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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Insulin-like 3

INSL3, relaxin-like factor, insulin-like 3, RGL2
The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, CAN, LGR7, V1a, HAD
Papers using INSL3 antibodies
T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.
Mei Lin, In PLoS ONE, 2006
... Cells with almost the 80% of ALP positivity were stimulated with human INSL3 (Phoenix Pharmaceuticals, Burlingame, CA, USA) (1 ...
Papers on INSL3
Polymorphisms and haplotypes of insulin-like factor 3 gene are associated with risk of polycystic ovary syndrome in Indian women.
Mukherjee et al., Mumbai, India. In Gene, Mar 2016
BACKGROUND: Insulin-like factor 3 (INSL3), secreted by the ovarian theca cells is involved in androgen production, follicular growth and oocyte maturation.
Association between phthalate metabolites and biomarkers of reproductive function in 1066 Chinese men of reproductive age.
Dai et al., Beijing, China. In J Hazard Mater, Jan 2016
We investigated associations between urinary phthalate metabolites and acrosin activity, along with that between insulin like-factor 3 (INSL3), a Leydig cell function marker, in Chinese adult men and assessed the association between the metabolites and male reproductive function.
Plasma insulin-like peptide 3 concentrations are acutely regulated by luteinizing hormone in pubertal Japanese Black beef bulls.
Tamada et al., Ōsaka, Japan. In Theriogenology, Dec 2015
Insulin-like peptide 3 (INSL3) is a major secretory product of testicular Leydig cells.
Anti-müllerian hormone and insulin-like 3 levels in healthy normal-weight ovulatory and anovulatory eumenorrheic late adolescent females: potential early biomarkers of ovarian dysfunction?
Pasquali et al., Bologna, Italy. In Eur J Obstet Gynecol Reprod Biol, Dec 2015
OBJECTIVE: The aim of this study was to evaluate differences in anti-müllerian hormone (AMH) and insulin-like 3 (INSL3) levels and their association with gonadotropin and ovarian steroid hormones, as expression of ovarian function, between healthy normal-weight ovulatory and anovulatory eumenorrheic late adolescent females.
Gibberellic Acid-Stimulated Arabidopsis6 Serves as an Integrator of Gibberellin, Abscisic Acid, and Glucose Signaling during Seed Germination in Arabidopsis.
Wang et al., Guangzhou, China. In Plant Physiol, Nov 2015
The DELLA protein REPRESSOR OF ga1-3-LIKE2 (RGL2) plays an important role in seed germination under different conditions through a number of transcription factors.
Phthalates might interfere with testicular function by reducing testosterone and insulin-like factor 3 levels.
Lee et al., Tainan City, Taiwan. In Hum Reprod, Nov 2015
STUDY QUESTION: Do phthalates create a male reproductive hormone imbalance by down-regulating the secretion of testosterone and insulin-like factor 3 (INSL3)?
Hormone Inhibition During Mini-Puberty and Testicular Function in Male Rats.
Dong et al., Shanghai, China. In Int J Endocrinol Metab, Oct 2015
The mRNA expression levels of testicular androgen receptor (AR), insulin-like growth factor 3 (INSL3), anti-Mullerian hormone (AMH), and ghrelin were determined by real-time polymerase chain reaction (PCR) assays on postnatal days 45 and 75.
Naglah et al., Aţ Ţā'if, Saudi Arabia. In J Biol Regul Homeost Agents, Jul 2015
In the present study, we found evidence suggesting that Bi+3/IMC possesses the capacity to protect the stomach, sperm, testes, cellular ATP, cellular NAD, INSL3, PGD2, PGE2 and antioxidant enzymes from deleterious actions of IMC.
The relaxin family peptide receptors and their ligands: new developments and paradigms in the evolution from jawless fish to mammals.
Good et al., Winnipeg, Canada. In Gen Comp Endocrinol, 2015
Duplication and loss of genes have varied across lineages: teleosts retained more WGD-derived genes, dominated by those thought to be involved in neuroendocrine regulation (rln3, insl5 and rxfp 3/4 genes), while eutherian mammals witnessed the diversification and rapid evolution of genes involved in reproduction (rln/insl3).
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.
Summers et al., Berlin, Germany. In Pharmacol Rev, 2014
Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate ligands for the relaxin family peptide (RXFP) receptors 1-4, respectively.
Genetic analysis of the human Insulin-like 3 gene: absence of mutations in a Greek paediatric cohort with testicular maldescent.
Sofikitis et al., Irákleion, Greece. In Andrologia, 2013
This study investigated the hypothesis that genetic alterations of the human insulin-like 3 (INSL3) gene are associated with testicular maldescent (TMD).
[Pathogenesis of undescended testis].
Toppari et al., In Duodecim, 2013
Testis-derived testosterone and insulin-like peptide 3 (INSL3) regulate the descent.
Spreading the clinical window for diagnosing fetal-onset hypogonadism in boys.
Rey et al., Buenos Aires, Argentina. In Front Endocrinol (lausanne), 2013
Follicle-stimulating hormone (FSH) controls Sertoli cell proliferation, responsible for testis volume increase and AMH and inhibin B secretion, whereas luteinizing hormone (LH) regulates Leydig cell androgen and INSL3 secretion, involved in the growth and trophism of male external genitalia and in testis descent.
Relaxin family peptides and their receptors.
Summers et al., Australia. In Physiol Rev, 2013
Insulin-like peptide-3 (INSL3) has clearly defined specialist roles in male and female reproduction, relaxin-3 is primarily a neuropeptide involved in stress and metabolic control, and INSL5 is widely distributed particularly in the gastrointestinal tract.
Replacement of disulfides by amide bonds in the relaxin-like factor (RLF/INSL3) reveals a role for the A11-B10 link in transmembrane signaling.
Schwabe et al., Charleston, United States. In Biochemistry, 2012
Cystin A11-B10 serves as an insulator between the two ports, whereas the amide functionality disturbs the signal transmission complex likely due to changes in polarity.
Basal insulin-like factor 3 levels predict functional ovarian hyperandrogenism in the polycystic ovary syndrome.
Pasquali et al., Bologna, Italy. In J Endocrinol Invest, 2011
Data suggest that insulin-like factor 3 is related to functional ovarian hyperandrogenism in women with polycystic ovary syndrome.
Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate.
Gray et al., United States. In Toxicol Sci, 2011
The observed postnatal difference in gubernacular malformations between two rate strains is due to different levels of the insl3 receptor differ among strains.
INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue.
Ivell et al., Adelaide, Australia. In Plos One, 2010
INSL3 provides the first example of a gender-specific fetal hormone with the potential to influence both placental and maternal physiology
Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts.
Foresta et al., Padova, Italy. In Plos One, 2010
study demonstrates that the INSL3/RXFP2 system is involved in bone metabolism by acting on the MAPK cascade and stimulating transcription of important genes of osteoblast maturation/differentiation and osteoclastogenesis
Genetic alterations associated with cryptorchidism.
Foresta et al., Padova, Italy. In Jama, 2008
There is a significant association between bilateral and persistent cryptorchidism and genetic alterations, including Klinefelter syndrome and INSL3 receptor gene mutations.
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