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Indoleamine 2,3-dioxygenase 1

Indo, indoleamine 2,3-dioxygenase, IDO
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, IL-10
Papers using Indo antibodies
To reg or not to reg: that is the question in COPD.
Idzko Marco, In PLoS ONE, 2007
... , the following molecules were added after T cell activation: indoleamine-2,3-dioxygenase-1 (IDO) inhibitor (L-1-methyl-tryptophan, L-1MT - Sigma Aldrich) [1 mM]; inhibitor of ...
MicroRNA-binding viral protein interferes with Arabidopsis development
Pooggin Mikhail M. et al., In Nucleic Acids Research, 2004
... This work was supported by the Swiss National Science Foundation, the Indo-Swiss Collaboration in Biotechnology, the Swiss Office for Education and Science as part of the EU Gene Silencing in Transgenic Plants Projects, and by ...
Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells
Opelz Gerhard et al., In The Journal of Experimental Medicine, 1994
... Finally, the linearized recombinant IDO plasmid was transfected by Effectene Transfection Reagent kit (QIAGEN) into adenovirus packaging cells ...
Papers on Indo
Smoking worsens multiple sclerosis prognosis: Two different pathways are involved.
Farez et al., Argentina. In J Neuroimmunol, 15 May 2015
Our study provides evidence that indoleamine 2,3-dioxygenase activity is reduced in MS patients who smoke, leading to increased production of IL-6 and IL-13.
Cancer prevention and therapy through the modulation of the tumor microenvironment.
Felsher et al., Stanford, United States. In Semin Cancer Biol, 09 May 2015
Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted.
Ex-Vivo Induced Regulatory Human/Murine Mesenchymal Stem Cells as Immune Modulators.
Or et al., Jerusalem, Israel. In Stem Cells, 07 May 2015
We show that pre-treated MSCs acquire an immunomodulatory phenotype, have improved regulatory functions, and up-regulate the expression of iNOS, IDO, COX2, HO-1, LIF and PD-L1.
The role of the kynurenine pathway in suicidality in adolescent major depressive disorder.
Gabbay et al., New York City, United States. In Psychiatry Res, 01 May 2015
The KP is initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (TRP) into kynurenine (KYN) en route to neurotoxins.
[Sodium butyrate down-regulates IFN-γ-induced indoleamine 2, 3 dioxygenase and promotes its acetylation and ubiquitination in CNE2 nasopharyngeal carcinoma cells].
Jiang et al., Hengyang, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 30 Apr 2015
Objective To investigate molecular mechanisms of posttranslational regulation of sodium butyrate (NaB) on indoleamine 2, 3-dioxygenase (IDO) expression induced by interferon γ (IFN-γ) in CNE2 nasopharyngeal carcinoma cells.
The good and bad of antioxidant foods - An immunological perspective -
Fuchs et al., Innsbruck, Austria. In Food Chem Toxicol, 16 Mar 2015
In this context, we discuss the immunoregulatory pathway of tryptophan breakdown by enzyme indoleamine 2,3-dioxygenase (IDO), which represents a central regulatory hub for immune, metabolic, and neuroendocrine processes.
Immune checkpoint modulation: Rational design of combination strategies.
Postow et al., New York City, United States. In Pharmacol Ther, Feb 2015
These include: 1) modalities that enhance antigen presentation, such as radiation, cryotherapy, chemotherapy, targeted agents, vaccines, toll-like receptor (TLR) agonists, type I interferon, and oncolytic viruses; 2) additional agents aiming to reverse T cell dysfunction, such as other immune checkpoint inhibitors; and 3) agents targeting other immune inhibitory mechanisms, such as inhibitors of indoleamine dioxygenase (IDO), regulatory T cells, and myeloid-derived suppressor cells (MDSC).
[The study of human pregnancy specific β1-glycoprotein immunomodulating effects].
In Fiziol Cheloveka, Jan 2015
Effect of human Pregnancy specific β1-glycoprotein (PSG) in physiological concentrations was analyzed against the expression of natural killer (NK)-, T-cells with natural killer functions (N KT-) and T-regulatory lymphocyte (Treg) markers, as well as on the activity of monocyte indolamine-2,3-dioxygenase (IDO) and lymphocyte apoptosis in vitro.
HIV and the Gut Microbiota, Partners in Crime: Breaking the Vicious Cycle to Unearth New Therapeutic Targets.
Routy et al., Montréal, Canada. In J Immunol Res, Dec 2014
Microbial translocation and their downstream effects such as increased indolamine 2,3-dioxygenase (IDO) enzyme expression and activity create a self-sustaining feedback loop which enhances HIV disease progression and constitute a vicious cycle of inflammation and immune activation combining viral and bacterial factors.
Tryptophan-degrading enzymes in tumoral immune resistance.
Van den Eynde et al., Brussels, Belgium. In Front Immunol, Dec 2014
Two enzymes, tryptophan-2,3-dioxygenase and indoleamine 2,3-dioxygenase 1, control tryptophan degradation through the kynurenine pathway.
Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
Puccetti et al., Perugia, Italy. In Nature, Aug 2014
However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1).
Neuroinflammation and comorbidity of pain and depression.
Dantzer et al., Houston, United States. In Pharmacol Rev, 2013
These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein-coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates neurotropic kynurenine metabolites, increased brain extracellular glutamate, and the switch of GABAergic neurotransmission from inhibition to excitation.
Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection.
Saito et al., Kyoto, Japan. In Cytokine, 2012
Inhibition of increased IDO activity maybe involved in the antiparasitic mechanism during Toxoplasma gondii (T. gondii) infection in vivo.
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.
Mao et al., Boston, United States. In J Clin Invest, 2012
Ido1 gene knockout or pharmacological inhibition of hippocampal IDO1 activity attenuated both nociceptive and depressive behavior
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
Saunders et al., New York City, United States. In Plos One, 2011
IDO-1-deficiency fails to impact on the immune control and the outcome of the infection in the mouse model of tuberculosis.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
Gorelik et al., Pittsburgh, United States. In Clin Dev Immunol, 2011
role in breast tumor cell proliferation, cell cycle regulation, and antiapoptotic signaling
Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.
Limwongse et al., Bangkok, Thailand. In Plos Negl Trop Dis, 2011
Activation of IDO1 appeared to be a defensive mechanism downstream of IFN-gamma that limited intracellular expansion of Orientia tsutsugamushi via tryptophan depletion.
Highlights of 10 years of immunology in Nature Reviews Immunology.
O'Garra et al., New Haven, United States. In Nat Rev Immunol, 2011
Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10.
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.
Grohmann et al., Perugia, Italy. In Nat Immunol, 2011
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
DeMatteo et al., New York City, United States. In Nat Med, 2011
Imatinib therapy activated CD8(+) T cells and induced regulatory T cell (T(reg) cell) apoptosis within the tumor by reducing tumor-cell expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (Ido).
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