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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin, alpha 1

Integrin alpha, VLA-1, Integrin alpha1, CD49a
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibronectin, Integrin alpha2, Alpha-1, HAD
Papers on Integrin alpha
Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation.
New
Kaplan et al., Minneapolis, United States. In J Immunol, Oct 2015
CXCR6(+)CD49a(+) NK cells are a liver-resident subset that can mediate inflammatory skin responses.
High-Throughput Screening of Surface Marker Expression on Undifferentiated and Differentiated Human Adipose-Derived Stromal Cells.
New
Longaker et al., Stanford, United States. In Tissue Eng Part A, Aug 2015
Osteogenic differentiation induced upregulation of CD164 and downregulation of CD49a, CD49b, CD49c, CD49d, CD55, CD58, CD105, and CD166 while adipogenic differentiation induced upregulation of CD36, CD40, CD146, CD164, and CD271 and downregulation of CD49b, CD49c, CD49d, CD71, CD105, and CD166.
Comparative characterization of stem cell marker expression, metabolic activity and resistance to doxorubicin in adherent and spheroid cells derived from the canine prostate adenocarcinoma cell line CT1258.
New
Murua Escobar et al., Rostock, Germany. In Anticancer Res, Apr 2015
RESULTS: Integrin alpha-6 (ITGA6) expression and metabolic activity were significantly up-regulated in CT1258-derived spheroid cells, while doxorubicin resistance remained comparable.
The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
New
Wang et al., Shanghai, China. In Plos Pathog, Apr 2015
H5N1 or H1N1), lung infiltrating ADAP-/- CD8+ T cells significantly reduced the expression levels of TGF-β1, CD103 and VLA-1.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
New
Impact
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
Liver-specific adhesion molecules CXCR6 and CD49a have been identified as surface markers in mice.
GPI-80 defines self-renewal ability in hematopoietic stem cells during human development.
New
Impact
Mikkola et al., Los Angeles, United States. In Cell Stem Cell, Feb 2015
GPI-80 colocalized on the surface of HSPCs with Integrin alpha-M (ITGAM), which in leukocytes cooperates with GPI-80 to support migration.
Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells.
Khoury et al., Santiago, Chile. In Stem Cell Res Ther, 2014
RESULTS: The phenotypic analysis of MenSCs revealed a profile largely similar to the BM-MSCs with the exception of a higher expression of the adhesion molecule CD49a (alpha1-integrin).
Impact of common variation in bone-related genes on type 2 diabetes and related traits.
GeneRIF
Florez et al., Boston, United States. In Diabetes, 2012
we have identified a new locus candidate, ITGA1, influencing both fasting glucose and BMD, that may begin to explain the genetic contribution to the epidemiological observations linking type 2 diabetes and osteoporosis
Integrin α1/β1 and α2/β1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy.
GeneRIF
Narita et al., Niigata, Japan. In Int Immunol, 2012
study identified integrin alpha1/beta1 and alpha2/beta1 heterodimer as a new candidate IgA1 receptor in human mesangial cells
Human fallopian tube epithelium constitutively expresses integrin endometrial receptivity markers: no evidence for a tubal implantation window.
GeneRIF
Horne et al., Edinburgh, United Kingdom. In Mol Hum Reprod, 2012
There was no evidence for differences in integrin alpha1, alpha4, beta1 and beta3 protein levels between the follicular and mid-luteal staged samples.
Structure of collagen receptor integrin α(1)I domain carrying the activating mutation E317A.
GeneRIF
Salminen et al., Turku, Finland. In J Biol Chem, 2012
study characterized the collagen binding properties of an activated variant of the alpha1I domain, harboring a gain-of-function mutation E317A; the activated alpha(1)I domain represents a novel conformation of the alphaI domain, mimicking the structural state where the Arg(287)-Glu(317) ion pair has just broken during the integrin activation
The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrins.
GeneRIF
Springer et al., Boston, United States. In J Biol Chem, 2012
the C-linker has a role as a spring-like element that allows relaxation of the alphaI domain in the resting state and controlled tension of the alphaI domain during activation, exerted by the beta chain
Radiolabeled RGD peptides as integrin alpha(v)beta3-targeted PET tracers.
Review
Inoue et al., Yokohama, Japan. In Curr Med Chem, 2011
Of these, the radiolabeled Arg-Gly- Asp (RGD) peptide has been focused because it has high affinity and selectivity for integrin alpha(v)beta3.
Integrin alpha 6 regulates glioblastoma stem cells.
Impact
Rich et al., Cleveland, United States. In Cell Stem Cell, 2010
Cancer stem cells (CSCs) are a subpopulation of tumor cells suggested to be critical for tumor maintenance, metastasis, and therapeutic resistance.
Integrin alpha 6: anchors away for glioma stem cells.
Impact
Martin-Villalba et al., Heidelberg, Germany. In Cell Stem Cell, 2010
The laminin receptor Integrin alpha6beta1 anchors adult neural stem cells to the niche vasculature.
Radiolabeled cyclic RGD peptides as integrin alpha(v)beta(3)-targeted radiotracers: maximizing binding affinity via bivalency.
Review
Liu, West Lafayette, United States. In Bioconjug Chem, 2009
Integrin alpha(v)beta(3) plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence.
Multiple ways to switch platelet integrins on and off.
Review
Heemskerk et al., Maastricht, Netherlands. In J Thromb Haemost, 2008
Integrin alpha(2)beta(1) is found to be activated by a mechanism that is directly linked to alpha(IIb)beta(3) activation.
Platelet integrin alpha(IIb)beta(3): activation mechanisms.
Review
Plow et al., Cleveland, United States. In J Thromb Haemost, 2007
Integrin alpha(IIb)beta(3) plays a critical role in platelet aggregation, a central response in hemostasis and thrombosis.
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.
Impact
GeneRIF
Nestle et al., Zürich, Switzerland. In Nat Med, 2007
results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment
Integrin alpha v beta 3 antagonists for anti-angiogenic cancer treatment.
Review
Chen et al., Stanford, United States. In Recent Pat Anticancer Drug Discov, 2007
Recent advances in the discovery and characterization of CAMs and their receptors, most notably integrin alpha(v)beta(3), and the clarification of their roles in disease states have laid the groundwork for the development and clinical implementation of novel anti-cancer treatments.
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