SerpinB1 Promotes Pancreatic β Cell Proliferation.
Boston, United States. In Cell Metab, Feb 2016
We previously reported that the liver is a source for such factors in the liver insulin receptor knockout (LIRKO) mouse, an insulin resistance model that manifests islet hyperplasia.
Diabetic Cardiomyopathy: Role of the E3 Ubiquitin Ligase.
Jilin, China. In Am J Physiol Endocrinol Metab, Feb 2016
In addition, the E3s degrade both insulin receptor and insulin receptor substrates and also regulate insulin gene transcription, leading to insulin resistance and insulin deficiency.
Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?
Nijmegen, Netherlands. In Diabetes, Jan 2016
Moreover, insulin receptor autophosphorylation is dependent on intracellular Mg(2+) concentrations, making Mg(2+) a direct factor in the development of insulin resistance.
The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy.
More papers using
Catania, Italy. In Front Oncol, 2014
Indeed, several components of this signaling network, including insulin, IGF-1, IGF-2, the IGF-binding proteins, the insulin receptor (IR), the IGF-1 receptor (IGF-1R), and IR substrate proteins 1 and 2 contribute to the transformation of normal colon epithelial cells.
Gene Expression Omnibus
In Genome Biology, 1998
... (Thr202/Tyr204), MEK1/2, phospho-MEK1/2 (Ser217/221), PDGF-BB, phospho-PDGFRβ (Tyr751), phospho-EGFR (Tyr1068), cKIT, Phospho-cKIT (Tyr719), IGF-IαR, and Phospho-IGF-IR (Tyr1131)/insulin receptor (Tyr1146) antibodies were obtained from Cell Signaling.