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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin, alpha 6

Integrin alpha6, VLA-6, CD49f
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, VLA-4, fibronectin, CD44, Integrin alpha2
Papers using Integrin alpha6 antibodies
Caveolin-1 is not essential for biosynthetic apical membrane transport.
Supplier
Du Quansheng, In PLoS ONE, 2004
Rabbit anti-cleaved caspase-3 was ...
Papers on Integrin alpha6
Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities.
New
Russo et al., Philadelphia, United States. In Cancer Med, Feb 2016
The two new cell lines exhibited CD44(+) /CD49f(+) and CD44(+) /EpCAM(+) cancer stem cell (CSC) characteristics, and the EGF-like domain of EpCAM was cleaved off.
Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway.
New
Kondo et al., Sapporo, Japan. In Cancer Res, Feb 2016
Eva1 was prominently expressed in GICs in vitro and in stem cell marker (Sox2, CD15, CD49f)-expressing cells derived from human GBM tissues.
Tumor suppressor control of the cancer stem cell niche.
New
Crowe et al., Chicago, United States. In Oncogene, Jan 2016
Loss of PPARγ expression reduced tumor latency, and expanded the CD24+/CD49f(hi) MSC population.
[EPCAM-positive normal hepatic progenitor cells transformation into liver stem cells and HBx-mediated effects on stability in adult mouse].
New
He et al., Chongqing, China. In Zhonghua Gan Zang Bing Za Zhi, Dec 2015
METHODS: Hepatic progenitor cells were obtained from mice by means of an optimized two-step digestion and perfusion method followed by joint differential centrifugation and density gradient centrifugation.Transformation of the hepatic progenitor cells into liver stem cells was observed by immunofluorescent detection of CD 133, EPCAM, CD49f and CK19.Differentiation of the resultant liver stem cells into hepatic cells and bile duct epithelial cells was observed after DMSO addition by Periodic Acid-Schiff (PAS) staining followed by cell immunofluorescence and flow cytometry.To determine the effects of HBx on these liver stem cells' ability to differentiate into hepatic cells, cell transfection was used followed by observation of morphology and proliferation capacity.
Targeting cancer stem cells in solid tumors by vitamin D.
Review
New
Suh et al., United States. In J Steroid Biochem Mol Biol, Apr 2015
A single or combination of various markers, such as CD44, EpCAM, CD49f, CD133, CXCR4, ALDH-1, and CD24, were utilized to isolate CSCs from various types of human cancers.
EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer.
Disseminated Cancer Cell Network (DCC Net) Duesseldorf et al., Düsseldorf, Germany. In Plos One, 2014
The expression of respective proteins (Trop2, CD49f, c-Met, CK8, CD44, ADAM8, CD146, TEM8, CD47) was verified by immunofluorescence on EpCAMpos (e.g.
[Prostate stem cells: an update].
Review
Yi et al., In Zhonghua Nan Ke Xue, 2014
The markers of the epithelial stem cells include cytokeratin, stem cell antigen-1, and integrins alpha2beta1, CD49f, CD133, CD117, and CD44.
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1.
Impact
Karin et al., San Diego, United States. In Cancer Cell, 2013
Here, we show that IKKα and its activator, NF-κB-inducing kinase (NIK), support the expansion of tumor-initiating cells (TICs) that copurify with a CD24(med)CD49f(hi) population from premalignant ErbB2-expressing mammary glands.
Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game?
Review
Morris et al., Austin, United States. In Exp Dermatol, 2012
What we find surprising is that the CD49f(+) /CD34(+) hair follicle stem cells should have an enriched expression profile of so many genes involved in innate immunity.
Inhibition of integrin α6 expression by cell-free varicella-zoster virus.
GeneRIF
Abendroth et al., Westmead, Australia. In J Gen Virol, 2012
This study identifies modulation of ITGA6 during cell-free varicella-zoster virus (VZV) infection, and provides the first evidence linking ITGA6 with post-entry productive VZV gene expression.
Tie2-dependent knockout of α6 integrin subunit in mice reduces post-ischaemic angiogenesis.
GeneRIF
Helley et al., Paris, France. In Cardiovasc Res, 2012
alpha6 plays a major role in both post-ischaemic angiogenesis and vasculogenesis.
Mammary gland stem cells: more puzzles than explanations.
Review
Kumar et al., Hyderābād, India. In J Biosci, 2012
At present, Lin (-) CD29 (i) CD49f (i) CD24 (+/mod) Sca- 1 (-) cells of the mammary gland have been reported to be enriched with MaSCs.
α6β4 integrin, a master regulator of expression of integrins in human keratinocytes.
GeneRIF
Jones et al., Chicago, United States. In J Biol Chem, 2012
data indicate that the alpha6beta4 integrin is a master regulator of transcription and translation of other integrin subunits and underscore its pivotal role in wound healing and cancer
Epidermal α6β4 integrin stimulates the influx of immunosuppressive cells during skin tumor promotion.
GeneRIF
Owens et al., New York City, United States. In J Dermatol Sci, 2012
aberrant expression of alpha6beta4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment
The androgen receptor and stem cell pathways in prostate and bladder cancers (review).
Review
Mongan et al., New York City, United States. In Int J Oncol, 2012
We highlight key proteins (CD49f, CD133, PTEN, CD44) which are implicated in both prostate and bladder cancers and are enriched in putative prostate and bladder cancer stem cells.
Epcam, CD44, and CD49f distinguish sphere-forming human prostate basal cells from a subpopulation with predominant tubule initiation capability.
GeneRIF
Garraway et al., Los Angeles, United States. In Plos One, 2011
Epcam+CD44-CD49fHi (non-sphere-forming) basal cells with significantly increased tubule induction activity compared to Epcam+CD44-CD49fLo (true) luminal cells.
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.
Impact
Dick et al., Toronto, Canada. In Science, 2011
By tracking the expression of several adhesion molecules in HSC-enriched subsets, we revealed CD49f as a specific HSC marker.
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Impact
Penninger et al., Vienna, Austria. In Nature, 2010
Genetic inactivation of the RANKL receptor RANK in mammary-gland epithelial cells prevents MPA-induced epithelial proliferation, impairs expansion of the CD49f(hi) stem-cell-enriched population, and sensitizes these cells to DNA-damage-induced cell death.
Integrin alpha 6: anchors away for glioma stem cells.
Impact
Martin-Villalba et al., Heidelberg, Germany. In Cell Stem Cell, 2010
In this issue of Cell Stem Cell, Lathia et al. (2010) show that glioblastoma stem cells highly express integrin alpha6 and that their interaction with laminin on endothelial cells directly regulates their tumorigenic capacity.
Integrin alpha 6 regulates glioblastoma stem cells.
Impact
GeneRIF
Rich et al., Cleveland, United States. In Cell Stem Cell, 2010
Glioblastoma stem cell express high levels of integrin alpha6.
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