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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Insulin-like growth factor binding protein 3

Insulin-Like Growth Factor Binding Protein 3, IGFBP-3
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, AGE, HAD, CAN
Papers on Insulin-Like Growth Factor Binding Protein 3
Agreement between circulating IGF-I, IGFBP-1 and IGFBP-3 levels measured by current assays versus unavailable assays previously used in epidemiological studies.
New
Kaplan et al., United States. In Growth Horm Igf Res, Feb 2016
DESIGN: In a split sample study among 1471 adults participating in the Cardiovascular Health Study, we compared values obtained using DSL assays with alternative assays for serum IGF-I (Immunodiagnostic Systems, IDS), IGFBP-1 (American Laboratory Products Company, ALPCO) and IGFBP-3 (IDS).
Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1.
New
Grant et al., Gainesville, United States. In Neurosci Lett, Feb 2016
UNASSIGNED: We recently found indicators of hypothalamic inflammation and neurodegeneration linked to the loss of neuroprotective factors including insulin-like growth factor (IGF-1) and IGF binding protein-2 (IGFBP-3) in mice made diabetic using streptozotocin (STZ).
Fish oil supplementation from 9 to 18 months of age affects the insulin-like growth factor axis in a sex-specific manner in Danish infants.
New
Lauritzen et al., Frederiksberg, Denmark. In Br J Nutr, Feb 2016
We explored whether FO v. sunflower oil (SO) supplementation from 9 to 18 months of age affected IGF-1 and its binding protein-3 (IGFBP-3) and whether the potential effects were sex specific.
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children.
New
Cano et al., Santiago, Chile. In Pediatr Nephrol, Feb 2016
METHODS: Serum GH-binding protein (GHBP), IGF-1 and IGFBP3 were measured in 15 prepubertal CKD stage-5 children on PD.
The growth endocrine axis and inflammatory responses after laparoscopic cholecystectomy.
New
Koutsilieris et al., In Hormones (athens), Feb 2016
The aim of this prospective study was to evaluate the growth hormone (GH)/insulin-like growth factor-1 (IGF-1)/IGF binding protein-3 (IGFBP-3) axis and acute phase (interleukin-6, IL-6, and C-reactive protein, CRP) responses in patients who underwent laparoscopic cholecystectomy.
Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence.
Review
New
Clayton et al., London, United Kingdom. In Arch Dis Child, Jan 2016
Such issues along with the use of adjunct biochemical markers such as IGF-I and IGFBP-3 for the diagnosis of GHD, will be discussed in this review.
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
New
Impact
Chambers et al., Tokyo, Japan. In Nat Genet, Nov 2015
The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function.
Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy.
New
Impact
Fiorina et al., Boston, United States. In Cell Stem Cell, Nov 2015
Proteomic profiling of T1D+DE patient serum revealed altered levels of insulin-like growth factor 1 (IGF-I) and its binding protein 3 (IGFBP3).
IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy.
New
Impact
Yilmaz et al., Cambridge, United States. In Cell Stem Cell, Nov 2015
Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and in T1D patients.
Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - Consensus and dissent on metabolic control and malignant potential.
Review
New
Russo et al., Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
IGFBP-1 and IGFBP-2 are suppressed by growth hormone and therefore represent less prominent members of the IGFBP family when compared to IGFBP-3 that carries most of the IGFs during circulation under normal conditions in humans in vivo.
Insulin-like growth factor binding-protein-3 (IGFBP-3).
Review
New
Ranke, Tübingen, Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
The IGFBPs, of which IGFBP-3 is the most abundant in postnatal blood, link with IGFs and prevent them from being degraded; they also facilitate IGF transport through body compartments.
Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus.
Review
New
Lee et al., Chŏnju, South Korea. In Ann Pediatr Endocrinol Metab, Jun 2015
Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM.
Targeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast Cancer.
Review
Martin et al., Sydney, Australia. In Biomed Res Int, 2014
Insulin-like growth factor binding protein-3 (IGFBP-3) is a key regulatory molecule of the IGF axis and can function in a tissue-specific way as both a tumor suppressor and promoter.
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.
Impact
Xu Cao et al., Baltimore, United States. In Nat Med, 2012
Notably, injection of IGF-1 plus IGF binding protein 3 (IGFBP3), but not injection of IGF-1 alone, increased the concentration of IGF-1 in the bone matrix and stimulated new bone formation in aged rats.
IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos.
GeneRIF
Duan et al., Ann Arbor, United States. In J Cell Sci, 2011
insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 in zebrafish embryos
Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies.
Impact
Roddam et al., In Lancet Oncol, 2010
Some published results have shown an association between circulating IGF1 and breast-cancer risk, but it has been unclear whether this relationship is consistent or whether it is modified by IGF binding protein 3 (IGFBP3), menopausal status, oestrogen receptor status or other factors.
Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation.
GeneRIF
Duan et al., Ann Arbor, United States. In J Biol Chem, 2005
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
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