gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Insulin

Insulin
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Insulin-Like Growth Factor I, HAD, AGE, CAN, fibrillin-1
Papers using Insulin antibodies
Radiation damage in room-temperature data acquisition with the PILATUS 6M pixel detector
Supplier
Schulze-Briese Clemens et al., In Journal of Synchrotron Radiation, 2010
... Insulin and thaumatin were obtained from Sigma Aldrich and crystallized ...
Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose
Supplier
Mingrone Geltrude et al., In Diabetes Care, 2009
... The European Group for the Study of Insulin Resistance (EGIR) is supported by Merck Santé (Lyon, France).
Homeostatic presynaptic suppression of neuronal network bursts.
Supplier
Dunaevsky Anna, In PLoS ONE, 2008
... Cells were initially grown in media containing minimal essential medium (MEM, Sigma), 25 mg/l Insulin (Sigma), 20 mM Glucose (Sigma), 2 mM L-Glutamine (Sigma), 5 µg/mL Gentamycin sulfate (Sigma) and 10% NuSerum (Becton Dickinson Labware, Bedford, Massachusetts, United ...
Cyanidin 3-glucoside anthocyanin from black beans has potential to protect insulin resistance on 3T3-L1 adipocytes by inhibiting TNF-α release
Supplier
Isoda Hiroko et al., In BMC Proceedings, 1999
... DEX Solution, IBMX Solution, and Insulin Solution were purchased from Cayman Chemicals (Ann ...
LIGAND: A versatile computerized approach for characterization of ligand binding systems.
Supplier
Simon Eric J et al., In BMC Pharmacology, 1979
... Insulin was obtained from University Hospital of New York University and PDGF was purchased from Biomol (Plymouth Meeting, PA) ...
Papers on Insulin
METFORMIN SUSTAINED WEIGHT LOSS AND REDUCED ANDROID FAT TISSUE AT 12 MONTHS IN EMPOWIR (ENHANCE THE METABOLIC PROFILE OF WOMEN WITH INSULIN RESISTANCE): A DOUBLE BLIND, PLACEBO-CONTROLLED, RANDOMIZED TRIAL OF NORMOGLYCEMIC WOMEN WITH MIDLIFE WEIGHT GAIN.
New
Nguyen et al., New York City, United States. In Endocr Pract, Feb 2016
METHODS: EMPOWIR (NCT00618072) was a double-blind, placebo controlled, 12-month trial of women with >20lb weight gain, normal glucose tolerance test, and increased Area-under-the-curve insulin.
EFFECT OF TOTAL DAILY DOSE ON EFFICACY, DOSING, AND SAFETY OF 2 DOSE TITRATION REGIMENS OF HUMAN REGULAR U-500 INSULIN IN SEVERELY INSULIN-RESISTANT PATIENTS WITH TYPE 2 DIABETES.
New
Jackson et al., Spokane, United States. In Endocr Pract, Feb 2016
OBJECTIVE: To examine the influence of baseline U-100 insulin total daily dose (TDD) on clinical outcomes in severely insulin-resistant patients with inadequately controlled type 2 diabetes treated with human regular U-500 insulin (U-500R) from the perspective of current dosing recommendations.
Nutritional Composition of Stevia rebaudiana- A sweet herb and its Hypoglycaemic and Hypolipidaemic Effect on Patients with Non Insulin Dependent Diabetes Mellitus.
New
Nandini et al., Ajmer, India. In J Sci Food Agric, Feb 2016
The chemical management of Diabetes has side effects and hence the present study was undertaken to assess the hypoglycemic and hypolipidaemic effect of Stevia rebaudiana on patients with Type - 2 Non Insulin Dependent Diabetes Mellitus (NIDDM).
Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma.
New
Naito et al., Tokyo, Japan. In Int J Oncol, Feb 2016
Insulin-like growth factor 2 mRNA-binding protein-3 (IGF2BP3, also known as IMP3) is thought of as a bona fide oncofetal protein, which is overexpressed and is involved in cell proliferation, migration, and invasion in several kinds of tumors.
HYPERGLYCEMIA MANAGEMENT IN PATIENTS WITH POST-TRANSPLANTATION DIABETES.
Review
New
Tamler et al., New York City, United States. In Endocr Pract, Jan 2016
Insulin therapy during the early post-transplantation period has shown promise in preventing PTDM development.
