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Inositol polyphosphate multikinase

inositol polyphosphate multikinase, IPMK, inositol 1,3,4,6-tetrakisphosphate 5-kinase
involved in the synthesis of inositol 1,4,5-trisphosphate and an inositol pyrophosphate [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, Akt, Itpkb, AMPK, p53
Papers on inositol polyphosphate multikinase
Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.
New
York et al., Nashville, United States. In Proc Natl Acad Sci U S A, Jan 2016
Inositol phosphate kinase 2 (Ipk2), also known as IP multikinase IPMK, is an evolutionarily conserved protein that initiates production of inositol phosphate intracellular messengers (IPs), which are critical for regulating nuclear and cytoplasmic processes.
IPMK: A versatile regulator of nuclear signaling events.
Review
New
Kim et al., Taejŏn, South Korea. In Adv Biol Regul, Jan 2016
Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually yield water-soluble inositol polyphosphates (e.g., IP4 and IP5) and lipid-bound phosphatidylinositol 3,4,5-trisphosphate.
Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase.
New
Snyder et al., Taejŏn, South Korea. In Proc Natl Acad Sci U S A, Sep 2015
Inositol polyphosphate multikinase (IPMK) is an enzyme that displays soluble inositol phosphate kinase activity, lipid kinase activity, and various noncatalytic interactions.
A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase.
New
Wank et al., Bethesda, United States. In Gastroenterology, Jul 2015
Linkage analysis and whole-exome sequencing identified a germline 4-bp deletion in the gene inositol polyphosphate multikinase (IPMK), which truncates the protein.
Cooked common beans (Phaseolus vulgaris L.) modulate renal genes in streptozotocin-induced diabetic rats.
New
Reynoso-Camacho et al., Querétaro, Mexico. In J Nutr Biochem, Jul 2015
Regarding the gene expression of kidneys evaluated using expressed sequence tag, consumption of cooked beans improved the expression of Glu1, Cps1, Ipmk, Cacna1c, Camk1, Pdhb, Ptbp3 and Pim1, which are related to the elimination of ammonium groups, the regulation of inflammatory and oxidative response, as well as cell signaling and apoptosis.
Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells.
New
Erneux et al., Brussels, Belgium. In Febs J, Jul 2015
Four inositol phosphate kinases catalyze phosphorylation of the second messenger inositol 1,4,5-trisphosphate [Ins(1,4,5)P3 ] to inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4 ]: these enzymes comprise three isoenzymes of inositol 1,4,5-trisphosphate 3-kinase (Itpk), referred to as Itpka, Itpkb and Itpkc, and the inositol polyphosphate multikinase (IPMK).
Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase.
Nalaskowski et al., Hamburg, Germany. In Biochimie, 2014
Human inositol phosphate multikinase (IPMK) is a nucleocytoplasmic shuttling protein involved in multiple signal transduction pathways located both in the nucleus and in the cytoplasm.
Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action.
Kim et al., Philadelphia, United States. In Mol Endocrinol, 2014
Recently, we have shown that inositol polyphosphate multikinase (IPMK) plays an important role in cellular energy metabolism and glucose-mediated AMPK regulation.
High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice.
Kim et al., Philadelphia, United States. In Neurobiol Dis, 2014
Importantly, we found that expression of brain IPMK, which is necessary for mTOR/Akt signaling, remained decreased in HFD mice upon activation of AMPK.
Inositol phosphates induce DAPI fluorescence shift.
Saiardi et al., London, United Kingdom. In Biochem J, 2014
We have employed this newly discovered feature of DAPI to study the enzymatic activity of the inositol polyphosphate multikinase and to monitor phytase phosphatase reactions.
Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes.
Review
Blind, San Francisco, United States. In Adv Biol Regul, 2014
This property is important since lipids bound to SF-1 are modified by lipid signaling enzymes (IPMK & PTEN), regulating SF-1 biological activity in gene expression.
Inositol polyphosphate multikinase signaling in the regulation of metabolism.
Review
Kim et al., Taejŏn, South Korea. In Ann N Y Acad Sci, 2012
Inositol polyphosphate multikinase (IPMK) generates inositol tetrakis- and pentakisphosphates (IP₄ and IP₅), acting as a key enzyme for inositol polyphosphate biosynthesis.
Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.
GeneRIF
Ingraham et al., San Francisco, United States. In Sci Signal, 2012
Data show that inositol polyphosphate multikinase (IPMK) interacts with the nuclear receptor steroidogenic factor 1 (SF-1) and phosphorylates its bound ligand Phosphatidylinositol 4,5-bisphosphate (PIP).
Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase.
Review
Kim et al., Baltimore, United States. In Biochem Biophys Res Commun, 2012
Recent evidence shows that inositol polyphosphate multikinase (IPMK), which possesses both inositol phosphate kinase and lipid inositol kinase activities, can physiologically regulate AMPK signaling in cultured cells and in the arcuate nucleus.
Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.
GeneRIF
Mayr et al., Hamburg, Germany. In Biol Chem, 2012
Phosphorylation of S284 by protein kinase CK2 significantly decreases nuclear targeting of IPMK in HEK-293 cells.
AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase.
GeneRIF
Kim et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2012
IPMK regulates glucose signaling to AMPK in a pathway whereby glucose activates phosphorylation of IPMK at tyrosine 174 enabling the enzyme to bind to AMPK and regulate its activation.
Inositol pyrophosphates as mammalian cell signals.
Review
Snyder et al., Baltimore, United States. In Sci Signal, 2011
More recently, mice with targeted deletion of IP₆K isoforms as well as the related inositol polyphosphate multikinase (IPMK) have substantially enhanced our understanding of inositol polyphosphate physiology.
Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.
Impact
Snyder et al., Baltimore, United States. In Cell Metab, 2011
Here we report that inositol polyphosphate multikinase (IPMK), which possesses both inositol phosphate kinase and lipid kinase activities, regulates amino acid signaling to mTORC1.
Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.
GeneRIF
Resnick et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2011
Data show that in MEFs lacking IPMK, synthesis of IP5 and IP7 is abolished, but IP6 formation is reduced about 90%.
An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production.
GeneRIF
York et al., Durham, United States. In Proc Natl Acad Sci U S A, 2005
Inositol polyphosphate multikinase (Ipk2) plays a major role in the synthesis of inositol polyphosphate messengers derived from inositol 1,4,5-trisphosphate in embryogenesis and normal development.
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