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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Insulin receptor

insulin receptor
receptor for insulin; involved in intracellular signalling; mutations in gene are associated with type 2 diabetes mellitus [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Insulin, Akt, IRS-1, CAN, V1a
Papers using insulin receptor antibodies
Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells*
Supplier
Maffucci Tania et al., In The Journal of Biological Chemistry, 2007
... The insulin receptor inhibitor AG1024 was from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold
Supplier
Gobel Verena et al., In Nature Cell Biology, 2007
... A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C ...
Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells
Supplier
Son Hyun-Shik et al., In Diabetes & Metabolism Journal, 2003
... Anti-insulin receptor beta subunit (Anti-IRβ) was from Santa Cruz Biotechnology Inc ...
SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer.
Supplier
Maedler Kathrin, In PLoS ONE, 2002
... Anti-insulin receptor β subunit antibodies were acquired from Santa Cruz Biotechnology Inc ...
Cerebral oedema as a possible complication of treatment with imatinib.
Supplier
Sandirasegarane Lakshman et al., In Molecular Vision, 2001
... The primary antibodies for IRS-1 and insulin receptor-β were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on insulin receptor
Reciprocal molecular interactions between the Aβ peptide linked to Alzheimer's Disease and insulin linked to Diabetes Mellitus type II.
New
Abrahams et al., In Acs Chem Neurosci, Feb 2016
In vivo studies have revealed that insulin promotes the production of Aβ, and that soluble Aβ competes with insulin for the insulin receptor.
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
New
Lu et al., Shanghai, China. In Acta Pharmacol Sin, Feb 2016
The expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), phosphorylated IGF-1R, fibronectin, and collagen IV was determined with Western blot analysis.
Insulin signaling disruption in male mice due to perinatal bisphenol A exposure: Role of insulin signaling in the brain.
New
Xiao et al., Nanjing, China. In Toxicol Lett, Feb 2016
Our data indicated that the insulin signaling including insulin, phosphorylated insulin receptor (IR), phosphorylated protein kinase B (p-AKT), phosphorylated glycogen synthase kinase 3β (p-GSK3β) and phosphorylated extracellular signal regulated protein kinase (p-ERK) were significantly decreased in the brain.
SerpinB1 Promotes Pancreatic β Cell Proliferation.
New
Impact
Kulkarni et al., Boston, United States. In Cell Metab, Feb 2016
We previously reported that the liver is a source for such factors in the liver insulin receptor knockout (LIRKO) mouse, an insulin resistance model that manifests islet hyperplasia.
Tipping the balance: Haemoglobinopathies and the risk of diabetes.
New
Patel et al., Nottingham, United Kingdom. In World J Diabetes, Feb 2016
This promotes oxidative stress which contributes to peripheral resistance to insulin in two ways: (1) reduced insulin/insulin receptor interaction; and (2) β-cell dysfunction.
Diabetic Cardiomyopathy: Role of the E3 Ubiquitin Ligase.
Review
New
Cai et al., Jilin, China. In Am J Physiol Endocrinol Metab, Feb 2016
In addition, the E3s degrade both insulin receptor and insulin receptor substrates and also regulate insulin gene transcription, leading to insulin resistance and insulin deficiency.
Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.
Review
New
Gelderblom et al., Leiden, Netherlands. In Eur J Cancer, Feb 2016
Future directions include dual insulin receptor/IGF-1R blockade with linsitinib as well as chemotherapy-PARP combinations.
Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?
Review
New
de Baaij et al., Nijmegen, Netherlands. In Diabetes, Jan 2016
Moreover, insulin receptor autophosphorylation is dependent on intracellular Mg(2+) concentrations, making Mg(2+) a direct factor in the development of insulin resistance.
From infancy to aging: Biological and behavioral modifiers of Fetuin-A.
Review
New
Teran-Garcia et al., Urbana, United States. In Biochimie, Jan 2016
UNASSIGNED: Fetuin-A is a multifunctional protein which inhibits ectopic calcification and insulin receptor phosphorylation.
Enhanced survival of Drosophila Akt1 hypomorphs during amino-acid starvation requires foxo.
