gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Integrin, beta 4

Integrin beta4
beta subunit of integrin alpha6/beta4 which is a cell surface receptor for laminin; involved in hemidesmosome formation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: beta-4, CAN, HAD, cytokeratin, ACID
Papers on Integrin beta4
TiO2 nanotube stimulate chondrogenic differentiation of limb mesenchymal cells by modulating focal activity.
Jin et al., Iksan, South Korea. In Exp Mol Med, 2011
Surfaces bearing nanotubes of 70 to 100 nm in diameter were found to trigger the morphological transition to a cortical actin pattern and rounded cell shape (both indicative of chondrocytic differentiation), as well as the up-regulation of type II collagen and integrin beta4 protein expression through the down-regulation of Erk activity.
Temporal expression pattern of adhesion genes in human oral mucosal keratinocytes on type IV collagen-coated titanium.
Tachikawa et al., Tokyo, Japan. In J Biomed Mater Res A, 2010
Real-time PCR was performed with four primers: gene laminin beta3, integrin beta4, integrin alpha1, and integrin alpha3.
ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4.
Lyle et al., Worcester, United States. In Oncogene, 2010
Large-scale genetic analyses of human tumor samples have been used to identify novel oncogenes, tumor suppressors and prognostic factors, but the functions and molecular interactions of many individual genes have not been determined.
Integrin beta4 was downregulated on the airway epithelia of asthma patients.
Qin et al., Changsha, China. In Acta Biochim Biophys Sin (shanghai), 2010
Our previous work showed that there were three variation sites in 5' flanking region of integrin beta4 in asthma patients, which was correlated with decreased expression of integrin beta4 in peripheral leukocytes.
Involvement of integrin beta4 in ozone stress-induced airway hyperresponsiveness.
GeneRIF
Qin et al., Changsha, China. In Biochem Biophys Res Commun, 2010
this study suggests that downregulation of integrin beta4 is important for the development ozone stress-induced airway hyperresponsiveness, presumably because it causes increased oxidative damage and epithelial apoptosis.
Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses.
Jacobson et al., Chicago, United States. In J Cell Biochem, 2010
We previously identified the marked upregulation of integrin beta4 in human lung endothelial cells (EC) treated with simvastatin, an HMG coA-reductase inhibitor with vascular-protective and anti-inflammatory properties in murine models of acute lung injury (ALI).
A novel copper complex of salicylaldehyde pyrazole hydrazone induces apoptosis through up-regulating integrin beta4 in H322 lung carcinoma cells.
Miao et al., Jinan, China. In Eur J Med Chem, 2010
Immunofluorescence and Western blot analyses showed an elevated protein level of integrin beta4 upon Cu-16 treatment, and knockdown of integrin beta4 significantly inhibited Cu-16 induced apoptosis in H322 cells.
Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells.
Ho et al., Cincinnati, United States. In Plos One, 2009
Western blot analysis validated a subset of targets related to disease development (proliferating cell nuclear antigen, maspin, integrin beta4, alpha-catenin, karyopherin [importin] beta1, and elongation factor 1A1).
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.
Impact
Waksman et al., France. In Lancet, 2009
Expression levels of genes encoding keratin 14, keratin 5, integrin alpha6, integrin beta4, collagen VII, and laminin 5 in these cells were similar to those in basal keratinocytes.
c-Jun, krox-20, and integrin beta4 expression following chronic nerve compression injury.
GeneRIF
Gupta et al., Irvine, United States. In Neurosci Lett, 2009
changes in transcription factor, c-Jun and krox-20, and integrin beta4 expression are temporally correlated with the process of demyelination, suggesting roles in regulating the myelin response to CNC injury
Advances and perspectives of the architecture of hemidesmosomes: lessons from structural biology.
Review
Sonnenberg et al., Salamanca, Spain. In Cell Adh Migr, 2009
Here we summarize the current knowledge of the structure of hemidesmosomal proteins, which includes the structures of the first and second fibronectin type III (FnIII) domains and the calx-beta domain of the integrin beta4 subunit, the actin binding domain of plectin, and two non-overlapping pairs of spectrin repeats of plectin and BPAG1e.
Electrical fields in wound healing-An overriding signal that directs cell migration.
Review
Zhao, Davis, United States. In Semin Cell Dev Biol, 2009
Genetic manipulation of PI3 kinase/Pten (Phosphoinositide 3-kinases/phosphatase and tensin homolog) and integrin beta4 demonstrated the importance of those molecules.
Targeting integrin beta4 for cancer and anti-angiogenic therapy.
Review
Giancotti, New York City, United States. In Trends Pharmacol Sci, 2007
Integrin beta4 is a laminin receptor upregulated in tumor cells and angiogenic endothelial cells.
Integrin beta4, keratinocytes and papillomavirus infection.
Review
Maksym et al., Warsaw, Poland. In Int J Mol Med, 2006
Integrin beta4 is a transmembrane protein expressed predominantly on epithelial cells.
Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.
GeneRIF
Notterpek et al., Gainesville, United States. In J Neurosci, 2006
During early stages of myelination, PMP22 and beta4 integrin are coexpressed at the DRG cell surface and can be coimmunoprecipitated together with laminin and alpha6 integrin.
Integrin beta4 signaling promotes tumor angiogenesis.
Impact
Giancotti et al., New York City, United States. In Cancer Cell, 2004
Mice carrying a targeted deletion of the signaling portion of the integrin beta4 subunit display drastically reduced angiogenesis in response to bFGF in the Matrigel plug assay and to hypoxia in the retinal neovascularization model.
Crucial role of the specificity-determining loop of the integrin beta4 subunit in the binding of cells to laminin-5 and outside-in signal transduction.
GeneRIF
Jones et al., Chicago, United States. In J Biol Chem, 2003
the SDL segment of the beta4 integrin subunit is required for ligand binding and is involved in outside-in signaling
share on facebooktweetadd +1mail to friends