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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Indoleamine 2,3-dioxygenase 1

Indo, indoleamine 2,3-dioxygenase, IDO
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, HAD, IL-10
Papers using Indo antibodies
To reg or not to reg: that is the question in COPD.
Supplier
Idzko Marco, In PLoS ONE, 2007
... , the following molecules were added after T cell activation: indoleamine-2,3-dioxygenase-1 (IDO) inhibitor (L-1-methyl-tryptophan, L-1MT - Sigma Aldrich) [1 mM]; inhibitor of ...
MicroRNA-binding viral protein interferes with Arabidopsis development
Supplier
Pooggin Mikhail M. et al., In Nucleic Acids Research, 2004
... This work was supported by the Swiss National Science Foundation, the Indo-Swiss Collaboration in Biotechnology, the Swiss Office for Education and Science as part of the EU Gene Silencing in Transgenic Plants Projects, and by ...
Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells
Supplier
Opelz Gerhard et al., In The Journal of Experimental Medicine, 1994
... Finally, the linearized recombinant IDO plasmid was transfected by Effectene Transfection Reagent kit (QIAGEN) into adenovirus packaging cells ...
Papers on Indo
Tolerogenic Effect of Mouse Fibroblasts on Dendritic Cells.
New
Ghahary et al., Vancouver, Canada. In Immunology, Feb 2016
Compared to non-activated DCs, fibroblast-primed DCs had significantly higher expression levels of IL-10 and IDO.
Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-resistant Mycobacterium tuberculosis Isolates.
New
Hsueh et al., Taipei, Taiwan. In Antimicrob Agents Chemother, Feb 2016
The prevalence of mutations at gyrA codons 88-94 and gyrB G512R mutation was higher among fluoroquinolone-susceptible East Asian (Beijing) and Indo-Oceanic strains than Euro-American strains, implying that molecular techniques to detect FQ resistance may be less specific in areas with a high prevalence of East Asian (Beijing) and Indo-Oceanic strains.
Low Major Histocompatibility Complex Class II Variation in the Endangered Indo-Pacific Humpback Dolphin (Sousa chinensis): Inferences About the Role of Balancing Selection.
New
Wu et al., Nehe, China. In J Hered, Feb 2016
Previously, a low level of genetic diversity has been reported among the Indo-Pacific humpback dolphin (Sousa chinensis) in the Pearl River Estuary (PRE) using both mitochondrial marker and microsatellite loci.
Effect of Indoleamine 2,3-Dioxygenase Expressed in HTR-8/SVneo Cells on Decidual NK Cell Cytotoxicity.
New
Qu et al., China. In Am J Reprod Immunol, Feb 2016
PROBLEM: To study the effect of indoleamine 2,3-dioxygenase (IDO) expressed in HTR-8/SVneo cells on NKG2D and NKp46 expression and cytotoxicity of decidual NK (dNK) and peripheral NK (pNK) cells.
L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: focus on cell type differences.
Review
New
Saito et al., Hiroshima, Japan. In Neuropharmacology, Feb 2016
During an inflammatory response, the initial KP metabolic step is primarily regulated by indoleamine 2,3-dioxygenase 1 (IDO1), which produces KYN from TRP.
Evaluation of genetic association of neurodevelopment and neuroimmunological genes with antipsychotic treatment response in schizophrenia in Indian populations.
New
Kukreti et al., Delhi, India. In Mol Genet Genomic Med, Jan 2016
We report genetic associations of antipsychotic response in 742 schizophrenia patients from Indian populations of Indo-European and Dravidian ancestry, segregated by disease severity.
[Research Progress on role of Abnormal Tryptophan Metabolism in Immune Thrombocytopenia].
Review
New
Chu et al., Yantai, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2015
The latest researches showed that the abnormal tryptophan metabolism mediated by indoleamine-2, 3-dioxygenase(IDO) is related with the pathogenesis of ITP.
Propelling Immunotherapy Combinations Into the Clinic.
Review
New
Antonia et al., In Oncology (williston Park), Dec 2015
Strategies that hold promise include dual immune checkpoint blockade, as well as the combination of immune checkpoint blockade with costimulatory receptor agonists, enhancers of innate immunity, inhibition of indoleamine 2,3-dioxygenase, adoptive T-cell transfer/T-cell engineering, therapeutic vaccines, small-molecule inhibitors, and radiation therapy.
Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements.
Review
New
Badawy, Cardiff, United Kingdom. In Neuropharmacology, Dec 2015
Flux is the major determinant of kynurenine metabolite formation and is more effective than induction of hepatic Trp 2,3-dioxygenase (TDO) or extrahepatic indoleamine 2,3-dioxygenase (IDO).
Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production.
New
Impact
Mallat et al., Paris, France. In Cell Metab, Oct 2015
Indoleamine 2,3-dioxygenase 1 (Ido1) is a rate-limiting enzyme that catalizes the degradation of tryptophan along the kynurenine pathway.
Targeting the indoleamine 2,3-dioxygenase pathway in cancer.
Review
Naing et al., South Korea. In J Immunother Cancer, 2014
Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors.
Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
Impact
Puccetti et al., Perugia, Italy. In Nature, 2014
However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1).
Neuroinflammation and comorbidity of pain and depression.
Review
Impact
Dantzer et al., Houston, United States. In Pharmacol Rev, 2013
These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein-coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates neurotropic kynurenine metabolites, increased brain extracellular glutamate, and the switch of GABAergic neurotransmission from inhibition to excitation.
Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection.
GeneRIF
Saito et al., Kyoto, Japan. In Cytokine, 2012
Inhibition of increased IDO activity maybe involved in the antiparasitic mechanism during Toxoplasma gondii (T. gondii) infection in vivo.
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.
GeneRIF
Mao et al., Boston, United States. In J Clin Invest, 2012
Ido1 gene knockout or pharmacological inhibition of hippocampal IDO1 activity attenuated both nociceptive and depressive behavior
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
GeneRIF
Saunders et al., New York City, United States. In Plos One, 2011
IDO-1-deficiency fails to impact on the immune control and the outcome of the infection in the mouse model of tuberculosis.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
GeneRIF
Gorelik et al., Pittsburgh, United States. In Clin Dev Immunol, 2011
role in breast tumor cell proliferation, cell cycle regulation, and antiapoptotic signaling
Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.
GeneRIF
Limwongse et al., Bangkok, Thailand. In Plos Negl Trop Dis, 2011
Activation of IDO1 appeared to be a defensive mechanism downstream of IFN-gamma that limited intracellular expansion of Orientia tsutsugamushi via tryptophan depletion.
Highlights of 10 years of immunology in Nature Reviews Immunology.
Impact
O'Garra et al., New Haven, United States. In Nat Rev Immunol, 2011
Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
Impact
DeMatteo et al., New York City, United States. In Nat Med, 2011
Imatinib therapy activated CD8(+) T cells and induced regulatory T cell (T(reg) cell) apoptosis within the tumor by reducing tumor-cell expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (Ido).
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