Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs.
Raleigh, United States. In Immunogenetics, Jan 2016
As many immune-mediated diseases in humans share polymorphisms among a common set of genes, we conducted a candidate gene study of 15 of these genes across four immune-mediated diseases (immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, immune-mediated polyarthritis (IMPA), and atopic dermatitis) in 195 affected and 206 unaffected dogs to assess whether causative or predictive polymorphisms might exist in similar genes in dogs.
Molecular actions and clinical pharmacogenetics of lithium therapy.
Baltimore, United States. In Pharmacol Biochem Behav, 2014
Here we discuss preclinical research suggesting mechanisms likely to underlie lithium's therapeutic actions including direct targets inositol monophosphatase and glycogen synthase kinase-3 (GSK-3) among others, as well as indirect actions including modulation of neurotrophic and neurotransmitter systems and circadian function.
The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche.
Los Angeles, United States. In Nature, 2012
IGF-II messenger RNA binding protein (Imp) counteracts endogenous small interfering RNAs to stabilize upd RNA; but similar to upd, Imp expression decreases in the hub cells of older males, which is due to the targeting of Imp by the heterochronic microRNA let-7; in the absence of Imp, upd mRNA therefore becomes unprotected and susceptible to degradation
Validating GSK3 as an in vivo target of lithium action.
Philadelphia, United States. In Biochem Soc Trans, 2009
However, lithium also inhibits inositol monophosphatase, several structurally related phosphomonoesterases, phosphoglucomutase and the scaffolding function of beta-arrestin-2.
Molecular targets of lithium action.
Philadelphia, United States. In Annu Rev Pharmacol Toxicol, 2000
A number of enzymes have been proposed as potential targets of lithium action, including inositol monophosphatase, a family of structurally related phosphomonoesterases, and the protein kinase glycogen synthase kinase-3.
Recent insights in phosphatidylinositol signaling.
Saint Louis, United States. In Cell, 1990
The recent cDNA cloning of inositol monophosphatase (Diehl et al., 1990), Ins(1,4,5)P3 3-kinase (Choi et al., 1990), and inositol polyphosphate 1-phosphatase (York and Majerus, 1991) should provide tools to define further the cell biology of the phosphatidylinositol signaling pathway.