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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin alpha 8

integrin alpha8, ITGA8
Top mentioned proteins: fibronectin, CAN, POLYMERASE, ADAMTS, Tenascin
Papers on integrin alpha8
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.
New
Shynlova et al., Toronto, Canada. In Reprod Sci, Feb 2016
increased transcript levels of collagen VII, multiple matrix metalloproteinases (MMP3, MMP7, MMP10, MMP12, MMP13, and MMP14), integrins (ITGA1, ITGA4, ITGA6, ITGA8, ITGB1, ITGB2, and ITGB3), and cell adhesion molecules as compared to control-HVCs.
ITGA2B and ITGA8 are predictive of prognosis in clear cell renal cell carcinoma patients.
New
Ye et al., Shanghai, China. In Tumour Biol, Aug 2015
In the TCGA cohort, after Cox proportional hazards analysis, ITGA2B (hazards ratio (HR) = 1.232, 95 % CI 1.097 to 1.383) and ITGA8 (HR = 0.804, 95 % CI 0.696 to 0.930) were shown predictive of ccRCC prognosis.
Identification of diagnostic markers in colorectal cancer via integrative epigenomics and genomics data.
New
Jamal et al., Kuala Lumpur, Malaysia. In Oncol Rep, Jul 2015
The most enriched molecular pathway identified was cell adhesion molecules that involved 4 overlapped genes, JAM2, NCAM1, ITGA8 and CNTN1.
Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.
Hildebrandt et al., Kao-hsiung, Taiwan. In J Am Soc Nephrol, 2014
In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.
Progesterone receptor-dependent regulation of genes in the oviducts of female mice.
Robker et al., Adelaide, Australia. In Physiol Genomics, 2014
Eight genes were confirmed to be downregulated (Adamts1, Itga8, Edn3, Prlr, Ptgfr, Des, Myocd, and Actg2) and one upregulated (Agtr2) in PGR null oviducts.
Analysis of non-synonymous-coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations.
Liu et al., Singapore, Singapore. In Hum Mol Genet, 2014
Moderate enrichment was also observed in FGF20, MCCC1, GBA and ITGA8.
Contribution of the α8 integrin chain to the expression of extracellular matrix components.
Marek et al., Erlangen, Germany. In Cell Commun Adhes, 2014
In the kidney, the α8 integrin chain (itga8) is expressed in mesenchymal cells and is upregulated in fibrotic disease.
Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans.
Jeanpierre et al., Paris, France. In Am J Hum Genet, 2014
By using a whole-exome sequencing approach in families with several fetuses with bilateral renal agenesis, we identified recessive mutations in the integrin α8-encoding gene ITGA8 in two families.
Effect of TiO2 scaffolds coated with alginate hydrogel containing a proline-rich peptide on osteoblast growth and differentiation in vitro.
Monjo et al., Palma, Spain. In J Biomed Mater Res A, 2013
Moreover, increased gene expression of integrin alpha8, bone morphogenetic protein 2, interleukin-6, and collagen-I was found on P2 alginate-coated TiO2 SC compared to alginate-coated TiO2 SC.
Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion molecules.
Giuliani et al., Parma, Italy. In Exp Hematol, 2013
We further investigated the effect of these drugs on the transcriptional profile of both MM cells and PreOBs by microarray analysis, which showed that adhesion molecules, such as ITGA8 and ICAM2, are significantly downregulated in MM cells.
Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle.
Miano et al., Rochester, United States. In Gene, 2013
Here, we analyzed the expression and promoter of a highly restricted integrin gene, Itga8.
A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients.
Hishimoto et al., Kōbe, Japan. In Prog Neuropsychopharmacol Biol Psychiatry, 2013
RESULTS: Genotypic and allelic distributions of rs2298033 in the ITGA8 gene between the schizophrenia and control groups were significantly different in the first batch (p=0.005 and 0.007, respectively).
Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.
GeneRIF
Sekiguchi et al., Suita, Japan. In J Cell Biol, 2012
The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome.
Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy.
GeneRIF
Hilgers et al., Erlangen, Germany. In Am J Physiol Renal Physiol, 2010
alpha8-integrin is protective for the structure and function of the glomerulus and maintains podocyte integrity during the development of diabetic nephropathy
Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells.
GeneRIF
Beaulieu et al., Sherbrooke, Canada. In Biochem Biophys Res Commun, 2010
alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance.
[Expression and significance of integrins subunits in laryngeal squamous cell carcinoma].
GeneRIF
Gao et al., Nanjing, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2010
The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues.
Lack of α8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells.
GeneRIF
Hartner et al., Erlangen, Germany. In Bmc Cell Biol, 2009
Lack of alpha8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells.
Mystery solved: discovery of a novel integrin ligand in the developing kidney.
Review
Miner, Saint Louis, United States. In J Cell Biol, 2001
Mutant mice lacking the integrin alpha8 subunit exhibit variable defects in kidney development with most mutants missing both kidneys.
Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1.
Impact
Müller et al., Basel, Switzerland. In Nat Genet, 2000
In mice homozygous for a targeted mutation of Itga8 (encoding the alphabeta8 subunit), this co-localization is perturbed and hair cells in the utricle, a vestibular subcompartment, lack stereocilia or contain malformed stereocilia.
Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis.
Impact
Reichardt et al., San Francisco, United States. In Cell, 1997
Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis.
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