Two Birds with One Stone: Dual p110δ and p110γ Inhibition.
Cambridge, United Kingdom. In Chem Biol, 21 Dec 2013
In this issue of Chemistry & Biology, Winkler and colleagues describe the discovery and preclinical development of IPI-145, a new inhibitor of the phosphoinositide 3-kinase (PI3K) isoforms p110δ and p110γ that have entered clinical trials.
Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions.
Houston, United States. In Cancer Treat Rev, Jun 2013
HSP90 inhibitors include geldanamycin and its derivatives (i.e., tanespimycin, alvespimycin, IPI-504), synthetic and small molecule inhibitors (i.e., AUY922, AT13387, STA9090, MPC3100), other inhibitors of HSP90 and its isoforms (i.e., shepherdin and 5'-N-ethylcarboxamideadenosine).