New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells.
Saint Louis, United States. In J Cell Physiol, 2011
The proteins that were overexpressed are cancer inhibitors (NME, DRG1, IL10), enhancers (SOD2, FAK, IL17, and CREB), and proteins that suppress cancer progression in cells of some cancers and promote it in others (FUT1, integrin beta3, serpin E1, TIAM1, and claudin 4).
Foxc2 transcription factor: a newly described regulator of angiogenesis.
Nashville, United States. In Trends Cardiovasc Med, 2008
Importantly, recent studies demonstrate that Forkhead transcription factor Foxc2 directly regulates expression of various genes involved in angiogenesis, CXCR4, integrin beta3, Delta-like 4 (Dll4), and angiopoietin 2, thereby controlling angiogenic processes.
Structural basis of integrin activation by talin.
Oxford, United Kingdom. In Cell, 2007
Here we define the structure of a complex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific contacts between talin and the integrin tail required for activation.
Genetic factors underlying differential blood platelet sensitivity to inhibitors.
Łódź, Poland. In Pharmacol Rep, 2005
In spite of some discrepancies between different studies, there is substantial evidence that the integrin beta3 P1(A2) allele, the variants GPIbalpha Met145 and GPIbalpha (-5C) haplotype or the integrin alpha2 haplotype 1 (807T) each contribute to the risk for and morbidity of thrombotic disease.