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Interferon regulatory factor 1
Interferon Regulatory Factor-1, IRF-1
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008] (from
Tarakanova et al., Milwaukee, United States. In J Virol, Jan 2016
We found that this gammaherpesvirus-driven germinal center expansion was exaggerated and had lost its transient nature in the absence of interferon regulatory factor-1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions.
Kordula et al., Richmond, United States. In Nat Immunol, 2014
Although interleukin 1 (IL-1) induces expression of the transcription factor IRF1 (interferon-regulatory factor 1), the roles of IRF1 in immune and inflammatory responses and mechanisms of its activation remain elusive.
Lei et al., Shanghai, China. In J Cell Biochem, 2012
Overexpression of Irf-1 accelerated the proliferation of VSMCs, and down-regulation of Irf-1 depressed the proliferative ability of VSMCs under high-glucose conditions, indicating that Irf-1 was a positive regulator for high glucose-induced proliferation.