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Insulin-like growth factor 2

Insulin-Like Growth Factor II, IGF-II, IGF2
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Insulin, CAN, Insulin-Like Growth Factor I, HAD, AGE
Papers using Insulin-Like Growth Factor II antibodies
LYVE-1, the lymphatic system and tumor lymphangiogenesis
Lahm Harald et al., In Journal of Carcinogenesis, 2000
... Identification of PEPCK-IGF-II transgenic animals and carcinogen treatment ...
Papers on Insulin-Like Growth Factor II
MicroRNA-150 functions as a tumor suppressor in osteosarcoma by targeting IGF2BP1.
Zhao et al., Changchun, China. In Tumour Biol, 11 Dec 2015
Mechanistically, IGF2 mRNA-binding protein 1(IGF2BP1) was confirmed to act as a direct target of miR-150, and the IGF2BP1 mRNA expression was inversely correlated with the level of miR-150 in OS tissues.
Role and mechanism of insulin-like growth factor 2 on the proliferation of human trophoblasts in vitro.
Song et al., Shenyang, China. In J Obstet Gynaecol Res, 10 Dec 2015
AIM: To study the effect and relevant molecular mechanisms of insulin-like growth factor 2 (IGF2) on the proliferative activity of first trimester human trophoblasts in vitro.
Gene expression profiles of some cytokines, growth factors, receptors, and enzymes (GM-CSF, IFNγ, MMP-2, IGF-II, EGF, TGF-β, IGF-IIR) during pregnancy in the cat uterus.
Schäfer-Somi et al., Burdur, Turkey. In Theriogenology, 23 Nov 2015
In the present study, the gene expression profiles of factors associated with pregnancy such as EGF, transforming growth factor beta, granulocyte-macrophage colony-stimulating factor, interferon gamma, insulin-like growth factor 2, insulin-like growth factor 2 receptor, and matrix metalloproteinase 2 were analyzed in uterine tissues of female cats.
Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates.
Lee et al., United States. In Science, 16 Nov 2015
We found that two RNA-binding proteins, IGF-II mRNA-binding protein (Imp) and Syncrip (Syp), display opposing high-to-low and low-to-high temporal gradients with lineage-specific temporal dynamics.
Insulin-like growth factor binding proteins 4-6.
Bach, Australia. In Best Pract Res Clin Endocrinol Metab, 31 Oct 2015
IGFBP-6 is unique among the IGFBPs for its marked IGF-II binding preference.
Soluble M6P/IGFIIR in the circulation.
Kiess et al., Sydney, Australia. In Best Pract Res Clin Endocrinol Metab, 31 Oct 2015
Soluble M6P/IGFIIR has the potential to be a significant carrier of IGF-II and mannose 6-P proteins in the circulation and play an important role as an antagonist to the cellular receptor.
Paternally Inherited IGF2 Mutation and Growth Restriction.
Eggermann et al., Tübingen, Germany. In N Engl J Med, Aug 2015
In humans, mutations in IGF1 or IGF1R cause intrauterine and postnatal growth restriction; however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking.
Dynamics of DNA methylation at IGF2 in preterm and term infants during the first year of life: an observational study.
Drake et al., Edinburgh, United Kingdom. In Lancet, Mar 2015
We hypothesised that preterm infants have altered 5mC at the linked differentially methylated region 2 (DMR2) of IGF2 and the H19 imprinting control region (H19 ICR) compared with term infants over the first year of life.
A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.
Domingo-Domenech et al., New York City, United States. In Cancer Cell, Mar 2015
Mechanistically, direct upregulation of the growth hormone IGF2 emerged as a mediator of the aggressive properties regulated by GATA2.
Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.
Gessler et al., Würzburg, Germany. In Cancer Cell, Mar 2015
Recurrent mutations included a hotspot mutation (Q177R) in the homeo-domain of SIX1 and SIX2 in tumors with high proliferative potential (18.1% of blastemal cases); mutations in the DROSHA/DGCR8 microprocessor genes (18.2% of blastemal cases); mutations in DICER1 and DIS3L2; and alterations in IGF2, MYCN, and TP53, the latter being strongly associated with dismal outcome.
MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones.
Díez-Pérez et al., Barcelona, Spain. In Bmc Med Genomics, Dec 2014
miR-320a is known to target CTNNB1 and predicted to regulate RUNX2 and LEPR, while miR-483-5p down-regulates IGF2.
Novel Insights into the Genetics and Pathophysiology of Adrenocortical Tumors.
Ragazzon et al., Paris, France. In Front Endocrinol (lausanne), Dec 2014
Most ACAs are associated with abnormalities of the cAMP signaling pathway, whereas most ACCs are linked to alterations in IGF2, TP53, or the Wnt/βcatenin pathways.
Insulin/Insulin-like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms, and new blocking strategies.
Tomblin et al., Huntington, United States. In Front Endocrinol (lausanne), Dec 2014
Molecular targeting therapies that have been used in solid tumors include anti-IGF1R antibodies, anti-IGF1/IGF2 antibodies, and small molecule inhibitors that suppress IGF1R and IR kinase activity.
The Efficient Derivation of Trophoblast Cells from Porcine In Vitro Fertilized and Parthenogenetic Blastocysts and Culture with ROCK Inhibitor Y-27632.
Li et al., Hohhot, China. In Plos One, Dec 2014
The expression of TR lineage markers, such as CDX2, KRT7, KRT18, TEAD4, ELF5 and HAND1, imprinted genes such as IGF2, PEG1 and PEG10, and telomerase activity related genes TERC and TERF2 were detected by immunofluorescence staining, reverse transcription PCR and quantitative real-time PCR analyses.
Imprinting genes associated with endometriosis.
Kobayashi, Nara, Japan. In Excli J, 2013
From the genomic imprinting database, we picked 10 genes that were highly associated with female reproduction; prominent among them were paternally expressed genes (DIRAS3, BMP8B, CYP1B1, ZFAT, IGF2, MIMT1, or MIR296) and maternally expressed genes (DVL1, FGFRL1, or CDKN1C).
Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.
Hammer et al., Ann Arbor, United States. In Am J Pathol, 2012
With the combination of stabilized beta-catenin and elevated Igf2 expression, adrenal glands were larger, displayed earlier onset of hyperplasia, and developed more frequent macroscopic adenomas.
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.
Millikan et al., Chapel Hill, United States. In Cancer Causes Control, 2012
Data indicate an inverse association between the insulin-like growth factor-2 (IGF-II) Apa1 A-variant and colon cancer risk (OR = 0.49, 95 % CI 0.28-0.88) in Whites only.
Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
Soares et al., Kansas City, United States. In Int J Dev Biol, 2011
Data show that both Akt1-/- and Igf2-/- mice exhibited decreased placental weight, fetal weight and viability.
Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.
Lumey et al., Leiden, Netherlands. In Plos One, 2011
Prenatal famine and genetic variation showed similar associations with IGF2/H19 methylation and their contributions were additive
Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
Freson et al., Leuven, Belgium. In Plos One, 2011
significant IGF2 hypermethylation (20 +/- 10 vs. 14 +/- 7%; p<0.05) and SNURF hypomethylation (23 +/- 6 vs. 32 6%; p<0.001) was found in Albright's hereditary osteodystrophy patients vs. controls.
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