NF-kB Essential MOdulator (NEMO) Is Critical for Thyroid Function.
Italy. In J Biol Chem, Feb 2016
UNASSIGNED: The I-kB kinase (IKK) subunit NEMO/IKKg; (NEMO) is an adapter molecule that is critical for canonical activation of NF-kB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis and apoptosis.
Molecular Pathways: Fatty Acid Synthase.
Nashville, United States. In Clin Cancer Res, Jan 2016
A new generation of molecules, including GSK2194069, JNJ-54302833, IPI-9119, and TVB-2640, are in development, but only TVB-2640 has moved into the clinic.
Mosaic Neurocutaneous Disorders and Their Causes.
Catania, Italy. In Semin Pediatr Neurol, Dec 2015
In this article we will focus on the well known, and less defined mosaic neurocutaneous phenotypes and their related molecular/genetic bases, including the mosaic neurofibromatoses and their related forms (ie, spinal neurofibromatosis and schwannomatosis); Legius syndrome; segmental arrangements in tuberous sclerosis; Sturge-Weber and Klippel-Trenaunay syndromes; microcephaly/megalencephaly-capillary malformation; blue rubber bleb nevus syndrome; Wyburn-Mason syndrome; mixed vascular nevus syndrome; PHACE syndrome; Incontinentia pigmenti; pigmentary mosaicism of the Ito type; neurocutaneous melanosis; cutis tricolor; speckled lentiginous syndrome; epidermal nevus syndromes; Becker's nevus syndrome; phacomatosis pigmentovascularis and pigmentokeratotica; Proteus syndrome; and encephalocraniocutaneous lipomatosis.
Novel Therapies for Chronic Lymphocytic Leukemia: A Canadian Perspective.
Calgary, Canada. In Clin Lymphoma Myeloma Leuk, Nov 2015
Two groups of novel therapeutic agents-anti-CD20 monoclonal antibodies and small molecule inhibitors-are attempting to address these issues, and 5 of these agents have progressed to phase 3 trials: obinutuzumab, idelalisib, ibrutinib, venetoclax (ABT-199), and duvelisib (IPI-145).