gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Insulinoma-associated 2

insulinoma-associated protein 2, mlt 1
Top mentioned proteins: Insulin, IA-2, AGE, ACID, HAD
Papers on insulinoma-associated protein 2
Baseline heterogeneity in glucose metabolism marks the risk for type 1 diabetes and complicates secondary prevention.
New
DiAPREV-IT study group et al., Malmö, Sweden. In Acta Diabetol, Jun 2015
years] with autoantibodies to glutamate decarboxylase (GAD65A) and at least one of insulinoma-associated protein 2 (IA-2A), insulin or ZnT8 transporter (ZnT8RA, ZnT8WA, ZnT8QA) were screened with IvGTT and OGTT and followed for a minimum of 2 years.
Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY).
New
TEDDY Study Group et al., Dresden, Germany. In Diabetes Care, May 2015
Insulin autoantibodies (IAAs), GAD65 autoantibodies (GADAs), and insulinoma-associated protein 2 autoantibodies (IA-2As) were measured every 3 months until 4 years of age and every 6 months thereafter; if results were positive, the autoantibodies were measured every 3 months.
Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skåne study.
Diabetes Prediction in Skåne study group et al., Kristianstad, Sweden. In Diabetologia, 2015
Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2).
Impact of islet autoimmunity on the progressive β-cell functional decline in type 2 diabetes.
Palmer et al., Seattle, United States. In Diabetes Care, 2014
RESEARCH DESIGN AND METHODS: Twenty-three T2D patients negative for islet autoantibodies (GAD antibody and insulinoma-associated protein 2) and islet-specific T cells were evaluated prospectively for up to 36 months.
Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease.
TEDDY Study Group et al., Malmö, Sweden. In Pediatr Diabetes, 2014
METHODS: Autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2) and insulin (IAA) were analyzed from 3 months of age in children with genetic risk.
Albuminuria according to status of autoimmunity and insulin sensitivity among youth with type 1 and type 2 diabetes.
SEARCH for Diabetes in Youth Study Group et al., In Diabetes Care, 2013
DAA status was based on positivity for the 65-kD isoform of glutamate decarboxylase and insulinoma-associated protein 2 antigens.
Alloantibody and autoantibody monitoring predicts islet transplantation outcome in human type 1 diabetes.
Terasaki et al., Milano, Italy. In Diabetes, 2013
Islet transplant outcome was analyzed in 59 consecutive pancreatic islet recipients in whom baseline and de novo posttransplant autoantibodies (GAD antibody, insulinoma-associated protein 2 antigen, zinc transporter type 8 antigen) and donor-specific alloantibodies (DSA) were quantified.
Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes.
BDD Study Group et al., Malmö, Sweden. In Pediatr Diabetes, 2013
OBJECTIVE: To establish the diagnostic sensitivity of and the relationships between autoantibodies to all three Zinc transporter 8 (Zinc transporter 8 autoantibody to either one, two, or all three amino acid variants at position 325, ZnT8A) variants to human leukocyte antigen (HLA)-DQ and to autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A), and insulin (IAA).
IA-2 autoantibody affinity in children at risk for type 1 diabetes.
Achenbach et al., München, Germany. In Clin Immunol, 2012
Autoantibodies to insulinoma-associated protein 2 (IA-2A) are associated with increased risk for type 1 diabetes.
Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes.
BABYDIAB-BABYDIET Study Group et al., München, Germany. In Diabetologia, 2012
Seroconversion to insulin autoantibodies occurred earlier than other autoantibodies (p<0.01 against glutamic acid decarboxylase [GAD]-, insulinoma-associated protein 2 [IA-2]- and zinc transporter 8 [ZnT8]-autoantibodies).
Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.
Type 1 Diabetes TrialNet Study Group et al., Aurora, United States. In Diabetes Care, 2012
OBJECTIVE: We assessed diabetes risk associated with zinc transporter-8 antibodies (ZnT8A), islet cell antibodies (ICA), and HLA type and age in relatives of people with type 1 diabetes with the standard biochemical autoantibodies (BAA) to insulin (IAA), GAD65 (GAD65A), and/or insulinoma-associated protein 2 antigen (IA-2A).
Time dynamics of autoantibodies are coupled to phenotypes and add to the heterogeneity of autoimmune diabetes in adults: the HUNT study, Norway.
Grill et al., Nehe, China. In Diabetologia, 2012
We cross-sectionally investigated the prevalence and prospectively the prediabetic and postdiabetic presence of antibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 and zinc transporter 8 in LADA and in type 1 diabetes.
An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age.
Belgian Diabetes Registry et al., Brussels, Belgium. In Diabetologia, 2012
METHODS: Abs against insulin (IAA), glutamate decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured during follow-up of 7,170 first-degree relatives.
Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes.
Lam et al., Changsha, China. In J Clin Endocrinol Metab, 2012
Furthermore, FGF21 levels correlated inversely with titers of glutamic acid decarboxylase and insulinoma-associated protein 2 autoantibodies in type 1 diabetic and LADA patients.
Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1.
GeneRIF
Notkins et al., Bethesda, United States. In Endocrinology, 2011
Results suggest that Insm2 plays an important role in the differentiation cascade of Ngn3/NeuroD1 signaling in pancreatic islets.
Prediabetes in children: natural history, diagnosis, and preventive strategies.
Review
Kulmala, Oulu, Finland. In Paediatr Drugs, 2002
T cells are thought to be the effector cells for the beta-cell destruction, and glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin represent the three major autoantigens.
share on facebooktweetadd +1mail to friends