Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?
Philadelphia, United States. In Endocr Rev, 2010
For instance, no conclusive support for a role of the T1D-associated INS gene has been reported in T2D; conversely, but similarly, no evidence has been found for the role of the T2D-associated genes IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, FTO, and TCF7L2 in T1D.
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Montréal, Canada. In Nature, 2007
These loci include a non-synonymous polymorphism in the zinc transporter SLC30A8, which is expressed exclusively in insulin-producing beta-cells, and two linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4).