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Fibroblast growth factor 3

int-2, Fibroblast Growth Factor 3, FGF3
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Fibroblast Growth Factor 4, erbB-2, c-Myc
Papers on int-2
Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study.
Stephens et al., Albany, United States. In Breast Cancer Res Treat, Feb 2016
Other frequently altered genes of interest in pmucBC were CCND1 and the FGF3/FGF4/FGF19 amplicon (27 %), often co-amplified together.
Retinoic Acid Signaling Mediates Hair Cell Regeneration by Repressing p27kip and sox2 in Supporting Cells.
Alsina et al., Barcelona, Spain. In J Neurosci, Dec 2015
Moreover, in neuromast, RA pathway regulates the transcription of p27(kip) and sox2 in supporting cells but not fgf3.
Hepatocellular Carcinoma in Noncirrhotic Liver with Glycogenotic Foci: Basic Science Meets Genomic Medicine.
Kato et al., New York City, United States. In Semin Liver Dis, Nov 2015
Precision genomic analysis of this tumor disclosed five alterations with amplifications of genes CCNE1, FGF3 and FGF4, MYCL1, and ARID1A.
Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms.
Krężel et al., Madrid, Spain. In J Neurosci, Nov 2015
Reduced expression of Fgf3 in the subventricular zone of the lateral ganglionic eminence (LGE) at embryonic day 13.5 may underlie such deficits by inducing premature differentiation of neuronal progenitors, as illustrated by reduced expression of the proneural gene Ascl1 (Mash1) and increased expression of Meis1, a marker of postmitotic LGE neurons.
Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there?
Cheng et al., Taipei, Taiwan. In World J Gastroenterol, Oct 2015
These studies identified tumor amplification of FGF3/FGF4 or VEGFA and tumor expression of phospho-Mapk14 and phospho-Atf2 as possible predictive markers that await validation.
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
Zucman-Rossi et al., Paris, France. In Nat Genet, May 2015
Analyses according to tumor stage progression identified TERT promoter mutation as an early event, whereas FGF3, FGF4, FGF19 or CCND1 amplification and TP53 and CDKN2A alterations appeared at more advanced stages in aggressive tumors.
A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage.
Tomlinson et al., Oxford, United Kingdom. In Ann Oncol, Apr 2015
Following meta-analysis, significant associations were seen for six tumor variants (mutant TP53 and PIK3CA, copy number gain of ERBB2/HER2, CCND1 and FGF3, and chromosomal instability/ploidy) and seven germline polymorphisms: ERCC1 rs3212986, ERCC2 rs1799793, TP53 rs1042522, MDM2 rs2279744, TYMS rs34743033, ABCB1 rs1045642 and MTHFR rs1801133.
Multidrug-Resistant Escherichia coli Strains Isolated from Patients Are Associated with Class 1 and 2 Integrons.
Mansouri et al., In Chemotherapy, 2014
CONCLUSION: Our results showed that int1 and int2 genes present in E. coli isolates obtained from patients cause MDR in this isolates.
Minimizing risk of hypomethylating agent failure in patients with higher-risk MDS and practical management recommendations.
List et al., Florence, Italy. In Leuk Res, 2014
In Europe, azacitidine is the only hypomethylating agent approved for the treatment of patients with int-2-/high-risk myelodysplastic syndromes, offering significantly improved survival compared with conventional care.
Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors.
Tabernero et al., Boston, United States. In Ann Oncol, 2014
Multikinase FGFR/vascular endothelial growth factor receptor (VEGFR) inhibitors have shown promising activity in breast cancer patients with FGFR1 and/or FGF3 amplification.
The evolving understanding of microRNA in bladder cancer.
Berman et al., Boston, United States. In Urol Oncol, 2014
Generalized down-regulation of miRs, including those that target the fibroblast growth factor 3 pathway, such as miR-145, miR-101, miR-100, and miR-99a, has been observed in low-grade, non-muscle invasive BC.
Conditions that influence the response to Fgf during otic placode induction.
Riley et al., College Station, United States. In Dev Biol, 2012
Activation of hs:fgf3 or hs:fgf8 during late blastula/early gastrula stages (5 hpf or earlier) resulted in complete dorsalization of the embryo
Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle.
Whitfield et al., Sheffield, United Kingdom. In Development, 2011
In lia(-/-) (fgf3(-/-)) mutants, anterior otic character is reduced, but not lost altogether.
Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.
Mansour et al., Salt Lake City, United States. In Dev Biol, 2011
Fgf3 and Fgf10 are not required for specification of cardiovascular progenitors, but rather for their normal developmental coordination.
Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients.
Brewer et al., Houston, United States. In Pediatr Nephrol, 2011
This study is the first to show a significant association between coronary calcification and elevated serum FGF 23 in children.
LAMM syndrome with middle ear dysplasia associated with compound heterozygosity for FGF3 mutations.
Martini et al., Ferrara, Italy. In Am J Med Genet A, 2011
confirm the absence of otodental syndrome in heterozygous FGF3 carriers, but report unilateral microtia in one of them
FGF-dependent mechanosensory organ patterning in zebrafish.
Raible et al., Seattle, United States. In Science, 2008
rosettes form cyclically from a progenitor pool at the leading zone of the posterior lateral line primordium as neuromasts are deposited from trailing region; fgf3/10 signals localized to leading zone required for rosette formation & primordium migration
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.
Andersson et al., Uppsala, Sweden. In Nat Genet, 2007
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Thisse et al., Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q.
James et al., Paris, France. In Nature, 1994
Here we report evidence for the localization of a previously undetected susceptibility locus for IDDM in the region of the FGF3 gene on chromosome 11q.
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