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Insulin-like growth factor 2

Insulin-Like Growth Factor II, IGF-II, IGF2
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, CAN, HAD, IGF-I receptor
Papers using Insulin-Like Growth Factor II antibodies
LYVE-1, the lymphatic system and tumor lymphangiogenesis
Lahm Harald et al., In Journal of Carcinogenesis, 2000
... Identification of PEPCK-IGF-II transgenic animals and carcinogen treatment ...
Papers on Insulin-Like Growth Factor II
Stress granules are dispensable for mRNA stabilization during cellular stress.
Hüttelmaier et al., Halle, Germany. In Nucleic Acids Res, 08 Jan 2015
Previously, we showed that the SG-recruited IGF2 mRNA-binding protein 1 (IGF2BP1) interferes with target mRNA degradation during cellular stress.
A Messenger RNA and Cognate MicroRNAs Localize in the Nucleolus.
Pederson et al., Worcester, United States. In Nucleus, 08 Jan 2015
Among the most abundant of these nucleolus-localized mRNAs is that encoding insulin-like growth factor 2 (IGF2), a regulator of myoblast proliferation and differentiation.
DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle?
Nielsen et al., Århus, Denmark. In Arch Toxicol, 06 Jan 2015
Further, a number of specific genes exemplified by CYP1A1, AhRR, FOXP3, TSLP, IGF2, AXL, PTPRO, C11orf52, FRMD4A and BDNF are shown to have altered DNA methylation patterns in at least one of these tissue types due to PEMCS.
Effects of sex steroids on expression of genes regulating growth-related mechanisms in rainbow trout (Oncorhynchus mykiss).
Weber et al., United States. In Gen Comp Endocrinol, 04 Jan 2015
Regulation of this system also occurred in white muscle in which E2 increased expression of igf1, igf2, and igfbp5, suggesting anabolic capacity may be maintained in white muscle in the presence of E2.
Insulin and IGF receptor signalling in neural-stem-cell homeostasis.
Wood et al., Newark, United States. In Nat Rev Endocrinol, 02 Jan 2015
IGF-II is of particular interest as a result of its production by the choroid plexus and presence in cerebrospinal fluid (CSF).
Portrait of the PI3K/AKT-pathway in colorectal cancer.
Lothe et al., Oslo, Norway. In Biochim Biophys Acta, 22 Dec 2014
In colorectal cancer the most commonly observed pathway changes are IGF2 overexpression, PIK3CA mutations and PTEN mutations and deletions.
Endothelial cells and the insulin-like growth factor system.
Bach, Melbourne, Australia. In J Mol Endocrinol, 28 Nov 2014
These actions are mediated by the IGF-I and IGF-II/mannose 6-phosphate receptors and are modulated by a family of high affinity IGF binding proteins.
The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer.
Hüttelmaier et al., Halle, Germany. In Semin Cancer Biol, Aug 2014
The IGF2 mRNA binding protein family (IGF2BPs) comprises three RBPs.
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture.
Kuo et al., Stanford, United States. In Nat Med, Jul 2014
Colon organoid culture functionally validated the microRNA miR-483 as a dominant driver oncogene at the IGF2 (insulin-like growth factor-2) 11p15.5 CRC amplicon, inducing dysplasia in vitro and tumorigenicity in vivo.
IGF binding proteins in cancer: mechanistic and clinical insights.
Baxter, Sydney, Australia. In Nat Rev Cancer, May 2014
IGFBPs also function in the pericellular and intracellular compartments to regulate cell growth and survival - they interact with many proteins, in addition to their canonical ligands IGF-I and IGF-II.
[Study of conformational mobility of insulin, proinsulin, and insulin-like growth factors].
In Zh Evol Biokhim Fiziol, Jan 2014
In this work, by method of molecular dynamics there was performed comparative analysis of conformational mobility of evolutionary related peptides--insulin, proinsulin, IGF1, and IGF2.
The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets.
Pivonello et al., Napoli, Italy. In Infect Agent Cancer, Dec 2013
Physiologically, GH-IGF-SST system plays a crucial role in liver growth and development since GH induces IGF1 and IGF2 secretion and the expression of their receptors, involved in hepatocytes cell proliferation, differentiation and metabolism.
An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Hassan et al., Bristol, United Kingdom. In Science, 2012
The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively.
Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.
Hammer et al., Ann Arbor, United States. In Am J Pathol, 2012
With the combination of stabilized beta-catenin and elevated Igf2 expression, adrenal glands were larger, displayed earlier onset of hyperplasia, and developed more frequent macroscopic adenomas.
Recurrent R-spondin fusions in colon cancer.
de Sauvage et al., San Francisco, United States. In Nature, 2012
Copy-number and RNA-seq data analysis identified amplifications and corresponding overexpression of IGF2 in a subset of colon tumours.
Comprehensive molecular characterization of human colon and rectal cancer.
Cancer Genome Atlas Network, In Nature, 2012
Recurrent copy-number alterations include potentially drug-targetable amplifications of ERBB2 and newly discovered amplification of IGF2.
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.
Millikan et al., Chapel Hill, United States. In Cancer Causes Control, 2012
Data indicate an inverse association between the insulin-like growth factor-2 (IGF-II) Apa1 A-variant and colon cancer risk (OR = 0.49, 95 % CI 0.28-0.88) in Whites only.
Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
Soares et al., Kansas City, United States. In Int J Dev Biol, 2011
Data show that both Akt1-/- and Igf2-/- mice exhibited decreased placental weight, fetal weight and viability.
Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.
Lumey et al., Leiden, Netherlands. In Plos One, 2011
Prenatal famine and genetic variation showed similar associations with IGF2/H19 methylation and their contributions were additive
Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction.
Freson et al., Leuven, Belgium. In Plos One, 2011
significant IGF2 hypermethylation (20 +/- 10 vs. 14 +/- 7%; p<0.05) and SNURF hypomethylation (23 +/- 6 vs. 32 6%; p<0.001) was found in Albright's hereditary osteodystrophy patients vs. controls.
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