Molecular Pathways: Fatty Acid Synthase.
United States. In Clin Cancer Res, 30 Nov 2015
A new generation of molecules including GSK 2194069, JNJ-54302833, IPI-9119, and TVB-2640 are in development, but only TVB-2640 has moved into the clinic.
Treatment approach to newly diagnosed diffuse large B-cell lymphoma.
Lyon, France. In Semin Hematol, Apr 2015
High prognostic heterogeneity is observed among patients with DLBCL with long-term survival ranging from 30% to more than 90% according to clinic-biological prognostics such as the International Prognostic Index (IPI) and its subsequent revised variants.
Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells.
Jacksonville, United States. In Clin Cancer Res, Mar 2015
However, to date, Hh inhibitors, specifically those targeting Smoothened [such as vismodegib, BMS-833923, saridegib (IPI-926), sonidegib/erismodegib (LDE225), PF-04449913, LY2940680, LEQ 506, and TAK-441], have demonstrated good efficacy as monotherapy in patients with basal cell carcinoma and medulloblastoma, but have shown limited activity in other tumor types.