; in addition, we have mapped the precise binding site for these factors in the BAFF promoter.
Characterization of Amphioxus IFN Regulatory Factor Family Reveals an Archaic Signaling Framework for Innate Immune Response.
Xu et al., Guangzhou, China. In J Immunol, Jan 2016
Interestingly, amphioxus IRF2, IRF8, and Rel were identified as target genes of bbtIRF1, bbtIRF7, and bbtIRF3, respectively, suggesting a dynamic feedback regulation among amphioxus IRF and NF-κB.
Fish IRF3 up-regulates the transcriptional level of IRF1, IRF2, IRF3 and IRF7 in CIK cells.
Hu et al., Nanchang, China. In Fish Shellfish Immunol, Dec 2015
Interferon Regulatory Factors (IRFs) belong to a family of transcription factor involved in transcriptional regulation of type I IFN and IFN-stimulated genes (ISG) in cells.
5-Azacytidine modulates interferon regulatory factor 1 in macrophages to exert a cardioprotective effect.
Ahn et al., Kwangju, South Korea. In Sci Rep, 2014
IRF1 is a critical transcription factor for iNOS induction and is antagonized by IRF2.
RelA-Induced Interferon Response Negatively Regulates Proliferation.
Iglehart et al., Boston, United States. In Plos One, 2014
Inactivation of Rb, down-regulation of RelA or IRF1, or upregulation of CDK4 or IRF2 rescues the RelA-IRF1-CDK4 induced proliferation arrest in HMEC and are points of disruption in aggressive tumors.
Dose rate in brachytherapy using after-loading machine: pulsed or high-dose rate?
Peiffert et al., Nice, France. In Cancer Radiother, 2014
Since February 2014, it is no longer possible to use low-dose rate 192 iridium wires due to the end of industrial production of IRF1 and IRF2 sources.
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression.
Knight et al., Oxford, United Kingdom. In Science, 2014
Induced innate immune activity reveals multiple master regulatory trans-eQTLs including the major histocompatibility complex (MHC), coding variants altering enzyme and receptor function, an IFN-β cytokine network showing temporal specificity, and an interferon regulatory factor 2 (IRF2) transcription factor-modulated network.
Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
Chen et al., Taipei, Taiwan. In World J Gastroenterol, 2014
High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, ARID2, MLL, MLL2, MLL3, MLL4, IRF2, ATM, CDKN2A, FGF19, PIK3CA, RPS6KA3, JAK1, KEAP1, NFE2L2, C16orf62, LEPR, RAC2, and IL6ST.
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
Zucman-Rossi et al., Paris, France. In Nat Genet, 2012
We found new recurrent alterations in four genes (ARID1A, RPS6KA3, NFE2L2 and IRF2) not previously described in HCC.
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Taki et al., Matsumoto, Japan. In J Immunol, 2012
In mice doubly deficient forIRF-2 and CD1d, the overall memory phenotype T cell population is contrastingly enlarged.
Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum.
Barnes et al., Baltimore, United States. In J Invest Dermatol, 2012
The results suggested that distinct markers in IRF2 may be associated with atopic dermatitis and eczema herpeticum (which may depend upon ethnic ancestry) and genetic variants in IRF2 may contribute to an abnormal immune response to herpes simplex virus.
IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells.
Jin et al., Shanghai, China. In Tumour Biol, 2012
these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer.
Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.
Matsuyama et al., Nagasaki, Japan. In Proc Natl Acad Sci U S A, 2011
IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3
Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.
Ohnishi et al., Akita, Japan. In Gastroenterology, 2011
IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion.
Ohteki et al., Akita, Japan. In Nat Med, 2009
Irf2-/- HSCs showed enhanced cell cycling status and failed to produce hematopoietic cells in competitive repopulation assays
Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses.
Bayless et al., College Station, United States. In Soc Reprod Fertil Suppl, 2008
By Day 12 of pregnancy, estrogens increase the expression of multiple genes in the uterine luminal epithelium including SPP1, STC1, IRF2 and STAT1 that likely have roles for implantation.
The role of IRF1 and IRF2 transcription factors in leukaemogenesis.
Dolnikov et al., Sydney, Australia. In Curr Gene Ther, 2006
IRF1 and its functional antagonist IRF2 originally discovered as transcription factors regulating the interferon-beta (IFN-beta) gene, are involved in the regulation of normal haematopoiesis and leukaemogenesis.
Cytokines in breast cancer.
Rossi et al., Pisa, Italy. In Cytokine Growth Factor Rev, 2006
New signalling pathways of interleukin (IL)-1 family, IL-6, IL-11, IL-18, interferons (IFNs) and interferon regulatory factors 1 (IRF-1) and 2 (IRF-2) have been found within tumour microenvironments and in metastatic sites.
IFN-gamma represses IL-4 expression via IRF-1 and IRF-2.
Li-Weber et al., Heidelberg, Germany. In Immunity, 2002
IRF-1 and IRF-2 induced by IFN-gamma bind to three distinct IL-4 promoter sites and function as transcriptional repressors
Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.
McMichael et al., Oxford, United Kingdom. In Immunity, 2001
In contrast, Nef exclusively upregulates factors positively regulating HIV, including Tat-SF1, U1 SNRNP, and IRF-2.
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