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Integrator complex subunit 7

Int7, Ints7, integrator complex subunit 7
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: POLYMERASE, DTL, E2F5, Rhino, int-2
Papers on Int7
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells.
Callahan et al., Bethesda, United States. In J Cell Physiol, 2012
Rspo2 was identified as a novel common integration site (CIS) for the mouse mammary tumor virus (MMTV) in viral induced mouse mammary tumors.
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
Impact
Elledge et al., Boston, United States. In Science, 2011
Three DDR candidates, the RNA processing protein INTS7, the circadian transcription factor CLOCK, and a previously uncharacterized protein RHINO, were recruited to sites of DNA damage.
Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study.
Knowles et al., Los Angeles, United States. In Mol Psychiatry, 2011
Two-point FBAT analysis detected association between Int2 (P = 0.0089) and Int7 (P = 0.0187) (genotypic model).
Phenotypic analysis of deflated/Ints7 function in Drosophila development.
Warren et al., Townsville, Australia. In Dev Dyn, 2009
The human orthologue of deflated (Ints7) encodes a subunit of the Integrator complex that associates with RNA polymerase II and has been implicated in snRNA processing.
Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population.
Kim et al., Taegu, South Korea. In Mol Cells, 2008
These four polymorphisms [-51096 G > A (C-399T), -50984A > G (T-287C), + 24999A > G (Int7 -33T > C), + 37339T > A] were genotyped in 474 ONFH patients and 349 control subjects.
Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7.
Yoshida et al., Kawasaki, Japan. In Plos One, 2007
METHODOLOGY/PRINCIPAL FINDINGS: Here we report on the identification of an intergenic region of non-homologous genes, CDT2, a regulator of DNA replication, and an integrator complex subunit 7 (INTS7), an interactor of the largest subunit of RNA polymerase II.
Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines.
Kordon et al., Buenos Aires, Argentina. In J Virol, 2006
In addition, we identified a new viral insertion upstream of the gene Rspo3, which is overexpressed in three of the eight independent tumor lines and codes for a protein very similar to the recently described protein encoded by Int7.
A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences.
Callahan et al., Bethesda, United States. In J Virol, 2005
A novel common integration site for the mouse mammary tumor virus (MMTV) was identified (designated Int7) in five independently arising mouse mammary tumors.
Inhibition of cell attachment, invasion and metastasis of human carcinoma cells by anti-integrin beta 1 subunit antibody.
Hirohashi et al., Tokyo, Japan. In Jpn J Cancer Res, 1992
We investigated the expression of beta 1 integrins in human carcinoma cell lines, and the anti-metastatic and anti-invasive effects of a newly established anti-human beta 1 subunit monoclonal antibody designated NCC-INT-7.
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