GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Incontinentia Pigmenti, NEMO, IPI, IKKgamma, IP2
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011] (from
NCBI)
Sponsored links
Papers using
Incontinentia Pigmenti
antibodies
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
Supplier
In PLoS ONE, 2008
... The Refseq ids were converted to IPI ids using an online server ...
Control of canonical NF-κB activation through the NIK-IKK complex pathway
Supplier
In Oncogene, 2007
... Anti-RET, IKKα, p50, NIK, TRAF3, TRAF2, RelB, and NEMO were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on
Incontinentia Pigmenti
Validation of the Omron HEM-7201 upper arm blood pressure monitor, for self-measurement in a high-altitude environment, according to the European Society of Hypertension International Protocol revision 2010.
New
Beijing, China. In J Hum Hypertens, 07 Apr 2013
The Omron HEM-7201 upper arm blood pressure monitor was tested for accuracy in Lhasa, Tibet, China (3650 m above sea level) according to the European Society of Hypertension International Protocol revision 2010 (ESH-IP2).
The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO.
New
München, Germany. In Mol Cell, 07 Apr 2013
Under cellular stress, parkin is recruited to the linear ubiquitin assembly complex and increases linear ubiquitination of NF-κB essential modulator (NEMO), which is essential for canonical NF-κB signaling.
Analysis of FOXO1 mutations in diffuse large B-cell lymphoma.
New
Vancouver, Canada. In Blood, 04 Apr 2013
This association was particularly evident (P = 0.003) in patients in the low-risk R-IPI categories.
The Glasgow Prognostic Score (GPS) as a novel and significant predictor of extranodal natural killer/T-cell lymphoma, nasal type.
New
Guangzhou, China. In Am J Hematol, 20 Mar 2013
The prognostic value of GPS was evaluated and compared to that of International Prognostic Index (IPI), Prognostic Index for Peripheral T-cell lymphoma unspecified (PIT), and Korean Prognostic Index (KPI).
Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation.
New
Burjassot, Spain. In Dev Biol, 18 Mar 2013
One of them is nemo (nmo), which encodes a MAP-like protein kinase that regulates the rate of rotation throughout the entire process, and serves as a link between core planar cell polarity (PCP) factors and the E-cadherin-β-catenin complex.
Linear ubiquitination: a novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex.
Review
New
Maebashi, Japan. In Endocr J, Oct 2012
We determined that LUBAC (linear ubiquitin chain assembly complex), composed of SHARPIN, HOIL-IL and HOIP, generates a novel type of Met1-linked linear polyubiquitin chain and specifically regulates the canonical NF-κB pathway via the linear ubiquitination of NEMO and RIP1.
Anaplastic large cell lymphoma, ALK-positive.
Review
New
Milano, Italy. In Crit Rev Oncol Hematol, Aug 2012
Near 40% of patients are low risk according to the International Prognostic Index (IPI).
Diagnosis and treatment in anhidrotic ectodermal dysplasia with immunodeficiency.
Review
New
Kyoto, Japan. In Allergol Int, Jun 2012
Two genes responsible for EDA-ID have been identified: nuclear factor-κB (NF-κB) essential modulator (NEMO) for X-linked EDA-ID (XL-EDA-ID) and IκBα for autosomal-dominant EDA-ID (AD-EDA-ID).
Neurological findings in incontinentia pigmenti; a review.
Review
New
Rotterdam, Netherlands. In Eur J Med Genet, May 2012
Incontinentia Pigmenti is a rare X-linked multisystem disorder with well described and pathognomonic skin manifestations.
DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.
Review
New
Madison, United States. In Immunol Rev, Mar 2012
Post-translational modification of NF-κB essential modulator (NEMO) plays a central role in linking the cellular DNA damage response to NF-κB via the ataxia telangiectasia mutated (ATM) kinase.
Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO.
GeneRIF
France. In Biochem Pharmacol, 2011
This study identified a new NEMO peptide inhibitor, termed UBI (ubiquitin binding inhibitor) that derives from the NOA/NUB/UBAN ubiquitin binding site located in the CC2-LZ domain of NEMO.
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.
Impact
Köln, Germany. In Nature, 2011
Epithelial-specific inhibition of CYLD, a deubiquitinase that regulates cellular necrosis, prevented colitis development in FADD(IEC-KO) but not in NEMO(IEC-KO) mice, showing that different mechanisms mediated death of colonic epithelial cells in these two models.
LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.
GeneRIF
Memphis, United States. In Embo J, 2011
The authors show that NEMO linear ubiquitination on K285/309 is critical for genotoxic NF-kappaB activation.
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
Impact
Boston, United States. In Cancer Cell, 2011
We show that agents that enhance proteotoxic stress, including the HSP90 inhibitor IPI-504, induce tumor regression in aggressive mouse models, but only when combined with rapamycin.
NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.
GeneRIF
New York City, United States. In J Allergy Clin Immunol, 2011
Herpes simplex encephalitis may occur in patients carrying NF-kappaB essential modulator mutations, due to the impairment of NF-kappaB- and interferon regulatory factor 3-dependent-TLR3-mediated antiviral IFN production.
Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.
GeneRIF
Philadelphia, United States. In Mol Cell Biol, 2011
tumor necrosis factor alpha-induced necroptosis requires the adaptor proteins FADD and NEMO.
Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/arfophilin-1 localization in mitotic cells.
GeneRIF
Kyoto, Japan. In Genes Cells, 2011
FIP3 localization to recycling endosomes in interphase and their transport to the intercellular bridge during cytokinesis depend on Rab11.
NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed.
Impact
GeneRIF
United States. In Cell, 2011
Findings identify NEMO as a clock kinase and demonstrate that long-range interactions between functionally distinct phospho-clusters collaborate to set circadian clock speed.
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Impact
Frankfurt am Main, Germany. In Nature, 2011
Coexpression of SHARPIN and HOIP promotes linear ubiquitination of NEMO (also known as IKBKG), an adaptor of the IκB kinases (IKKs) and subsequent activation of NF-κB signalling, whereas SHARPIN deficiency in mice causes an impaired activation of the IKK complex and NF-κB in B cells, macrophages and mouse embryonic fibroblasts (MEFs).
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling.
Impact
GeneRIF
San Francisco, United States. In Cell, 2011
Extensive DNA lesions stimulated 2 sequential NF-kappaB activation phases, requiring ATM and NEMO/IKK-gamma: first TNF-alpha-TNFR1 feedforward signaling, promoting the second phase and driving RIP1 phosphorylation.
