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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Insulin-like growth factor 2

Insulin-Like Growth Factor II, IGF-II, IGF2
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, CAN, HAD, IGF-I receptor
Papers using Insulin-Like Growth Factor II antibodies
LYVE-1, the lymphatic system and tumor lymphangiogenesis
Supplier
Lahm Harald et al., In Journal of Carcinogenesis, 2000
... Identification of PEPCK-IGF-II transgenic animals and carcinogen treatment ...
Papers on Insulin-Like Growth Factor II
A genomewide association study for average daily gain in Italian Large White pigs.
New
Russo et al., Bologna, Italy. In J Anim Sci, 30 Apr 2014
Other regions that were associated with ADG in previous candidate gene studies (e.g., MC4R on SSC1, IGF2 and LDHA on SSC2, MUC4 on SSC13) 1) included markers with Praw < 0.01 that, however, did not pass the stringent threshold of significance adopted in this study or 2) could not be tested because not assigned to the Sscrofa10.2
Involvement of IGF-II receptors in the antioxidant and neuroprotective effects of IGF-II on adult cortical neuronal cultures.
New
Garcia-Fernandez et al., Málaga, Spain. In Biochim Biophys Acta, 22 Apr 2014
UNLABELLED: Insulin-like growth factor-II (IGF-II) is a naturally occurring peptide that exerts known pleiotropic effects ranging from metabolic modulation to cellular development, growth and survival.
Enhancement of Memories by Systemic Administration of Insulin-like Growth Factor II.
New
Alberini et al., New York City, United States. In Neuropsychopharmacology, 19 Apr 2014
Previous studies showed that a bilateral injection of insulin-like growth factor II (IGF-II) into the dorsal hippocampus of rats or mice enhances fear memories and facilitates fear extinction.
Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects.
Review
New
Leroith et al., Tel Aviv-Yafo, Israel. In Eur Neuropsychopharmacol, 03 Mar 2014
UNLABELLED: The involvement of insulin, the insulin-like growth factors (IGF1, IGF2) and their receptors in central nervous system development and function has been the focus of scientific interest for more than 30 years.
Development of a Human Breast-Cancer Derived Cell Line Stably Expressing a Bioluminescence Resonance Energy Transfer (BRET)-Based Phosphatidyl Inositol-3 Phosphate (PIP3) Biosensor.
New
Issad et al., Paris, France. In Plos One, Dec 2013
This BRET biosensor pair permits to monitor, in real time, in living cells, PIP3 production at the plasma membrane upon stimulation by different ligands, including insulin, the insulin analogue glargine, IGF1, IGF2 and EGF.
Epigenetic susceptibility factors for prostate cancer with aging.
Review
New
Jarrard et al., Madison, United States. In Prostate, Dec 2013
A loss of genomic imprinting is responsible for biallelic expression of the well-known Insulin-like Growth Factor 2 (IGF2) gene.
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.
New
Yang et al., Taipei, Taiwan. In Nat Commun, Dec 2013
Specifically, we find that IGF1R signalling activation in cancer cells in the presence of CAFs expressing IGF-II can induce Nanog expression and promote stemness.
Fetal growth in relation to maternal and fetal IGF-axes: a systematic review and meta-analysis.
Review
New
Lashen et al., Libya. In Acta Obstet Gynecol Scand, Sep 2013
LGA and AGA babies had similar IGF-II levels, whereas SGA and AGA babies had comparable IGF-I levels.
Clinical implications of current developments in genitourinary pathology.
Review
New
Jiang et al., Worcester, United States. In Arch Pathol Lab Med, Jul 2013
OBJECTIVE: To review 5 stories in genitourinary pathology: (1) fusion in the ETS (E26) gene family in prostatic adenocarcinoma; (2) insulin-like growth factor II messenger RNA-binding protein 3 (IMP3), an important prognostic biomarker for kidney and bladder cancers; (3) translocation renal cell carcinoma; (4) UroVysion fluorescence in situ hybridization test in urine cytology for detection of bladder cancer; and (5) the use of triple immunostaining for diagnosis of prostate cancer.
Epigenetic and genetic alterations of the imprinting disorder Beckwith-Wiedemann syndrome and related disorders.
Review
New
Higashimoto et al., Saga, Japan. In J Hum Genet, Jul 2013
The relevant imprinted chromosomal region in BWS is 11p15.5, which consists of two imprinting domains, IGF2/H19 and CDKN1C/KCNQ1OT1.
An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Impact
Hassan et al., Bristol, United Kingdom. In Science, 2012
The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively.
Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.
GeneRIF
Hammer et al., Ann Arbor, United States. In Am J Pathol, 2012
With the combination of stabilized beta-catenin and elevated Igf2 expression, adrenal glands were larger, displayed earlier onset of hyperplasia, and developed more frequent macroscopic adenomas.
Recurrent R-spondin fusions in colon cancer.
Impact
de Sauvage et al., San Francisco, United States. In Nature, 2012
Copy-number and RNA-seq data analysis identified amplifications and corresponding overexpression of IGF2 in a subset of colon tumours.
Comprehensive molecular characterization of human colon and rectal cancer.
Impact
Cancer Genome Atlas Network, In Nature, 2012
Recurrent copy-number alterations include potentially drug-targetable amplifications of ERBB2 and newly discovered amplification of IGF2.
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.
GeneRIF
Millikan et al., Chapel Hill, United States. In Cancer Causes Control, 2012
Data indicate an inverse association between the insulin-like growth factor-2 (IGF-II) Apa1 A-variant and colon cancer risk (OR = 0.49, 95 % CI 0.28-0.88) in Whites only.
The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche.
Impact
Jones et al., Los Angeles, United States. In Nature, 2012
Here we demonstrate that IGF-II messenger RNA binding protein (Imp) counteracts endogenous small interfering RNAs to stabilize upd (also known as os) RNA.
The many faces of insulin-like peptide signalling in the brain.
Review
Impact
Torres-Alemán et al., Madrid, Spain. In Nat Rev Neurosci, 2012
Central and peripheral insulin-like peptides (ILPs), which include insulin, insulin-like growth factor 1 (IGF1) and IGF2, exert many effects in the brain.
Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
GeneRIF
Soares et al., Kansas City, United States. In Int J Dev Biol, 2011
Data show that both Akt1-/- and Igf2-/- mice exhibited decreased placental weight, fetal weight and viability.
Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.
GeneRIF
Lumey et al., Leiden, Netherlands. In Plos One, 2011
Prenatal famine and genetic variation showed similar associations with IGF2/H19 methylation and their contributions were additive
Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
GeneRIF
Freson et al., Leuven, Belgium. In Plos One, 2011
significant IGF2 hypermethylation (20 +/- 10 vs. 14 +/- 7%; p<0.05) and SNURF hypomethylation (23 +/- 6 vs. 32 6%; p<0.001) was found in Albright's hereditary osteodystrophy patients vs. controls.
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