New
Staveley et al., St. John's, Canada. In Genome, Dec 2015
The conserved insulin receptor signalling pathway acts to regulate energy balance and nutrient intake, and its central component Akt1 and endpoint effector foxo are pivotal for survival during nutritional stress.
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.
New
Impact
Parsons et al., New York City, United States. In Cancer Cell, Jul 2015
Interestingly, BET inhibitors lowered PI3K signaling and dissociated BRD4 from chromatin at regulatory regions of insulin receptor and EGFR family RTKs to reduce their expression.
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study.
New
Impact
Hammer et al., Würzburg, Germany. In Lancet Oncol, Apr 2015
Linsitinib (OSI-906) is a potent, oral small molecule inhibitor of both IGF-1R and the insulin receptor, which has shown acceptable tolerability and preliminary evidence of anti-tumour activity.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
New
Impact
Zou et al., Oklahoma City, United States. In Nat Med, Apr 2015
Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia.
Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome.
New
Impact
Tomlinson et al., Birmingham, United Kingdom. In Lancet, Mar 2015
Women with insulin receptor (INSR) mutations develop severe hyperandrogenism secondary to hyperinsulinaemia.
The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy.
Review
Manzella et al., Catania, Italy. In Front Oncol, 2014
Indeed, several components of this signaling network, including insulin, IGF-1, IGF-2, the IGF-binding proteins, the insulin receptor (IR), the IGF-1 receptor (IGF-1R), and IR substrate proteins 1 and 2 contribute to the transformation of normal colon epithelial cells.
Developmental regulation of insulin receptor gene in sciatic nerves and role of insulin on glycoprotein P0 in the Schwann cells.
GeneRIF
Muttagi et al., India. In Peptides, 2012
steady-state levels of insulin receptor mRNA increase during development and after postnatal day 10, when the peak of myelin structural gene (P0) expression occurs, increasing further in parallel with the growth of the myelin sheath
Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle.
GeneRIF
Webster et al., Miami, United States. In Diabetologia, 2012
Data suggest that the insulin receptor is a direct target of AMP-activated protein kinase (AMPK); such activation of the insulin receptor/IRS1 pathway promotes energy conservation and survival of muscle exposed to severe glucose deprivation.
Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain.
GeneRIF
Sherwin et al., New Haven, United States. In Am J Physiol Endocrinol Metab, 2011
Chronic suppression of ventromedial hypothalamus-IR gene expression is sufficient to impair glucose metabolism as well as alpha-cell and beta-cell function in nondiabetic, nonobese rats.
Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways.
GeneRIF
Hsu et al., Tainan City, Taiwan. In Neuropharmacology, 2011
Insulin receptor signaling is linked to regulation of dendritic spine formation and excitatory synapse development through activation of the PI3K/Akt/mTOR and Rac1 signaling pathways in hippocampal neurons.
si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder.
GeneRIF
Moskal et al., Providence, United States. In Mol Brain, 2010
Early postnatal inhibition of brain InR expression, and to lesser extents, IGF-R, causes structural and functional abnormalities that resemble effects of fetal alcohol spectrum disorder.
More papers using insulin receptor antibodies
The role of hepatic nuclear factor 1a and PDX-1 in transcriptional regulation of the pdx-1 gene
Supplier
Brunetti Antonio et al., In Scientific Reports, 2000
... Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels ...
Gene Expression Omnibus
Supplier
Golub Todd R et al., In Genome Biology, 1998
... (Thr202/Tyr204), MEK1/2, phospho-MEK1/2 (Ser217/221), PDGF-BB, phospho-PDGFRβ (Tyr751), phospho-EGFR (Tyr1068), cKIT, Phospho-cKIT (Tyr719), IGF-IαR, and Phospho-IGF-IR (Tyr1131)/insulin receptor (Tyr1146) antibodies were obtained from Cell Signaling.
Cryosputtering - a combined freeze-drying and sputtering method for high-resolution electron microscopy.
Supplier
Cao Yihai, In PLoS ONE, 1990
... Anti-insulin receptor β-chain rabbit polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Antioxidant action of natural health products and Chinese herbs
Supplier
Sato Yuzo et al., In Evidence-based Complementary and Alternative Medicine, 1985
... Anti-insulin receptor (IR)-β, anti-insulin receptor substrate (IRS)-1 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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