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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin, beta 7

integrin beta 7, ITGB7, integrin beta 7 subunit
Top mentioned proteins: HAD, CAN, ACID, MAdCAM-1, CD4
Papers using integrin beta 7 antibodies
Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.
Baltz Jay M., In PLoS ONE, 1991
... (Developmental Studies Hybridoma Bank, University of Iowa); anti-ITGB7 rat monoclonal antibody FIB27 [87] (Pharmingen/BD Biosciences); anti-ITGB7 rat monoclonal antibody ...
Papers on integrin beta 7
The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival.
Anderson et al., Boston, United States. In Nat Commun, Dec 2015
Importantly, silencing of KDM3A, KLF2 or IRF4 both decreases MM cell adhesion to bone marrow stromal cells and reduces MM cell homing to the bone marrow, in association with decreased ITGB7 expression in MAF-translocated MM cell lines.
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach.
Ancuta et al., Montréal, Canada. In Retrovirology, 2014
A meta-analysis using the NCBI HIV Interaction Database revealed a set of Th17-specific HIV dependency factors (HDFs): PARG, PAK2, KLF2, ITGB7, PTEN, ATG16L1, Alix/AIP1/PDCD6IP, LGALS3, JAK1, TRIM8, MALT1, FOXO3, ARNTL/BMAL1, ABCB1/MDR1, TNFSF13B/BAFF, and CDKN1B.
A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations.
Wallace et al., Cambridge, United Kingdom. In Genet Epidemiol, 2014
Support, including replication evidence, was obtained for nine T1D associated variants in genes ITGB7 (rs11170466, P=7.86×10-9), NRP1 (rs722988, 4.88×10-8), BAD (rs694739, 2.37×10-7), CTSB (rs1296023, 2.79×10-7), FYN (rs11964650, P=5.60×10-7), UBE2G1 (rs9906760, 5.08×10-7), MAP3K14 (rs17759555, 9.67×10-7), ITGB1 (rs1557150, 1.93×10-6), and IL7R (rs1445898, 2.76×10-6).
Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations.
Gribben et al., London, United Kingdom. In Blood, 2014
Here, we demonstrate that circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b, CD18, CD29, and ITGB7, and the adhesion molecule CD323.
Modulation of gut-specific mechanisms by chronic δ(9)-tetrahydrocannabinol administration in male rhesus macaques infected with simian immunodeficiency virus: a systems biology analysis.
Birke et al., New Orleans, United States. In Aids Res Hum Retroviruses, 2014
Duodenal tissue samples excised from chronic THC- (N=4) and vehicle (VEH)-treated (N=4) subjects at ∼5 months postinoculation showed lower viral load, increased duodenal integrin beta 7(+)(β7) CD4(+) and CD8(+) central memory T cells, and a significant preferential increase in Th2 cytokine expression.
Conservation of the α4β7 lymphocyte homing receptor in HIV-infected patients with distinct transmission routes and disease progression profiles.
Soares et al., Rio de Janeiro, Brazil. In Aids Res Hum Retroviruses, 2014
Subjects displaying distinct categories of disease progression or transmission routes (HIV-positive adults, vertically infected infants, and seronegative subjects) had their ITGA4 and ITGB7 gene segments corresponding to virus binding sites and C-terminal domains PCR amplified and sequenced.
Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells.
Corbí et al., Madrid, Spain. In Blood, 2013
In addition, ERK upregulated CCL2 expression while impairing the expression of DC maturation markers (RUNX3, ITGB7, IDO1).
Expression of adhesion, attachment and invasion markers in eutopic and ectopic endometrium: a link to the aetiology of endometriosis.
Lalitkumar et al., Stockholm, Sweden. In Hum Reprod, 2012
Expression of apolipoprotein E (ApoE), integrin β-2 (ITGB2), integrin β-7 (ITGB7), Laminin γ-1 (LAMC1), CD24 molecule (CD24) and junctional adhesion molecule-1 (JAM-1) was evaluated with real-time reverse transcriptase polymerase chain reaction and immunohistochemistry. RESULTS: The endometrium from controls and women with endometriosis expressed ApoE, ITGB2, ITGB7, LAMC1, CD24 and JAM-1.