Potential use of durian fruit (Durio zibenthinus Linn) as an adjunct to treat infertility in polycystic ovarian syndrome.
Review
New
Ansari, Kuala Selangor, Malaysia. In J Integr Med, Jan 2016
Insulin resistance, the prime factor of PCOS, induces comorbid metabolic syndrome as well.
Effects of a Combination Therapy of Sclerostin Antibody III and Raloxifene on Bone Formation Markers in Ovariectomized Rats.
New
Gad Allam, Riyadh, Saudi Arabia. In J Coll Physicians Surg Pak, Jan 2016
At the end of treatment, serum levels of Bone Specific Alkaline Phosphatase (BSAP), alkaline phosphatase, osteocalcin, Insulin-like Growth Factor-1 (IGF-1), Parathyroid Hormone (PTH), Ca2+ and phosphorus were measured.
EXPRESSION OF RECEPTORS FOR INSULIN AND LEPTIN IN THE VENTRAL TEGMENTAL AREA/SUBSTANTIA NIGRA (VTA/SN) OF THE RAT:HISTORICAL PERSPECTIVE.
Review
New
Figlewicz, Seattle, United States. In Brain Res, Jan 2016
UNASSIGNED: Since the publication of the observation that dopaminergic neurons in the ventral tegmental area/substantia nigra of the rat express receptors for insulin and leptin, numerous studies have extended and validated these findings.
IGF-binding protein 2 is a candidate target of therapeutic potential in cancer.
Review
New
Zhang et al., Tianjin, China. In Tumour Biol, Jan 2016
UNASSIGNED: Insulin-like growth factor (IGF)-binding protein 2(IGFBP2), a key member of IGF family, has been reported as a notable oncogene in most human epithelium cancers.
Bile acid receptors and nonalcoholic fatty liver disease.
Review
New
Bambha et al., Los Angeles, United States. In World J Hepatol, Jan 2016
Insulin resistance and derangement of lipid metabolism, accompanied by activation of the pro-inflammatory response and fibrogenesis, are essential pathways in the development of the more clinically significant form of NAFLD, known as nonalcoholic steatohepatitis (NASH).
ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.
New
Impact
Reversade et al., Singapore, Singapore. In Cell Stem Cell, Nov 2015
INSULIN and ELA have partially overlapping functions in hESC medium, but only ELA can potentiate the TGFβ pathway to prime hESCs toward the endoderm lineage.
PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
New
Impact
Yan et al., Beijing, China. In Science, Aug 2015
Insulin-induced gene 1 (Insig-1) and Insig-2 are endoplasmic reticulum membrane-embedded sterol sensors that regulate the cellular accumulation of sterols.
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.
New
Impact
Dillin et al., Los Angeles, United States. In Cell Metab, Aug 2015
FOXO family transcription factors are downstream effectors of Insulin/IGF-1 signaling (IIS) and major determinants of aging in organisms ranging from worms to man.
Heart failure in diabetes: effects of anti-hyperglycaemic drug therapy.
Review
New
Impact
Krum et al., Toronto, Canada. In Lancet, Jun 2015
Insulin, for example, induces sodium retention and thiazolidinediones increase the risk of heart failure.
Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial.
Impact
Kaufman et al., Derby, United Kingdom. In Lancet Oncol, 2013
BACKGROUND: Insulin-like growth factors (IGF-1 and IGF-2) bind to the IGF-1 receptor (IGF-1R), increasing cell proliferation and survival.
Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.
GeneRIF
Schneyer et al., Springfield, United States. In Am J Physiol Endocrinol Metab, 2012
No differences were observed in fasting glucose/insulin levels, glucose tolerance, insulin sensitivity, or insulin secretion in comparing young or older males on in comparing insulin secretion from islets of wild type or activin B knockout males.
Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells.
GeneRIF
Fornoni et al., Miami, United States. In J Biol Chem, 2012
Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells.
Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells.
GeneRIF
Yada et al., Tochigi, Japan. In Febs Lett, 2012
Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet beta-cells
Disulfide bridges remain intact while native insulin converts into amyloid fibrils.
GeneRIF
Lednev et al., Albany, United States. In Plos One, 2011
The structure of insulin fibrils was characterized by deep ultraviolet resonance Raman (DUVRR) and Nuclear Magnetic Resonance (NMR) spectroscopy combined with hydrogen-deuterium exchange.
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity.
GeneRIF
Hennige et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity
share on facebooktweetadd +1mail to friends