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Integrin, alpha 3

Integrin alpha3, CD49c
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: fibronectin, CAN, Intercellular Adhesion Molecule-1, VLA-4, HAD
Papers on Integrin alpha3
Markers for Distinguishing Cultured Human Corneal Endothelial Cells from Corneal Stromal Myofibroblasts.
New
Yamagami et al., Kōbe, Japan. In Curr Eye Res, Dec 2015
RESULTS: Among the genes identified by microarray analysis, cultured human CECs, but not CSMFs, expressed integrin alpha 3 (ITGA3 and CD49c) protein according to immunocytochemistry and western blotting.
Data supporting chitosan facilitates structure formation of the salivary gland by regulating the basement membrane components.
New
Yang et al., Taipei, Taiwan. In Data Brief, Sep 2015
Immunofluorescence revealed that the corresponding receptors for BM components, including CD49c, CD49f, CD29, and dystroglycan, were locally enriched at the epithelial-mesenchymal junction around BM areas.
High-Throughput Screening of Surface Marker Expression on Undifferentiated and Differentiated Human Adipose-Derived Stromal Cells.
New
Longaker et al., Stanford, United States. In Tissue Eng Part A, Aug 2015
Osteogenic differentiation induced upregulation of CD164 and downregulation of CD49a, CD49b, CD49c, CD49d, CD55, CD58, CD105, and CD166 while adipogenic differentiation induced upregulation of CD36, CD40, CD146, CD164, and CD271 and downregulation of CD49b, CD49c, CD49d, CD71, CD105, and CD166.
Claudin-7 promotes the epithelial-mesenchymal transition in human colorectal cancer.
New
Thuma et al., Heidelberg, Germany. In Oncotarget, Mar 2015
In line with this, migratory and invasive potential of cld7kd clones is strongly impaired, migration being inhibited by anti-CD49c, but not anti-EpCAM, although motility is reduced in EpCAM siRNA-treated cells.
Passage-dependent relationship between mesenchymal stem cell mobilization and chondrogenic potential.
New
Hung et al., New York City, United States. In Osteoarthritis Cartilage, Feb 2015
METHODS: Over four passages of SDSCs, we measured the expression of cell surface markers (CD31, CD34, CD49c, CD73) and assessed their migratory potential in response to applied direct current (DC) electric field.
Modifications in integrin expression and extracellular matrix composition in children with biliary atresia.
Auth et al., Liverpool, United Kingdom. In Klin Padiatr, 2015
Conversely, integrin alpha 3 was increased in BA vs. NLA and CLD (p<0.05).
Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent.
Kim et al., Amsterdam, Netherlands. In Blood, 2015
In this study, we report that integrin α3β1 (VLA-3; CD49c/CD29) is dramatically upregulated on neutrophils isolated from both human septic patients and in mouse models of sepsis.
Expression of CD151/Tspan24 and integrin alpha 3 complex in aid of prognostication of HER2-negative high-grade ductal carcinoma in situ.
Kordek et al., Poland. In Int J Clin Exp Pathol, 2014
The pro-tumorigenic and pro-metastatic functions of the tetraspanin protein CD151 (Tspan24) are thought to be dependent on its ability to form complexes with laminin-binding integrin receptors (i.e.
Role of magnesium ions on osteogenic response in bone marrow stromal cells.
Sfeir et al., Oral, Kazakhstan. In Connect Tissue Res, 2014
Quantitative PCR array data indicated increased mRNA expression of collagen type X and insulin-like growth factor 2, and decreased expression of integrin alpha 3 in the presence of 10 mM MgSO4.
Integrin α3 mutations with kidney, lung, and skin disease.
Impact
GeneRIF
Laube et al., Freiburg, Germany. In N Engl J Med, 2012
We identified three patients with homozygous mutations in the integrin alpha(3) gene that were associated with disrupted basement-membrane structures and compromised barrier functions in kidney, lung, and skin.
Fibroblast expression of α-smooth muscle actin, α2β1 integrin and αvβ3 integrin: influence of surface rigidity.
GeneRIF
Ehrlich et al., United States. In Exp Mol Pathol, 2011
With increased tension cytoskeletal stress fibers develop that contain alphaSMA and alphavbeta3 integrin that replaces alpha2beta1 integrin, consistent with cell switching from collagen to non-collagen proteins interactions.
α3β1 integrin promotes radiation-induced migration of meningioma cells.
GeneRIF
Rao et al., Peoria, United States. In Int J Oncol, 2011
radiation treatment enhances the migration of meningioma cells with the involvement of alpha3beta1 integrin-mediated signaling via FAK and ERK.
Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors.
GeneRIF
Patarroyo et al., Stockholm, Sweden. In Exp Cell Res, 2011
Data suggest that the alpha5 laminins emerge as putative primary extracellular matrix mediators of melanoma invasion and metastasis via alpha3/alpha6beta1 and other integrin receptors.
Lack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample.
GeneRIF
Anney et al., Dublin, Ireland. In Autism Res, 2010
Studies have shown that ITGA3 plays a key role during cortical development, involved in neuronal migration and placement, as well as cortical layering
The Muscleblind family of proteins: an emerging class of regulators of developmentally programmed alternative splicing.
Review
Artero et al., Valencia, Spain. In Differentiation, 2006
MBNL2, on the other hand, participates in a new RNA-dependent protein localization mechanism involving recruitment of integrin alpha3 protein to focal adhesions.
RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1.
Impact
GeneRIF
Hsu et al., Charleston, United States. In Nat Cell Biol, 2005
localized expression of the integrin alpha3 protein is regulated at the level of RNA localization by MBNL1; integrin alpha3 transcripts are physically associated with MLP1 in cells and MLP1 binds to a specific ACACCC motif in the integrin alpha3 3' UTR
Neuronal migration.
Review
Goffinet et al., Namur, Belgium. In Mech Dev, 2001
Other known components of the pathway include members of the lipoprotein receptor family, the intracellular adaptor Dab1, and possibly integrin alpha 3 beta 1. Defective Reelin leads to poor lamination and, in humans, to a lissencephaly phenotype different from type 1 lissencephaly.
Function of fusion regulatory proteins (FRPs) in immune cells and virus-infected cells.
Review
Ito et al., Tsu, Japan. In Crit Rev Immunol, 1999
FRP-1 heavy chain is identical to 4F2/CD98 heavy chain, whereas FRP-2 is identical to integrin alpha3 subunit.
Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung.
Impact
Miyake et al., Ōsaka, Japan. In J Clin Oncol, 1998
PURPOSE: We investigated the possible association between integrin alpha3 and motility-related protein (MRP-1), cluster of differentiation antigen 9 (CD9) gene expression in non-small-cell lung cancer (NSCLC) and evaluated the prognostic significance of integrin alpha3 expression.
Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes.
Impact
Gahr et al., Seattle, United States. In Cell, 1991
Epiligrin is a new glycoprotein in most epithelial basement membranes (BMs) and is a ligand for cell adhesion via integrin alpha 3 beta 1.
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