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Indoleamine 2,3-dioxygenase 1

Indo, indoleamine 2,3-dioxygenase, IDO
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, HAD, IL-10
Papers using Indo antibodies
To reg or not to reg: that is the question in COPD.
Idzko Marco, In PLoS ONE, 2007
... , the following molecules were added after T cell activation: indoleamine-2,3-dioxygenase-1 (IDO) inhibitor (L-1-methyl-tryptophan, L-1MT - Sigma Aldrich) [1 mM]; inhibitor of ...
MicroRNA-binding viral protein interferes with Arabidopsis development
Pooggin Mikhail M. et al., In Nucleic Acids Research, 2004
... This work was supported by the Swiss National Science Foundation, the Indo-Swiss Collaboration in Biotechnology, the Swiss Office for Education and Science as part of the EU Gene Silencing in Transgenic Plants Projects, and by ...
Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells
Opelz Gerhard et al., In The Journal of Experimental Medicine, 1994
... Finally, the linearized recombinant IDO plasmid was transfected by Effectene Transfection Reagent kit (QIAGEN) into adenovirus packaging cells ...
Papers on Indo
A modified HPLC method improves the simultaneous determination of plasma kynurenine and tryptophan concentrations in patients following maintenance hemodialysis.
Shi et al., Guangzhou, China. In Exp Ther Med, 30 Apr 2014
UNLABELLED: The ratio between plasma kynurenine (Kyn) and tryptophan (Trp) serves as a marker of indoleamine 2,3-dioxygenase, a critical immunomodulatory molecule.
Unravelling the distinct strains of Tharu ancestry.
Thangaraj et al., Tartu, Estonia. In Eur J Hum Genet, 26 Apr 2014
Several Tharu groups speak a variety of Indo-Aryan languages, but have traditionally been described by ethnographers as representing East Asian phenotype.
Activation of the Kynurenine Pathway in the Acute Phase of Stroke and its Role in Fatigue and Depression Following Stroke.
Sandvik et al., Drammen, Norway. In J Mol Neurosci, 25 Apr 2014
These findings together with those of previous studies suggest that the immune response and indoleamine 2,3-dioxygenase activation that follows AIS can predict PSF but not PSD.
Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy.
Amant et al., Leuven, Belgium. In Cancer Immunol Immunother, 22 Apr 2014
In an attempt to shed more light on the immunosuppressive environment in uterine tumors, we analyzed the presence of PD-L1, PD-L2, B7-H4, indoleamine 2,3-dioxygenase (IDO), galectin-1, galectin-3, arginase-1 activity and myeloid-derived suppressor cell (MDSC) infiltration.
Neuroinflammation and comorbidity of pain and depression.
Dantzer et al., Houston, United States. In Pharmacol Rev, Jan 2014
These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein-coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates neurotropic kynurenine metabolites, increased brain extracellular glutamate, and the switch of GABAergic neurotransmission from inhibition to excitation.
Human Bone Marrow- and Adipose Tissue-derived Mesenchymal Stromal Cells are Immunosuppressive In vitro and in a Humanized Allograft Rejection Model.
Reinders et al., Rotterdam, Netherlands. In J Stem Cell Res Ther, Dec 2013
RESULTS: BM-MSC and ASC expressed TGFβ, CXCL-10 and IDO.
The role of placental indoleamine 2,3-dioxygenase in human pregnancy.
Kudo, Hiroshima, Japan. In Obstet Gynecol Sci, Jul 2013
For the first time they showed that in the mammal the fetus does survive an immune attack mounted by the mother, and that the mechanism responsible for the survival depends on the fetus and placenta 'actively' defending itself from attack by maternal T cells by means of an enzyme indoleamine 2,3-dioxygenase (EC dependent localised depletion of L-tryptophan.
Population genetic structure of malaria vector Anopheles stephensi Liston (Diptera: Culicidae).
Sharma et al., Rohtak, India. In Indian J Exp Biol, Apr 2013
Anopheles stephensi Liston is urban vector of malaria in Indo-Pakistan subcontinent.
Dendritic Cell Vaccination, Immune Regulation, and Clinical Outcomes in Ovarian Cancer.
Cannon et al., Little Rock, United States. In Front Immunol, 2012
Mechanisms of immune suppression include infiltration by regulatory T cells (Treg) and myeloid suppressor cell populations, expression of co-inhibitory receptors, and expression of indoleamine 2,3-dioxygenase (IDO).
The Control of the Specificity of CD4 T Cell Responses: Thresholds, Breakpoints, and Ceilings.
Tung et al., Rochester, United States. In Front Immunol, 2012
In the last decade, our laboratory has evaluated the mechanisms that underlie the preferential specificity of CD4 T cells and have discovered that both intracellular events within antigen presenting cells, particular selective DM editing, and intercellular regulatory pathways, involving IFN-γ, indoleamine 2,3-dioxygenase, and regulatory T cells, play a role in selecting the final peptide specificity of CD4 T cells.
Immunomodulatory properties of cacao extracts - potential consequences for medical applications.
Gostner et al., Innsbruck, Austria. In Front Pharmacol, 2012
The pro-inflammatory cytokine interferon-γ (IFN-γ) and related biochemical pathways like tryptophan breakdown by indoleamine 2,3-dioxygenase (IDO) and neopterin formation are deeply involved in their pathogenesis.
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.
Mao et al., Boston, United States. In J Clin Invest, 2012
Ido1 gene knockout or pharmacological inhibition of hippocampal IDO1 activity attenuated both nociceptive and depressive behavior
Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection.
Saito et al., Kyoto, Japan. In Cytokine, 2012
Inhibition of increased IDO activity maybe involved in the antiparasitic mechanism during Toxoplasma gondii (T. gondii) infection in vivo.
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
Saunders et al., New York City, United States. In Plos One, 2011
IDO-1-deficiency fails to impact on the immune control and the outcome of the infection in the mouse model of tuberculosis.
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.
Gorelik et al., Pittsburgh, United States. In Clin Dev Immunol, 2011
role in breast tumor cell proliferation, cell cycle regulation, and antiapoptotic signaling
Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.
Limwongse et al., Bangkok, Thailand. In Plos Negl Trop Dis, 2011
Activation of IDO1 appeared to be a defensive mechanism downstream of IFN-gamma that limited intracellular expansion of Orientia tsutsugamushi via tryptophan depletion.
Highlights of 10 years of immunology in Nature Reviews Immunology.
O'Garra et al., New Haven, United States. In Nat Rev Immunol, 2011
Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10.
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.
DeMatteo et al., New York City, United States. In Nat Med, 2011
Imatinib therapy activated CD8(+) T cells and induced regulatory T cell (T(reg) cell) apoptosis within the tumor by reducing tumor-cell expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (Ido).
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.
Grohmann et al., Perugia, Italy. In Nat Immunol, 2011
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.
Munn et al., Augusta, United States. In Immunity, 2011
In hosts with established tumors, Treg cell reprogramming was suppressed by tumor-induced indoleamine 2,3-dioxygenase (IDO) and vaccination failed because of lack of help.
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