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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inhibitor of growth family, member 4

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bax, CAN, bcl-2, p53, V1a
Papers using ING4 antibodies
Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities
Yang J et al., In Cancer Gene Therapy, 2003
... The polyclonal goat anti-ING4 antibody was purchased from Abcam (Shanghai, China) ...
Papers on ING4
Adenovirus-mediated p53 and ING4 gene co‑transfer elicits synergistic antitumor effects through enhancement of p53 acetylation in breast cancer.
Tao et al., Suzhou, China. In Oncol Rep, Jan 2016
Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably enhancing p53 acetylation and its transcriptional activity.
Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer.
Xie et al., Suzhou, China. In Cancer Gene Ther, Jan 2016
Both inhibitor of growth 4 (ING4) and phosphatase and tensin homolog (PTEN) have been shown to be strong candidate tumor suppressors.
Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.
Jin et al., Hangzhou, China. In Oncotarget, Jan 2016
Here we found that Ras downregulated thymine-DNA glycosylase (TDG), a DNA demethylation enzyme, by inhibiting the interaction of transcription activator ING4 with TDG promoter.
The role of the metastasis suppressor gene KAI1 in melanoma angiogenesis.
Ong et al., Vancouver, Canada. In Pigment Cell Melanoma Res, Nov 2015
Using nude mice in the in vivo study, we showed that KAI1, through the regulation of ING4, inhibited blood vessel formation in matrigel plugs along with the downregulation of IL-6 and VEGF, and the recruitment of CD31-positive cells.
MicroRNA-650 in a copy number-variable region regulates the production of interleukin 6 in human osteosarcoma cells.
Kim et al., Ch'ŏngju, South Korea. In Oncol Lett, Oct 2015
Overexpression of miR-650 decreased the expression of inhibitor of growth family member 4 (ING4) in the MG-63 cells and increased interleukin (IL)6 transcription, as well as IL6 secretion in IL1B-stimulated cells.
Recombinant ING4 suppresses the migration of SW579 thyroid cancer cells via epithelial to mesenchymal transition.
Luo et al., Shenyang, China. In Exp Ther Med, Aug 2015
Inhibitor of growth 4 (ING4) has been identified in various types of carcinoma; however, to the best of our knowledge, no previous studies have investigated the effects of ING4 on thyroid cancer.
ING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivo.
Xu et al., Hefei, China. In Int J Clin Exp Pathol, 2014
Inhibitor of growth 4 (ING4) is a tumor suppressor that can inhibit cell growth and induce apoptosis.
Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.
Wallis et al., College Station, United States. In Plos One, 2014
Adnp2, Epc1, and Ing4).
The emerging role of inhibitor of growth 4 as a tumor suppressor in multiple human cancers.
Chen et al., Nanjing, China. In Cell Physiol Biochem, 2014
Inhibitor of growth 4 (ING4), a member of the conserved ING family, has been identified as an important tumor suppressor since it plays a critical role in the regulation of chromatin modification, cell proliferation, angiogenesis and cell migration.
MiR-761 Promotes Progression and Metastasis of Non-Small Cell Lung Cancer by Targeting ING4 and TIMP2.
Cai et al., Harbin, China. In Cell Physiol Biochem, 2014
Finally, we investigated whether miR-761 promotes proliferation and metastasis in NSCLC cell lines by targeting ING4 (inhibitor of growth family, member 4) and TIMP2 (tissue inhibitor of metalloproteinase 2).
Wnt signaling pathway in non-small cell lung cancer.
Stewart, Ottawa, Canada. In J Natl Cancer Inst, 2014
Downregulation of Wnt inhibitors (eg, by hypermethylation) is common in NSCLC tumor cell lines and resected samples; may be associated with high stage, dedifferentiation, and poor prognosis; and has been reported for AXIN, sFRPs 1-5, WIF-1, Dkk-1, Dkk-3, HDPR1, RUNX3, APC, CDX2, DACT2, TMEM88, Chibby, NKD1, EMX2, ING4, and miR-487b.
ING1 and ING2: multifaceted tumor suppressor genes.
Pedeux et al., Rennes, France. In Cell Mol Life Sci, 2013
Subsequently, four more genes, also characterized as "candidate" tumor suppressor genes, were identified by homology search: ING2, ING3, ING4, and ING5.
Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density.
Zhang et al., Harbin, China. In J Cancer Res Clin Oncol, 2012
Data suggest that ING4 may be a promising target for the treatment for ovarian cancer.
Inhibitor of growth-4 mediates chromatin modification and has a suppressive effect on tumorigenesis and innate immunity.
Koh et al., Cheju, South Korea. In Tumour Biol, 2012
In this review, the different properties of ING4 are discussed, and its activities are correlated with different aspects of cell physiology. [Review]
[Mechanism of ING4 mediated inhibition of the proliferation and migration of human glioma cell line U251].
Lu et al., Zhenjiang, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
Mechanism of ING4 mediated inhibition of the proliferation and migration of human glioma cell line U251.
Downregulated expression of inhibitor of growth 4 (ING4) in advanced colorectal cancers: a non-randomized experimental study.
Jin et al., Harbin, China. In Pathol Oncol Res, 2011
Downregulated expression of inhibitor of growth 4 is associated with colorectal cancers.
Reviewing the current classification of inhibitor of growth family proteins.
Harris et al., Tokyo, Japan. In Cancer Sci, 2009
Additionally, knockdown of ING4 and ING5 by siRNA shows an inhibitory effect on the transition from G(2)/M to G(1) phase and DNA replication, respectively, suggesting that these proteins may play roles during cell proliferation in some context.
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Jain et al., Boston, United States. In Nature, 2004
In mice, xenografts of human glioblastoma U87MG, which has decreased expression of ING4, grow significantly faster and have higher vascular volume fractions than control tumours
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