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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interferon regulatory factor 1

Interferon Regulatory Factor-1, IRF-1
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, STAT1, IFN-gamma, CAN, V1a
Papers on Interferon Regulatory Factor-1
Identification of KSHV vIRF1 as a novel interaction partner of human deubiquitinase USP7.
Saridakis et al., Canada. In J Biol Chem, Feb 2016
UNASSIGNED: Viral Interferon Regulatory Factor 1 (vIRF1), a Kaposis sarcoma herpes virus protein, destabilizes p53 by inhibiting p53 acetylation and Hdm2 phosphorylation.
Whole-exome sequencing reveals potential molecular predictors of relapse after discontinuation of the targeted therapy in chronic myeloid leukemia patients.
Kutsev et al., Moscow, Russia. In Leuk Lymphoma, Feb 2016
We found variants in genes CYP1B1, ALPK2, and IRF1 in group of patients with relapse and one variant in gene PARP9 in group of patients without relapse.
Vigneri et al., Catania, Italy. In Curr Cancer Drug Targets, Feb 2016
UNASSIGNED: The Interferon Regulatory Factor (IRF) family consists of multiple transcription factors involved in the regulation of a variety of biological processes.
Tumor suppressor IRF-1 counteracts germinal center reaction driven by a cancer-associated gammaherpesvirus.
Tarakanova et al., Milwaukee, United States. In J Virol, Jan 2016
We found that this gammaherpesvirus-driven germinal center expansion was exaggerated and had lost its transient nature in the absence of interferon regulatory factor-1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.
The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases.
Li et al., Wuhan, China. In Br J Pharmacol, Dec 2015
UNLABELLED: The family of interferon regulatory factors (IRFs) consists of nine members (IRF1-IRF9) in mammals.
Sequence and Expression Analysis of Interferon Regulatory Factor 10 (IRF10) in Three Diverse Teleost Fish Reveals Its Role in Antiviral Defense.
Wang et al., Jingzhou, China. In Plos One, Dec 2015
BACKGROUND: Interferon regulatory factor (IRF) 10 was first found in birds and is present in the genome of other tetrapods (but not humans and mice), as well as in teleost fish.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Shair et al., Cambridge, United States. In Nature, Nov 2015
In AML cells, CA upregulated SE-associated genes with tumour suppressor and lineage-controlling functions, including the transcription factors CEBPA, IRF8, IRF1 and ETV6 (refs 6-8).
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
Kanneganti et al., Memphis, United States. In Nat Immunol, May 2015
Here we found that the transcription factor IRF1 was required for activation of the AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F.
The regulation role of interferon regulatory factor-1 gene and clinical relevance.
Chen et al., Wuhan, China. In Hum Immunol, 2014
IRF-1, a kind of transcription factors, is expressed constitutively in all cells types except early embryonal cells.
Dose rate in brachytherapy using after-loading machine: pulsed or high-dose rate?
Peiffert et al., Nice, France. In Cancer Radiother, 2014
Since February 2014, it is no longer possible to use low-dose rate 192 iridium wires due to the end of industrial production of IRF1 and IRF2 sources.
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.
Apetoh et al., Dijon, France. In Nat Immunol, 2014
Here we found that the transcription factor IRF1 enhanced the effector function of TH9 cells and dictated their anticancer properties.
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
Kordula et al., Richmond, United States. In Nat Immunol, 2014
Although interleukin 1 (IL-1) induces expression of the transcription factor IRF1 (interferon-regulatory factor 1), the roles of IRF1 in immune and inflammatory responses and mechanisms of its activation remain elusive.
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.
Ivashkiv et al., New York City, United States. In Immunity, 2013
Rather, we found that IFN-γ induced sustained occupancy of transcription factors STAT1, IRF-1, and associated histone acetylation at promoters and enhancers at the TNF, IL6, and IL12B loci.
[Prolactin as an immunomodulatory factor in psoriatic arthritis].
Piwowar et al., Piastów, Poland. In Postepy Hig Med Dosw (online), 2012
For T lymphocyte stimulated PRL, that factor is mainly the interferon regulatory factor (IRF-1), which gives the possibility of adjusting the prolactin immune response.
Immune quiescence: a model of protection against HIV infection.
Fowke et al., In Retrovirology, 2012
Furthermore, expression of interferon regulatory factor 1 (IRF-1) is reduced in HESN as a consequence of genetic polymorphisms and differential epigenetic regulation.
Interferon regulatory factor-1 as a positive regulator for high glucose-induced proliferation of vascular smooth muscle cells.
Lei et al., Shanghai, China. In J Cell Biochem, 2012
Overexpression of Irf-1 accelerated the proliferation of VSMCs, and down-regulation of Irf-1 depressed the proliferative ability of VSMCs under high-glucose conditions, indicating that Irf-1 was a positive regulator for high glucose-induced proliferation.
The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
Moilanen et al., Tampere, Finland. In Mol Immunol, 2012
MKP-1 increases the expression of IL-12 by enhancing the expression of IRF1
Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.
Wang et al., Nanjing, China. In J Biol Chem, 2012
Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.
Gene expression analysis of rheumatoid arthritis synovial lining regions by cDNA microarray combined with laser microdissection: up-regulation of inflammation-associated STAT1, IRF1, CXCL9, CXCL10, and CCL5.
Ohshima et al., Kurume, Japan. In Scand J Rheumatol, 2012
Immunohistochemically, the lining synovium of Rheumatoid Aarthritis clearly expressed IRF1
Interferon regulatory factor 1 transactivates expression of human DNA polymerase η in response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine.
Shao et al., Hangzhou, China. In J Biol Chem, 2012
We propose that IRF1 activation is responsible for carcinogen-induced Poleta up-regulation, which contributes to mutagenesis and ultimately carcinogenesis in cells.
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