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Indoleamine 2,3-dioxygenase 1

Indo, indoleamine 2,3-dioxygenase, IDO
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, IL-10
Papers using Indo antibodies
To reg or not to reg: that is the question in COPD.
Idzko Marco, In PLoS ONE, 2007
... , the following molecules were added after T cell activation: indoleamine-2,3-dioxygenase-1 (IDO) inhibitor (L-1-methyl-tryptophan, L-1MT - Sigma Aldrich) [1 mM]; inhibitor of ...
MicroRNA-binding viral protein interferes with Arabidopsis development
Pooggin Mikhail M. et al., In Nucleic Acids Research, 2004
... This work was supported by the Swiss National Science Foundation, the Indo-Swiss Collaboration in Biotechnology, the Swiss Office for Education and Science as part of the EU Gene Silencing in Transgenic Plants Projects, and by ...
Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells
Opelz Gerhard et al., In The Journal of Experimental Medicine, 1994
... Finally, the linearized recombinant IDO plasmid was transfected by Effectene Transfection Reagent kit (QIAGEN) into adenovirus packaging cells ...
Papers on Indo
Role of indoleamine 2,3-dioxygenase in health and disease.
Thomas et al., Sydney, Australia. In Clin Sci (lond), 01 Nov 2015
IDO1 (indoleamine 2,3-dioxygenase 1) is a member of a unique class of mammalian haem dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino acid, L-Trp (L-tryptophan), along the kynurenine pathway.
Immunosuppressive properties of Wharton's jelly-derived mesenchymal stromal cells in vitro.
Tojo et al., Tokyo, Japan. In Int J Hematol, 31 Aug 2015
These inhibitory effects were reversed in a dose-dependent manner in the presence of 1-methyl-DL-tryptophan, an inhibitor of the soluble factor indoleamine 2, 3-dioxygenase (IDO).
Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production.
Mallat et al., Paris, France. In Cell Metab, 29 Aug 2015
UNASSIGNED: Indoleamine 2,3-dioxygenase 1 (Ido1) is a rate-limiting enzyme that catalizes the degradation of tryptophan along the kynurenine pathway.
Long-term impact of pneumococcal polysaccharide vaccination on nasopharyngeal carriage in children following a reduced dose pneumococcal conjugate vaccine primary series in infancy.
Satzke et al., Australia. In Vaccine, 29 Aug 2015
However, differences were observed between the two main ethnic groups: Fijian children of Indian descent (Indo-Fijian) were less likely to carry S. pneumoniae, H. influenzae and M. catarrhalis, and there was evidence of a higher carriage rate of S. aureus compared with indigenous Fijian (iTaukei) children.
PD-L1 blockade for cancer treatment: MEDI4736.
Shalabi et al., Cambridge, United Kingdom. In Semin Oncol, Jun 2015
In addition, multiple phase I combination studies are ongoing with different agents, including those targeting MEK/BRAF in melanoma, epidermal growth factor receptor, programmed cell death-1, cytotoxic T-lymphocyte antigen-4, OX40, chemokine (C-C motif) receptor 4, and indoleamine 2,3-dioxygenase.
Cancer prevention and therapy through the modulation of the tumor microenvironment.
Felsher et al., Stanford, United States. In Semin Cancer Biol, May 2015
Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted.
The Mechanisms of Human Renal Epithelial Cell Modulation of Autologous Dendritic Cell Phenotype and Function.
Wilkinson et al., Brisbane, Australia. In Plos One, Dec 2014
We demonstrate that PTEC express three inhibitory molecules: (i) cell surface PD-L1 that induces MoDC expression of PD-L1; (ii) intracellular IDO that maintains the expression of MoDC CD14, drives the expression of CD80, PD-L1 and IL-10 by MoDC and inhibits T cell stimulatory capacity; and (iii) soluble HLA-G (sHLA-G) that inhibits HLA-DR and induces IL-10 expression by MoDC.
Immunomodulatory effects mediated by serotonin.
Pavón et al., Mexico. In J Immunol Res, Dec 2014
Three classes of genes regulating 5-HT function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-HT, such as SERT, 5HTR-GPCR, and the 5HT3-ion channels; (b) downstream signaling transduction proteins; and (c) enzymes controlling 5-HT metabolism, such as IDO and MAO, which can generate biologically active catabolites, including melatonin, kynurenines, and kynurenamines.
Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions.
Krueger et al., New York City, United States. In F1000res, Dec 2014
These regulators include: interleukin-10, cytotoxic T lymphocyte-associated 4 (CTLA4), programmed cell death 1 (PD1), programmed cell death 1 ligand 1 (PDL1), programmed cell death 1 ligand 2 (PDL2), and indoleamine 2,3-dioxygenase (IDO1).
H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein.
Gonzalez et al., Gainesville, United States. In Front Microbiol, Dec 2014
L. johnsonii N6.2 by decreasing IDO activity, is able to modify the tryptophan/kynurenine ratio in the host blood with further systemic consequences.
Trial watch: IDO inhibitors in cancer therapy.
Galluzzi et al., Villejuif, France. In Oncoimmunology, Nov 2014
UNASSIGNED: Indoleamine 2,3-dioxigenase 1 (IDO1) is the main enzyme that catalyzes the first, rate-limiting step of the so-called "kynurenine pathway", i.e., the metabolic cascade that converts the essential amino acid L-tryptophan (Trp) into L-kynurenine (Kyn).
Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
Puccetti et al., Perugia, Italy. In Nature, Aug 2014
However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1).
Neuroinflammation and comorbidity of pain and depression.
Dantzer et al., Houston, United States. In Pharmacol Rev, 2013
These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein-coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates neurotropic kynurenine metabolites, increased brain extracellular glutamate, and the switch of GABAergic neurotransmission from inhibition to excitation.
Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection.
Saito et al., Kyoto, Japan. In Cytokine, 2012
Inhibition of increased IDO activity maybe involved in the antiparasitic mechanism during Toxoplasma gondii (T. gondii) infection in vivo.
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.
Mao et al., Boston, United States. In J Clin Invest, 2012
Ido1 gene knockout or pharmacological inhibition of hippocampal IDO1 activity attenuated both nociceptive and depressive behavior
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
Saunders et al., New York City, United States. In Plos One, 2011
IDO-1-deficiency fails to impact on the immune control and the outcome of the infection in the mouse model of tuberculosis.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
Gorelik et al., Pittsburgh, United States. In Clin Dev Immunol, 2011
role in breast tumor cell proliferation, cell cycle regulation, and antiapoptotic signaling
Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.
Limwongse et al., Bangkok, Thailand. In Plos Negl Trop Dis, 2011
Activation of IDO1 appeared to be a defensive mechanism downstream of IFN-gamma that limited intracellular expansion of Orientia tsutsugamushi via tryptophan depletion.
Highlights of 10 years of immunology in Nature Reviews Immunology.
O'Garra et al., New Haven, United States. In Nat Rev Immunol, 2011
Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
DeMatteo et al., New York City, United States. In Nat Med, 2011
Imatinib therapy activated CD8(+) T cells and induced regulatory T cell (T(reg) cell) apoptosis within the tumor by reducing tumor-cell expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (Ido).
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