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Inositol hexakisphosphate kinase 1

inositol hexakisphosphate kinase
mouse homolog catalyzes the phosphorylation of inositol hexaphosphate; may play a role in phosphoinositide-mediated signaling [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Interferon-beta, Akt, CAN, InsP6, p53
Papers on inositol hexakisphosphate kinase
Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation.
New
Takizawa et al., Isehara, Japan. In Mol Neurobiol, Nov 2015
We previously reported that inositol hexakisphosphate kinase type 2 (InsP6K2), which converts inositol hexakisphosphate (InsP6) to InsP7, mediates cell death in mammalian cells.
Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.
Saiardi et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2013
Here, we demonstrate that inositol hexakisphosphate kinase 1 (IP6K1), the enzyme responsible for the synthesis of the high-energy inositol pyrophosphates (IP7), is associated with chromatin and interacts with Jumonji domain containing 2C (JMJD2C), a recently identified histone lysine demethylase.
The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.
Stains et al., Baltimore, United States. In J Bone Miner Res, 2013
Knockdown of expression and/or inhibition of function of phospholipase Cγ1, inositol polyphosphate multikinase, which generates inositol 1,3,4,5-tetrakisphosphate (InsP₄) and InsP₅, and inositol hexakisphosphate kinase 1/2, which generates inositol pyrophosphates, prevented the ability of Cx43 to potentiate FGF2-induced signaling through Runx2.
Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair.
Bhandari et al., Hyderābād, India. In J Biol Chem, 2013
Inositol hexakisphosphate kinase 1 (IP6K1) participates in inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7).
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron.
GeneRIF
Berggren et al., Stockholm, Sweden. In Proc Natl Acad Sci U S A, 2012
InsP6 suppresses excitatory neurotransmission via inhibition of the presynaptic synaptotagmin-1 C2B domain-mediated fusion via an interaction with the synaptotagmin Ca2+-binding sites.
Inositol pyrophosphates as mammalian cell signals.
Review
Snyder et al., Baltimore, United States. In Sci Signal, 2011
Phenotypic alterations in mice lacking inositol hexakisphosphate kinase 1 (IP₆K1) reveal signaling roles for these molecules in insulin homeostasis, obesity, and immunological functions.
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.
Impact
Luo et al., Boston, United States. In Nat Immunol, 2011
Here we demonstrate that disruption of inositol hexakisphosphate kinase 1 (InsP6K1), one of the three mammalian inositol hexakisphosphate kinases (InsP6Ks) that convert inositol hexakisphosphate (InsP6) to InsP7, conferred enhanced phosphatidylinositol-(3,4,5)-trisphosphate (PtdIns(3,4,5)P3)-mediated membrane translocation of the pleckstrin homology domain of the kinase Akt and thus augmented downstream PtdIns(3,4,5)P3 signaling in mouse neutrophils.
Inositol hexakisphosphate kinases induce cell death in Huntington disease.
Takagi et al., Japan. In J Biol Chem, 2011
We have previously reported that inositol hexakisphosphate kinase type 2 (InsP(6)K2), which converts inositol hexakisphosphate to inositol pyrophosphate diphosphoinositol pentakisphosphate, mediates apoptotic cell death via its translocation from the nucleus to the cytoplasm.
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.
Snyder et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2011
Inositol hexakisphosphate kinase-2 (IP6K2), one of the major inositol pyrophosphate synthesizing enzymes, mediates p53-linked apoptotic cell death.
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
Snyder et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2011
Inositol hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death.
Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway.
Wente et al., Nashville, United States. In Proc Natl Acad Sci U S A, 2010
Here, we report a previously uncharacterized cellular function in Hedgehog (Hh) signaling for the IP kinase designated inositol hexakisphosphate kinase-2 (IP6K2) that produces diphosphoryl inositol phosphates (PP-IPs).
Synthesis of InsP7 by the Inositol Hexakisphosphate Kinase 1 (IP6K1).
Saiardi et al., London, United Kingdom. In Methods Mol Biol, 2009
We begin by purifying recombinant mouse inositol hexakisphosphate kinase (IP6K1) from Escherichia coli.
Inositol pyrophosphates modulate hydrogen peroxide signalling.
Saiardi et al., London, United Kingdom. In Biochem J, 2009
Yeast lacking kcs1 [the S. cerevisiae IP6K (inositol hexakisphosphate kinase)] have greatly reduced IP7 (diphosphoinositol pentakisphosphate) and IP8 (bisdiphosphoinositol tetrakisphosphate) levels, and display increased resistance to cell death caused by H2O2, consistent with a sustained activation of DNA repair mechanisms controlled by the Rad53 pathway.
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
Lindner et al., Cleveland, United States. In Oncogene, 2009
Inositol hexakisphosphate kinase 2 (IP6K2), a member of the inositol hexakisphosphate kinase family, functions as a growth suppressive and apoptosis-enhancing kinase during cell stress.
Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.
Mayr et al., Hamburg, Germany. In J Biol Chem, 2009
We have also unequivocally determined that 1/3,5-(PP)2-IP4 is the isomeric structure of the bis-diphosphoinositol tetrakisphosphate that is synthesized by yeasts and mammals, through a collaboration between the inositol hexakisphosphate kinase and VIP/PPIP5K enzymes.
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.
Snyder et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2008
We have created mice with a targeted deletion of IP6K1 in which production of inositol pyrophosphates is markedly diminished.
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