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Insulin induced gene 1

Insig-1, CL-6
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: Insulin, ACID, HAD, CAN, Sterol Regulatory Element Binding Protein 1
Papers on Insig-1
Purified Betacyanins from Hylocereus undatus Peel Ameliorate Obesity and Insulin Resistance in High-Fat-Diet-Fed Mice.
Zheng et al., Hangzhou, China. In J Agric Food Chem, Feb 2016
Moreover, the hepatic gene expression analysis indicated that PPBN supplementation increased the expression levels of lipid-metabolism-related genes (AdipoR2, Cpt1a, Cpt1b, Acox1, PPARγ, Insig1, and Insig2) and FGF21-related genes (β-Klotho and FGFR1/2) but decreased the expression level of Fads2, Fas, and FGF21, suggesting that the protective effect of PPBNs might be associated with the induced fatty acid oxidation, decreased fatty acid biosynthesis, and alleviated FGF21 resistance.
Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.
Alman et al., Toronto, Canada. In Arthritis Rheumatol, Jan 2016
To investigate the effects of chondrocyte-specific sterol accumulation, we generated mice lacking Insig1 and Insig2, which are major negative regulators of cholesterol homeostasis, under Col2a1 regulatory elements.
Overexpression of SREBP1 (sterol regulatory element binding protein 1) promotes de novo fatty acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells.
Bionaz et al., China. In J Dairy Sci, Jan 2016
We observed a >10-fold increase in expression of INSIG1 but SCAP was downregulated by Ad-nSREBP1.
Characterization of a human isolate of Tritrichomonas foetus (cattle/swine genotype) infected by a zoonotic opportunistic infection.
Iwata et al., Tokyo, Japan. In J Vet Med Sci, Jan 2016
Moreover, inoculation via orogastric intubation caused infection in the cecum on Day 5 in CBA mice co-infected with Entamoeba histolytica (HM-1: IMSS cl6).
Sex difference of autosomal alleles in populations of European and African descent.
Luo et al., New Haven, United States. In Journal 2093-4947, Jan 2016
We found 13 markers that were genome-wide significant (p≤5×10(-8)) between females and males in the meta-analysis of all cohorts of European descent, including rs7740449 at SYNE1, rs7531151 at PLD5, rs697455 at PPP1R12B, rs6745746 at LOC100128413, rs17000079 at PARM1, rs11948070 at PDE4D, rs7801825 at INSIG1, rs9551642 at MTUS2, rs2932174 at TPTE2, rs1961597 at SALL3, rs4117529 at METTL4, rs6021473 at SALL4 and rs6092466 at RAE1, and one marker, i.e., rs10145208 at PCNX, that was genome-wide significant in the meta-analysis of all cohorts of African descent.
Veterinary Medicine and Omics (Veterinomics): Metabolic Transition of Milk Triacylglycerol Synthesis in Sows from Late Pregnancy to Lactation.
Liao et al., Guangzhou, China. In Omics, Oct 2015
Robust upregulation with high relative mRNA abundance was evident during lactation for genes associated with FA uptake (VLDLR, LPL, CD36), FA activation (ACSS2, ACSL3), and intracellar transport (FABP3), de novo FA synthesis (ACACA, FASN), FA elongation (ELOVL1), FA desaturation (SCD, FADS1), TAG synthesis (GPAM, AGPAT1, LPIN1, DGAT1), lipid droplet formation (BTN2A1, XDH, PLIN2), and transcription factors and nuclear receptors (SREBP1, SCAP, INSIG1/2).
Flavonoids from Triticum aestivum inhibit adipogenesis in 3T3-L1 cells by upregulating the insig pathway.
Lee et al., Iksan, South Korea. In Mol Med Report, Aug 2015
Notably, the cells treated with the flavonoids demonstrated increased expression levels of the insulin-induced genes, insig-1 and insig-2, which may have inhibited the activation of the adipogenic transcription factor, SREBP, eventually leading to the inhibition of adipogenesis.
New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression.
Roxo-Rosa et al., Rio de Mouro, Portugal. In World J Gastroenterol, Jul 2015
RESULTS: Compared with the parental cell line, the most promising NCI-hTERT-derived clones (CL5 and CL6) were composed of cells with homogenous phenotype, presented higher relative telomerase activities, better adhesion properties, ability to be maintained in culture for longer periods after confluency, and were more efficient in PAS-reactive mucins secretion.
The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
Wang et al., Shanghai, China. In Immunity, 2015
We report here that, upon cytoplasmic DNA stimulation, the endoplasmic reticulum (ER) protein AMFR was recruited to and interacted with STING in an insulin-induced gene 1 (INSIG1)-dependent manner.
Insulin Sensitivity in Adipose and Skeletal Muscle Tissue of Dairy Cows in Response to Dietary Energy Level and 2,4-Thiazolidinedione (TZD).
Loor et al., Urbana, United States. In Plos One, 2014
The OVE cows had greater expression of the insulin sensitivity-related genes IRS1, SLC2A4, INSR, SCD, INSIG1, DGAT2, and ADIPOQ in SAT.
Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Molnár et al., Budapest, Hungary. In Plos One, 2014
INSIG1, LIPG), messenger molecule genes (i.e.
Haplotype combination of the bovine INSIG1 gene sequence variants and association with growth traits in Nanyang cattle.
Chen et al., China. In Genome, 2012
In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs.
Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.
Tsai et al., Taipei, Taiwan. In Pharmacogenomics J, 2012
No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 interactions were found in the significant 3-locus and 4-locus gene-gene interaction models.
Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
Mo et al., Changsha, China. In J Biomed Sci, 2010
Overexpression of Insig-1 protects beta cells against glucolipotoxicity via SREBP-1c.
No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.
Loos et al., Cambridge, United Kingdom. In Am J Clin Nutr, 2010
Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans.
mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle.
Yang et al., Zhengzhou, China. In Genet Mol Res, 2009
analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle
Oxysterols: novel biologic roles for the 21st century.
Javitt, New York City, United States. In Steroids, 2008
This view is now supported by a new mouse model, the double knockout Insig1 & 2 (insulin-induced genes 1 & 2) in which lack of the protein product results in a greater production of lanosterol compared to cholesterol during fetal life with severe dysmorphic consequences.
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Yamada et al., Tsukuba, Japan. In Nat Med, 2006
IRS2, HK2 and INSIG1 are direct targets of TFE3
Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs).
Rawson, Dallas, United States. In Biochem Soc Symp, 2002
Recent work has additionally uncovered integral membrane proteins, insig-1 and insig-2, that are required to retain the SREBP-SCAP complex in the ER in the presence of sterols, thus providing a more complete understanding of the control of proteolysis in this complex regulatory pathway.
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.
Brown et al., Dallas, United States. In Cell, 2002
Using coimmunoprecipitation and tandem mass spectrometry, we identify INSIG-1 as an ER protein that binds the sterol-sensing domain of SREBP cleavage-activating protein (SCAP) and facilitates retention of the SCAP/SREBP complex in the ER.
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