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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Insulin-like receptor

InR, insulin receptor, insulin-like receptor
Top mentioned proteins: Insulin, Akt, IRS-1, CAN, V1a
Papers using InR antibodies
Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells*
Maffucci Tania et al., In The Journal of Biological Chemistry, 2007
... The insulin receptor inhibitor AG1024 was from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold
Gobel Verena et al., In Nature Cell Biology, 2007
... A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C ...
Insulin-like growth factor I receptors are more abundant than insulin receptors in human micro- and macrovascular endothelial cells
Son Hyun-Shik et al., In Diabetes & Metabolism Journal, 2003
... Anti-insulin receptor beta subunit (Anti-IRβ) was from Santa Cruz Biotechnology Inc ...
SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer.
Maedler Kathrin, In PLoS ONE, 2002
... Anti-insulin receptor β subunit antibodies were acquired from Santa Cruz Biotechnology Inc ...
Cerebral oedema as a possible complication of treatment with imatinib.
Sandirasegarane Lakshman et al., In Molecular Vision, 2001
... The primary antibodies for IRS-1 and insulin receptor-β were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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Papers on InR
Reciprocal molecular interactions between the Aβ peptide linked to Alzheimer's Disease and insulin linked to Diabetes Mellitus type II.
Abrahams et al., In Acs Chem Neurosci, Feb 2016
In vivo studies have revealed that insulin promotes the production of Aβ, and that soluble Aβ competes with insulin for the insulin receptor.
Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.
Lu et al., Shanghai, China. In Acta Pharmacol Sin, Feb 2016
The expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), phosphorylated IGF-1R, fibronectin, and collagen IV was determined with Western blot analysis.
Insulin signaling disruption in male mice due to perinatal bisphenol A exposure: Role of insulin signaling in the brain.
Xiao et al., Nanjing, China. In Toxicol Lett, Feb 2016
Our data indicated that the insulin signaling including insulin, phosphorylated insulin receptor (IR), phosphorylated protein kinase B (p-AKT), phosphorylated glycogen synthase kinase 3β (p-GSK3β) and phosphorylated extracellular signal regulated protein kinase (p-ERK) were significantly decreased in the brain.
SerpinB1 Promotes Pancreatic β Cell Proliferation.
Kulkarni et al., Boston, United States. In Cell Metab, Feb 2016
We previously reported that the liver is a source for such factors in the liver insulin receptor knockout (LIRKO) mouse, an insulin resistance model that manifests islet hyperplasia.
Tipping the balance: Haemoglobinopathies and the risk of diabetes.
Patel et al., Nottingham, United Kingdom. In World J Diabetes, Feb 2016
This promotes oxidative stress which contributes to peripheral resistance to insulin in two ways: (1) reduced insulin/insulin receptor interaction; and (2) β-cell dysfunction.
Diabetic Cardiomyopathy: Role of the E3 Ubiquitin Ligase.
Cai et al., Jilin, China. In Am J Physiol Endocrinol Metab, Feb 2016
In addition, the E3s degrade both insulin receptor and insulin receptor substrates and also regulate insulin gene transcription, leading to insulin resistance and insulin deficiency.
Ewing sarcoma: The clinical relevance of the insulin-like growth factor 1 and the poly-ADP-ribose-polymerase pathway.
Gelderblom et al., Leiden, Netherlands. In Eur J Cancer, Feb 2016
Future directions include dual insulin receptor/IGF-1R blockade with linsitinib as well as chemotherapy-PARP combinations.
Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?
de Baaij et al., Nijmegen, Netherlands. In Diabetes, Jan 2016
Moreover, insulin receptor autophosphorylation is dependent on intracellular Mg(2+) concentrations, making Mg(2+) a direct factor in the development of insulin resistance.
From infancy to aging: Biological and behavioral modifiers of Fetuin-A.
Teran-Garcia et al., Urbana, United States. In Biochimie, Jan 2016
UNASSIGNED: Fetuin-A is a multifunctional protein which inhibits ectopic calcification and insulin receptor phosphorylation.