β7 integrin controls immunogenic and tolerogenic mucosal B cell responses.
Wagner et al., Aachen, Germany. In Clin Immunol, 2012
beta7 integrin expression on cells of the innate immune system contributes to the critical role of beta7 integrin in the process of B cell tolerance.
The α4β7 integrin binds HIV envelope but does not mediate bystander killing of γδ T cells.
Pauza et al., In Blood, 2012
Integrin alpha4beta7 binds gp120 but does not mediate HIV envelope-induced death signaling.
A proteomic approach to investigate the distribution and abundance of surface and internal Fasciola hepatica proteins during the chronic stage of natural liver fluke infection in cattle.
Baykal et al., Kocaeli, Turkey. In J Proteome Res, 2012
Potentially novel F. hepatica proteins showing homology with AKT interacting protein (Xenopus tropicalis), sterol O-acyltransferase 2 (Homo sapiens), and integrin beta 7 (Mus musculus) were identified with high quantities in only the surface fraction of the parasite and may be possible candidates for future control strategies.
PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS).
Robinson et al., Vancouver, Canada. In Pregnancy Hypertens, 2012
dNK but not dNK-CM reduced IL18 methylation and increased methylation on ITGAL (integrin, alpha L) and ITGB7.
Identification, characterization, and epitope mapping of human monoclonal antibody J19 that specifically recognizes activated integrin α4β7.
Chen et al., Shanghai, China. In J Biol Chem, 2012
Data suggest that monoclonal antibody J19 is a potentially powerful tool for both studies on alpha(4)beta(7) activation mechanism and development of novel therapeutics targeting the activated lymphocyte expressing high affinity alpha(4)beta(7).
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
Stossel et al., Boston, United States. In Nature, 2011
Consistent with structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP to dissociate from FLNA, providing a direct and specific molecular basis for cellular mechanotransduction
Role for E-cadherin as an inhibitory receptor on epidermal gammadelta T cells.
Kanekura et al., Kagoshima, Japan. In J Immunol, 2011
E-cadherin and alpha(E)beta(7) integrin on dendritic epidermal T cells regulate their activation threshold through binding to E-cadherin on keratinocytes
New markers for minimal residual disease detection in acute lymphoblastic leukemia.
Campana et al., Memphis, United States. In Blood, 2011
Of the 30 markers, 22 (CD44, BCL2, HSPB1, CD73, CD24, CD123, CD72, CD86, CD200, CD79b, CD164, CD304, CD97, CD102, CD99, CD300a, CD130, PBX1, CTNNA1, ITGB7, CD69, CD49f) were differentially expressed in up to 81.4% of ALL cases; expression of some markers was associated with the presence of genetic abnormalities.
Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.
Bahlis et al., Calgary, Canada. In Blood, 2011
a role for integrin-beta7 in MM-cell adhesion, migration, and BM homing, and pave the way for a novel therapeutic approach targeting this molecule.
Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin.
Ruiz et al., São Paulo, Brazil. In Toxicon, 2011
However, jararhagin 30ng/μl upregulated genes TP53, CDKN1A, CDKN2A, CASP3, CASP5, CASP6, CASP8, and E-CDH in SK-Mel-28, and genes ITGB6, ITGB7, CASP3, TP53, and CDKN1B in fibroblasts.
ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization.
Evans et al., Baltimore, United States. In Plos One, 2009
Antibody and siRNA studies demonstrate that ITGB7 is the β subunit contributing to RPMI 8866 adhesion to ADAM2.
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
Staudt et al., Bethesda, United States. In Cancer Cell, 2004
By gene expression profiling, we identified three c-maf target genes: cyclin D2, integrin beta7, and CCR1.
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