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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin beta 6

integrin beta6, ITGB6
Top mentioned proteins: fibronectin, TGF-beta, CAN, HAD, ACID
Papers on integrin beta6
Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.
New
Popov et al., Guangzhou, China. In Hepatology, Jan 2016
Freshly isolated αvβ6(+) liver cells demonstrate clonogenic potential and differentiate into cholangiocytes and functional hepatocytes in vitro, whereas colony formation by epithelial cell adhesion molecule-positive progenitor cells is blocked by αvβ6-neutralizing antibody and in integrin beta 6-deficient cells.
Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability.
New
Leal et al., Islamabad, Pakistan. In Eur J Hum Genet, Jan 2016
Using homozygosity mapping, linkage analysis and exome sequencing, we identified a novel rare missense variant c.898G>A (p.(Glu300Lys)) in ITGB6, which co-segregates with the phenotype within the family and is predicted to be deleterious.
Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties.
New
Lee et al., Taiwan. In Oncotarget, Dec 2015
In chromatin immunoprecipitation assays, β-catenin binding to the proximal promoter regions of ITGA2-4 and ITGA10-11 in brain, colon and lung cancer cell lines could be triggered by CD133, and β-catenin also bound to the proximal promoter regions of ITGB6 and ITGB8 in cell lines from gastric and breast cancers.
Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion.
New
Ridky et al., Philadelphia, United States. In J Cell Sci, Dec 2015
These phenotypes depend only on the binding partners of integrin-αv - integrin β5 and integrin β6 (also known as ITGB5 and ITGB6, respectively).
Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.
New
Yuan et al., Wuhan, China. In Tumour Biol, Nov 2015
We hypothesized that polymorphisms in αvβ6 integrin genes (ITGAV and ITGB6) might be associated with the risk of radiation pneumonitis (RP) in lung cancer patients treated with thoracic radiation.
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.
New
Peitsch et al., Neuchâtel, Switzerland. In Inflamm Res, Jul 2015
More importantly, RCR predicted potential molecular mechanisms that are less well-established, including increased transcriptional activity of PU.1, STAT1, C/EBP, FOXM1, YY1, and N-COR, and reduced protein abundance of ITGB6 and CFTR.
Heterozygosity at the SNP (rs136500299) of ITGB6 receptor gene possibly influences the susceptibility among crossbred bull to foot and mouth disease infection.
New
Sengar et al., Meerut, India. In Virusdisease, Jun 2015
To understand the susceptibility of two cattle species to FMDV infection in terms of viral receptors, the present study reports the cloning, characterization and sequence analysis of Zebu ITGB6 gene.
Novel ITGB6 mutation in autosomal recessive amelogenesis imperfecta.
New
Kim et al., İstanbul, Turkey. In Oral Dis, May 2015
RESULTS: Autozygosity mapping and exome sequencing identified a novel homozygous ITGB6 transversion mutation in exon 4 (c.517G>C,
Integrinβ6-targeted immunoliposomes mediate tumor-specific drug delivery and enhance therapeutic efficacy in colon carcinoma.
New
Niu et al., Jinan, China. In Clin Cancer Res, Apr 2015
Integrinβ6 (ITGB6) is expressed in malignant colonic epithelia, but not in normal epithelia, and is associated with the progression, metastasis, and chemotherapeutic resistance of colon cancer.
Single tube tetraplex PCR based screening of a SNP at exon 14 region of bovine ITGB6 among different Zebu breeds.
New
Sharma et al., Meerut, India. In Meta Gene, Feb 2015
The present study was aimed to screen genetic variation within a SNP (rs136500299) located at exon 14 region of bovine ITGB6 gene among different Zebu cattle breeds.
Cloning and characterization of the human integrin β6 gene promoter.
Deng et al., Xiamen, China. In Plos One, 2014
The integrin β6 (ITGB6) gene, which encodes the limiting subunit of the integrin αvβ6 heterodimer, plays an important role in wound healing and carcinogenesis.
A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure.
Maltecca et al., Raleigh, United States. In Plos One, 2014
Other genes on chromosome 2 were also involved in regulating immune response (IFIH1, LY75, and DPP4), or are themselves regulated in the presence of specific pathogens (ITGB6, NR4A2).
Integrin alphavbeta6 is involved in measles protein-induced airway immune suppression.
GeneRIF
Zang et al., Shenyang, China. In Cytokine, 2012
This study aims to investigate into the mechanism by which measles C protein (MVP)-induced integrin alphavbeta6 contributes the generation of regulatory T cells in the lung.
Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer.
GeneRIF
Yang et al., Beijing, China. In Cancer Immunol Immunother, 2012
Data suggest that colorectal cancer (CRC)-derived integrin alphavbeta6 is involved in the establishment of tumor immune tolerance in local tissues.
Integrin β6-deficient mice show enhanced keratinocyte proliferation and retarded hair follicle regression after depilation.
GeneRIF
Larjava et al., Vancouver, Canada. In J Invest Dermatol, 2012
This study indicated that integrin beta6 has an important inhibitory role in keratinocyte proliferation in both hair follicles and interfollicular epidermis.
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
GeneRIF
Sheppard et al., San Francisco, United States. In J Clin Invest, 2012
These results suggest that intraepithelial activation of TGF-beta by the alphavbeta6 integrin regulates airway responsiveness by modulating mast cell protease expression.
RNA interference characterization of proteins discovered by proteomic analysis of pancreatic cancer reveals function in cell growth and survival.
GeneRIF
Moore et al., Rockville, United States. In Pancreas, 2012
Data indicate that integrin beta6, CD46, tissue factor, and chromosome 14 open reading frame 1 (C14ORF1), were identified as overexpressed on pancreatic cancer cell lines.
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
Impact
Settleman et al., Palo Alto, United States. In Cancer Cell, 2009
Several of these genes encode pharmacologically tractable proteins, such as Syk and Ron kinases and integrin beta6, depletion of which induces epithelial-mesenchymal transformation (EMT) and apoptosis specifically in K-Ras-dependent cells.
Integrin beta4, keratinocytes and papillomavirus infection.
Review
Maksym et al., Warsaw, Poland. In Int J Mol Med, 2006
In human epidermis integrin beta4 associates with integrin beta6.
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.
Impact
GeneRIF
Sheppard et al., San Francisco, United States. In Nature, 2003
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
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