Enhanced survival of Drosophila Akt1 hypomorphs during amino-acid starvation requires foxo.
Staveley et al., St. John's, Canada. In Genome, Dec 2015
The conserved insulin receptor signalling pathway acts to regulate energy balance and nutrient intake, and its central component Akt1 and endpoint effector foxo are pivotal for survival during nutritional stress.
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.
Parsons et al., New York City, United States. In Cancer Cell, Jul 2015
Interestingly, BET inhibitors lowered PI3K signaling and dissociated BRD4 from chromatin at regulatory regions of insulin receptor and EGFR family RTKs to reduce their expression.
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study.
Hammer et al., Würzburg, Germany. In Lancet Oncol, Apr 2015
Linsitinib (OSI-906) is a potent, oral small molecule inhibitor of both IGF-1R and the insulin receptor, which has shown acceptable tolerability and preliminary evidence of anti-tumour activity.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
Zou et al., Oklahoma City, United States. In Nat Med, Apr 2015
Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia.
Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome.
Tomlinson et al., Birmingham, United Kingdom. In Lancet, Mar 2015
Women with insulin receptor (INSR) mutations develop severe hyperandrogenism secondary to hyperinsulinaemia.
The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy.
Manzella et al., Catania, Italy. In Front Oncol, 2014
Indeed, several components of this signaling network, including insulin, IGF-1, IGF-2, the IGF-binding proteins, the insulin receptor (IR), the IGF-1 receptor (IGF-1R), and IR substrate proteins 1 and 2 contribute to the transformation of normal colon epithelial cells.
Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain.
Bateman et al., London, United Kingdom. In Development, 2012
Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain
Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila.
Riesgo-Escovar et al., Querétaro, Mexico. In Plos One, 2010
The phospholipase C-gamma (PLC-gamma) encoded by small wing (sl) acts as such a link between growth and patterning/differentiation by modulating some MAPK outputs once activated by the insulin pathway.
A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting.
Tatar et al., Providence, United States. In Plos One, 2009
IRES mediated translation of dFoxO and dInR may be essential to ensure function and sensitivity of the insulin signaling pathway during fasting.
Positive selection has driven the evolution of the Drosophila insulin-like receptor (InR) at different timescales.
Aguadé et al., Barcelona, Spain. In Mol Biol Evol, 2009
In Drosophila melanogaster the level and pattern of variation at the 8-kb region of InR surveyed did not provide any indication of a recent selective event in this region.
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.
Ruohola-Baker et al., Seattle, United States. In Development, 2009
Dcr-1 and Dap are required for nutrition-dependent cell cycle regulation in germline stem cells (GSCs) and reduction of dap partially rescues the cell cycle defect of Insulin receptor-deficient GSCs
More papers using InR antibodies
The role of hepatic nuclear factor 1a and PDX-1 in transcriptional regulation of the pdx-1 gene
Brunetti Antonio et al., In Scientific Reports, 2000
... Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels ...
Gene Expression Omnibus
Golub Todd R et al., In Genome Biology, 1998
... (Thr202/Tyr204), MEK1/2, phospho-MEK1/2 (Ser217/221), PDGF-BB, phospho-PDGFRβ (Tyr751), phospho-EGFR (Tyr1068), cKIT, Phospho-cKIT (Tyr719), IGF-IαR, and Phospho-IGF-IR (Tyr1131)/insulin receptor (Tyr1146) antibodies were obtained from Cell Signaling.
Cryosputtering - a combined freeze-drying and sputtering method for high-resolution electron microscopy.
Cao Yihai, In PLoS ONE, 1990
... Anti-insulin receptor β-chain rabbit polyclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Antioxidant action of natural health products and Chinese herbs
Sato Yuzo et al., In Evidence-based Complementary and Alternative Medicine, 1985
... Anti-insulin receptor (IR)-β, anti-insulin receptor substrate (IRS)-1 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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