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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Indoleamine 2,3-dioxygenase 1

Indo, indoleamine 2,3-dioxygenase, IDO
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, HAD, IL-10
Papers using Indo antibodies
To reg or not to reg: that is the question in COPD.
Supplier
Idzko Marco, In PLoS ONE, 2007
... , the following molecules were added after T cell activation: indoleamine-2,3-dioxygenase-1 (IDO) inhibitor (L-1-methyl-tryptophan, L-1MT - Sigma Aldrich) [1 mM]; inhibitor of ...
MicroRNA-binding viral protein interferes with Arabidopsis development
Supplier
Pooggin Mikhail M. et al., In Nucleic Acids Research, 2004
... This work was supported by the Swiss National Science Foundation, the Indo-Swiss Collaboration in Biotechnology, the Swiss Office for Education and Science as part of the EU Gene Silencing in Transgenic Plants Projects, and by ...
Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells
Supplier
Opelz Gerhard et al., In The Journal of Experimental Medicine, 1994
... Finally, the linearized recombinant IDO plasmid was transfected by Effectene Transfection Reagent kit (QIAGEN) into adenovirus packaging cells ...
Papers on Indo
The complete mitochondrial genome of the Japanese fan lobster Ibacus ciliatus (Crustacea, Achelata, Scyllaridae).
New
Min et al., Inch'ŏn, South Korea. In Mitochondrial Dna, 20 Nov 2014
The genus Ibacus (Leach, 1815) (Achelata, Scyllaridae, Ibacinae) consists of eight recognized species to date, all of which occur in the Indo-West Pacific Ocean and are commercially important seafood species.
[Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases].
New
Amano et al., Japan. In Gan To Kagaku Ryoho, 31 Oct 2014
We evaluated the significance of indoleamine 2,3-dioxygenase(IDO)activity in breast cancer patients with local recurrence or distant metastases.
[Indoleamine 2,3-Dioxygenase Activity during Toremifene Therapy for Aromatase Inhibitor-Resistant Metastatic Breast Cancer].
New
Amano et al., Japan. In Gan To Kagaku Ryoho, 31 Oct 2014
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)activity during toremifene(TOR)therapy for aromatase inhibitor(AI) / -resistant metastatic breast cancer.
A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors.
New
Antonia et al., Ames, United States. In Oncotarget, 30 Oct 2014
BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) is an enzyme that tumors use to create a state of immunosuppression.
The importance of cytokines and autoantibodies in depression.
Review
New
Appenzeller et al., Campinas, Brazil. In Autoimmun Rev, 18 Oct 2014
Tumor necrosis factor alpha (TNF-α) may underlie the mechanism of depression by an activation of the hypothalamo-pituitary-adrenocortical (HPA) axis, an activation of neuronal serotonin transporters and the stimulation of the indoleamine 2,3-dioxygenase which leads to tryptophan depletion.
Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
New
Impact
Puccetti et al., Perugia, Italy. In Nature, Aug 2014
However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1).
The tryptophan utilization concept in pregnancy.
Review
New
Badawy, Cardiff, United Kingdom. In Obstet Gynecol Sci, Jul 2014
The decrease in maternal plasma total (free + albumin-bound) tryptophan (Trp) during the third pregnancy trimester is attributed to induction of indoleamine 2,3-dioxygenase (IDO).
Antioxidants, inflammation and cardiovascular disease.
Review
New
Gostner et al., Graz, Austria. In World J Cardiol, Jul 2014
During cellular immune response, interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase (IDO) in monocyte-derived macrophages, fibroblasts, endothelial and epithelial cells.
Neuroinflammation and comorbidity of pain and depression.
Review
New
Impact
Dantzer et al., Houston, United States. In Pharmacol Rev, Dec 2013
These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein-coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates neurotropic kynurenine metabolites, increased brain extracellular glutamate, and the switch of GABAergic neurotransmission from inhibition to excitation.
The role of placental tryptophan catabolism.
Review
New
Stocker et al., Graz, Austria. In Front Immunol, Dec 2013
This review discusses the mechanisms and consequences of degradation of tryptophan (Trp) in the placenta, focusing mainly on the role of indoleamine 2,3-dioxygenase-1 (IDO1), one of three enzymes catalyzing the first step of the kynurenine pathway of Trp degradation.
The aryl hydrocarbon receptor meets immunology: friend or foe? A little of both.
Review
New
Mezrich et al., Madison, United States. In Front Immunol, Dec 2013
Expression of indoleamine 2,3-dioxygenase by dendritic cells causes accumulation of kynurenine and results in subsequent tolerogenic effects including increased regulatory T-cell activity.
Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy.
New
Hanks et al., Durham, United States. In Front Immunol, Dec 2013
The indoleamine 2,3-dioxygenase-1 (IDO) immunoregulatory enzyme is emerging as a key player in tumor-mediated immune tolerance.
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.
GeneRIF
Mao et al., Boston, United States. In J Clin Invest, 2012
Ido1 gene knockout or pharmacological inhibition of hippocampal IDO1 activity attenuated both nociceptive and depressive behavior
Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection.
GeneRIF
Saito et al., Kyoto, Japan. In Cytokine, 2012
Inhibition of increased IDO activity maybe involved in the antiparasitic mechanism during Toxoplasma gondii (T. gondii) infection in vivo.
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
GeneRIF
Saunders et al., New York City, United States. In Plos One, 2011
IDO-1-deficiency fails to impact on the immune control and the outcome of the infection in the mouse model of tuberculosis.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
GeneRIF
Gorelik et al., Pittsburgh, United States. In Clin Dev Immunol, 2011
role in breast tumor cell proliferation, cell cycle regulation, and antiapoptotic signaling
Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.
GeneRIF
Limwongse et al., Bangkok, Thailand. In Plos Negl Trop Dis, 2011
Activation of IDO1 appeared to be a defensive mechanism downstream of IFN-gamma that limited intracellular expansion of Orientia tsutsugamushi via tryptophan depletion.
Highlights of 10 years of immunology in Nature Reviews Immunology.
Impact
O'Garra et al., New Haven, United States. In Nat Rev Immunol, 2011
Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10.
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.
Impact
GeneRIF
Grohmann et al., Perugia, Italy. In Nat Immunol, 2011
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
Impact
DeMatteo et al., New York City, United States. In Nat Med, 2011
Imatinib therapy activated CD8(+) T cells and induced regulatory T cell (T(reg) cell) apoptosis within the tumor by reducing tumor-cell expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (Ido).
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