NF-kB Essential MOdulator (NEMO) Is Critical for Thyroid Function.
Italy. In J Biol Chem, Feb 2016
UNASSIGNED: The I-kB kinase (IKK) subunit NEMO/IKKg; (NEMO) is an adapter molecule that is critical for canonical activation of NF-kB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis and apoptosis.
Toll-like receptor signaling in primary immune deficiencies.
New York City, United States. In Ann N Y Acad Sci, Nov 2015
Defects in interleukin-1 receptor-associated kinase-4 and myeloid differentiation factor 88 (MyD88) lead to susceptibility to infections with bacteria, while mutations in nuclear factor-κB essential modulator (NEMO) and other downstream mediators generally induce broader susceptibility to bacteria, viruses, and fungi.